Selective inhibition of mucosal serotonin as treatment for IBD?

Gut

Volumn 63, Issue 6, 2014, Pages 866-867

  Levin, Alon D ^a   Van Den Brink, Gijs R ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); GASTROINTESTINAL AGENT; LX 1031; ONDANSETRON; PRUCALOPRIDE; SEROTONIN; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER; TRYPTOPHAN HYDROXYLASE; TRYPTOPHAN HYDROXYLASE 1; TRYPTOPHAN HYDROXYLASE 1 INHIBITOR; TRYPTOPHAN HYDROXYLASE INHIBITOR; UNCLASSIFIED DRUG;

CATABOLISM; CELLULAR SECRETION; COLITIS; CONSTIPATION; DISEASE SEVERITY; DRUG EFFICACY; DRUG TARGETING; DRUG TOLERABILITY; ENTEROCHROMAFFIN CELL; ENZYME INHIBITION; HUMAN; IMMUNOMODULATION; INFLAMMATORY BOWEL DISEASE; INTERNALIZATION; INTESTINE EPITHELIUM; INTESTINE MUCOSA; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION; UNSPECIFIED SIDE EFFECT; VOMITING;

INFLAMMATORY BOWEL DISEASE; PHARMACOTHERAPY; SEROTONIN;

ANIMALS; COLITIS; DOWN-REGULATION; ENZYME INHIBITORS; GENE EXPRESSION; INTESTINAL MUCOSA; MALE; NEURONS; SEROTONIN;

EID: 84899928849     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2013-305283     Document Type: Note

References (10)

1. Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 2007;132:397-414. (Pubitemid 46127672)
2. Margolis KG, Stevanovic K, Li Z, et al. Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine. Gut 2014;63:928-37.
3. Kidd M, Gustafsson BI, Drozdov I, et al. IL1beta- and LPS-induced serotonin secretion is increased in EC cells derived from Crohn's disease. Neurogastroenterol Motil 2009;21:439-50.
4. Bischoff SC, Mailer R, Pabst O, et al. Role of serotonin in intestinal in flammation: knockout of serotonin reuptake transporter exacerbates 2,4,6-trinitrobenzene sulfonic acid colitis in mice. Am J Physiol Gastrointest Liver Physiol 2009;296:G685-95.
5. Haub S, Ritze Y, Bergheim I, et al. Enhancement of intestinal inflammation in mice lacking interleukin 10 by deletion of the serotonin reuptake transporter. Neurogastroenterol Motil 2010;22:826-34, e229.
6. Ghia JE, Li N, Wang H, et al. Serotonin has a key role in pathogenesis of experimental colitis. Gastroenterology 2009;137:1649-60.
7. Khan WI, Ghia JE. Gut hormones: emerging role in immune activation and inflammation. Clin Exp Immunol 2010;161:19-27.
8. Walther DJ, Peter JU, Bashammakh S, et al. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 2003;299:76. (Pubitemid 36042402)
9. Liu Q, Yang Q, Sun W, et al. Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract. J Pharmacol Exp Ther 2008;325:47-55. (Pubitemid 351439163)
10. Brown PM, Drossman DA, Wood AJ, et al. The tryptophan hydroxylase inhibitor LX1031 shows clinical benefit in patients with nonconstipating irritable bowel syndrome. Gastroenterology 2011;141:507-16.