Two-year clinical and radiologic follow-up of early RA patients treated with initial step up monotherapy or initial step down therapy with glucocorticoids, followed by a tight control approach: Lessons from a cohort study in daily practice

Clinical Rheumatology

Volumn 33, Issue 1, 2014, Pages 125-130

  De Cock, D ^a   Vanderschueren, G ^b   Meyfroidt, S ^a   Joly, J ^b   Westhovens, R ^a,b   Verschueren, P ^a,b  

^a SKELETAL BIOLOGY AND ENGINEERING RESEARCH CENTER   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Early RA; Epidemiology; Radiologic outcome; Rapid radiographic progress; Remission; Steroids

Indexed keywords

ADALIMUMAB; AZATHIOPRINE; C REACTIVE PROTEIN; DISEASE MODIFYING ANTIRHEUMATIC DRUG; ETANERCEPT; HYDROXYCHLOROQUINE; INFLIXIMAB; METHOTREXATE; PREDNISOLONE; RITUXIMAB; SALAZOSULFAPYRIDINE;

ADULT; ARTICLE; CLINICAL PRACTICE; COHORT ANALYSIS; DAS28; DISEASE COURSE; DISEASE DURATION; DISEASE SEVERITY; DRUG DOSE REDUCTION; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; FOOT RADIOGRAPHY; HAND RADIOGRAPHY; HUMAN; JOINT SWELLING; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; PRIORITY JOURNAL; RADIOGRAPHY; REMISSION; RHEUMATOID ARTHRITIS; SCORING SYSTEM; TREATMENT DURATION; TREATMENT OUTCOME; UNIVERSITY HOSPITAL;

AGED; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; COHORT STUDIES; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; FOOT; GLUCOCORTICOIDS; HAND; HUMANS; MALE; MIDDLE AGED; QUESTIONNAIRES; REMISSION INDUCTION; SEVERITY OF ILLNESS INDEX; STEROIDS; TIME FACTORS; TREATMENT OUTCOME; X-RAYS;

EID: 84900351852     PISSN: 07703198     EISSN: 14349949     Source Type: Journal    
DOI: 10.1007/s10067-013-2398-9     Document Type: Article

References (15)

1. Boers M, Verhoeven AC, Markusse HM, van de Laar MA, Westhovens R, van Denderen JC et al (1997) Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis. Lancet 350(9074):309-318
2. Calguneri M, Pay S, Caliskaner Z, Apras S, Kiraz S, Ertenli I et al (1999) Combination therapy versus monotherapy for the treatment of patients with rheumatoid arthritis. Clin Exp Rheumatol 17(6):699-704
3. Mottonen T, Hannonen P, Leirisalo-Repo M, Nissila M, Kautiainen H, Korpela M et al (1999) Comparison of combination therapy with single-drug therapy in early rheumatoid arthritis: a randomised trial. FIN-RACo trial group. Lancet 353(9164):1568-1573
4. Goekoop-Ruiterman YP, de Vries-Bouwstra JK, Allaart CF, van Zeben D, Kerstens PJ, Hazes JM et al (2007) Comparison of treatment strategies in early rheumatoid arthritis: a randomized trial. Ann Intern Med 146(6):406-415
5. Verschueren P, Esselens G, Westhovens R (2008) Daily practice effectiveness of a step-down treatment in comparison with a tight step-up for early rheumatoid arthritis. Rheumatology (Oxford) 47(1): 59-64
6. Durnez A, Vanderschueren G, Lateur L,Westhovens R, Verschueren P (2011) Effectiveness of initial treatment allocation based on expert opinion for prevention of rapid radiographic progression in daily practice of an early RA cohort. Ann Rheum Dis 70(4):634-637
7. Verschueren P, Esselens G, Westhovens R (2009) Predictors of remission, normalized physical function, and changes in the working situation during follow-up of patients with early rheumatoid arthritis: an observational study. Scand J Rheumatol 38(3):166-172
8. Boers M, Verhoeven AC, van der Linden S (1997) Combination therapy in early rheumatoid arthritis: the COBRA study. Ned Tijdschr Geneeskd 141(50):2428-2432
9. van der Heijde D (1999) How to read radiographs according to the Sharp/van der Heijde method. J Rheumatol 26(3):743-745
10. Benhamou M, Rincheval N, Roy C, Foltz V, Rozenberg S, Sibilia J et al (2009) The gap between practice and guidelines in the choice of first-line disease modifying antirheumatic drug in early rheumatoid arthritis: results from the ESPOIR cohort. J Rheumatol 36(5):934-942
11. Schipper LG, Vermeer M, Kuper HH, Hoekstra MO, Haagsma CJ, Den Broeder AA et al (2012) A tight control treatment strategy aiming for remission in early rheumatoid arthritis is more effective than usual care treatment in daily clinical practice: a study of two cohorts in the Dutch Rheumatoid Arthritis Monitoring registry. Ann Rheum Dis 71(6):845-850
12. Kirwan JR, Bijlsma JW, Boers M, Shea BJ (2007) Effects of glucocorticoids on radiological progression in rheumatoid arthritis. Cochrane Database Syst Rev 1, CD006356
13. Welsing PM, Borm GF, van Riel P (2006) Minimal clinically important difference in radiological progression of joint damage. A definition based on patient perspective. J Rheumatol 33(3):501-507
14. Bruynesteyn K, van der Heijde D, Boers M, Lassere M, Boonen A, Edmonds J et al (2001) Minimal clinically important difference in radiological progression of joint damage over 1 year in rheumatoid arthritis: preliminary results of a validation study with clinical experts. J Rheumatol 28(4):904-910
15. Avouac J, Gossec L, Dougados M (2006) Diagnostic and predictive value of anti-cyclic citrullinated protein antibodies in rheumatoid arthritis: a systematic literature review. Ann Rheum Dis 65(7):845-851