Managing cancer pain at the end of life with multiple strong opioids: A population-based retrospective cohort study in primary care

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Gao, Wei ^a   Gulliford, Martin ^a   Bennett, Michael I ^b   Murtagh, Fliss E M ^a   Higginson, Irene J ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALFENTANIL; DEXTROMORAMIDE; DIAMORPHINE; DIPIPANONE; FENTANYL; MORPHINE; NARCOTIC ANALGESIC AGENT; OPIATE; PENTAZOCINE; PETHIDINE; REMIFENTANIL; TAPENTADOL; TRAMADOL;

ADULT; ADVANCED CANCER; AGED; ANALGESIA; ARTICLE; BREAST CANCER; CANCER PAIN; CANCER PATIENT; CANCER THERAPY; COHORT ANALYSIS; COLORECTAL CANCER; FEMALE; HEAD AND NECK CANCER; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYPHARMACY; POPULATION BASED CASE CONTROL STUDY; PRESCRIPTION; PRIMARY MEDICAL CARE; PROSTATE CANCER; QUALITY OF LIFE; RETROSPECTIVE STUDY; TERMINAL CARE; TREND STUDY;

ANALGESICS, OPIOID; CHRONIC PAIN; COHORT STUDIES; DRUG UTILIZATION; HUMANS; MODELS, STATISTICAL; NEOPLASMS; PHYSICIAN'S PRACTICE PATTERNS; PRIMARY HEALTH CARE; RETROSPECTIVE STUDIES; TERMINAL CARE;

EID: 84900320660     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0079266     Document Type: Article

References (31)

1. Costantini M, Ripamonti C, Beccaro M, Montella M, Borgia P, et al. (2009) Prevalence, distress, management, and relief of pain during the last 3 months of cancer patients' life. Results of an Italian mortality follow-back survey. Ann Oncol 20: 729-735.
2. Portenoy RK (2011) Treatment of cancer pain. Lancet 377: 2236-2247.
3. Qaseem A, Snow V, Shekelle P, Casey DE Jr, Cross JT Jr, et al. (2008) Evidence-based interventions to improve the palliative care of pain, dyspnea, and depression at the end of life: a clinical practice guideline from the American College of Physicians. Annals of Internal Medicine 148: 141-146. (Pubitemid 351651556)
4. Caraceni A, Hanks G, Kaasa S, Bennett MI, Brunelli C, et al. (2012) Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC. Lancet Oncol 13: e58-68.
5. Mercadante S, Caraceni A (2011) Conversion ratios for opioid switching in the treatment of cancer pain: a systematic review. Palliat Med 25: 504-515.
6. Rurup ML, Rhodius CA, Borgsteede SD, Boddaert MS, Keijser AG, et al. (2010) The use of opioids at the end of life: the knowledge level of Dutch physicians as a potential barrier to effective pain management. BMC Palliat Care 9: 23.
7. Potter VT, Wiseman CE, Dunn SM, Boyle FM (2003) Patient barriers to optimal cancer pain control. Psychooncology 12: 153-160. (Pubitemid 36362043)
8. Oldenmenger WH, Sillevis Smitt PA, van Dooren S, Stoter G, van der Rijt CC (2009) A systematic review on barriers hindering adequate cancer pain management and interventions to reduce them: a critical appraisal. Eur J Cancer 45: 1370-1380.
9. Mercadante S, Ferrera P, Villari P, Casuccio A (2006) Opioid escalation in patients with cancer pain: the effect of age. J Pain Symptom Manage 32: 413-419. (Pubitemid 44755107)
10. Gardiner C, Gott M, Ingleton C, Hughes P, Winslow M, et al. (2012) Attitudes of Health Care Professionals to Opioid Prescribing in End-of-Life Care: A Qualitative Focus Group Study. J Pain Symptom Manage.
11. Gao W, Gulliford M, Higginson IJ (2011) Prescription patterns of analgesics in the last 3 months of life: a retrospective analysis of 10202 lung cancer patients. Br J Cancer 104: 1704-1710.
12. Bennett MI, Graham J, Schmidt-Hansen M, Prettyjohns M, Arnold S, et al. (2012) Prescribing strong opioids for pain in adult palliative care: summary of NICE guidance. BMJ 344: e2806.
13. Cherny N, Ripamonti C, Pereira J, Davis C, Fallon M, et al. (2001) Strategies to manage the adverse effects of oral morphine: an evidence-based report. J Clin Oncol 19: 2542-2554. (Pubitemid 32391226)
14. Jacobsen R, Sjogren P, Moldrup C, Christrup L (2007) Physician-related barriers to cancer pain management with opioid analgesics: a systematic review. J Opioid Manag 3: 207-214. (Pubitemid 47611012)
15. Lussier D, Huskey AG, Portenoy RK (2004) Adjuvant analgesics in cancer pain management. Oncologist 9: 571-591. (Pubitemid 39332322)
16. Mitra R, Jones S (2012) Adjuvant analgesics in cancer pain: a review. Am J Hosp Palliat Care 29: 70-79.
17. Higginson IJ, Gao W (2012) Opioid Prescribing for Cancer Pain During the Last 3 Months of Life: Associated Factors and 9-Year Trends in a Nationwide United Kingdom Cohort Study. J Clin Oncol.
18. Zeppetella G, Ribeiro MD (2006) Opioids for the management of breakthrough (episodic) pain in cancer patients. Cochrane Database Syst Rev: CD004311.
19. Khan NF, Perera R, Harper S, Rose PW (2010) Adaptation and validation of the Charlson Index for Read/OXMIS coded databases. BMC Fam Pract 11: 1.
20. The Information Centre NHS (2006) Hospital Prescribing, 2005: England.
21. Deandrea S, Montanari M, Moja L, Apolone G (2008) Prevalence of undertreatment in cancer pain. A review of published literature. Ann Oncol 19: 1985-1991.
22. Smith DJ (2004) The Regulation of Controlled Drugs in the Community. 262 p.
23. Finch R (2004) Shipman has made GPs wary of prescribing strong opioids. PULSE.
24. Skollerud LM, Fredheim OM, Svendsen K, Skurtveit S, Borchgrevink PC (2012) Laxative prescriptions to cancer outpatients receiving opioids: a study from the Norwegian prescription database. Support Care Cancer.
25. NICE (2011) Opioids in palliative care: safe and effective prescribing of strong opioids for pain in palliative care of adults. NICE Clinical Guideline.
26. Mercadante S, Valle A, Porzio G, Fusco F, Aielli F, et al. (2012) Opioid Switching in Patients With Advanced Cancer Followed at Home. A Retrospective Analysis. J Pain Symptom Manage.
27. Droney J, Riley J, Ross J (2012) Opioid genetics in the context of opioid switching. Curr Opin Support Palliat Care 6: 10-16.
28. Moksnes K, Kaasa S, Paulsen O, Rosland JH, Spigset O, et al. (2012) Serum concentrations of opioids when comparing two switching strategies to methadone for cancer pain. Eur J Clin Pharmacol 68: 1147-1156.
29. Mercadante S, Bruera E (2012) The effect of age on opioid switching to methadone: a systematic review. J Palliat Med 15: 347-351.
30. Raijmakers NJ, van Zuylen L, Furst CJ, Beccaro M, Maiorana L, et al. (2012) Variation in medication use in cancer patients at the end of life: a cross-sectional analysis. Support Care Cancer.
31. Bennett MI, Flemming K, Closs SJ (2011) Education in cancer pain management. Curr Opin Support Palliat Care 5: 20-24.