Genetic test to stop smoking (GeTSS) trial protocol: Randomised controlled trial of a genetic test (Respiragene) and Auckland formula to assess lung cancer risk

BMC Pulmonary Medicine

Volumn 14, Issue 1, 2014, Pages

  Nichols, John A A ^a   Grob, Paul ^a   de Lusignan, Simon ^a   Kite, Wendy ^b   Williams, Peter ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b Smokefree Consultancy Ltd   (United Kingdom)

Author keywords

Genetic test; Lung cancer; Smoking cessation

Indexed keywords

ADULT; ARTICLE; CANCER RISK; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC SCREENING; HUMAN; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; POPULATION; PRIMARY MEDICAL CARE; RANDOMIZED CONTROLLED TRIAL; SMOKING; SMOKING CESSATION; AGE; AGED; ATTITUDE TO HEALTH; COMPARATIVE STUDY; GENETICS; LUNG NEOPLASMS; MIDDLE AGED; PREDICTIVE VALUE; PRIMARY HEALTH CARE; PROCEDURES; REFERENCE VALUE; RISK ASSESSMENT; SEX DIFFERENCE; STATISTICS AND NUMERICAL DATA; UNITED KINGDOM; YOUNG ADULT;

ADULT; AGE FACTORS; AGED; ATTITUDE TO HEALTH; FEMALE; GENETIC TESTING; GREAT BRITAIN; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PRIMARY HEALTH CARE; REFERENCE VALUES; RISK ASSESSMENT; SEX FACTORS; SMOKING; SMOKING CESSATION; YOUNG ADULT;

EID: 84900384795     PISSN: None     EISSN: 14712466     Source Type: Journal    
DOI: 10.1186/1471-2466-14-77     Document Type: Article

References (33)

1. Wetterstrand KA, DNA Sequencing Costs Data from the NHGRI Large-Scale Genome Sequencing Program http://en.wikipedia.org/wiki/Personal_genomics#cite_note-18, DNA Sequencing Costs.
2. Smerecnik C, Grispen JEJ, Quaak M. Effectiveness of testing for genetic susceptibility to smoking-related diseases on smoking cessation outcomes: a systematic review and meta-analysis. Tob Control 2012, 21(3):347-354. 10.1136/tc.2011.042739, 21948804.
3. Smith SM, Campbell MC, Macleod U. Factors contributing to the time taken to consult with symptoms of lung cancer: a cross sectional study. Thorax 2009, 64:1953-531.
4. Sanderson SC, O'Neill SC, White DB, Bepler G, Bastian L, Lipkus IM, McBride CM. Responses to online GSTM1 genetic test results among smokers related to patients with lung cancer: a pilot study. Cancer Epidemiol Biomarkers Prev 2009, 18(7):1953-1961. 10.1158/1055-9965.EPI-08-0620, 3417294, 19567511.
5. Young RP, Hopkins R, Black PN, Eddy C, Wu L, Gamble GD, Mills GD, Garrett JE, Eaton TE, Rees MI. Functional variants of antioxidant genes in smokers with COPD and in those with normal lung function. Thorax 2006, 61(5):394-399. 10.1136/thx.2005.048512, 2111196, 16467073.
6. Young RP, Hopkins RJ, Christmas T, Black PN, Metcalf P, Gamble GD. COPD prevalence is increased in lung cancer, independent of age, sex and smoking history. Eur Respir J 2009, 34(2):380-386. 10.1183/09031936.00144208, 19196816.
7. Young RP, Hopkins RJ, Hay BA, Epton MJ, Mills GD, Black PN, Gardner HD, Sullivan R, Gamble GD. Lung cancer susceptibility model based on age, family history and genetic variants. PLoS ONE [Electronic Resource] 2009, 4(4):e5302.
8. Young RP, Hopkins RJ, Hay BA, Gamble GD. GWAS And Candidate SNPs For COPD And Lung Cancer Combine To Identify Lung Cancer Susceptibility: Validation In A Prospective Study. Am J Respir Crit Care Med 2010, 181:A3738.
9. Young RP, Hopkins RJ, Hay BA, Epton MJ, Mills GD, Black PN, Gardner HD, Sullivan R, Gamble GD. A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. Postgrad Med J 2009, 85:515-524. 10.1136/pgmj.2008.077107, 19789190.
10. Young RP, Hopkins RJ, Hay BA, Epton MJ, Black PN, Gamble GD. Lung cancer gene associated with COPD: triple whammy or possible confounding effect?. Eur Respir J 2008, 32(5):1158-1164. 10.1183/09031936.00093908, 18978134.
11. McBride CM, Bepler G, Lipkus IM, Lyna P, Samsa G, Albright J, Datta S, Rimer BK. Incorporating genetic susceptibility feedback into a smoking cessation program for African-American smokers with low income. Cancer Epidemiol Biomarkers Prev 2002, 11(6):521-528.
12. Sanderson SC, Humphries SE, Hubbart C, Hughes E, Jarvis MJ, Wardle J. Psychological and Behavioural Impact of Genetic Testing Smokers for Lung Cancer Risk: A Phase II Exploratory Trial. J Health Psychol 2008, 13:481-494. 10.1177/1359105308088519, 18420756.
13. Wells S, de Lusignan S. Does screening for loss of lung function help smokers give up?. Br J Nurs 2003, 12(12):744-750.
14. Parkes G, Greenhalgh T, Griffin M, Dent R. Effect on smoking quit rate of telling patients their lung age: The Step2quit randomised control trial. BMJ 2008, 336:598-600. 10.1136/bmj.39503.582396.25, 2267989, 18326503.
15. Hopkins RJ, Young RP, Hay B, Gamble GD. Lung cancer risk testing enhances NRT uptake and quit rates in randomly recruited smokers offered a gene based risk test. Am J Respir Crit Care Med 2012, 185:A2590.
16. Hopkins RJ, Young RP, Hay B, Gamble GD. Gene-based lung cancer risk score triggers smoking cessation in randomly recruited smokers. Am J Respir Crit Care Med 2011, 183:A5441.
17. West R, Shiffman S, McLean D. Fast Facts: Smoking Cessation (Fast Facts series) - Paperback 2007, London: Health Press.
18. Young RP, Hopkins RJ, Smith M, Hogarth DK. Smoking cessation: the potential role of risk assessment tools as motivational triggers [Review]. Postgrad Med J 2010, 86(1011):26-33. 10.1136/pgmj.2009.084947, 20065338.
19. Cabebe E. Recruitment details: REACT Clinical Trial Lung Cancer Detection Study. http://www.elcaminohospital.org/Cancer_Center/Clinical_Trials/Lung_Cancer_Detection_Study.
20. McClure JB, Ludman EJ, Grothaus L, Pabiniak C, Richards J. Impact of spirometry feedback and brief motivational counseling on long-term smoking outcomes: a comparison of smokers with and without lung impairment. Patient Education & Counseling 2010, 80(2):280-283. 10.1016/j.pec.2009.11.002, 2897973, 20434863.
21. Sanderson SK, Humphries SE, Hubbart C. Psychological and behavioural impact of genetic testing smokers for lung cancer risk. J Health Psychol 2010, 13(4):481-494.
22. Croghan E. NHS Local stop smoking services, services delivery and monitoring guidance 2011/12. https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/213755/dh_125939.pdf.
23. Barnfather KD, Cope GF, Chapple IL. Effect of incorporating a 10 minute point of care test for salivary nicotine metabolites into a general practice based smoking cessation programme: randomised controlled trial. BMJ 2005, 331:999. 10.1136/bmj.38621.463900.7C, 1273454, 16210250.
24. West R. Smoking toolkit study: protocol and methods. 2006, http://www.smokinginengland.info/sts-documents/ (ST5001).
25. Moher D, Hopewell S, Schulz KF, Montori V, Gotzsche PC, Devereaux PJ, Elbourne D, Egger M, Altman DG. CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. BMJ 2010, 340:c869. 10.1136/bmj.c869, 2844943, 20332511.
26. DH/IPU/Patient Confidentiality Department of Health: Confidentiality - NHS Code of practice. 2003, http://webarchive.nationalarchives.gov.uk/20130107105354/http://www.dh.gov.uk/prod_consum_dh/groups/dh_digitalassets/@dh/@en/documents/digitalasset/dh_4069254.pdf, DH/IPU/Patient Confidentiality.
27. Lee JH, Jones PG, Bybee K, O'Keefe JH. A longer course of varenicline therapy improves smoking cessation rates [Review]. Prev Cardiol 2008, 11(4):210-214. 10.1111/j.1751-7141.2008.00003.x, 19476573.
28. West R, Sohal T. " Catastrophic" pathways to smoking cessation: findings from national survey. BMJ 2006, 332:458-460. 10.1136/bmj.38723.573866.AE, 1382540, 16443610.
29. Kahenda JW, Loomis BR, Anhikara B, Marshall L. A review of economic evaluations of tobacco control programs. Int J Environ Res Public Health 2009, 6(1):51-68. 2672319, 19440269.
30. Sanders D, Fowler G, Mant D, Fuller A, Jones L, Marzillier J. Randomized controlled trial of anti-smoking advice by nurses in general practice. J R Coll Gen Pract 1989, 39(324):273-276. 1711904, 2556540.
31. Wennike P, Danielsson T, Björn B, Westin A, Tøneson P. Smoking reduction promotes smoking cessation: results from a double blind, randomized, placebo-controlled trial of nicotine gum with 2-year follow-up. Addiction 2003, 98(10):1395-1402. 10.1046/j.1360-0443.2003.00489.x, 14519176.
32. MacPherson L, Stipelman BA, Duplinsky M, Lejuez CW. Distress tolerance and pre-smoking treatment attrition: examination of moderating relationships. Addict Behaviour 2008, 33(11):1385-1393.
33. Soulier-Parmeggiani L, Griscom S, Bongard O, Avvanzino R, Bounameaux H. One-year results of a smoking-cessation programme. Journal Suisse de Médecine 1999, 129(10):395-398.