Miro1: New wheels for transferring mitochondria

EMBO Journal

Volumn 33, Issue 9, 2014, Pages 939-941

  Las, Guy ^a,b   Shirihai, Orian S ^a,b  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; MIRO1 PROTEIN; MITOCHONDRIAL DNA; NANOTUBE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; ROTENONE; TUNNELING NANOTUBE; UNCLASSIFIED DRUG;

ACUTE LUNG INJURY; ALLERGIC AIRWAY INFLAMMATION; APOPTOSIS; ARTICLE; BIOENERGY; EPITHELIUM CELL; FIBROBLAST; IN VITRO STUDY; INTRACELLULAR TRANSPORT; LUNG INJURY; MESENCHYMAL STEM CELL; MICROTUBULE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; RESPIRATORY FUNCTION; RESPIRATORY TRACT ALLERGY;

ANIMALS; HUMANS; LUNG INJURY; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MITOCHONDRIA; RHO GTP-BINDING PROTEINS;

EID: 84899860563     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1002/embj.201488441     Document Type: Article

References (9)

1. Acquistapace A, Bru T, Lesault PF, Figeac F, Coudert AE, Le CO, Christov C, Baudin X, Auber F, Yiou R, Dubois-Rande JL, Rodriguez AM, (2011) Human mesenchymal stem cells reprogram adult cardiomyocytes toward a progenitor-like state through partial cell fusion and mitochondria transfer. Stem Cells, 29: 812-824
2. Ahmad T, Mukherjee S, Pattnaik B, Kumar M, Singh S, Kumar M, Rehman R, Tiwari BK, Jha KA, Barhanpurkar AP, Wani MR, Roy SS, Mabalirajan U, Ghosh B, Agrawal A, (2014) Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy. EMBO J doi: 10.1002/embj. 201386030
3. Cho YM, Kim JH, Kim M, Park SJ, Koh SH, Ahn HS, Kang GH, Lee JB, Park KS, Lee HK, (2012) Mesenchymal stem cells transfer mitochondria to the cells with virtually no mitochondrial function but not with pathogenic mtDNA mutations. PLoS One 7: e32778
4. Fransson S, Ruusala A, Aspenstrom P, (2006) The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. Biochem Biophys Res Commun 344: 500-510
5. Islam MN, Das SR, Emin MT, Wei M, Sun L, Westphalen K, Rowlands DJ, Quadri SK, Bhattacharya S, Bhattacharya J, (2012) Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury. Nat Med 18: 759-765
6. Macaskill AF, Rinholm JE, Twelvetrees AE, Arancibia-Carcamo IL, Muir J, Fransson A, Aspenstrom P, Attwell D, Kittler JT, (2009) Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses. Neuron 61: 541-555
7. Pasquier J, Guerrouahen BS, Al TH, Ghiabi P, Maleki M, Abu-Kaoud N, Jacob A, Mirshahi M, Galas L, Rafii S, Le FF, Rafii A, (2013) Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance. J Transl Med 11: 94
8. Saotome M, Safiulina D, Szabadkai G, Das S, Fransson A, Aspenstrom P, Rizzuto R, Hajnoczky G, (2008) Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase. Proc Natl Acad Sci U S A 105: 20728-20733
9. Spees JL, Olson SD, Whitney MJ, Prockop DJ, (2006) Mitochondrial transfer between cells can rescue aerobic respiration. Proc Natl Acad Sci U S A 103: 1283-1288