A3 Adenosine receptors, HIF-1 modulation and atherosclerosis

A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics

Volumn , Issue , 2010, Pages 281-288

  Gessi, Stefania ^a   MacLennan, Stephen ^b   Leung, Edward ^b   Borea, Pier Andrea ^a  

^a Interdisciplinary Center for the Study of Inflammation   (Italy)

^b King Pharmaceuticals Research and Development Inc   (United States)

Author keywords

arteries; Atherosclerosis; cardiovascular disease; heart disease; lipids; stroke

Indexed keywords

EID: 84900277271     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-90-481-3144-0_14     Document Type: Chapter

References (39)

1. Adhikari N, Charles N, Lehmann U, Hall J (2006) Transcription factor and kinase-mediated signaling in atherosclerosis and vascular injury. Curr Atheroscler Rep 8(3):252-260
2. Alchera E, Tacchini L, Imarisio C, Dal Ponte C, De Ponti C, Gammella E, Cairo G, Albano E, Carini R (2008) Adenosine-dependent activation of hypoxia-inducible factor-1 induces late preconditioning in liver cells. Hepatology 48(1):230-239
3. Björnheden T, Levin M, Evaldsson M, Wiklund O (1999) Evidence of hypoxic areas within the arterial wall in vivo. Arterioscler Thromb Vasc Biol 19(4):870-876
4. Blay J, White TD, Hoskin DW (1997) The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine. Cancer Res 57(13):2602-2605
5. Clark AN, Youkey R, Liu X, Jia L, Blatt R, Day YJ, Sullivan GW, Linden J, Tucker AL (2007) A1 adenosine receptor activation promotes angiogenesis and release of VEGF from monocytes. Circ Res 101(11):1130-1138
6. Cramer T, Yamanishi Y, Clausen BE, Förster I, Pawlinski R, Mackman N, Haase VH, Jaenisch R, Corr M, Nizet V, Firestein GS, Gerber HP, Ferrara N, Johnson RS (2003) HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell 112(5):645-657
7. Decking UK, Schlieper G, Kroll K, Schrader J (1997) Hypoxia-induced inhibition of adenosine kinase potentiates cardiac adenosine release. Circ Res 81(2):154-164
8. De Ponti C, Carini R, Alchera E, Nitti MP, Locati M, Albano E, Cairo G, Tacchini L (2007) Adenosine A2a receptor-mediated, normoxic induction of HIF-1 through PKC and PI-3K-dependent pathways in macrophages. J Leukoc Biol 82(2):392-402
9. Fonarow, G.C. and Watson, K.E. (2003). Effective strategies for long-term statin use. The American Journal of Cardiology 92 (1A), 27I-34I.
10. Herrmann J, Lerman LO, Mukhopadhyay D, Napoli C, Lerman A (2006) Angiogenesis in atherogenesis. Arterioscler Thromb Vasc Biol 26(9):1948-1957
11. Inoue M, Itoh H, Ueda M, Naruko T, Kojima A, Komatsu R, Doi K, Ogawa Y, Tamura N, Takaya K, Igaki T, Yamashita J, Chun TH, Masatsugu K, Becker AE, Nakao K (1998) Vascular endothe-lial growth factor (VEGF) expression in human coronary atherosclerotic lesions: Possible pathophysiological significance of VEGF in progression of atherosclerosis. Circulation 98(20):2108-2116
12. Jacobson KA, Gao ZG (2006) Adenosine receptors as therapeutic targets. Nat Rev Drug Discov 5(3):247-264
13. Jiang G, Li T, Qiu Y, Rui Y, Chen W, Lou Y (2007) RNA interference for HIF-1alpha inhibits foam cells formation in vitro. Eur J Pharmacol 562(3):183-190
14. 3 adenosine receptor deficiency does not influence atherogenesis. J Cell Biochem 92(5):1034-1043
15. Kastelein JJ (2003) The future of lipid-lowering therapy: the big picture. Neth J Med 61(Suppl 5):35-39
16. Kobayashi S, Zimmermann H, Millhorn DE (2000) Chronic hypoxia enhances adenosine release in rat PC12 cells by altering adenosine metabolism and membrane transport. J Neurochem 74(2):621-632
17. Kolodgie FD, Narula J, Yuan C, Burke AP, Finn AV, Virmani R (2007) Elimination of neoangio-genesis for plaque stabilization: is there a role for local drug therapy? J Am Coll Cardiol 49(21):2093-101
18. Libby P (2002) Inflammation in atherosclerosis. Nature 420(6917):868-874
19. Lusis AJ (2000) Atherosclerosis. Nature 407(6801):233-241
20. 3 adenosine receptors modulate hypoxia-inducible factor-1alpha expression in human A375 melanoma cells. Neoplasia 7(10):894-903
21. Merighi S, Benini A, Mirandola P, Gessi S, Varani K, Leung E, Maclennan S, Borea PA (2006) Adenosine modulates vascular endothelial growth factor expression via hypoxia-inducible factor-1 in human glioblastoma cells. Biochem Pharmacol 72(1):19-31
22. Merighi S, Benini A, Mirandola P, Gessi S, Varani K, Simioni C, Leung E, Maclennan S, Baraldi PG, Borea PA (2007) Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells. Mol Pharmacol 72(2):395-406
23. Moreno PR, Purushothaman KR, Zias E, Sanz J, Fuster V (2006) Neovascularization in human atherosclerosis. Curr Mol Med 6(5):457-77
24. Paul SA, Simons JW, Mabjeesh NJ (2004) HIF at the crossroads between ischemia and carcino-genesis. J Cell Physiol 200(1):20-30
25. Pennings M, Meurs I, Ye D, Out R, Hoekstra M, van Berkel T, van Eck M (2006) Regulation of cholesterol homeostasis in macrophages and consequences for atherosclerotic lesion development. FEBS Lett 580(23):5588-5596
26. Ramanathan M, Pinhal-Enfield G, Hao I, Leibovich SJ (2007) Synergistic up-regulation of vascular endothelial growth factor (VEGF) expression in macrophages by adenosine A2A receptor agonists and endotoxin involves transcriptional regulation via the hypoxia response element in the VEGF promoter. Mol Biol Cell 18(1):14-23
27. Semenza GL (2001) Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends Mol Med 7(8):345-350
28. Ross R (1999) Atherosclerosis an inflammatory disease. N Eng J Med 340(2):115-126
29. Shatrov VA, Sumbayev VV, Zhou J, Brüne B (2003) Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1alpha (HIF-1alpha) accumulation via redox-dependent mechanisms. Blood 101(12):4847-9
30. Sluimer JC, Gasc JM, van Wanroij JL, Kisters N, Groeneweg M, Sollewijn Gelpke MD, Cleutjens JP, van den Akker LH, Corvol P, Wouters BG, Daemen MJ, Bijnens AP (2008) Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis. J Am Coll Cardiol 51(13):1258-1265
31. Sluimer JC, Daemen MJ (2009) Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis. J Pathol 218(1):7-29
32. Stoll G, Bendszus M (2006) Inflammation and atherosclerosis. Novel insights into plaque formation and destabilization. Stroke 37(7):1923-1932
33. Synnestvedt K, Furuta GT, Comerford KM, Louis N, Karhausen J, Eltzschig HK, Hansen KR, Thompson LF, Colgan SP (2002) Ecto-5¢-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. J Clin Invest 110(7):993-1002
34. Thompson LF, Eltzschig HK, Ibla JC, Van De Wiele CJ, Resta R, Morote-Garcia JC, Colgan SP (2004) Crucial role for ecto-5¢-nucleotidase (CD73) in vascular leakage during hypoxia. J Exp Med 200(11):1395-1405
35. Toi M, Bando H, Ogawa T, Muta M, Hornig C, Weich HA (2002) Significance of vascular endothelial growth factor (VEGF)/soluble VEGF receptor-1 relationship in breast cancer. Int J Cancer 98(1):14-18
36. van Belle H, Goossens F, Wynants J (1987) Formation and release of purine catabolites during hypoperfusion, anoxia, and ischemia. Am J Physiol 252(5 Pt 2):H886-H893
37. Vink A, Schoneveld AH, Lamers D, Houben AJ, van der Groep P, van Diest PJ, Pasterkamp G (2007) HIF-1 alpha expression is associated with an atheromatous inflammatory plaque phe-notype and upregulated in activated macrophages. Atherosclerosis 195(2):e69-75
38. Wendler CC, Amatya S, McClaskey C, Ghatpande S, Fredholm BB, Rivkees SA (2007) A1 adenosine receptors play an essential role in protecting the embryo against hypoxia. Proc Natl Acad Sci USA 104(23):9697-9702
39. Zhao Q, Egashira K, Inoue S, Usui M, Kitamoto S, Ni W, Ishibashi M, Hiasa Ki K, Ichiki T, Shibuya M, Takeshita A (2002) Vascular endothelial growth factor is necessary in the development of arteriosclerosis by recruiting/activating monocytes in a rat model of long-term inhibition of nitric oxide synthesis. Circulation 105(9):1110-1115