Rational design of lyophilized high concentration protein formulations-mitigating the challenge of slow reconstitution with multidisciplinary strategies

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V

Volumn 85, Issue 2, 2013, Pages 287-293

  Cao, Wenjin ^a   Krishnan, Sampathkumar ^a   Ricci, Margaret S peed ^a   Shih, Liang Yu ^a   Liu, Dingjiang ^a   Gu, Jian H ua ^a   Jameel, Feroz ^a  

^a AMGEN INC   (United States)

Author keywords

Annealing; BET; Brunauer Emmett Teller; Diluent; Fc fusion protein; Formulation; High concentration; Lyophilized; mAb; monoclonal antibody; Reconstitution; sc; Scanning Electron Microscopy; SEC; SEM; size exclusion chromatography; Stability; subcutaneous; UF DF; Ultrafiltration Diafiltration; X ray powder diffraction; XRPD

Indexed keywords

PROTEIN; WETTING AGENT;

CHEMISTRY; DRUG STABILITY; FREEZE DRYING; MEDICINAL CHEMISTRY; PROCEDURES;

CHEMISTRY, PHARMACEUTICAL; DRUG STABILITY; FREEZE DRYING; PROTEINS; WETTING AGENTS;

EID: 84899780303     PISSN: None     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.05.001     Document Type: Article

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