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Volumn 28, Issue 2, 2014, Pages 269-279

Ethical issues raised by whole genome sequencing

Author keywords

Medical ethics; Next generation sequencing; Whole genome sequencing

Indexed keywords

ARTICLE; CLINICAL PRACTICE; DNA SEQUENCE; ETHICS; EXOME; GENE SEQUENCE; GENETIC VARIABILITY; GENOME; HUMAN; INFORMATION PROCESSING; INFORMED CONSENT;

EID: 84899839648     PISSN: 15216918     EISSN: 15321916     Source Type: Journal    
DOI: 10.1016/j.bpg.2014.02.004     Document Type: Review
Times cited : (51)

References (45)
  • 1
    • 84863880574 scopus 로고    scopus 로고
    • The clinical implementation of whole genome sequencing: A conversation with seven scientific experts
    • J.P. Lerner-Ellis The clinical implementation of whole genome sequencing: a conversation with seven scientific experts J Inherit Metab Dis 35 2012 689 693
    • (2012) J Inherit Metab Dis , vol.35 , pp. 689-693
    • Lerner-Ellis, J.P.1
  • 2
    • 85028110080 scopus 로고    scopus 로고
    • http://www.technologyreview.com/news/523601/does-illumina-have-the-first- 1000-genome/.
  • 4
    • 85028100701 scopus 로고    scopus 로고
    • http://www.theguardian.com/science/2013/jun/08/genome-sequenced.
  • 5
    • 84866467254 scopus 로고    scopus 로고
    • Key principles and clinical applications of "next-generation" DNA sequencing
    • J.M. Rizzo, and M.J. Buck Key principles and clinical applications of "next-generation" DNA sequencing Cancer Prev Res 5 2012 887 900
    • (2012) Cancer Prev Res , vol.5 , pp. 887-900
    • Rizzo, J.M.1    Buck, M.J.2
  • 6
    • 84876948617 scopus 로고    scopus 로고
    • Next generation sequencing and a new era of medicine
    • G. Casey, D. Conti, R. Haile, and D. Duggan Next generation sequencing and a new era of medicine Gut 62 2013 920 932
    • (2013) Gut , vol.62 , pp. 920-932
    • Casey, G.1    Conti, D.2    Haile, R.3    Duggan, D.4
  • 7
    • 84859583108 scopus 로고    scopus 로고
    • Opportunities and challenges for the integration of massively parallel genomic sequencing into clinical practice: Lessons from the ClinSeq project
    • L.G. Biesecker Opportunities and challenges for the integration of massively parallel genomic sequencing into clinical practice: lessons from the ClinSeq project Genet Med 14 2012 393 398
    • (2012) Genet Med , vol.14 , pp. 393-398
    • Biesecker, L.G.1
  • 8
    • 84868118711 scopus 로고    scopus 로고
    • Exome and whole-genome sequencing as clinical tests: A transformative practice in molecular diagnostics
    • Y. Yu, B.L. Wu, J. Wu, and Y. Shen Exome and whole-genome sequencing as clinical tests: a transformative practice in molecular diagnostics Clin Chem 58 2012 1507 1509
    • (2012) Clin Chem , vol.58 , pp. 1507-1509
    • Yu, Y.1    Wu, B.L.2    Wu, J.3    Shen, Y.4
  • 9
    • 84893615971 scopus 로고    scopus 로고
    • The promise and challenges of next-generation genome sequencing for clinical care
    • K.A. Johansen Taber, B.D. Dickinson, and M. Wilson The promise and challenges of next-generation genome sequencing for clinical care JAMA Intern Med 174 2 2014 275 280
    • (2014) JAMA Intern Med , vol.174 , Issue.2 , pp. 275-280
    • Johansen Taber, K.A.1    Dickinson, B.D.2    Wilson, M.3
  • 10
    • 84857100461 scopus 로고    scopus 로고
    • Sequencing set to alter clinical landscape
    • E.C. Hayden Sequencing set to alter clinical landscape Nature 482 7385 2012 288
    • (2012) Nature , vol.482 , Issue.7385 , pp. 288
    • Hayden, E.C.1
  • 11
    • 84860570409 scopus 로고    scopus 로고
    • Next-generation sequencing: Ready for the clinics?
    • A.N. Desai, and A. Jere Next-generation sequencing: ready for the clinics? Clin Genet 81 2012 503 510
    • (2012) Clin Genet , vol.81 , pp. 503-510
    • Desai, A.N.1    Jere, A.2
  • 13
    • 78650775954 scopus 로고    scopus 로고
    • The $1,000 genome, the $100,000 analysis?
    • E.R. Mardis The $1,000 genome, the $100,000 analysis? Genome Med 2 2010 84 93
    • (2010) Genome Med , vol.2 , pp. 84-93
    • Mardis, E.R.1
  • 14
    • 84899808119 scopus 로고    scopus 로고
    • From genetic counseling to genomic counseling
    • K.E. Ormond From genetic counseling to genomic counseling Mol Genet Genomic Med 1 2013 189 193
    • (2013) Mol Genet Genomic Med , vol.1 , pp. 189-193
    • Ormond, K.E.1
  • 15
    • 41849095185 scopus 로고    scopus 로고
    • Research ethics recommendations for whole-genome research: Consensus statement
    • T. Caulfield, A.L. McGuire, M. Cho, and J.A. Buchanan Research ethics recommendations for whole-genome research: consensus statement PLoS Biol 6 3 2008 e73
    • (2008) PLoS Biol , vol.6 , Issue.3 , pp. 73
    • Caulfield, T.1    McGuire, A.L.2    Cho, M.3    Buchanan, J.A.4
  • 16
    • 77949653046 scopus 로고    scopus 로고
    • Ethical implications of the use of whole genome methods in medical research
    • J. Kaye, P. Boddington, J. de Vries, N. Hawkins, and K. Melham Ethical implications of the use of whole genome methods in medical research Eur J Hum Genet 18 2010 398 403
    • (2010) Eur J Hum Genet , vol.18 , pp. 398-403
    • Kaye, J.1    Boddington, P.2    De Vries, J.3    Hawkins, N.4    Melham, K.5
  • 17
    • 84884587533 scopus 로고    scopus 로고
    • Informed consent for whole-genome sequencing studies in the clinical setting. Proposed recommendations on essential content and process
    • C. Ayuso, J.M. Millán, M. Mancheoño, and R. Dal-Ré Informed consent for whole-genome sequencing studies in the clinical setting. Proposed recommendations on essential content and process Eur J Hum Genet 21 10 2013 1054 1059
    • (2013) Eur J Hum Genet , vol.21 , Issue.10 , pp. 1054-1059
    • Ayuso, C.1    Millán, J.M.2    Mancheoño, M.3    Dal-Ré, R.4
  • 18
    • 84880535720 scopus 로고    scopus 로고
    • ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing
    • R.C. Green, J.S. Berg, W.W. Grody, S.S. Kalia, B.R. Korf, and C.L. Martin et al. ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing Genet Med 15 2013 565 574
    • (2013) Genet Med , vol.15 , pp. 565-574
    • Green, R.C.1    Berg, J.S.2    Grody, W.W.3    Kalia, S.S.4    Korf, B.R.5    Martin, C.L.6
  • 19
    • 84881420673 scopus 로고    scopus 로고
    • Whole-genome sequencing in health care: Recommendations of the European Society of Human Genetics
    • C.G. van El, M.C. Cornel, P. Borry, R.J. Hastings, F. Fellmann, and S.V. Hodgson et al. Whole-genome sequencing in health care: recommendations of the European Society of Human Genetics Eur J Hum Genet 21 2013 580 584
    • (2013) Eur J Hum Genet , vol.21 , pp. 580-584
    • Van El, C.G.1    Cornel, M.C.2    Borry, P.3    Hastings, R.J.4    Fellmann, F.5    Hodgson, S.V.6
  • 20
    • 84904249148 scopus 로고    scopus 로고
    • Stakeholders' opinions on the implementation of pediatric whole exome sequencing: Implications for informed consent
    • B.L. Levenseller, D.J. Soucier, V.A. Miller, D. Harris, L. Conway, and B.A. Bernhardt Stakeholders' opinions on the implementation of pediatric whole exome sequencing: implications for informed consent J Genet Couns 2013
    • (2013) J Genet Couns
    • Levenseller, B.L.1    Soucier, D.J.2    Miller, V.A.3    Harris, D.4    Conway, L.5    Bernhardt, B.A.6
  • 21
    • 38549085235 scopus 로고    scopus 로고
    • Research ethics and the challenge of whole-genome sequencing
    • A.L. McGuire, T. Caulfield, and M.K. Cho Research ethics and the challenge of whole-genome sequencing Nat Rev Genet 9 2 2008 152 156
    • (2008) Nat Rev Genet , vol.9 , Issue.2 , pp. 152-156
    • McGuire, A.L.1    Caulfield, T.2    Cho, M.K.3
  • 22
    • 84865155513 scopus 로고    scopus 로고
    • Arrays in postnatal and prenatal diagnosis: An exploration of the ethics of consent
    • W. Dondorp, B. Sikkema-Raddatz, C. de Die-Smulders, and G. de Wert Arrays in postnatal and prenatal diagnosis: an exploration of the ethics of consent Hum Mutat 33 2012 916 922
    • (2012) Hum Mutat , vol.33 , pp. 916-922
    • Dondorp, W.1    Sikkema-Raddatz, B.2    De Die-Smulders, C.3    De Wert, G.4
  • 23
    • 84861658359 scopus 로고    scopus 로고
    • Whole-genome sequencing: The new standard of care?
    • L.R. Brunham, and M.R. Hayden Whole-genome sequencing: the new standard of care? Science 336 6085 2012 1112 1113
    • (2012) Science , vol.336 , Issue.6085 , pp. 1112-1113
    • Brunham, L.R.1    Hayden, M.R.2
  • 25
    • 81955167410 scopus 로고    scopus 로고
    • Genomics really gets personal: How exome and whole genome sequencing challenge the ethical framework of human genetics research
    • H.K. Tabor, B.E. Berkman, S.C. Hull, and M.J. Bamshad Genomics really gets personal: how exome and whole genome sequencing challenge the ethical framework of human genetics research Am J Med Genet 155 2011 2916 2924
    • (2011) Am J Med Genet , vol.155 , pp. 2916-2924
    • Tabor, H.K.1    Berkman, B.E.2    Hull, S.C.3    Bamshad, M.J.4
  • 26
    • 85028127712 scopus 로고    scopus 로고
    • Is there a right time to know? the right not to know and genetic testing in children
    • n.d.
    • Borry P, Shabani M, Howard HC. Is there a right time to know? The right not to know and genetic testing in children. J Law Med Ethics n.d.
    • J Law Med Ethics
    • Borry, P.1    Shabani, M.2    Howard, H.C.3
  • 29
    • 79959276553 scopus 로고    scopus 로고
    • Deploying whole genome sequencing in clinical practice and public health: Meeting the challenge one bin at a time
    • J.S. Berg, M.J. Khoury, and J.P. Evans Deploying whole genome sequencing in clinical practice and public health: meeting the challenge one bin at a time Genet Med 2011 13(6):499-504
    • (2011) Genet Med , vol.504
    • Berg, J.S.1    Khoury, M.J.2    Evans, J.P.3
  • 32
    • 84859610203 scopus 로고    scopus 로고
    • Return of results: Not that complicated?
    • J.P. Evans, and B.B. Rothschild Return of results: not that complicated? Genet Med 14 4 2012 358 360
    • (2012) Genet Med , vol.14 , Issue.4 , pp. 358-360
    • Evans, J.P.1    Rothschild, B.B.2
  • 33
    • 84884299829 scopus 로고    scopus 로고
    • Return of individual research results and incidental findings: Facing the challenges of translational science
    • S.M. Wolf Return of individual research results and incidental findings: facing the challenges of translational science Annu Rev Genomics Hum Genet 14 2013 557 577
    • (2013) Annu Rev Genomics Hum Genet , vol.14 , pp. 557-577
    • Wolf, S.M.1
  • 34
    • 77951914791 scopus 로고    scopus 로고
    • Personal genome research: What should the participant be told?
    • A.L. McGuire, and J.R. Lupski Personal genome research: what should the participant be told? Trends Genet 26 5 2010 199 201
    • (2010) Trends Genet , vol.26 , Issue.5 , pp. 199-201
    • McGuire, A.L.1    Lupski, J.R.2
  • 35
    • 84859619831 scopus 로고    scopus 로고
    • Return of individual research results from genome-wide association studies: Experience of the Electronic Medical Records and Genomics (eMERGE) Network
    • S.M. Fullerton, W.A. Wolf, K.B. Brothers, E.W. Clayton, D.C. Crawford, and J.C. Denny et al. Return of individual research results from genome-wide association studies: experience of the Electronic Medical Records and Genomics (eMERGE) Network Genet Med 14 2012 424 431
    • (2012) Genet Med , vol.14 , pp. 424-431
    • Fullerton, S.M.1    Wolf, W.A.2    Brothers, K.B.3    Clayton, E.W.4    Crawford, D.C.5    Denny, J.C.6
  • 36
    • 84873884799 scopus 로고    scopus 로고
    • Do researchers have an obligation to actively look for genetic incidental findings?
    • C. Gliwa, and B.E. Berkman Do researchers have an obligation to actively look for genetic incidental findings? Am J Bioeth 13 2 2013 32 42
    • (2013) Am J Bioeth , vol.13 , Issue.2 , pp. 32-42
    • Gliwa, C.1    Berkman, B.E.2
  • 38
    • 84878364688 scopus 로고    scopus 로고
    • Patient autonomy and incidental findings in clinical genomics
    • S.M. Wolf, G.J. Annas, and S. Elias Patient autonomy and incidental findings in clinical genomics Science 340 6136 2013 1049 1050
    • (2013) Science , vol.340 , Issue.6136 , pp. 1049-1050
    • Wolf, S.M.1    Annas, G.J.2    Elias, S.3
  • 39
    • 80053386108 scopus 로고    scopus 로고
    • Public perspectives on returning genetics and genomics research results
    • J. O'Daniel, and S.B. Haga Public perspectives on returning genetics and genomics research results Public Health Genomics 14 2011 346 355
    • (2011) Public Health Genomics , vol.14 , pp. 346-355
    • O'Daniel, J.1    Haga, S.B.2
  • 40
    • 44449162023 scopus 로고    scopus 로고
    • Communicating the results of clinical research to participants: Attitudes, practices, and future directions
    • D.I. Shalowitz, and F.G. Miller Communicating the results of clinical research to participants: attitudes, practices, and future directions PloS Med 5 2008 e91
    • (2008) PloS Med , vol.5 , pp. 91
    • Shalowitz, D.I.1    Miller, F.G.2
  • 41
    • 57449115536 scopus 로고    scopus 로고
    • Subjects matter: A survey of public opinions about a large genetic cohort study
    • D. Kaufman, J. Murphy, J. Scott, and K. Hudson Subjects matter: a survey of public opinions about a large genetic cohort study Genet Med 10 11 2008 831 839
    • (2008) Genet Med , vol.10 , Issue.11 , pp. 831-839
    • Kaufman, D.1    Murphy, J.2    Scott, J.3    Hudson, K.4
  • 42
    • 40849106526 scopus 로고    scopus 로고
    • When research seems like clinical care: A qualitative study of the communication of individual cancer genetic research results
    • F.A. Miller, M. Giacomini, C. Ahern, J.S. Robert, and S. de Laat When research seems like clinical care: a qualitative study of the communication of individual cancer genetic research results BMC Med Ethics 9 2008 4
    • (2008) BMC Med Ethics , vol.9 , pp. 4
    • Miller, F.A.1    Giacomini, M.2    Ahern, C.3    Robert, J.S.4    De Laat, S.5
  • 43
    • 57349167685 scopus 로고    scopus 로고
    • Public expectations for return of results from large-cohort genetic research
    • J. Murphy, J. Scott, D. Kaufman, G. Geller, L. LeRoy, and K. Hudson Public expectations for return of results from large-cohort genetic research Am J Bioeth 8 2008 36 43
    • (2008) Am J Bioeth , vol.8 , pp. 36-43
    • Murphy, J.1    Scott, J.2    Kaufman, D.3    Geller, G.4    Leroy, L.5    Hudson, K.6
  • 44
    • 84859577332 scopus 로고    scopus 로고
    • Exploring concordance and discordance for return of incidental findings from clinical sequencing
    • R.C. Green, J.S. Berg, G.T. Berry, L.G. Biesecker, D.P. Dimmock, and J.P. Evans et al. Exploring concordance and discordance for return of incidental findings from clinical sequencing Genet Med 14 2012 405 410
    • (2012) Genet Med , vol.14 , pp. 405-410
    • Green, R.C.1    Berg, J.S.2    Berry, G.T.3    Biesecker, L.G.4    Dimmock, D.P.5    Evans, J.P.6
  • 45
    • 84866491890 scopus 로고    scopus 로고
    • "i want to know what's in Pandora's Box": Comparing stakeholder perspectives on incidental findings in clinical whole genomic sequencing
    • A. Townsend, S. Adam, P.H. Birch, Z. Lohn, F. Rousseau, and J.M. Friedman "I want to know what's in Pandora's Box": comparing stakeholder perspectives on incidental findings in clinical whole genomic sequencing Am J Med Genet A 158A 2012 2519 2525
    • (2012) Am J Med Genet A , vol.158 A , pp. 2519-2525
    • Townsend, A.1    Adam, S.2    Birch, P.H.3    Lohn, Z.4    Rousseau, F.5    Friedman, J.M.6


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