Immunohistochemical analysis of PDK1 expression in breast cancer

Diagnostic Pathology

Volumn 9, Issue 1, 2014, Pages

  Arsenic, Ruza ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Breast cancer; PDK1; PIK3CA

Indexed keywords

3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE; PDPK1 PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3 KINASE; PIK3CA PROTEIN, HUMAN; TUMOR MARKER;

BREAST TUMOR; ENZYMOLOGY; FEMALE; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; MUTATION; PATHOLOGY; PREDICTIVE VALUE; PROGNOSIS;

3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES; BREAST NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MUTATION; PHOSPHATIDYLINOSITOL 3-KINASES; PREDICTIVE VALUE OF TESTS; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84899909540     PISSN: None     EISSN: 17461596     Source Type: Journal    
DOI: 10.1186/1746-1596-9-82     Document Type: Letter

References (12)

1. Bayascas JR, Leslie NR, Parsons R, Fleming S, Alessi DR. Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice. Curr Biol 2005, 15:1839-1846. 10.1016/j.cub.2005.08.066, 16243031.
2. Fyffe C, Falasca M. 3-Phosphoinositide-dependent protein kinase-1 as an emerging target in the management of breast cancer. Cancer Manag Res 2013, 5:271-280. 3771848, 24039447.
3. Eser S, Reiff N, Messer M, Seidler B, Gottschalk K, Dobler M, Hieber M, Arbeiter A, Klein S, Kong B, Michalski CV, Schlitter AM, Esposito I, Kind AJ, Rad L, Schnieke AE, Baccarini M, Alessi DR, Rad R, Schmid RM, Schneider G, Saur D. Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer. Cancer Cell 2013, 23:406-420. 10.1016/j.ccr.2013.01.023, 23453624.
4. Fujiwara S, Kawano Y, Yuki H, Okuno J, Nosaka K, Mitsuya H, Hata H. PDK1 inhibition is a novel therapeutic target in multiple myeloma. Br J Cancer 2013, 108:170-178. 10.1038/bjc.2012.527, 3553526, 23321518.
5. Pearn L, Fisher J, Burnett AK, Darley RL. The role of PKC and PDK1 in monocyte lineage specification by Ras. Blood 2007, 109:4461-4469. 10.1182/blood-2006-09-047217, 17255356.
6. Tan JLP, Li Z, Jiang X, Lim YC, Hooi SC, Yu Q. B55β-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer. Cancer Cell 2010, 18:459-471. 10.1016/j.ccr.2010.10.021, 21075311.
7. Zabkiewicz J, Pearn L, Hills RK, Morgan RG, Tonks A, Burnett AK, Darley RL. The PDK1 master kinase is overexpressed in acute myeloid leukemia and promotes PKC-mediated survival of leukemic blasts. Haematologica 2013, 98:xxx.
8. Vasudevan KM, Barbie DA, Davies MA, Rabinovsky R, McNear CJ, Kim JJ, Hennessy BT, Tseng H, Pochanard P, Kim SY, Dunn IF, Schinzel AC, Sandy P, Hoersch S, Sheng Q, Gupta PB, Boehm JS, Reiling JH, Silver S, Lu Y, Stemke-Hale K, Dutta B, Joy C, Sahin AA, Gonzales-Angulo AM, Lluch A, Rameh LE, Jacks T, Root DE, Lander ES, Mills GB, Hahn WC, Sellers WR, Garraway LA. AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell 2009, 16:21-32. 10.1016/j.ccr.2009.04.012, 2752826, 19573809.
9. Oger M, Allaoui M, Elie N, Marnay J, Herlin P, Plancoulaine B, Chasle J, Becette V, Bor-Amgelier C. Impact of tumor heterogeneity on disease-free survival in a series of 368 patients treated for a breast cancer. Diagn Pathol 2013, 8:S43.
10. Cheng H, Qin Y, Fan H, Su P, Zhang X, Zhang H, Zhou G. Overexpression of CARM1 in breast cancer is correlated with poorly characterized clinicopathologic parameters and molecular subtypes. Diagn Pathol 2013, 8:129. 10.1186/1746-1596-8-129, 3766166, 23915145.
11. Maurer M, Su T, Saal LH, Koujak S, Hopkins BD, Barkley CR, Wu J, Nandula S, Dutta B, Xie Y, Chin YR, Kim DI, Ferris JS, Gruvberger-Saal SK, Laakso M, Wang X, Memeo L, Rojtman A, Matos T, Yu JS, Cordon-Cardo C, Isola J, Terry MB, Toker A, Mills GB, Zhao JJ, Murty W, Hibshoosh H, Parson R. 3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma. Cancer Res 2009, 69:6299-6306. 10.1158/0008-5472.CAN-09-0820, 2727605, 19602588.
12. Arsenic R, Lehmann A, Budczies J, Koch I, Prinzler J, Kleine-Tebbe A, Schewe C, Loibl S, Dietel M, Denkert C. Analysis of PIK3CA mutations in breast cancer subtypes. Appl Immunohistochemistry Mol Morphol:AIMM/Offic Publ Soc Appl Immunohistochemistry 2014, 22:50-56.