Pandemic H1N1 virus transmission and shedding dynamics in index case households of a prospective Vietnamese cohort

Journal of Infection

Volumn 68, Issue 6, 2014, Pages 581-590

  Thai, Pham Quang ^a   Mai, Le Quynh ^a   Welkers, Matthijs R A ^b   Hang, Nguyen Le Khanh ^a   Thanh, Le Thi ^a   Dung, Vu Tien Viet ^c   Yen, Nguyen Thi Thu ^a   Duong, Tran Nhu ^a   Hoa, Le Nguyen Minh ^c   Thoang, Dang Dinh ^d   Trang, Hoang Thi Huyen ^c   de Jong, Menno D ^b   Wertheim, Heiman ^c,e   Hien, Nguyen Tran ^a   Horby, Peter ^c,e   Fox, Annette ^c,e,f  

^a NATIONAL INSTITUTE OF HYGIENE AND EPIDEMIOLOGY   (Viet Nam)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c OXFORD UNIVERSITY CLINICAL RESEARCH UNIT   (Viet Nam)

^d Ha Nam Centre for Preventive Medicine   (Viet Nam)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Antibody; Household; Index; Influenza; Pandemic; Secondary; Serial interval; Shedding; Symptoms; Transmission

Indexed keywords

2009 H1N1 INFLUENZA; ADULT; ARTICLE; CASE FINDING; CHILD; CLINICAL ASSESSMENT; COHORT ANALYSIS; ETHNIC GROUP; FEMALE; GENETIC VARIABILITY; HOUSEHOLD; HUMAN; INFECTION RISK; INFLUENZA VIRUS A H1N1; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PROSPECTIVE STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK FACTOR; RNA ANALYSIS; SCHOOL CHILD; SECONDARY INFECTION; SUSCEPTIBLE POPULATION; SYMPTOMATOLOGY; VIETNAMESE; VIRUS SHEDDING; VIRUS TRANSMISSION; ADOLESCENT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD; DNA SEQUENCE; FAMILY SIZE; GENETICS; INFANT; INFLUENZA; ISOLATION AND PURIFICATION; MIDDLE AGED; NEWBORN; PRESCHOOL CHILD; TRANSMISSION; VERY ELDERLY; VIROLOGY; VIRUS LOAD; YOUNG ADULT;

VIRUS ANTIBODY; VIRUS RNA;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, VIRAL; ASIAN CONTINENTAL ANCESTRY GROUP; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; FAMILY CHARACTERISTICS; FEMALE; GENETIC VARIATION; HUMANS; INFANT; INFANT, NEWBORN; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA, HUMAN; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RNA, VIRAL; SEQUENCE ANALYSIS, DNA; VIRAL LOAD; VIRUS SHEDDING; YOUNG ADULT;

EID: 84899941228     PISSN: 01634453     EISSN: 15322742     Source Type: Journal    
DOI: 10.1016/j.jinf.2014.01.008     Document Type: Article

References (45)

1. Mathews J.D., Mccaw C.T., Mcvernon J., Mcbryde E.S., Mccaw J.M. A biological model for influenza transmission: pandemic planning implications of asymptomatic infection and immunity. PLoS One 2007, 2(11):e1220.
2. Horby P., Pham Q.T., Hens N., Nguyen T.T., Le Q.M., Dang D.T., et al. Social contact patterns in Vietnam and implications for the control of infectious diseases. PLoS One 2011, 6(2):e16965.
3. Donnelly C.A., Finelli L., Cauchemez S., Olsen S.J., Doshi S., Jackson M.L., et al. Serial intervals and the temporal distribution of secondary infections within households of 2009 pandemic influenza A (H1N1): implications for influenza control recommendations. Clin Infect Dis 2011 Jan 1, 52(Suppl. 1):S123-S130.
4. Ferguson N.M., Cummings D.A., Fraser C., Cajka J.C., Cooley P.C., Burke D.S. Strategies for mitigating an influenza pandemic. Nature 2006 Jul 27, 442(7101):448-452.
5. Cauchemez S., Donnelly C.A., Reed C., Ghani A.C., Fraser C., Kent C.K., et al. Household transmission of 2009 pandemic influenza A (H1N1) virus in the United States. N Engl J Med 2009 Dec 31, 361(27):2619-2627.
6. Papenburg J., Baz M., Hamelin M.E., Rheaume C., Carbonneau J., Ouakki M., et al. Household transmission of the 2009 pandemic A/H1N1 influenza virus: elevated laboratory-confirmed secondary attack rates and evidence of asymptomatic infections. Clin Infect Dis 2010 Nov 1, 51(9):1033-1041.
7. Morgan O.W., Parks S., Shim T., Blevins P.A., Lucas P.M., Sanchez R., et al. Household transmission of pandemic (H1N1) 2009, San Antonio, Texas, USA, April-May 2009. Emerg Infect Dis 2010 Apr, 16(4):631-637.
8. France A.M., Jackson M., Schrag S., Lynch M., Zimmerman C., Biggerstaff M., et al. Household transmission of 2009 influenza A (H1N1) virus after a school-based outbreak in New York City, April-May 2009. J Infect Dis 2010 Apr 1, 201(7):984-992.
9. Sikora C., Fan S., Golonka R., Sturtevant D., Gratrix J., Lee B.E., et al. Transmission of pandemic influenza A (H1N1) 2009 within households: Edmonton. Can J Clin Virol 2010 Oct, 49(2):90-93.
10. Komiya N., Gu Y., Kamiya H., Yahata Y., Yasui Y., Taniguchi K., et al. Household transmission of pandemic 2009 influenza A (H1N1) virus in Osaka, Japan in May 2009. J Infect 2010 Oct, 61(4):284-288.
11. Looker C., Carville K., Grant K., Kelly H., Influenza A. (H1N1) in Victoria, Australia: a community case series and analysis of household transmission. PLoS One 2010, 5(10):e13702.
12. Loustalot F., Silk B.J., Gaither A., Shim T., Lamias M., Dawood F., et al. Household transmission of 2009 pandemic influenza A (H1N1) and nonpharmaceutical interventions among households of high school students in San Antonio, Texas. Clin Infect Dis 2011 Jan 1, 52(Suppl. 1):S146-S153.
13. Carcione D., Giele C.M., Goggin L.S., Kwan K.S., Smith D.W., Dowse G.K., et al. Secondary attack rate of pandemic influenza A(H1N1) 2009 in Western Australian households, 29 May-7 August 2009. Euro Surveill 2011, 16(3).
14. Lau L.L., Cowling B.J., Fang V.J., Chan K.H., Lau E.H., Lipsitch M., et al. Viral shedding and clinical illness in naturally acquired influenza virus infections. J Infect Dis 2010 May 15, 201(10):1509-1516.
15. Suess T., Buchholz U., Dupke S., Grunow R., An Der Heiden M., Heider A., et al. Shedding and transmission of novel influenza virus A/H1N1 infection in households - Germany, 2009. Am J Epidemiol 2010 Jun 1, 171(11):1157-1164.
16. Cowling B.J., Chan K.H., Fang V.J., Lau L.L., So H.C., Fung R.O., et al. Comparative epidemiology of pandemic and seasonal influenza A in households. N Engl J Med 2010 Jun 10, 362(23):2175-2184.
17. Chang L.Y., Chen W.H., Lu C.Y., Shao P.L., Fan T.Y., Cheng A.L., et al. Household transmission of pandemic (H1N1) 2009 virus, Taiwan. Emerg Infect Dis 2011 Oct, 17(10):1928-1931.
18. Simmerman J.M., Suntarattiwong P., Levy J., Jarman R.G., Kaewchana S., Gibbons R.V., et al. Findings from a household randomized controlled trial of hand washing and face masks to reduce influenza transmission in Bangkok, Thailand. Influenza Other Respir Viruses 2011 Jul, 5(4):256-267.
19. Pebody R.G., Harris R., Kafatos G., Chamberland M., Campbell C., Nguyen-Van-Tam J.S., et al. Use of antiviral drugs to reduce household transmission of pandemic (H1N1) 2009, United Kingdom. Emerg Infect Dis 2011 Jun, 17(6):990-999.
20. Suess T., Remschmidt C., Schink S.B., Schweiger B., Heider A., Milde J., et al. Comparison of shedding characteristics of seasonal influenza virus (sub)types and influenza A(H1N1)pdm09; Germany, 2007-2011. PLoS One 2012, 7(12):e51653.
21. Lau L.L., Nishiura H., Kelly H., Ip D.K., Leung G.M., Cowling B.J. Household transmission of 2009 pandemic influenza A (H1N1): a systematic review and meta-analysis. Epidemiology 2012 Jul, 23(4):531-542.
22. Calatayud L., Kurkela S., Neave P.E., Brock A., Perkins S., Zuckerman M., et al. Pandemic (H1N1) 2009 virus outbreak in a school in London, April-May 2009: an observational study. Epidemiol Infect 2010 Feb, 138(2):183-191.
23. Sugimoto J.D., Borse N.N., Ta M.L., Stockman L.J., Fischer G.E., Yang Y., et al. The effect of age on transmission of 2009 pandemic influenza A (H1N1) in a camp and associated households. Epidemiology 2011 Mar, 22(2):180-187.
24. Klick B., Nishiura H., Ng S., Fang V.J., Leung G.M., Peiris J.S., et al. Transmissibility of seasonal and pandemic influenza in a cohort of households in Hong Kong in 2009. Epidemiology 2011 Nov, 22(6):793-796.
25. Klick B., Leung G.M., Cowling B.J. Optimal design of studies of influenza transmission in households. I: case-ascertained studies. Epidemiol Infect 2012 Jan, 140(1):106-114.
26. Horby P., Mai le Q., Fox A., Thai P.Q., Thi Thu Yen N., Thanh le T., et al. The epidemiology of interpandemic and pandemic influenza in Vietnam, 2007-2010: the Ha Nam household cohort study I. Am J Epidemiol 2012 May 15, 175(10):1062-1074.
27. de Jong M.D., Bach V.C., Phan T.Q., Vo M.H., Tran T.T., Nguyen B.H., et al. Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma. N Engl J Med 2005 Feb 17, 352(7):686-691.
28. Zhou B., Donnelly M.E., Scholes D.T., St George K., Hatta M., Kawaoka Y., et al. Single-reaction genomic amplification accelerates sequencing and vaccine production for classical and Swine origin human influenza a viruses. J Virol 2009 Oct, 83(19):10309-10313.
29. Brooks-Pollock E., Tilston N., Edmunds W.J., Eames K.T. Using an online survey of healthcare-seeking behaviour to estimate the magnitude and severity of the 2009 H1N1v influenza epidemic in England. BMC Infect Dis 2011, 11:68.
30. Van Cauteren D., Vaux S., de Valk H., Le Strat Y., Vaillant V., Levy-Bruhl D. Burden of influenza, healthcare seeking behaviour and hygiene measures during the A(H1N1)2009 pandemic in France: a population based study. BMC Public Health 2012, 12:947.
31. Gubareva L.V., Novikov D.V., Hayden F.G. Assessment of hemagglutinin sequence heterogeneity during influenza virus transmission in families. J Infect Dis 2002 Dec 1, 186(11):1575-1581.
32. Teo S.S., Ellis J.S., Aitken C., Booy R. Transmission of influenza A in families. Pediatr Infect Dis J 2007 Jul, 26(7):645-647.
33. Poon L.L., Chan K.H., Chu D.K., Fung C.C., Cheng C.K., Ip D.K., et al. Viral genetic sequence variations in pandemic H1N1/2009 and seasonal H3N2 influenza viruses within an individual, a household and a community. J Clin Virol 2011 Oct, 52(2):146-150.
34. Pascalis H., Temmam S., Wilkinson D.A., Dsouli N., Turpin M., de Lamballerie X., et al. Molecular evolutionary analysis of pH1N1 2009 influenza virus in Reunion Island, South West Indian Ocean region: a cohort study. PLoS One 2012, 7(8):e43742.
35. Badger G.F., Dingle J.H., Feller A.E., Hodges R.G., Jordan W.S., Rammelkamp C.H. A study of illness in a group of Cleveland families. III. Introduction of respiratory infections into families. Am J Hyg 1953 Jul, 58(1):41-46.
36. Badger G.F., Dingle J.H., Feller A.E., Hodges R.G., Jordan W.S., Rammelkamp C.H. A study of illness in a group of Cleveland families. IV. The spread of respiratory infections within the home. Am J Hyg 1953 Sep, 58(2):174-178.
37. Buck C. Acute upper respiratory infections in families. Am J Hyg 1956 Jan, 63(1):1-12.
38. Viboud C., Tam T., Fleming D., Handel A., Miller M.A., Simonsen L. Transmissibility and mortality impact of epidemic and pandemic influenza, with emphasis on the unusually deadly 1951 epidemic. Vaccine 2006 Nov 10, 24(44-46):6701-6707.
39. Loeb M., Singh P.K., Fox J., Russell M.L., Pabbaraju K., Zarra D., et al. Longitudinal study of influenza molecular viral shedding in Hutterite communities. J Infect Dis 2012 Oct 1, 206(7):1078-1084.
40. Fielding J.E., Kelly H.A., Mercer G.N., Glass K. Systematic review of influenza A(H1N1)pdm09 virus shedding: duration is affected by severity, but not age. Influenza Other Respir Viruses 2013 Dec 2, 10.1111/irv.12216.
41. Patrozou E., Mermel L.A. Does influenza transmission occur from asymptomatic infection or prior to symptom onset?. Public Health Rep 2009 Mar-Apr, 124(2):193-196.
42. Hermes J., Bernard H., Buchholz U., Spackova M., Low J., Loytved G., et al. Lack of evidence for pre-symptomatic transmission of pandemic influenza virus A(H1N1) 2009 in an outbreak among teenagers; Germany, 2009. Influenza Other Respir Viruses 2011 Nov, 5(6):e499-e503.
43. Gu Y., Komiya N., Kamiya H., Yasui Y., Taniguchi K., Okabe N. Pandemic (H1N1) 2009 transmission during presymptomatic phase. Jpn Emerg Infect Dis 2011 Sep, 17(9):1737-1739.
44. Roberts K.L., Shelton H., Stilwell P., Barclay W.S. Transmission of a 2009 H1N1 pandemic influenza virus occurs before fever is detected, in the ferret model. PLoS One 2012, 7(8):e43303.
45. Bischoff W.E., Swett K., Leng I., Peters T.R. Exposure to influenza virus aerosols during routine patient care. J Infect Dis 2013 Apr, 207(7):1037-1046.