Do we really need ribavirin in the treatment of crimean-congo hemorrhagic fever?

Journal of Chemotherapy

Volumn 26, Issue 3, 2014, Pages 146-149

  Kalin, Gamze ^a   Metan, Gökhan ^a   Demiraslan, Hayati ^a   Doganay, Mehmet ^a  

^a ERCIYES UNIVERSITY   (Turkey)

Author keywords

CCHF; Crimean congo hemorrhagic fever; Ribavirin; Treatment; Turkey

Indexed keywords

C REACTIVE PROTEIN; CREATINE KINASE; FRESH FROZEN PLASMA; IMMUNOGLOBULIN M; RIBAVIRIN; ANTIVIRUS AGENT;

ADOLESCENT; ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; CRIMEAN CONGO HEMORRHAGIC FEVER; ERYTHROCYTE SEDIMENTATION RATE; FATALITY; FEMALE; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HISTOPATHOLOGY; HOSPITALIZATION; HUMAN; LACTATE DEHYDROGENASE BLOOD LEVEL; LEUKOCYTE COUNT; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; PARTIAL THROMBOPLASTIN TIME; RETROSPECTIVE STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THROMBOCYTE COUNT; HEMORRHAGIC FEVER, CRIMEAN; MIDDLE AGED; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANTIVIRAL AGENTS; FEMALE; HEMORRHAGIC FEVER, CRIMEAN; HUMANS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBAVIRIN; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84900335220     PISSN: 1120009X     EISSN: 19739478     Source Type: Journal    
DOI: 10.1179/1973947813Y.0000000123     Document Type: Article

References (24)

1. Ergonul O. Crimean-Congo hemorrhagic fever. Lancet Infect Dis. 2006;6:203-14.
2. Yilmaz GR, Buzgan T, Irmak H, Safran A, Uzun R, Cevik MA. The epidemiology of Crimean-Congo Hemorrhagic Fever in Turkey, 2002-2007. Int J Infect Dis. 2009;13:380-6.
3. Gözalan A, Akin L, Rolain JM, Tapar FS, Oncul O, Yoshikura H, et al. Epidemiological evaluation of a possible outbreak in and nearby Tokat province. Mikrobiol Bul. 2004;38:33-44.
4. Pittalis S, Meschi S, Castilletti MC, Di Caro A, Puro V. Crimean-Congo haemorrhagic fever: an enemy at the gates. Infez Med. 2009;17:133-4.
5. Estrada-Pena A, Palomar AM, Santribanez P, Sanchez N, Habela MA, Portillo A. Crimean-Congo hemorrhagic fever virus in ticks, southwestern Europe, 2010. Emerg Infect Dis. 2012;18:179-80.
6. Ergonul O, Celikbas A, Baykam N, Eren S, Dokuzoguz B. Analysis of risk factors among patients with Crimian-Congo hemorrhagic fever infection severity criteria revisited. Clin Microbiol Infect. 2006;12:551-4.
7. Leblebicioglu H. Crimean-Congo hemorrhagic fever in Eurasia. Int J Antimicrob Agents. 2010;36:43-6.
8. Ascioglu S, Leblebicioglu H, Vahaboglu H. Ribavirin for patients with Crimean-Congo hemorrhagic fever: a systematic review and meta-analysis. J Antimicrob Chemother. 2011;66:1215-22.
9. Leblebicioglu H, Bodur H, Dokuzoguz B, Elaldi N, Guner R, Koksal I, et al. Case management and supportive treatment for patients with Crimean-Congo hemorrhagic fever. Vector Borne Zoonotic Dis. 2012;12:805-11.
10. Ergonul O. Treatment of Crimean-Congo hemorrhagic fever. Antiviral Res. 2008;78:125-31.
11. Ergonul O, Celikbas A, Dokuzoguz B, Eren S, Baykam N, Esener H. The characteristics of Crimean-Congo hemorrhagic fever in a recent outbreak in Turkey and the impact of oral ribavirin therapy. Clin Infect Dis. 2004;39:285-9.
12. Mardani MD, Jahromi MK, Naieni KH, Zeinali M. The efficacy of oral ribavirin in the treatment of Crimean-Congo hemorrhagic fever in Iran. Clin Infect Dis. 2003;36:1613-8.
13. Tasdelen NF, Ergonul O, Doganci L, Tulek N. The role of ribavirin in the therapy of Crimian-Congo hemorrhagic fever: early use is promising. Eur J Clin Microbiol Infect Dis. 2009;28:929-33.
14. Cevik MA, Erbay A, Bodur H, Eren SS, Akinci E, Sener K, et al. Viral load as a predictor of outcome in Crimean-Congo hemorrhagic fever. Clin Infect Dis. 2007;45:96-100.
15. Yapar M, Aydogan H, Pahsa A, Besirbellioglu BA, Bodur H, Basustaoglu AC, et al. Rapid and quantitative detection of Crimean-Congo hemorrhagic fever virus by one-step real-time reverse transcriptase-PCR. Jpn J Infect Dis. 58:358-62.
16. Swanepoel R, Gill DE, Shepherd AJ, Leman PA, Mynhardt JH, Harvey S. The clinical pathology of Crimian-Congo hemorrhagic fever. Rev Infect Dis. 1989;11:794-800.
17. Ergönü l O, Celikbaş A, Dokuzoǧuz B, Eren S, Baykam N, Esener H. Ribavirin in crimean-congo hemorrhagic fever: primum non nicer. Clin Infect Dis. 2009;49:1621-2.
18. Ozkurt Z, Kikib I, Erola S, Erdem F, Yilmaz N, Parlak M. Crimean-Congo hemorrhagic fever in Eastern Turkey: clinical features, risk factors and efficacy of ribavirin therapy. J Infect. 2006;52:207-15.
19. Kurnaz F, Metan G, Coskun R, Kaynar L, Eser B, Doganay M. A case of Crimean Congo hemorrhagic fever successfully treated with therapeutic plasma exchange and ribavirin. Trop Doct. 2011;41:181-2.
20. Koksal I, Yimaz G, Aksoy F, Aydin H, Yavuz I, Iskender S. The efficacy of ribavirin in the treatment of Crimean-Congo hemorrhagic fever in Eastern Black Sea region in Turkey. J Clin Virol. 2010;47:65-8.
21. Bodur H, Erbay A, Akinci E, Öngürü P, Bayazit N, Eren SS, et al. Effect of oral ribavirin treatment on the viral load and disease progression in Crimean-Congo hemorrhagic fever. Int J Infect Dis. 2011;15:44-7.
22. Duygu F, Kaya T, Baysan P. Re-Evaluation of 400 Crimean- Congo hemorrhagic fever cases in an endemic area: is ribavirin treatment suitable? Vector Borne Zoonotic Dis. 2012;12:812-6.
23. Saleem J, Usman M, Nadeem A, Sethi SA, Salman M. Crimean-Congo hemorrhagic fever: a first case from Abbottabad, Pakistan. Int J Infect Dis. 2009;13:121-3.
24. Tütüncü EE, Gurbuz Y, Ozturk B, Kuscu F, Sencan I. Crimean Congo hemorrhagic fever, precautions and ribavirin prophylaxis: a case report. Scand J Infect Dis. 2009;41:378-80.