Promoter variants in interleukin-6 and tumor necrosis factor alpha and risk of coronary artery disease in a population from Western India

Indian Journal of Human Genetics

Volumn 19, Issue 4, 2013, Pages 430-436

  Bhanushali, Aparna A ^a   Das, B R ^a  

^a Super Religare Laboratories Ltd   (India)

Author keywords

Association study; coronary artery disease; India; interleukin 6; single nucleotide polymorphisms; SNaPshot; tumor necrosis factor alpha

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 6; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORONARY RISK; DYSLIPIDEMIA; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; INDIA; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; POPULATION RESEARCH; PROMOTER REGION; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 84900305236     PISSN: 09716866     EISSN: 1998362X     Source Type: Journal    
DOI: 10.4103/0971-6866.124371     Document Type: Article

References (38)

1. Ross R. Atherosclerosis - An inflammatory disease. N Engl J Med 1999;340:115-26.
2. Libby P, Ridker PM, Hansson GK, Leducq Transatlantic Network on Atherothrombosis. Inflammation in atherosclerosis: From pathophysiology to practice. J Am Coll Cardiol 2009;54:2129-38.
3. Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 2006;354:610-21.
4. Viola A, Luster AD. Chemokines and their receptors: Drug targets in immunity and inflammation. Annu Rev Pharmacol Toxicol 2008;48:171-97.
5. Libby P, Theroux P. Pathophysiology of coronary artery disease. Circulation 2005;111:3481-8.
6. Sandhu MS, Waterworth DM, Debenham SL, Wheeler E, Papadakis K, Zhao JH, et al. LDL-cholesterol concentrations: A genome-wide association study. Lancet 2008;371:483-91.
7. Melzer D, Perry JR, Hernandez D, Corsi AM, Stevens K, Rafferty I, et al. A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet 2008;4:e1000072.
8. Wallace C, Newhouse SJ, Braund P, Zhang F, Tobin M, Falchi M, et al. Genome-wide association study identifies genes for biomarkers of cardiovascular disease: Serum urate and dyslipidemia. Am J Hum Genet 2008;82:139-49.
9. Willer CJ, Sanna S, Jackson AU, Scuteri A, Bonnycastle LL, Clarke R, et al. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet 2008;40:161-9.
10. Kroeger KM, Carville KS, Abraham LJ. The-308 tumor necrosis factor-alpha promoter polymorphism effects transcription. Mol Immunol 1997;34:391-9.
11. Rosenwasser LJ, Borish L. Promoter polymorphisms predisposing to the development of asthma and atopy. Clin Exp Allergy 1998;28 Suppl 5:13-5.
12. Turner DM, Williams DM, Sankaran D, Lazarus M, Sinnott PJ, Hutchinson IV. An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet 1997;24:1-8.
13. Licastro F, Chiapelli M, Caldarera CM, Caruso C, Lio D, Corder EH. Acute myocardial infarction and proinflammatory gene variants. Ann N Y Acad Sci 2007;1119:227-42.
14. Olomolaiye O, Wood NA, Bidwell JL. A novel NlaIII polymorphism in the human IL-6 promoter. Eur J Immunogenet 1998;25:267.
15. Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S, et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998;102:1369-76.
16. Castell JV, Gomez-Lechon MJ, David M, Andus T, Geiger T, Trullenque R, et al. Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes. FEBS Lett 1989;242:237-9.
17. Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW. Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci U S A 1997;94:3195-9.
18. Louis E, Franchimont D, Piron A, Gevaert Y, Schaaf-Lafontaine N, Roland S, et al. Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans. Clin Exp Immunol 1998;113:401-6.
19. Blake GJ, Ridker PM. Novel clinical markers of vascular wall inflammation. Circ Res 2001;89:763-71.
20. Nicola PJ, Maradit-Kremers H, Roger VL, Jacobsen SJ, Crowson CS, Ballman KV, et al. The risk of congestive heart failure in rheumatoid arthritis: A population-based study over 46 years. Arthritis Rheum 2005;52:412-20.
21. Ridker PM, Brown NJ, Vaughan DE, Harrison DG, Mehta JL. Established and emerging plasma biomarkers in the prediction of first atherothrombotic events. Circulation 2004;109:IV6-19.
22. Kilpinen S, Hulkkonen J, Wang XY, Hurme M. The promoter polymorphism of the interleukin-6 gene regulates interleukin-6 production in neonates but not in adults. Eur Cytokine Netw 2001;12:62-8.
23. Veres A, Prohászka Z, Kilpinen S, Singh M, Füst G, Hurme M. The promoter polymorphism of the IL-6 gene is associated with levels of antibodies to 60-kDa heat-shock proteins. Immunogenetics 2002;53:851-6.
24. Rauramaa R, Väisänen SB, Luong LA, Schmidt-Trucksass A, Penttilä IM, Bouchard C, et al. Stromelysin-1 and interleukin-6 gene promoter polymorphisms are determinants of asymptomatic carotid artery atherosclerosis. Arterioscler Thromb Vasc Biol 2000;20:2657-62.
25. Gupta V, Sehajpal PK. Rapid detection of single nucleotide (-308) polymorphism in TNF-á promoter using ARMS-PCR. Curr Sci 2003;85:1521-3.
26. Perrey C, Pravica V, Sinnott PJ, Hutchinson IV. Genotyping for polymorphisms in interferon-gamma, interleukin-10, transforming growth factor-beta 1 and tumour necrosis factor-alpha genes: A technical report. Transpl Immunol 1998;6:193-7.
27. Parra-Rojas I, Ruiz-Madrigal B, Martinez-Lopez E, Panduro A. Influence of the-308 TNF-alpha and-174 IL-6 polymorphisms on lipid profile in Mexican subjects. Hereditas 2006;143:167-72.
28. Shen J, Arnett DK, Perez-Martinez P, Parnell LD, Lai CQ, Peacock JM, et al. The effect of IL6-174C/G polymorphism on postprandial triglyceride metabolism in the GOLDN studyboxs. J Lipid Res 2008;49:1839-45.
29. Grunfeld C, Zhao C, Fuller J, Pollack A, Moser A, Friedman J, et al. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. J Clin Invest 1996;97:2152-7.
30. Sie MP, Sayed-Tabatabaei FA, Oei HH, Uitterlinden AG, Pols HA, Hofman A, et al. Interleukin 6-174 g/c promoter polymorphism and risk of coronary heart disease: Results from the rotterdam study and a meta-analysis. Arterioscler Thromb Vasc Biol 2006;26:212-7.
31. Lieb W, Pavlik R, Erdmann J, Mayer B, Holmer SR, Fischer M, et al. No association of interleukin-6 gene polymorphism (-174 G/C) with myocardial infarction or traditional cardiovascular risk factors. Int J Cardiol 2004;97:205-12.
32. Nauck M, Winkelmann BR, Hoffmann MM, Böhm BO, Wieland H, März W. The interleukin-6 G(-174) C promoter polymorphism in the LURIC cohort: No association with plasma interleukin-6, coronary artery disease, and myocardial infarction. J Mol Med (Berl) 2002;80:507-13.
33. Georges JL, Loukaci V, Poirier O, Evans A, Luc G, Arveiler D, et al. Interleukin-6 gene polymorphisms and susceptibility to myocardial infarction: The ECTIM study. Etude Cas-Temoin de l'Infarctus du Myocarde. J Mol Med (Berl) 2001;79:300-5.
34. Maitra A, Shanker J, Dash D, John S, Sannappa PR, Rao VS, et al. Polymorphisms in the IL6 gene in Asian Indian families with premature coronary artery disease - The Indian Atherosclerosis Research Study. Thromb Haemost 2008;99:944-50.
35. Banerjee I, Pandey U, Hasan OM, Parihar R, Tripathi V, Ganesh S. Association between inflammatory gene polymorphisms and coronary artery disease in an Indian population. J Thromb Thrombolysis 2009;27:88-94.
36. Koch W, Kastrati A, Böttiger C, Mehilli J, von Beckerath N, Schömig A. Interleukin-10 and tumor necrosis factor gene polymorphisms and risk of coronary artery disease and myocardial infarction. Atherosclerosis 2001;159:137-44.
37. Shanker J, Kakkar VV. Implications of genetic polymorphisms in inflammation-induced atherosclerosis. Open Cardiovasc Med J 2010;4:30-7.
38. Zhang HF, Xie SL, Wang JF, Chen YX, Wang Y, Huang TC. Tumor necrosis factor-alpha G-308A gene polymorphism and coronary heart disease susceptibility: An updated meta-analysis. Thromb Res 2011;127:400-5