The high throughput biomedicine unit at the Institute for Molecular medicine finland: High throughput screening meets precision medicine

Combinatorial Chemistry and High Throughput Screening

Volumn 17, Issue 4, 2014, Pages 377-386

  Pietiäinen, Vilja ^a   Saarela, Jani ^a   Von Schantz, Carina ^a   Turunen, Laura ^a   Östling, Päivi ^a   Wennerberg, Krister ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Chemical biology; High throughput screening; Microarrays; Miniaturization; Personalized medicine; RNAi; Translational research

Indexed keywords

BIOMEDICINE; DRUG SENSITIVITY; FINLAND; HIGH THROUGHPUT BIOMEDICINE; HIGH THROUGHPUT SCREENING; HUMAN; LABORATORY AUTOMATION; MICROARRAY ANALYSIS; MICROSCOPY; MOLECULAR MEDICINE; PRIORITY JOURNAL; PROTEIN MICROARRAY; REVERSE PHASE PROTEIN ARRAY; REVIEW; TRANSLATIONAL RESEARCH; COOPERATION; DRUG DEVELOPMENT; EUROPE; GENOMICS; HEALTH CARE FACILITY; MANPOWER; ORGANIZATION AND MANAGEMENT; PERSONALIZED MEDICINE; PROCEDURES; RNA INTERFERENCE;

SMALL INTERFERING RNA;

BIOLOGICAL SPECIMEN BANKS; COOPERATIVE BEHAVIOR; DRUG DISCOVERY; EUROPE; FINLAND; GENOMICS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INDIVIDUALIZED MEDICINE; MICROSCOPY; MOLECULAR MEDICINE; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84899801112     PISSN: 13862073     EISSN: 18755402     Source Type: Journal    
DOI: 10.2174/1386207317666140323195927     Document Type: Review

References (10)

1. Pemovska, T.; Kontro, M.; Yadav, B.; Edgren, H.; Eldfors, S.; Szwajda, A.; Almusa, H.; Bespalov, M. M.; Ellonen, P.; Elonen, E.; Gjertsen, B. T.; Karjalainen, R.; Kulesskiy, E.; Lagstrom, S.; Lehto, A.; Lepisto, M.; Lundan, T.; Majumder, M. M.; Lopez Marti, J. M.; Mattila, P.; Murumagi, A.; Mustjoki, S.; Palva, A.; Parsons, A.; Pirttinen, T.; Ramet, M. E.; Suvela, M.; Turunen, L.; Vastrik, I.; Wolf, M.; Knowles, J.; Aittokallio, T.; Heckman, C. A.; Porkka, K; Kallioniemi, O.; Wennerberg, K. Individualized Systems Medicine (ISM) strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia. Cancer Discov., 2013, 3(12), 1416-1429.
2. Denisova, O. V.; Kakkola, L.; Feng, L.; Stenman, J.; Nagaraj, A.; Lampe, J.; Yadav, B.; Aittokallio, T.; Kaukinen, P.; Ahola, T.; Kuivanen, S.; Vapalahti, O.; Kantele, A.; Tynell, J.; Julkunen, I.; Kallio-Kokko, H.; Paavilainen, H.; Hukkanen, V.; Elliott, R. M.; De Brabander, J. K; Saelens, X.; Kainov, D. E. Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection. J. Biol. Chem., 2012, 287(42), 35324-35332.
3. Knapp, S.; Arruda, P.; Blagg, J.; Burley, S.; Drewry, D. H.; Edwards, A.; Fabbro, D.; Gillespie, P.; Gray, N. S.; Kuster, B.; Lackey, K. E.; Mazzafera, P.; Tomkinson, N. C; Willson, T. M.; Workman, P.; Zuercher, W. J. A public-private partnership to unlock the untargeted kinome. Nat. Chem. Biol, 2013, 9(1), 3-6.
4. Rantala, J. K; Makela, R.; Aaltola, A. R.; Laasola, P.; Mpindi, J. P.; Nees, M.; Saviranta, P.; Kallioniemi, O. A cell spot microarray method for production of high density siRNA transfection microarrays. BMC Genomics, 2011, 12, 162.
5. Erfle, H.; Neumann, B.; Liebel, U.; Rogers, P.; Held, M.; Walter, T.; Ellenberg, J.; Pepperkok, R. Reverse transfection on cell arrays for high content screening microscopy. Nature protocols, 2007, 2(2), 392-399.
6. Erfle, H.; Eskova, A.; Reymann, J.; Starkuviene, V. Cell arrays and high-content screening. Methods Mol Biol, 2011, 785, 277-287.
7. Paweletz, C. P.; Charboneau, L.; Bichsel, V. E.; Simone, N. L.; Chen, T.; Gillespie, J. W.; Emmert-Buck, M. R.; Roth, M. J.; Petricoin, I. E.; Liotta, L. A. Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front. Oncogene, 2001, 20(16), 1981-1989.
8. Liotta, L. A.; Espina, V.; Mehta, A. I.; Calvert, V.; Rosenblatt, K.; Geho, D.; Munson, P. J.; Young, L.; Wulfkuhle, J.; Petricoin, E. F. 3rd, Protein microarrays: meeting analytical challenges for clinical applications. Cancer Cell, 2003, 3(4), 317-325.
9. Leivonen, S. K.; Makela, R.; Ostling, P.; Kohonen, P.; Haapa-Paananen, S.; Kleivi, K.; Enerly, E.; Aakula, A.; Hellstrom, K.; Sahlberg, N.; Kristensen, V. N.; Borresen-Dale, A. L.; Saviranta, P.; Perala, M.; Kallioniemi, O. Protein lysate microarray analysis to identify microRNAs regulating estrogen receptor signaling in breast cancer cell lines. Oncogene, 2009, 28(44), 3926-3936.
10. Stylianou, M.; Kulesskiy, E.; Lopes, J. P.; Granlund, M.; Wennerberg, K; Urban, C. F. Antifungal application of nonantifungal drugs. Antimicrob. Agents Chemother., 2014, 58(2), 1055-1062.