메뉴 건너뛰기




Volumn 23, Issue 3, 2014, Pages 201-208

The therapeutic role of fulvestrant in the management of patients with hormone receptor-positive breast cancer

Author keywords

Aromatase inhibitor; Endocrine treatment; Fulvestrant; Hormone receptor positive breast cancer; Selective estrogen receptor down regulators; Selective estrogen receptor modulators

Indexed keywords

ANASTROZOLE; APITOLISIB; BEVACIZUMAB; BUPARLISIB; ESTROGEN RECEPTOR; EVEROLIMUS; EXEMESTANE; FULVESTRANT; GEFITINIB; GOSERELIN; LETROZOLE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PICTILISIB; PLACEBO; TAMOXIFEN; VASCULOTROPIN ANTIBODY; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; ESTRADIOL; ESTROGEN RECEPTOR ANTAGONIST; SELECTIVE ESTROGEN RECEPTOR MODULATOR;

EID: 84899894839     PISSN: 09609776     EISSN: 15323080     Source Type: Journal    
DOI: 10.1016/j.breast.2014.01.016     Document Type: Review
Times cited : (68)

References (51)
  • 1
    • 34249033328 scopus 로고    scopus 로고
    • Breast cancer mortality trends in the United States according to estrogen receptor status and age at diagnosis
    • Jatoi I., Chen B.E., Anderson W.F., Rosenberg P.S. Breast cancer mortality trends in the United States according to estrogen receptor status and age at diagnosis. J Clin Oncol 2007, 25:1683-1690.
    • (2007) J Clin Oncol , vol.25 , pp. 1683-1690
    • Jatoi, I.1    Chen, B.E.2    Anderson, W.F.3    Rosenberg, P.S.4
  • 3
    • 84899909424 scopus 로고    scopus 로고
    • EMA. Faslodex. Product Information.
    • EMA. Faslodex. Product Information.
  • 4
    • 0026395885 scopus 로고
    • A potent specific pure antiestrogen with clinical potential
    • Wakeling A.E., Dukes M., Bowler J. A potent specific pure antiestrogen with clinical potential. Cancer Res. 1991, 51:3867-3873.
    • (1991) Cancer Res. , vol.51 , pp. 3867-3873
    • Wakeling, A.E.1    Dukes, M.2    Bowler, J.3
  • 5
    • 33644984327 scopus 로고    scopus 로고
    • Fulvestrant in women with advanced breast cancer after progression on prior aromatase inhibitor therapy: North Central Cancer Treatment Group Trial N0032
    • Ingle J.N., Suman V.J., Rowland K.M., Mirchandani D., Bernath A.M., Camoriano J.K., et al. Fulvestrant in women with advanced breast cancer after progression on prior aromatase inhibitor therapy: North Central Cancer Treatment Group Trial N0032. J Clin Oncol 2006, 24:1052-1056.
    • (2006) J Clin Oncol , vol.24 , pp. 1052-1056
    • Ingle, J.N.1    Suman, V.J.2    Rowland, K.M.3    Mirchandani, D.4    Bernath, A.M.5    Camoriano, J.K.6
  • 6
    • 33846543806 scopus 로고    scopus 로고
    • Clinical benefit of fulvestrant in postmenopausal women with advanced breast cancer and primary or acquired resistance to aromatase inhibitors: final results of phase II Swiss Group for Clinical Cancer Research Trial (SAKK 21/00)
    • Perey L., Paridaens R., Hawle H., Zaman K., Nole F., Wildiers H., et al. Clinical benefit of fulvestrant in postmenopausal women with advanced breast cancer and primary or acquired resistance to aromatase inhibitors: final results of phase II Swiss Group for Clinical Cancer Research Trial (SAKK 21/00). Ann Oncol 2007, 18:64-69.
    • (2007) Ann Oncol , vol.18 , pp. 64-69
    • Perey, L.1    Paridaens, R.2    Hawle, H.3    Zaman, K.4    Nole, F.5    Wildiers, H.6
  • 7
    • 43249130208 scopus 로고    scopus 로고
    • Double-blind, randomized placebo controlled trial of fulvestrant compared with exemestane after prior nonsteroidal aromatase inhibitor therapy in postmenopausal women with hormone receptor-positive, advanced breast cancer: results from EFECT
    • Chia S., Gradishar W., Mauriac L., Bines J., Amant F., Federico M., et al. Double-blind, randomized placebo controlled trial of fulvestrant compared with exemestane after prior nonsteroidal aromatase inhibitor therapy in postmenopausal women with hormone receptor-positive, advanced breast cancer: results from EFECT. J Clin Oncol 2008, 26:1664-1670.
    • (2008) J Clin Oncol , vol.26 , pp. 1664-1670
    • Chia, S.1    Gradishar, W.2    Mauriac, L.3    Bines, J.4    Amant, F.5    Federico, M.6
  • 8
    • 0030737720 scopus 로고    scopus 로고
    • Selective inhibition of estrogen-regulated gene expression in vivo by the pure antiestrogen ICI 182,780
    • Hyder S.M., Chiappetta C., Murthy L., Stancel G.M. Selective inhibition of estrogen-regulated gene expression in vivo by the pure antiestrogen ICI 182,780. Cancer Res. 1997, 57:2547-2549.
    • (1997) Cancer Res. , vol.57 , pp. 2547-2549
    • Hyder, S.M.1    Chiappetta, C.2    Murthy, L.3    Stancel, G.M.4
  • 9
    • 0027768899 scopus 로고
    • The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling
    • Dauvois S., White R., Parker M.G. The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling. J Cell Sci. 1993, 106(Pt 4):1377-1388.
    • (1993) J Cell Sci. , vol.106 , Issue.PART 4 , pp. 1377-1388
    • Dauvois, S.1    White, R.2    Parker, M.G.3
  • 10
    • 0027179615 scopus 로고
    • Action of "pure" antiestrogens in inhibiting estrogen receptor action
    • Parker M.G. Action of "pure" antiestrogens in inhibiting estrogen receptor action. Breast Cancer Res Treat 1993, 26:131-137.
    • (1993) Breast Cancer Res Treat , vol.26 , pp. 131-137
    • Parker, M.G.1
  • 11
    • 0029883292 scopus 로고    scopus 로고
    • Models of estrogen receptor regulation by estrogens and antiestrogens in breast cancer cell lines
    • Pink J.J., Jordan V.C. Models of estrogen receptor regulation by estrogens and antiestrogens in breast cancer cell lines. Cancer Res. 1996, 56:2321-2330.
    • (1996) Cancer Res. , vol.56 , pp. 2321-2330
    • Pink, J.J.1    Jordan, V.C.2
  • 12
    • 0034023827 scopus 로고    scopus 로고
    • Similarities and distinctions in the mode of action of different classes of antioestrogens
    • Wakeling A.E. Similarities and distinctions in the mode of action of different classes of antioestrogens. Endocr Relat Cancer 2000, 7:17-28.
    • (2000) Endocr Relat Cancer , vol.7 , pp. 17-28
    • Wakeling, A.E.1
  • 13
    • 0035884408 scopus 로고    scopus 로고
    • Comparison of the short-term biological effects of 7alpha-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)-nonyl]estra-1,3,5, (10)-triene-3,17beta-diol (Faslodex) versus tamoxifen in postmenopausal women with primary breast cancer
    • Robertson J.F., Nicholson R.I., Bundred N.J., Anderson E., Rayter Z., Dowsett M., et al. Comparison of the short-term biological effects of 7alpha-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)-nonyl]estra-1,3,5, (10)-triene-3,17beta-diol (Faslodex) versus tamoxifen in postmenopausal women with primary breast cancer. Cancer Res. 2001, 61:6739-6746.
    • (2001) Cancer Res. , vol.61 , pp. 6739-6746
    • Robertson, J.F.1    Nicholson, R.I.2    Bundred, N.J.3    Anderson, E.4    Rayter, Z.5    Dowsett, M.6
  • 14
    • 0034663421 scopus 로고    scopus 로고
    • ICI 182,780 (Faslodex): development of a novel, "pure" antiestrogen
    • Howell A., Osborne C.K., Morris C., Wakeling A.E. ICI 182,780 (Faslodex): development of a novel, "pure" antiestrogen. Cancer 2000, 89:817-825.
    • (2000) Cancer , vol.89 , pp. 817-825
    • Howell, A.1    Osborne, C.K.2    Morris, C.3    Wakeling, A.E.4
  • 15
    • 79952281614 scopus 로고    scopus 로고
    • MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways
    • Rao X., Di Leva G., Li M., Fang F., Devlin C., Hartman-Frey C., et al. MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways. Oncogene 2011, 30:1082-1097.
    • (2011) Oncogene , vol.30 , pp. 1082-1097
    • Rao, X.1    Di Leva, G.2    Li, M.3    Fang, F.4    Devlin, C.5    Hartman-Frey, C.6
  • 16
    • 0027933048 scopus 로고
    • Effects of 4-hydroxytamoxifen and a novel pure antioestrogen (ICI 182780) on the clonogenic growth of human breast cancer cells in vitro
    • DeFriend D.J., Anderson E., Bell J., Wilks D.P., West C.M., Mansel R.E., et al. Effects of 4-hydroxytamoxifen and a novel pure antioestrogen (ICI 182780) on the clonogenic growth of human breast cancer cells in vitro. Br J Cancer 1994, 70:204-211.
    • (1994) Br J Cancer , vol.70 , pp. 204-211
    • DeFriend, D.J.1    Anderson, E.2    Bell, J.3    Wilks, D.P.4    West, C.M.5    Mansel, R.E.6
  • 18
    • 0028084758 scopus 로고
    • Investigation of a new pure antiestrogen (ICI 182780) in women with primary breast cancer
    • DeFriend D.J., Howell A., Nicholson R.I., Anderson E., Dowsett M., Mansel R.E., et al. Investigation of a new pure antiestrogen (ICI 182780) in women with primary breast cancer. Cancer Res. 1994, 54:408-414.
    • (1994) Cancer Res. , vol.54 , pp. 408-414
    • DeFriend, D.J.1    Howell, A.2    Nicholson, R.I.3    Anderson, E.4    Dowsett, M.5    Mansel, R.E.6
  • 19
    • 0028861402 scopus 로고
    • Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer
    • Howell A., DeFriend D., Robertson J., Blamey R., Walton P. Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer. Lancet 1995, 345:29-30.
    • (1995) Lancet , vol.345 , pp. 29-30
    • Howell, A.1    DeFriend, D.2    Robertson, J.3    Blamey, R.4    Walton, P.5
  • 20
    • 0030016280 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacological and anti-tumour effects of the specific anti-oestrogen ICI 182780 in women with advanced breast cancer
    • Howell A., DeFriend D.J., Robertson J.F., Blamey R.W., Anderson L., Anderson E., et al. Pharmacokinetics, pharmacological and anti-tumour effects of the specific anti-oestrogen ICI 182780 in women with advanced breast cancer. Br J Cancer 1996, 74:300-308.
    • (1996) Br J Cancer , vol.74 , pp. 300-308
    • Howell, A.1    DeFriend, D.J.2    Robertson, J.F.3    Blamey, R.W.4    Anderson, L.5    Anderson, E.6
  • 21
    • 0037102121 scopus 로고    scopus 로고
    • Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment
    • Howell A., Robertson J.F., Quaresma Albano J., Aschermannova A., Mauriac L., Kleeberg U.R., et al. Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment. J Clin Oncol 2002, 20:3396-3403.
    • (2002) J Clin Oncol , vol.20 , pp. 3396-3403
    • Howell, A.1    Robertson, J.F.2    Quaresma Albano, J.3    Aschermannova, A.4    Mauriac, L.5    Kleeberg, U.R.6
  • 22
    • 0037102126 scopus 로고    scopus 로고
    • Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: results of a North American trial
    • Osborne C.K., Pippen J., Jones S.E., Parker L.M., Ellis M., Come S., et al. Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: results of a North American trial. J Clin Oncol 2002, 20:3386-3395.
    • (2002) J Clin Oncol , vol.20 , pp. 3386-3395
    • Osborne, C.K.1    Pippen, J.2    Jones, S.E.3    Parker, L.M.4    Ellis, M.5    Come, S.6
  • 23
    • 0035498544 scopus 로고    scopus 로고
    • Anastrozole is superior to tamoxifen as first-line therapy in hormone receptor positive advanced breast carcinoma
    • Bonneterre J., Buzdar A., Nabholtz J.M., Robertson J.F., Thurlimann B., von Euler M., et al. Anastrozole is superior to tamoxifen as first-line therapy in hormone receptor positive advanced breast carcinoma. Cancer 2001, 92:2247-2258.
    • (2001) Cancer , vol.92 , pp. 2247-2258
    • Bonneterre, J.1    Buzdar, A.2    Nabholtz, J.M.3    Robertson, J.F.4    Thurlimann, B.5    von Euler, M.6
  • 24
    • 0032530988 scopus 로고    scopus 로고
    • Anastrozole versus megestrol acetate in the treatment of postmenopausal women with advanced breast carcinoma: results of a survival update based on a combined analysis of data from two mature phase III trials. Arimidex Study Group
    • Buzdar A.U., Jonat W., Howell A., Jones S.E., Blomqvist C.P., Vogel C.L., et al. Anastrozole versus megestrol acetate in the treatment of postmenopausal women with advanced breast carcinoma: results of a survival update based on a combined analysis of data from two mature phase III trials. Arimidex Study Group. Cancer 1998, 83:1142-1152.
    • (1998) Cancer , vol.83 , pp. 1142-1152
    • Buzdar, A.U.1    Jonat, W.2    Howell, A.3    Jones, S.E.4    Blomqvist, C.P.5    Vogel, C.L.6
  • 25
    • 0142181118 scopus 로고    scopus 로고
    • Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early-stage breast cancer: results of the ATAC (Arimidex, Tamoxifen Alone or in Combination) trial efficacy and safety update analyses
    • Baum M., Buzdar A., Cuzick J., Forbes J., Houghton J., Howell A., et al. Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early-stage breast cancer: results of the ATAC (Arimidex, Tamoxifen Alone or in Combination) trial efficacy and safety update analyses. Cancer 2003, 98:1802-1810.
    • (2003) Cancer , vol.98 , pp. 1802-1810
    • Baum, M.1    Buzdar, A.2    Cuzick, J.3    Forbes, J.4    Houghton, J.5    Howell, A.6
  • 26
    • 0038683988 scopus 로고    scopus 로고
    • Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma in postmenopausal women: a prospective combined analysis of two multicenter trials
    • Robertson J.F., Osborne C.K., Howell A., Jones S.E., Mauriac L., Ellis M., et al. Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma in postmenopausal women: a prospective combined analysis of two multicenter trials. Cancer 2003, 98:229-238.
    • (2003) Cancer , vol.98 , pp. 229-238
    • Robertson, J.F.1    Osborne, C.K.2    Howell, A.3    Jones, S.E.4    Mauriac, L.5    Ellis, M.6
  • 27
    • 22244449598 scopus 로고    scopus 로고
    • Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma: a prospectively planned combined survival analysis of two multicenter trials
    • Howell A., Pippen J., Elledge R.M., Mauriac L., Vergote I., Jones S.E., et al. Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma: a prospectively planned combined survival analysis of two multicenter trials. Cancer 2005, 104:236-239.
    • (2005) Cancer , vol.104 , pp. 236-239
    • Howell, A.1    Pippen, J.2    Elledge, R.M.3    Mauriac, L.4    Vergote, I.5    Jones, S.E.6
  • 28
    • 2442648038 scopus 로고    scopus 로고
    • Comparison of fulvestrant versus tamoxifen for the treatment of advanced breast cancer in postmenopausal women previously untreated with endocrine therapy: a multinational, double-blind, randomized trial
    • Howell A., Robertson J.F., Abram P., Lichinitser M.R., Elledge R., Bajetta E., et al. Comparison of fulvestrant versus tamoxifen for the treatment of advanced breast cancer in postmenopausal women previously untreated with endocrine therapy: a multinational, double-blind, randomized trial. J Clin Oncol 2004, 22:1605-1613.
    • (2004) J Clin Oncol , vol.22 , pp. 1605-1613
    • Howell, A.1    Robertson, J.F.2    Abram, P.3    Lichinitser, M.R.4    Elledge, R.5    Bajetta, E.6
  • 29
    • 31544469565 scopus 로고    scopus 로고
    • Patients' preference for administration of endocrine treatments by injection or tablets: results from a study of women with breast cancer
    • Fallowfield L., Atkins L., Catt S., Cox A., Coxon C., Langridge C., et al. Patients' preference for administration of endocrine treatments by injection or tablets: results from a study of women with breast cancer. Ann Oncol 2006, 17:205-210.
    • (2006) Ann Oncol , vol.17 , pp. 205-210
    • Fallowfield, L.1    Atkins, L.2    Catt, S.3    Cox, A.4    Coxon, C.5    Langridge, C.6
  • 30
    • 20444448539 scopus 로고    scopus 로고
    • Additive antitumor effect of aromatase inhibitor letrozole and antiestrogen fulvestrant in a postmenopausal breast cancer model
    • Jelovac D., Macedo L., Goloubeva O.G., Handratta V., Brodie A.M. Additive antitumor effect of aromatase inhibitor letrozole and antiestrogen fulvestrant in a postmenopausal breast cancer model. Cancer Res. 2005, 65:5439-5444.
    • (2005) Cancer Res. , vol.65 , pp. 5439-5444
    • Jelovac, D.1    Macedo, L.2    Goloubeva, O.G.3    Handratta, V.4    Brodie, A.M.5
  • 31
    • 44849089392 scopus 로고    scopus 로고
    • Combination of anastrozole with fulvestrant in the intratumoral aromatase xenograft model
    • Macedo L.F., Sabnis G.J., Goloubeva O.G., Brodie A. Combination of anastrozole with fulvestrant in the intratumoral aromatase xenograft model. Cancer Res. 2008, 68:3516-3522.
    • (2008) Cancer Res. , vol.68 , pp. 3516-3522
    • Macedo, L.F.1    Sabnis, G.J.2    Goloubeva, O.G.3    Brodie, A.4
  • 32
    • 84863892191 scopus 로고    scopus 로고
    • FACT: an open-label randomized phase III study of fulvestrant and anastrozole in combination compared with anastrozole alone as first-line therapy for patients with receptor-positive postmenopausal breast cancer
    • Bergh J., Jonsson P.E., Lidbrink E.K., Trudeau M., Eiermann W., Brattstrom D., et al. FACT: an open-label randomized phase III study of fulvestrant and anastrozole in combination compared with anastrozole alone as first-line therapy for patients with receptor-positive postmenopausal breast cancer. J Clin Oncol 2012, 30:1919-1925.
    • (2012) J Clin Oncol , vol.30 , pp. 1919-1925
    • Bergh, J.1    Jonsson, P.E.2    Lidbrink, E.K.3    Trudeau, M.4    Eiermann, W.5    Brattstrom, D.6
  • 34
    • 0019237077 scopus 로고
    • Serum concentrations of tamoxifen and major metabolite during long-term nolvadex therapy, correlated with clinical response
    • Patterson J.S., Settatree R.S., Adam H.K., Kemp J.V. Serum concentrations of tamoxifen and major metabolite during long-term nolvadex therapy, correlated with clinical response. Eur J Cancer 1980, 1:89-92. Suppl.
    • (1980) Eur J Cancer , vol.1 , Issue.SUPPL , pp. 89-92
    • Patterson, J.S.1    Settatree, R.S.2    Adam, H.K.3    Kemp, J.V.4
  • 35
    • 84860322213 scopus 로고    scopus 로고
    • Dose-dependent change in biomarkers during neoadjuvant endocrine therapy with fulvestrant: results from NEWEST, a randomized Phase II study
    • Kuter I., Gee J.M., Hegg R., Singer C.F., Badwe R.A., Lowe E.S., et al. Dose-dependent change in biomarkers during neoadjuvant endocrine therapy with fulvestrant: results from NEWEST, a randomized Phase II study. Breast Cancer Res Treat 2012, 133:237-246.
    • (2012) Breast Cancer Res Treat , vol.133 , pp. 237-246
    • Kuter, I.1    Gee, J.M.2    Hegg, R.3    Singer, C.F.4    Badwe, R.A.5    Lowe, E.S.6
  • 36
    • 78049523306 scopus 로고    scopus 로고
    • Results of the CONFIRM phase III trial comparing fulvestrant 250 mg with fulvestrant 500 mg in postmenopausal women with estrogen receptor-positive advanced breast cancer
    • Di Leo A., Jerusalem G., Petruzelka L., Torres R., Bondarenko I.N., Khasanov R., et al. Results of the CONFIRM phase III trial comparing fulvestrant 250 mg with fulvestrant 500 mg in postmenopausal women with estrogen receptor-positive advanced breast cancer. J Clin Oncol 2010, 28:4594-4600.
    • (2010) J Clin Oncol , vol.28 , pp. 4594-4600
    • Di Leo, A.1    Jerusalem, G.2    Petruzelka, L.3    Torres, R.4    Bondarenko, I.N.5    Khasanov, R.6
  • 37
    • 76749091057 scopus 로고    scopus 로고
    • Activity of fulvestrant 500 mg versus anastrozole 1 mg as first-line treatment for advanced breast cancer: results from the FIRST study
    • Robertson J.F., Llombart-Cussac A., Rolski J., Feltl D., Dewar J., Macpherson E., et al. Activity of fulvestrant 500 mg versus anastrozole 1 mg as first-line treatment for advanced breast cancer: results from the FIRST study. J Clin Oncol 2009, 27:4530-4535.
    • (2009) J Clin Oncol , vol.27 , pp. 4530-4535
    • Robertson, J.F.1    Llombart-Cussac, A.2    Rolski, J.3    Feltl, D.4    Dewar, J.5    Macpherson, E.6
  • 38
    • 84868207599 scopus 로고    scopus 로고
    • Fulvestrant 500 mg versus anastrozole 1 mg for the first-line treatment of advanced breast cancer: follow-up analysis from the randomized 'FIRST' study
    • Robertson J.F., Lindemann J.P., Llombart-Cussac A., Rolski J., Feltl D., Dewar J., et al. Fulvestrant 500 mg versus anastrozole 1 mg for the first-line treatment of advanced breast cancer: follow-up analysis from the randomized 'FIRST' study. Breast Cancer Res Treat 2012, 136:503-511.
    • (2012) Breast Cancer Res Treat , vol.136 , pp. 503-511
    • Robertson, J.F.1    Lindemann, J.P.2    Llombart-Cussac, A.3    Rolski, J.4    Feltl, D.5    Dewar, J.6
  • 40
    • 84879474493 scopus 로고    scopus 로고
    • Phase III trial evaluating the addition of bevacizumab to endocrine therapy as first-line treatment for advanced breast cancer - first efficacy results from the LEA study
    • Martin M., Loibl S., von Minckwitz G., Morales S., Crespo C., Anton A., et al. Phase III trial evaluating the addition of bevacizumab to endocrine therapy as first-line treatment for advanced breast cancer - first efficacy results from the LEA study. Cancer Research 2012, 72.
    • (2012) Cancer Research , pp. 72
    • Martin, M.1    Loibl, S.2    von Minckwitz, G.3    Morales, S.4    Crespo, C.5    Anton, A.6
  • 41
    • 33644755478 scopus 로고    scopus 로고
    • The association between Akt activation and resistance to hormone therapy in metastatic breast cancer
    • Tokunaga E., Kataoka A., Kimura Y., Oki E., Mashino K., Nishida K., et al. The association between Akt activation and resistance to hormone therapy in metastatic breast cancer. Eur J Cancer 2006, 42:629-635.
    • (2006) Eur J Cancer , vol.42 , pp. 629-635
    • Tokunaga, E.1    Kataoka, A.2    Kimura, Y.3    Oki, E.4    Mashino, K.5    Nishida, K.6
  • 42
    • 13844273087 scopus 로고    scopus 로고
    • PI3K-Akt pathway: its functions and alterations in human cancer
    • Osaki M., Oshimura M., Ito H. PI3K-Akt pathway: its functions and alterations in human cancer. Apoptosis 2004, 9:667-676.
    • (2004) Apoptosis , vol.9 , pp. 667-676
    • Osaki, M.1    Oshimura, M.2    Ito, H.3
  • 43
    • 20644465808 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinase in xenografts and cells during prolonged treatment with aromatase inhibitor letrozole
    • Jelovac D., Sabnis G., Long B.J., Macedo L., Goloubeva O.G., Brodie A.M. Activation of mitogen-activated protein kinase in xenografts and cells during prolonged treatment with aromatase inhibitor letrozole. Cancer Res. 2005, 65:5380-5389.
    • (2005) Cancer Res. , vol.65 , pp. 5380-5389
    • Jelovac, D.1    Sabnis, G.2    Long, B.J.3    Macedo, L.4    Goloubeva, O.G.5    Brodie, A.M.6
  • 44
  • 45
    • 66849136781 scopus 로고    scopus 로고
    • Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer
    • Baselga J., Semiglazov V., van Dam P., Manikhas A., Bellet M., Mayordomo J., et al. Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer. J Clin Oncol 2009, 27:2630-2637.
    • (2009) J Clin Oncol , vol.27 , pp. 2630-2637
    • Baselga, J.1    Semiglazov, V.2    van Dam, P.3    Manikhas, A.4    Bellet, M.5    Mayordomo, J.6
  • 46
    • 84863078767 scopus 로고    scopus 로고
    • Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
    • Baselga J., Campone M., Piccart M., Burris H.A., Rugo H.S., Sahmoud T., et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med 2012, 366:520-529.
    • (2012) N Engl J Med , vol.366 , pp. 520-529
    • Baselga, J.1    Campone, M.2    Piccart, M.3    Burris, H.A.4    Rugo, H.S.5    Sahmoud, T.6
  • 47
    • 84864558874 scopus 로고    scopus 로고
    • Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: a GINECO study
    • Bachelot T., Bourgier C., Cropet C., Ray-Coquard I., Ferrero J.M., Freyer G., et al. Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: a GINECO study. J Clin Oncol 2012, 30:2718-2724.
    • (2012) J Clin Oncol , vol.30 , pp. 2718-2724
    • Bachelot, T.1    Bourgier, C.2    Cropet, C.3    Ray-Coquard, I.4    Ferrero, J.M.5    Freyer, G.6
  • 48
    • 84875950102 scopus 로고    scopus 로고
    • BYL719, a next generation PI3K alpha specific inhibitor: preliminary safety, PK, and efficacy results from the first-in-human study
    • Abstract CT-01
    • Juric D., Rodon J., González-Angulo A.M., Burris H.A., Bendell J., Berlin J.D., et al. BYL719, a next generation PI3K alpha specific inhibitor: preliminary safety, PK, and efficacy results from the first-in-human study. Cancer Res. 2012, 72(Suppl 8). Abstract CT-01.
    • (2012) Cancer Res. , vol.72 , Issue.SUPPL 8
    • Juric, D.1    Rodon, J.2    González-Angulo, A.M.3    Burris, H.A.4    Bendell, J.5    Berlin, J.D.6
  • 49
    • 84899902676 scopus 로고    scopus 로고
    • Fulvestrant (FUL) and goserelin (GOS) in premenopausal women with advanced, hormone-sensitive breast cancer: a pilot study
    • Abstract 708
    • Steger G., Bartsch R., Wenzel C., Hussian D., Sevelda U., Pluschnig U., et al. Fulvestrant (FUL) and goserelin (GOS) in premenopausal women with advanced, hormone-sensitive breast cancer: a pilot study. ASCO Meeting Abstracts 2005, 23. Abstract 708.
    • (2005) ASCO Meeting Abstracts , vol.23
    • Steger, G.1    Bartsch, R.2    Wenzel, C.3    Hussian, D.4    Sevelda, U.5    Pluschnig, U.6
  • 50
    • 34247154393 scopus 로고    scopus 로고
    • Adherence to endocrine therapy for breast cancer
    • Chlebowski R.T., Geller M.L. Adherence to endocrine therapy for breast cancer. Oncology 2006, 71:1-9.
    • (2006) Oncology , vol.71 , pp. 1-9
    • Chlebowski, R.T.1    Geller, M.L.2
  • 51
    • 77957936884 scopus 로고    scopus 로고
    • Early discontinuation and nonadherence to adjuvant hormonal therapy in a cohort of 8,769 early-stage breast cancer patients
    • Hershman D.L., Kushi L.H., Shao T., Buono D., Kershenbaum A., Tsai W.Y., et al. Early discontinuation and nonadherence to adjuvant hormonal therapy in a cohort of 8,769 early-stage breast cancer patients. J Clin Oncol 2010, 28:4120-4128.
    • (2010) J Clin Oncol , vol.28 , pp. 4120-4128
    • Hershman, D.L.1    Kushi, L.H.2    Shao, T.3    Buono, D.4    Kershenbaum, A.5    Tsai, W.Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.