Micropatterned array to assess the interaction of single platelets with platelet factor 4-heparin-IgG complexes

Thrombosis and Haemostasis

Volumn 111, Issue 5, 2014, Pages 862-872

  Medvedev, Nikolay ^a   Palankar, Raghavendra ^a   Krauel, Krystin ^b   Greinacher, Andreas ^b   Delcea, Mihaela ^a  

^a ZIK HIKE Zentrum für Innovationskompetenz 'Humorale Immunreaktionen bei kardiovaskulären Erkrankungen'   (Germany)

^b Institut fur Immunologie und Transfusionsmedizin   (Germany)

Author keywords

Electron beam lithography; Heparin induced thrombocytopenia; Micropatterned arrays; Platelet activation; Platelet factor 4

Indexed keywords

CALCIUM; HEPARIN; IMMUNOGLOBULIN G; LIGAND; QUANTUM DOT; STREPTAVIDIN; THROMBOCYTE FACTOR 4; ANTIGEN ANTIBODY COMPLEX; MACROGOL DERIVATIVE; PROTEIN BINDING;

ARTICLE; BINDING AFFINITY; BIOTINYLATION; BLOOD CLOTTING; CONTROLLED STUDY; ELECTRON BEAM LITHOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMAGING; IMMOBILIZATION; IMMUNE RESPONSE; LIVE CELL IMAGING; MICROARRAY ANALYSIS; PARTICLE RADIATION; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; ANTIGEN ANTIBODY COMPLEX; CALCIUM SIGNALING; CELL CULTURE; CHEMISTRY; HIGH THROUGHPUT SCREENING; IMMUNOHISTOCHEMISTRY; METABOLISM; MICROFLUIDICS; PHYSIOLOGY; PROCEDURES; SINGLE CELL ANALYSIS; THROMBOCYTE;

ANTIGEN-ANTIBODY COMPLEX; BLOOD PLATELETS; CALCIUM SIGNALING; CELLS, CULTURED; HEPARIN; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; IMMUNOGLOBULIN G; IMMUNOHISTOCHEMISTRY; MICROARRAY ANALYSIS; MICROFLUIDICS; PLATELET ACTIVATION; PLATELET FACTOR 4; POLYETHYLENE GLYCOLS; PROTEIN BINDING; QUANTUM DOTS; SINGLE-CELL ANALYSIS;

EID: 84899753983     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH13-09-0752     Document Type: Article

References (28)

1. Cattaneo M, Cerletti C, Harrison P, et al. Recommendations for the Standardisation of Light Transmission Aggregometry: A Consensus of the Working Party from the Platelet Physiology Subcommittee of SSC/ISTH. J Thromb Haemost 2013; epub ahead of print.
2. Arepally GM, Ortel TL. Clinical practice. Heparin-induced thrombocytopenia. N Engl J Med 2006; 355: 809-817.
3. Kelton JG, Arnold DM, Bates SM. Nonheparin anticoagulants for heparin-induced thrombocytopenia. N Engl J Med 2013; 368: 737-744.
4. Amiral J, Bridey F, Dreyfus M, et al. Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia. Thromb Haemost 1992; 68: 95-96.
5. Greinacher A, Liebenhoff U, Kiefel V, et al. Heparin-associated thrombocytopenia: the effects of various intravenous IgG preparations on antibody mediated platelet activation--a possible new indication for high dose i.v. IgG. Thromb Haemost 1994; 71: 641-645.
6. Chong BH, Fawaz I, Chesterman CN, et al. Heparin-induced thrombocytopenia: mechanism of interaction of the heparin-dependent antibody with platelets. Br J Haematol 1989; 73: 235-240.
7. Li ZQ, Liu W, Park KS, et al. Defining a second epitope for heparin-induced thrombocytopenia/thrombosis antibodies using KKO, a murine HIT-like monoclonal antibody. Blood 2002; 99: 1230-1236.
8. Greinacher A, Gopinadhan M, Gunther JU, et al. Close approximation of two platelet factor 4 tetramers by charge neutralisation forms the antigens recognized by HIT antibodies. Arterioscl Thromb Vasc Biol 2006; 26: 2386-2393.
9. Kelton JG, Sheridan D, Santos A, et al. Heparin-induced thrombocytopenia: laboratory studies. Blood 1988; 72: 925-930.
10. Newman PM, Swanson RL, Chong BH. Heparin-induced thrombocytopenia: IgG binding to PF4-heparin complexes in the fluid phase and cross-reactivity with low molecular weight heparin and heparinoid. Thromb Haemost 1998; 80: 292-297.
11. Palankar R, Medvedev N, Rong A, Delcea M. Fabrication of quantum dot microarrays using electron beam lithography for applications in analyte sensing and cellular dynamics. ACS Nano 2013; 7: 4617-4628.
12. Krauel K, Potschke C, Weber C, et al. Platelet factor 4 binds to bacteria, [corrected] inducing antibodies cross-reacting with the major antigen in heparininduced thrombocytopenia. Blood 2011; 117: 1370-1378.
13. Juhl D, Eichler P, Lubenow N, et al. Incidence and clinical significance of anti-PF4/heparin antibodies of the IgG, IgM, and IgA class in 755 consecutive patient samples referred for diagnostic testing for heparin-induced thrombocytopenia. Eur J Haematol 2006; 76: 420-426.
14. Warkentin TE, Greinacher A. Laboratory testing for heparin-induced thrombocytopenia. Heparin-induced Thrombocytopenia New York, NY: Informa Healthcare; 2007: pp. 227-238.
15. Hong Y, Krsko P, Libera M. Protein surface patterning using nanoscale PEG hydrogels. Langmuir 2004; 20: 11123-11126.
16. Krsko P, McCann TE, Thach TT, et al. Length-scale mediated adhesion and directed growth of neural cells by surface-patterned poly(ethylene glycol) hydrogels. Biomaterials 2009; 30: 721-729.
17. Andrade JJ, Brasil AG, Barbosa BJAP, et al. Biocompatible Water Soluble UVBlue Emitting ZnSe Quantum Dots for Biomedical Applications. Colloidal Quantum Dots for Biomedical Applications V. 2010; 7575.
18. Yu WW, Chang E, Drezek R, et al. Water-soluble quantum dots for biomedical applications. Biochem Biophys Res Commun 2006; 348: 781-786.
19. Bruchez M, Jr., Moronne M, Gin P, et al. Semiconductor nanocrystals as fluorescent biological labels. Science 1998; 281: 2013-2016.
20. Basabe-Desmonts L, Ramstrom S, Meade G, et al. Single-step separation of platelets from whole blood coupled with digital quantification by interfacial platelet cytometry (iPC). Langmuir 2010; 26: 14700-14706.
21. Corum LE, Eichinger CD, Hsiao TW, et al. Using microcontact printing of fibrinogen to control surface-induced platelet adhesion and activation. Langmuir 2011; 27: 8316-8322.
22. Kita A, Sakurai Y, Myers DR, et al. Microenvironmental geometry guides platelet adhesion and spreading: a quantitative analysis at the single cell level. PLoS One 2011; 6: e26437.
23. Lopez-Alonso A, Jose B, Somers M, et al. Individual Platelet Adhesion Assay: Measuring Platelet Function and Antiplatelet Therapies in Whole Blood via Digital Quantification of Cell Adhesion. Anal Chem 2013; 85: 6497-6504.
24. Zhang F, Li G, Yang P, et al. Fabrication of biomolecule-PEG micropattern on titanium surface and its effects on platelet adhesion. Colloids Surf B Biointerfaces 2013; 102: 457-465.
25. Van de Walle AB, Fontenot J, Spain TG, et al. The role of fibrinogen spacing and patch size on platelet adhesion under flow. Acta Biomater 2012; 8: 4080-4091.
26. Horsewood P, Hayward CP, Warkentin TE, et al. Investigation of the mechanisms of monoclonal antibody-induced platelet activation. Blood 1991; 78: 1019-1026.
27. Warkentin TE. Clinical picture of heparin induced thrombocytopenia. In: Warkentin TE, Greinacher A, eds. Heparin induced thrombocytopenia. Boca Raton, London, New York CrC Press 2013: pp. 24-76.
28. Warkentin TE. Agents for the treatment of heparin-induced thrombocytopenia. Hematol Oncol Clin North Am 2010; 24: 755-775.