Specific hydrolysis and accumulation of antiproliferative lignans in the fruit of Leuzea carthamoides (Willd.) DC.

Natural Product Research

Volumn 28, Issue 10, 2014, Pages 732-739

  Sólyomváry, Anna ^a   Mervai, Zsolt ^b   Molnár Perl, Ibolya ^a   Boldizsár, Imre ^a  

^a EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Analysis of lignans; Antiproliferative activity; Arctigenin; Carthamogenin; Leuzea; Trachelogenin

Indexed keywords

AGLYCONE; ARCTIGENIN; CARTHAMOGENIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIGNAN; TRACHELOGENIN; UNCLASSIFIED DRUG;

ACHENE; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL PROLIFERATION; COLLISIONALLY ACTIVATED DISSOCIATION; COLON ADENOCARCINOMA; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG HYDROLYSIS; DRUG IDENTIFICATION; EMBRYO; FRUIT; GAS LIQUID CHROMATOGRAPHY; HEPG2 CELL LINE; LEUZEA; LEUZEA CARTHAMOIDES; MASS FRAGMENTOGRAPHY; NONHUMAN; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY;

LEUZEA; LEUZEA CARTHAMOIDES;

ANALYSIS OF LIGNANS; ANTIPROLIFERATIVE ACTIVITY; ARCTIGENIN; CARTHAMOGENIN; LEUZEA; TRACHELOGENIN;

4-BUTYROLACTONE; ANTINEOPLASTIC AGENTS, PHYTOGENIC; DRUG SCREENING ASSAYS, ANTITUMOR; FRUIT; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLYCOSIDES; HUMANS; HUNGARY; HYDROLYSIS; LEUZEA; LIGNANS; MOLECULAR STRUCTURE;

EID: 84900427928     PISSN: 14786419     EISSN: 14786427     Source Type: Journal    
DOI: 10.1080/14786419.2013.879473     Document Type: Article

References (14)

1. Boldizsár I, Füzfai Zs, Molnár-Perl I. 2011. Characteristic fragmentation patterns of trimethylsilyl and trimethylsilyloxime derivatives of plant disaccharides as obtained by gas chromatography coupled to ion-Trap mass spectrometry. J Chromatogr A. 1218:7864-7868
2. Boldizsár I, Füzfai Zs, Molnár-Perl I. 2013. Characterization of the endogenous enzymatic hydrolyses of Petroselinum crispum glycosides: Determined by chromatography upon their sugar and flavonoid products. J Chromatogr A. 1293:100-106
3. Boldizsár I, Füzfai Zs, Tóth F, Sedlák Á Borsodi L, Molnár-Perl I. 2010a. Mass fragmentation study of the trimethylsilyl derivatives of arctiin, matairesinoside, arctigenin, phylligenin, matairesinol, pinoresinol and methylarctigenin: Their gas and liquid chromatographic analysis in plant extracts. J Chromatogr A. 1217:1674-1682
4. Boldizsár I, Kraszni M, Tóth F, Noszál B, Molnár-Perl I. 2010b. Complementary fragmentation pattern analysis by gas chromatography-mass spectrometry and liquid chromatography tandem mass spectrometry confirmed the precious lignan content of Cirsium weeds. J Chromatogr A. 1217:6281-6289
5. Boldizsár I, Kraszni M, Tóth F, Tóth G, Sólyomváry A, Noszál B, Záray Gy, Molnár-Perl I. 2012. The role of harmonized, gas and liquid chromatography mass spectrometry in the discovery of the neolignan balanophonin in the fruit wall of Cirsium vulgare. J Chromatogr A. 1264:143-147
6. Boldizsár I, Szücs Z, Füzfai Zs, Molnár-Perl I. 2006. Identification and quantification of the constituents of madder root by gas chromatography and high-performance liquid chromatography. J Chromatogr A. 1133:259-274
7. Crotti AEM, Fonseca T, Hong H, Staunton J, Galembeck SE, Lopes NP, Gates PJ. 2004. The fragmentation mechanism of five-membered lactones by electrospray ionisation tandem mass spectrometry. Int J Mass Spectrom. 232:271-276
8. Harmatha J, Buděšínský M, Vokáč K, Pavlík M, Grüner K, LaudovÁV. 2007. Lignan glucosides and serotonin phenylpropanoids from the seeds of Leuzea carthamoides. Collect Czechoslov Chem Commun. 72:334-346
9. Kang K, Lee HJ, Kim CY, Lee SB, Tunsag J, Batsuren D, Nho CW. 2007. The chemopreventive effects of Saussurea salicifolia through induction of apoptosis and phase II detoxification enzyme. Biol Pharm Bull. 30:2352-2359
10. Kokoska L, Janovska D. 2009. Chemistry and pharmacology of Rhaponticum carthamoides: A review. Phytochemistry. 70:842-855
11. Sedlák Á Boldizsár I, Borsodi L, Füzfai Zs, Molnár-Perl I, Preininger É Gyurján I. 2008. Identification and quantification of lignans carboxylic acids and sugars in the leaves of Forsythia species and cultivars. Chromatographia. 68:S35-S41
12. Szokol-Borsodi L, Sólyomváry A, Molnár-Perl I, Boldizsár I. 2012. Optimum yields of dibenzylbutyrolactone-Type lignans from Cynareae fruits, during their ripening, germination and enzymatic hydrolysis processes, determined by on-line chromatographic methods. Phytochem Anal. 23:598-603
13. Yoo JH, Lee HJ, Kang K, Jho EH, Kim CY, Baturen D, Tunsag J, Nho CW. 2010. Lignans inhibit cell growth via regulation of Wnt/b-catenin signaling. Food Chem Toxicol. 48:2247-2252
14. Zhu C, Jing L, Yu N, Yang X, Zhao Y. 2013. A new lignan and active compounds inhibiting NF-kB signaling pathway from Caulis Trachelospermi. Acta Pharm Sin B. 3:109-112.