The dynamics of herpesvirus reactivations during and after severe drug eruptions: Their relation to the clinical phenotype and therapeutic outcome

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 69, Issue 6, 2014, Pages 798-805

  Ishida, T ^a   Kano, Y ^a   Mizukawa, Y ^a   Shiohara, T ^a  

^a KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

cytomegalovirus; drug induced hypersensitivity syndrome drug rash with eosinophilia and systemic symptoms; Epstein Barr virus; human herpesvirus 6; Stevens Johnson syndrome toxic epidermal necrolysis

Indexed keywords

CORTICOSTEROID DERIVATIVE; DNA; GANCICLOVIR; IMMUNOSUPPRESSIVE AGENT; VIRUS DNA;

ADULT; ARTICLE; BLOODY DIARRHEA; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; DISEASE SEVERITY; DRESS SYNDROME; DRUG EFFECT; DRUG ERUPTION; DYNAMICS; ENTEROCOLITIS; EPSTEIN BARR VIRUS; FEMALE; FOLLOW UP; HERPES VIRUS; HUMAN; HUMAN HERPESVIRUS 6; IMMUNOSUPPRESSIVE TREATMENT; LONGITUDINAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDY; STEVENS JOHNSON SYNDROME; TOXIC EPIDERMAL NECROLYSIS; VIRUS REACTIVATION; AGED; COMPLICATION; DRUG EFFECTS; DRUG ERUPTIONS; GENETICS; HERPES VIRUS INFECTION; HERPESVIRIDAE; MIDDLE AGED; OUTCOME ASSESSMENT; STEVENS-JOHNSON SYNDROME; TIME; VIROLOGY; VIRUS ACTIVATION; VIRUS LOAD;

ADULT; AGED; DNA, VIRAL; DRUG ERUPTIONS; FEMALE; FOLLOW-UP STUDIES; HERPESVIRIDAE; HERPESVIRIDAE INFECTIONS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MIDDLE AGED; OUTCOME ASSESSMENT (HEALTH CARE); PHENOTYPE; RETROSPECTIVE STUDIES; STEVENS-JOHNSON SYNDROME; TIME FACTORS; VIRAL LOAD; VIRUS ACTIVATION;

EID: 84899920963     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/all.12410     Document Type: Article

References (29)

1. Roujeau JC, Stern RS,. Severe adverse cutaneous reactions to drugs. N Engl J Med 1994; 331: 1272-1285.
2. Pereira FA, Mudgil AV, Rosmarin DM,. Toxic epidermal necrolysis. J Am Acad Dermatol 2007; 56: 181-200.
3. Tay YK, Huff JC, Weston WL,. Mycoplasma pneumoniae infection is associated with Stevens-Johnson syndrome, not erythema multiforme (von Hebra). J Am Acad Dermatol 1996; 35: 757-760.
4. Schalock PC, Dinulos JG,. Mycoplasma pneumoniae-induced Stevens-Johnson syndrome without skin lesions: fact or fiction? J Am Acad Dermatol 2005; 52: 312-315.
5. Ravin KA, Rappaport LD, Zuckerbraun NS, Wadowsky RM, Wald ER, Michaels MM,. Mycoplasma pneumoniae and atypical Stevens-Johnson syndrome: a case series. Pediatrics 2007; 119: 1002-1005.
6. Forman R, Koren G, Shear NH,. Erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis in children: a review of 10 years' experience. Drug Saf 2002; 25: 965-972.
7. Burrows SR, Silins SL, Moss DJ, Khanna R, Misko IS, Argaet VP,. T cell receptor repertoire for a viral epitope in humans is diversified by tolerance to a background major histocompatibility complex antigen. J Exp Med 1995; 182: 1703-1715.
8. Rist M, Smith C, Bell MJ, Burrows SR, Khanna R,. Cross-recognition of HLA DR4 alloantigen by virus-specific CD8+ T cells: a new paradigm for self-/nonself-recognition. Blood 2009; 114: 2244-2253.
9. Williams H, Crawford DH,. Epstein-Barr virus: the impact of scientific advances on clinical practice. Blood 2006; 107: 862-869.
10. Suzuki Y, Inagi R, Aono T, Yamanishi K, Shiohara T,. Human herpesvirus 6 infection as a risk factor for the development of severe drug-induced hypersensitivity syndrome. Arch Dermatol 1998; 134: 1108-1112.
11. Shiohara T, Kano Y,. A complex interaction between drug allergy and viral infection. Clin Rev Allergy Immunol 2007; 33: 124-133.
12. Kamada N, Kinoshita K, Togawa Y, Kobayashi T, Matsubara H, Kohno M, et al. Chronic pulmonary complications associated with toxic epidermal necrolysis: report of a severe case with anti-Ro/SS-A and a review of the published work. J Dermatol 2006; 33: 616-622.
13. Chiou CC, Yang LC, Hung SI, Chang YC, Kuo TT, Ho HC, et al. Clinicopathological features and prognosis of drug rash with eosinophilia and systemic symptoms: a study of 30 cases in Taiwan. J Eur Acad Dermatol Venereol 2008; 22: 1044-1049.
14. Aota N, Shiohara T,. Viral connection between drug rashes and autoimmune diseases: how autoimmune responses are generated after resolution of drug rashes. Autoimmun Rev 2009; 8: 488-494.
15. Asano Y, Kagawa H, Kano Y, Shiohara T,. Cytomegalovirus disease during severe drug eruptions: report of 2 cases and retrospective study of 18 patients with drug-induced hypersensitivity syndrome. Arch Dermatol 2009; 145: 1030-1036.
16. Brown RJ, Rother KI, Artman H, Mercurio MG, Wang R, Looney RJ, et al. Minocycline-induced drug hypersensitivity syndrome followed by multiple autoimmune sequelae. Arch Dermatol 2009; 145: 63-66.
17. Eshki M, Allanore L, Musette P, Milpied B, Grange A, Guillaume JC, et al. Twelve-year analysis of severe cases of drug reaction with eosinophilia and systemic symptoms: a cause of unpredictable multiorgan failure. Arch Dermatol 2009; 145: 67-72.
18. Bastuji-Garin S, Rzany B, Stern RS, Shear NH, Naldi L, Roujeau JC,. Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme. Arch Dermatol 1993; 129: 92-96.
19. Shiohara T, Iijima M, Ikezawa Z, Hashimoto K,. The diagnosis of a DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations. Br J Dermatol 2007; 156: 1083-1084.
20. Côté B, Wechsler J, Bastuji-Garin S, Assier H, Revuz J, Roujeau JC,. Clinicopathologic correlation in erythema multiforme and Stevens-Johnson syndrome. Arch Dermatol 1995; 131: 1268-1272.
21. Hirahara K, Kano Y, Ishida T, Shiohara T,. Diffuse large B-cell lymphoma as a sequela of Stevens-Johnson syndrome associated with an increased Epstein-Barr virus load. Eur J Dermatol 2012; 22: 144-145.
22. Yip LW, Thong BY, Lim J, Tan AW, Wong HB, Handa S, et al. Ocular manifestations and complications of Stevens-Johnson syndrome and toxic epidermal necrolysis: an Asian series. Allergy 2007; 62: 527-531.
23. Gregory DG,. The ophthalmologic management of acute Stevens-Johnson syndrome. Ocul Surf 2008; 6: 87-95.
24. Mockenhaupt M,. The current understanding of Stevens-Johnson syndrome and toxic epidermal necrolysis. Expert Rev Clin Immunol 2011; 7: 803-813.
25. Sugino K, Hebisawa A, Uekusa T, Hatanaka K, Abe H, Homma S,. Bronchiolitis obliterans associated with Stevens-Johnson Syndrome: histopathological bronchial reconstruction of the whole lung and immunohistochemical study. Diagn Pathol 2013; 8: 134.
26. Hirahara K, Kano Y, Mitsuyama Y, Takahashi R, Kimishima M, Shiohara T,. Differences in immunological alterations and underlying viral infections in two well-defined severe drug eruptions. Clin Exp Dermatol 2010; 35: 863-868.
27. Rickinson AB, Kieff E,. Epstein-Barr virus. In:, Knipe DM, Howley PM, editors. Fields Virology, 4th edn. Philadelphia, PA: Raven Press; 2001: 2575-2627.
28. Young LS, Murray PG,. Epstein-Barr virus and oncogenesis: from latent genes to tumours. Oncogene 2003; 22: 5108-5121.
29. Ushigome Y, Kano Y, Ishida T, Hirahara K, Shiohara T,. Short- and long-term outcomes of 34 patients with drug-induced hypersensitivity syndrome in a single institution. J Am Acad Dermatol 2013; 68: 721-728.