Abnormal structure and function of the esophagogastric junction and proximal stomach in gastroesophageal reflux disease

American Journal of Gastroenterology

Volumn 109, Issue 5, 2014, Pages 658-667

  Curcic, Jelena ^a,b   Roy, Shammodip ^c   Schwizer, Alexandra ^b   Kaufman, Elad ^b   Forras Kaufman, Zsofia ^b   Menne, Dieter ^d   Hebbard, Geoffrey S ^e   Treier, Reto ^a   Boesiger, Peter ^a,f   Steingoetter, Andreas ^a,b   Fried, Michael ^b,f   Schwizer, Werner ^b,f   Pal, Anupam ^c   Fox, Mark ^b,g  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c INDIAN INSTITUTE OF TECHNOLOGY KANPUR   (India)

^d Menne Biomed   (Germany)

^e ROYAL MELBOURNE HOSPITAL   (Australia)

^f UNIVERSITY OF ZURICH   (Switzerland)

^g NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ESOPHAGUS FUNCTION; FEMALE; GASTROESOPHAGEAL REFLUX; HUMAN; HYPOTHESIS; IMAGE ANALYSIS; LOWER ESOPHAGUS SPHINCTER; MAJOR CLINICAL STUDY; MALE; MANOMETRY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROXIMAL STOMACH; STOMACH; STOMACH FUNCTION; TEST MEAL;

ADULT; CASE-CONTROL STUDIES; ESOPHAGOGASTRIC JUNCTION; FEMALE; GASTROESOPHAGEAL REFLUX; HUMANS; IMAGING, THREE-DIMENSIONAL; MAGNETIC RESONANCE IMAGING, CINE; MALE; MANOMETRY; MIDDLE AGED; MODELS, STATISTICAL; PROSPECTIVE STUDIES; STOMACH;

EID: 84899934098     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2014.25     Document Type: Article

References (33)

1. Mittal RK, Balaban DH. The esophagogastric junction. N Engl J Med 1997; 336: 924-32.
2. Brasseur JG, Ulerich R, Daii Q et al. Pharmacological dissection of the human gastro-oesophageal segment into three sphincteric components. J Physiol 2007; 580: 961-75.
3. Holloway RH, Hongo M, Berger K et al. Gastric distention: a mechanism for postprandial gastroesophageal reflux. Gastroenterology 1985; 89: 779-84.
4. Dent J, Holloway RH, Toouli J et al. Mechanisms of lower oesophageal sphincter incompetence in patients with symptomatic gastrooesophageal reflux. Gut 1988; 29: 1020-8.
5. Trudgill NJ, Riley SA. Transient lower esophageal sphincter relaxations are no more frequent in patients with gastroesophageal reflux disease than in asymptomatic volunteers. Am J Gastroenterol 2001; 96: 2569-74.
6. Grossi L, Ciccaglione AF, Travaglini N et al. Transient lower esophageal sphincter relaxations and gastroesophageal reflux episodes in healthy subjects and GERD patients during 24 hours. Dig Dis Sci 2001; 46: 815-21.
7. Bredenoord AJ, Weusten BLAM, Carmagnola S et al. Double-peaked highpressure zone at the esophagogastric junction in controls and in patients with a hiatal hernia: a study using high-resolution manometry. Dig Dis Sci 2004; 49: 1128-35.
8. Scheffer RCH, Gooszen HG, Hebbard GS et al. The role of transsphincteric pressure and proximal gastric volume in acid reflux before and aft er fundoplication. Gastroenterology 2005; 129: 1900-9.
9. Atkinson M. Mechanisms protecting against gastro-oesophageal reflux: a review. Gut 1962; 3: 1-15.
10. McMahon BP, Jobe BA, Pandolfino JE et al. Do we really understand the role of the oesophagogastric junction in disease? World J Gastroenterol 2009; 15: 144-50.
11. Bardaji C, Boix-Ochoa J. Contribution of the His angle to the gastro-esophageal antireflux mechanism. Pediatr Surg Int 1986; 1: 172-6.
12. Hill LD, Kozarek RA, Kraemer SJ et al. The gastroesophageal flap valve: in vitro and in vivo observations. Gastrointest Endosc 1996; 44: 541-7.
13. Fujiwara Y, Nakagawa K, Kusunoki M et al. Gastroesophageal reflux aft er distal gastrectomy: possible significance of the angle of His. Am J Gastroenterol 1998; 93: 11-5.
14. Pandolfino JE, Bianchi LK, Lee TJ et al. Esophagogastric junction morphology predicts susceptibility to exercise-induced reflux. Am J Gastroenterol 2004; 99: 1430-6.
15. Fukazawa K, Furuta K, Adachi K et al. Continuous imaging of esophagogastric junction in patients with reflux esophagitis using 320-row area detector CT: a feasibility study. J Gastroenterol Hepatol 2013; 28: 1600-7.
16. Curcic J, Fox M, Kaufman E et al. Gastroesophageal junction: structure and function as assessed by using MR imaging. Radiology 2010; 257: 115-24.
17. Roy S, Fox MR, Curcic J et al. The gastro-esophageal reflux barrier: biophysical analysis on 3D models of anatomy from magnetic resonance imaging. Neurogastroenterol Motil 2012; 24: 616-25.
18. Pandolfino JE, Shi G, Trueworthy B et al. Esophagogastric junction opening during relaxation distinguishes nonhernia reflux patients, hernia patients, and normal subjects. Gastroenterology 2003; 125: 1018-24.
19. van Herwaarden MA, Katzka DA, Smout AJ et al. Effect of different recumbent positions on postprandial gastroesophageal reflux in normal subjects. Am J Gastroenterol 2000; 95: 2731-6.
20. Cohen M, Ellett MC, Perkins S et al. Accurate localization of the position of the tip of a naso/orogastric tube in children; where is the location of the gastro-esophageal junction? Pediatric Radiol 2011; 41: 1266-71.
21. Cohen BR, Wolf BS, Som M et al. Correlation of Manometric, Oesophagoscopic, and Radiological Findings in the Columnar-Lined Gullet (Barrett Syndrome). Gut 1963; 4: 406-12.
22. Roman S, Zerbib F, Belhocine K et al. High resolution manometry to detect transient lower oesophageal sphincter relaxations: diagnostic accuracy compared with perfused-sleeve manometry, and the definition of new detection criteria. Aliment Pharmacol Ther 2011; 34: 384-93.
23. Kaufman E, Curcic J, Pal A et al. The structure and function of the gastroesophageal junction in health and reflux disease assessed by magnetic resonance imaging and high resolution manometry. Gastroenterology 2009; 136 (Suppl 1): A-17.
24. Curcic J, Schwizer A, Roy S et al. Effect of baclofen on the mechanism of reflux protection in healthy volunteers and patients with gastro-esophageal reflux disease (GERD) assessed by magnetic resonance imaging (MRI) and high resolution manometry (HRM): a randomized controlled study. Gastroenterology 2013; 142: S-304.
25. Lundell LR, Dent J, Bennett JR et al. Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut 1999; 45: 172-80.
26. Bredenoord AJ, Weusten BL, Curvers WL et al. Determinants of perception of heartburn and regurgitation. Gut 2006; 55: 313-8.
27. Penagini R, Hebbard G, Horowitz M et al. Motor function of the proximal stomach and visceral perception in gastro-oesophageal reflux disease. Gut 1998; 42: 251-7.
28. Zerbib F, des Varannes SB, Ropert A et al. Proximal gastric tone in gastrooesophageal reflux disease. Eur J Gastroenterol Hepatol 1999; 11: 511-5.
29. McCallum RW, Berkowitz DM, Lerner E. Gastric emptying in patients with gastroesophageal reflux. Gastroenterology 1981; 80: 285-91.
30. Schwizer W, Hinder RA, DeMeester TR. Does delayed gastric emptying contribute to gastroesophageal reflux disease? Am J Surg 1989; 157: 74-81.
31. Kahrilas PJ, Jonsson A, Denison H et al. Regurgitation is less responsive to acid suppression than heartburn in patients with gastroesophageal reflux disease. Clin Gastroenterol Hepatol 2012; 10: 612-9.
32. Lee J, Anggiansah A, Anggiansah R et al. Effects of age on the gastroesophageal junction, esophageal motility, and reflux disease. Clin Gastroenterol Hepatol 2007; 5: 1392-8.
33. Anggiansah R, Sweis R, Anggiansah A et al. The effects of obesity on oesophageal function, acid exposure and the symptoms of gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2013; 37: 555-63.