Extremely elevated cerebrospinal fluid protein levels in a child with neurologic symptoms: Beware of haemophagocytic lymphohistiocytosis

European Journal of Paediatric Neurology

Volumn 18, Issue 3, 2014, Pages 427-429

  Voeten, Michiel ^a   Maes, Philip ^a   Wojciechowski, Marek ^a   Vandenbossche, Luc ^b   Meyts, Isabelle ^c   Ceulemans, Berten ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b Maria Hospital Overpelt Department of Paediatrics   (Belgium)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Acute disseminated encephalomyelitis; Central nervous system; Cerebrospinal fluid protein; Encephalitis; Haemophagocytic lymphohistiocytosis; X linked lymphoproliferative disease

Indexed keywords

C REACTIVE PROTEIN; CYCLOSPORIN; DEXAMETHASONE; ETOPOSIDE; FERRITIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; METHOTREXATE; METHYLPREDNISOLONE; PREDNISOLONE; PROTEIN; SIGNALING LYMPHOCYTE ACTIVATION MOLECULE ASSOCIATED PROTEIN; PROTEIN CEREBROSPINAL FLUID LEVEL;

ACUTE DISSEMINATED ENCEPHALOMYELITIS; APRAXIA; ARTICLE; ATAXIA; BLOOD ANALYSIS; BONE MARROW BIOPSY; BRAIN ATROPHY; CASE REPORT; CEREBROSPINAL FLUID ANALYSIS; CHEMOTHERAPY; CHILD; COGNITIVE DEFECT; CONSCIOUSNESS LEVEL; DISEASE MARKER; DRUG MEGADOSE; EPSTEIN BARR VIRUS INFECTION; FERRITIN BLOOD LEVEL; FEVER; FOLLOW UP; GENE MUTATION; HEMISPHERE; HEMOPHAGOCYTIC SYNDROME; HEPATITIS; HUMAN; HYPERTRIGLYCERIDEMIA; IMMUNOGLOBULIN DEFICIENCY; IMMUNOTHERAPY; INDUCTION CHEMOTHERAPY; LUMBAR PUNCTURE; LYMPHOPROLIFERATIVE DISEASE; MALE; NEUROIMAGING; NEUROLOGIC DISEASE; NEUTROPENIA; NUCLEAR MAGNETIC RESONANCE IMAGING; ORIENTATION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; RECURRENT INFECTION; SEIZURE; SPLENOMEGALY; STEROID THERAPY; THALAMUS; THROMBOCYTOPENIA; TREATMENT DURATION; TREATMENT RESPONSE; UPPER RESPIRATORY TRACT INFECTION; X CHROMOSOME LINKED DISORDER; CEREBROSPINAL FLUID; DIFFERENTIAL DIAGNOSIS; ENCEPHALITIS; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; PROCEDURES;

CEREBROSPINAL FLUID PROTEINS; CHILD, PRESCHOOL; DIAGNOSIS, DIFFERENTIAL; ENCEPHALITIS; HUMANS; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; MAGNETIC RESONANCE IMAGING; MALE;

EID: 84900327698     PISSN: 10903798     EISSN: 15322130     Source Type: Journal    
DOI: 10.1016/j.ejpn.2013.11.012     Document Type: Article

References (5)

1. S. Yang, L. Zhang, and C. Jia et al. Frequency and development of CNS involvement in Chinese children with hemophagocytic lymphohistiocytosis Pediatr Blood Cancer 54 3 2010 Mar 408 415
2. K. Deiva, N. Mahlaoui, and F. Beaudonnet et al. CNS involvement at the onset of primary hemophagocytic lymphohistiocytosis Neurology 78 15 2012 Apr 10 1150 1156 Epub 2012 Mar 14
3. A. Horne, H. Trottestam, and M. Aricoò et al. Frequency and spectrum of central nervous system involvement in 193 children with haemophagocytic lymphohistiocytosis Br J Haematol 140 3 2008 Feb 327 335 Epub 2007 Dec 10
4. D.A. Seehusen, M.M. Reeves, and D.A. Fomin Cerebrospinal fluid analysis Am Fam Physician 68 6 2003 Sep 15 1103 1108
5. J.I. Henter, and I. Nennesmo Neuropathologic findings and neurologic symptoms in twenty-three children with hemophagocytic lymphohistiocytosis J Pediatr 130 3 1997 Mar 358 365