Identification of OppA2 linear epitopes as serodiagnostic markers for lyme disease

Clinical and Vaccine Immunology

Volumn 21, Issue 5, 2014, Pages 704-711

  Signorino, Giacomo ^a,c   Arnaboldi, Paul M ^a,b   Petzke, Mary M ^a   Dattwyler, Raymond J ^a,b  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b Biopeptides Corp   (United States)

^c UNIVERSITY OF MESSINA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; OLIGOPEPTIDE PERMEASE A2; PEPTIDE ANTIBODY; PERMEASE; UNCLASSIFIED DRUG; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; BACTERIUM ANTIBODY; CARRIER PROTEIN; OLIGOPEPTIDE PERMEASE, BACTERIA; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ANTIBODY TITER; ARTICLE; BACTERIUM DETECTION; BACTERIUM IDENTIFICATION; BLOOD ANALYSIS; BORRELIA BURGDORFERI; CONTROLLED STUDY; CROSS REACTION; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIFFERENTIAL DIAGNOSIS; DISEASE MARKER; EARLY DIAGNOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; ERYTHEMA CHRONICUM MIGRANS; GENE IDENTIFICATION; GENETIC CONSERVATION; GENETIC SCREENING; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; LYME DISEASE; MAJOR CLINICAL STUDY; NONHUMAN; OPPA2 GENE; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SENSITIVITY AND SPECIFICITY; SERODIAGNOSIS; SYPHILIS; ADULT; BLOOD; DIAGNOSTIC USE; EUROPE; IMMUNOLOGY; NORTH AMERICA; PROCEDURES; SEROLOGY;

ADULT; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BORRELIA BURGDORFERI; EPITOPES; EUROPE; HUMANS; LYME DISEASE; MEMBRANE TRANSPORT PROTEINS; NORTH AMERICA; RECOMBINANT PROTEINS; SENSITIVITY AND SPECIFICITY; SEROLOGIC TESTS;

EID: 84899738815     PISSN: 15566811     EISSN: 1556679X     Source Type: Journal    
DOI: 10.1128/CVI.00792-13     Document Type: Article

References (39)

1. Steere AC. 2001. Lyme disease. N. Engl. J. Med. 345:115-125. http://dx.doi.org/10.1056/NEJM200107123450207. (Pubitemid 32640193)
2. Stanek G, Wormser GP, Gray J, Strle F. 2012. Lyme borreliosis. Lancet 379:461-473. http://dx.doi.org/10.1016/S0140-6736(11)60103-7.
3. Asch ES, Bujak DI, Weiss M, Peterson MG, Weinstein A. 1994. Lyme disease: an infectious and postinfectious syndrome. J. Rheumatol. 21: 454-461. (Pubitemid 24102829)
4. Kowalski TJ, Tata S, Berth W, Mathiason MA, Agger WA. 2010. Antibiotic treatment duration and long-term outcomes of patients with early Lyme disease from a Lyme disease-hyperendemic area. Clin. Infect. Dis. 50:512-520. http://dx.doi.org/10.1086/649920.
5. Dattwyler RJ. 2010. A commentary on the treatment of early Lyme disease. Clin. Infect. Dis. 50:521-522. http://dx.doi.org/10.1086/649921.
6. Coyle PK, Schutzer SE. 2002. Neurologic aspects of Lyme disease. Med. Clin. North Am. 86: 261-284. http://dx.doi.org/10.1016/S0025-7125(03)00086-5. (Pubitemid 34327086)
7. Halperin JJ. 2009. Nervous system Lyme disease: diagnosis and treatment. Rev. Neurol. Dis. 6:4-12. http://dx.doi.org/10.1007/s11940-013-0240-y.
8. Nardelli DT, Callister SM, Schell RF. 2008. Lyme arthritis: current concepts and a change in paradigm. Clin. Vaccine Immunol. 15:21-34. http://dx.doi.org/10.1128/CVI.00330-07. (Pubitemid 351966525)
9. Steere AC, Schoen RT, Taylor E. 1987. The clinical evolution of Lyme arthritis. Ann. Intern. Med. 107:725-731. (Pubitemid 18041872)
10. Nadelman RB, Wormser GP. 1998. Lyme borreliosis. Lancet 352:557-565. http://dx.doi.org/10.1016/S0140-6736(98)01146-5. (Pubitemid 28372237)
11. Centers for Disease Control and Prevention (CDC). 1995. Recommendations for test performance and interpretation from the Second National Conference on Serologic Diagnosis of Lyme Dis. MMWR Morb. Mortal. Wkly. Rep. 44:590-591.
12. Aguero-Rosenfeld ME, Wang G, Schwartz I, Wormser GP. 2005. Diagnosis of Lyme borreliosis. Clin. Microbiol. Rev. 18:484-509. http://dx.doi.org/10.1128/ CMR.18.3.484-509.2005. (Pubitemid 40995113)
13. Wormser GP, Dattwyler RJ, Shapiro ED, Halperin JJ, Steere AC, Klempner MS, Krause PJ, Bakken JS, Strle F, Stanek G, Bockenstedt L, Fish D, Dumler JS, Nadelman RB. 2006. The clinical assessment, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America. Clin. Infect. Dis. 43:1089-1134. http://dx.doi.org/10.1086/508667. (Pubitemid 44637131)
14. Centers for Disease Control and Prevention (CDC). 1997. Lyme disease - United States, 1996. Morb. Mortal. Wkly. Rep. 46:531-535.
15. Wormser GP, Aguero-Rosenfeld ME, Nadelman RB. 1999. Lyme disease serology: problems and opportunities. JAMA 282:79-80. (Pubitemid 29318938)
16. Liang FT, Steere AC, Marques AR, Johnson BJ, Miller JN, Philipp MT. 1999. Sensitive and specific serodiagnosis of Lyme disease by enzymelinked immunosorbent assay with a peptide based on an immunodominant conserved region of Borrelia burgdorferi vlsE. J. Clin. Microbiol. 37: 3990-3996.
17. Bacon RM, Biggerstaff BJ, Schriefer ME, Gilmore RD, Jr, Philipp MT, Steere AC, Wormser GP, Marques AR, Johnson BJ. 2003. Serodiagnosis of Lyme disease by kinetic enzyme-linked immunosorbent assay using recombinant VlsE1 or peptide antigens of Borrelia burgdorferi compared with 2-tiered testing using whole-cell lysates. J. Infect. Dis. 187:1187-1199. http://dx.doi.org/10.1086/ 374395. (Pubitemid 36438958)
18. Wormser GP, Schriefer M, Aguero-Rosenfeld ME, Levin A, Steere AC, Nadelman RB, Nowakowski J, Marques A, Johnson BJ, Dumler JS. Single-tier testing with the C6 peptide ELISA kit compared with two-tier testing for Lyme disease. Diagn. Microbiol. Infect. Dis. 75:9-15. http://dx.doi.org/10.1016/j. diagmicrobio.2012.09.003.
19. Arnaboldi PM, Seedarnee R, Sambir M, Callister SM, Imparato JA, Dattwyler RJ. 2013. Outer surface protein C peptide derived from Borrelia burgdorferi sensu stricto as a target for serodiagnosis of early Lyme disease. Clin. Vaccine Immunol. 20:474-481. http://dx.doi.org/10.1128/CVI.00608-12; http://dx.doi.org/10.1128/CVI.00608-12.
20. Gomes-Solecki MJ, Meirelles L, Glass J, Dattwyler RJ. 2007. Epitope length, genospecies dependency, and serum panel effect in the IR6 enzyme-linked immunosorbent assay for detection of antibodies to Borrelia burgdorferi. Clin. Vaccine Immunol. 14:875-879. http://dx.doi.org/10.1128/CVI.00122-07.
21. Coleman AS, Rossmann E, Yang X, Song H, Lamichhane CM, Iyer R, Schwartz I, Pal U. 2011. BBK07 immunodominant peptides as serodiagnostic markers of Lyme disease. Clin. Vaccine Immunol. 18:406-413. http://dx.doi.org/10.1128/CVI.00461- 10.
22. Barbour AG, Jasinskas A, Kayala MA, Davies DH, Steere AC, Baldi P, Felgner PL. 2008. A genome-wide proteome array reveals a limited set of immunogens in natural infections of humans and white-footed mice with Borrelia burgdorferi. Infect. Immun. 76:3374-3389. http://dx.doi.org/10.1128/IAI.00048- 08.
23. Engstrom SM, Shoop E, Johnson RC. 1995. Immunoblot interpretation criteria for serodiagnosis of early Lyme disease. J. Clin. Microbiol. 33: 419-427.
24. Magnarelli LA, Ijdo JW, Padula SJ, Flavell RA, Fikrig E. 2000. Serologic diagnosis of Lyme borreliosis by using enzyme-linked immunosorbent assays with recombinant antigens. J. Clin. Microbiol. 38:1735-1739. (Pubitemid 30253906)
25. Nowalk AJ, Gilmore RD, Jr, Carroll JA. 2006. Serologic proteome analysis of Borrelia burgdorferi membrane-associated proteins. Infect. Immun. 74:3864-3873. http://dx.doi.org/10.1128/IAI.00189-06. (Pubitemid 43993317)
26. Brissette CA, Rossmann E, Bowman A, Cooley AE, Riley SP, Hunfeld KP, Bechtel M, Kraiczy P, Stevenson B. 2010. The borrelial fibronectinbinding protein RevA is an early antigen of human Lyme disease. Clin. Vaccine Immunol. 17:274-280. http://dx.doi.org/10.1128/CVI.00437-09.
27. Gomes-Solecki MJ, Wormser GP, Schriefer M, Neuman G, Hannafey L, Glass JD, Dattwyler RJ. 2002. Recombinant assay for serodiagnosis of Lyme disease regardless of OspA vaccination status. J. Clin. Microbiol. 40:193-197. http://dx.doi.org/10.1128/JCM.40.1.193-197.2002. (Pubitemid 34027623)
28. Nowakowski J, Schwartz I, Liveris D, Wang G, Aguero-Rosenfeld ME, Girao G, McKenna D, Nadelman RB, Cavaliere LF, Wormser GP; Lyme Disease Study Group. 2001. Laboratory diagnostic techniques for patients with early Lyme disease associated with erythema migrans: a comparison of different techniques. Clin. Infect. Dis. 33:2023-2027. http://dx.doi.org/10.1086/324490. (Pubitemid 33152397)
29. Wang XG, Lin B, Kidder JM, Telford S, Hu LT. 2002. Effects of environmental changes on expression of the oligopeptide permease (opp) genes of Borrelia burgdorferi. J. Bacteriol. 184:6198-6206. http://dx.doi.org/10.1128/JB. 184.22.6198-6206.2002. (Pubitemid 35265901)
30. Crother TR, Champion CI, Whitelegge JP, Aguilera R, Wu XY, Blanco DR, Miller JN, Lovett MA. 2004. Temporal analysis of the antigenic composition of Borrelia burgdorferi during infection in rabbit skin. Infect. Immun. 72: 5063-5072. http://dx.doi.org/10.1128/IAI.72.9.5063-5072.2004. (Pubitemid 39223390)
31. Kornacki JA, Oliver DB. 1998. Lyme disease-causing Borrelia species encode multiple lipoproteins homologous to peptide-binding proteins of ABC-type transporters. Infect. Immun. 66:4115-4122. (Pubitemid 28402680)
32. Lin B, Short SA, Eskildsen M, Klempner MS, Hu LT. 2001. Functional testing of putative oligopeptide permease (Opp) proteins of Borrelia burgdorferi: a complementation model in opp(-) Escherichia coli. Biochim. Biophys. Acta 1499:222-231. http://dx.doi.org/10.1016/S0167-4889(00) 00121-X.
33. Ohnishi J, Schneider B, Messer WB, Piesman J, de Silva AM. 2003. Genetic variation at the vlsE locus of Borrelia burgdorferi within ticks and mice over the course of a single transmission cycle. J. Bacteriol. 185:4432-4441. http://dx.doi.org/10.1128/JB.185.15.4432-4441.2003. (Pubitemid 36890490)
34. Bykowski T, Woodman ME, Cooley AE, Brissette CA, Wallich R, Brade V, Kraiczy P, Stevenson B. 2008. Borrelia burgdorferi complement regulator- acquiring surface proteins (BbCRASPs): expression patterns during the mammal-tick infection cycle. Int. J. Med. Microbiol. 298(Suppl 1): 249-256. http://dx.doi.org/10.1016/j.ijmm.2007.10.002.
35. Mathiesen MJ, Christiansen M, Hansen K, Holm A, Åsbrink E, Theisen M. 1998. Peptide-based OspC enzyme-linked immunosorbent assay for serodiagnosis of Lyme borreliosis. J. Clin. Microbiol. 36:3474-3479. (Pubitemid 28533213)
36. Burbelo PD, Issa AT, Ching KH, Cohen JI, Iadarola MJ, Marques A. 2010. Rapid, simple, quantitative, and highly sensitive antibody detection for Lyme disease. Clin. Vaccine Immunol. 17:904-909. http://dx.doi.org/10.1128/CVI.00476- 09; http://dx.doi.org/10.1128/CVI.00476-09.
37. Hodzic E, Feng S, Freet KJ, Barthold SW. 2003. Borrelia burgdorferi population dynamics and prototype gene expression during infection of immunocompetent and immunodeficient mice. Infect. Immun. 71:5042-5055. http://dx.doi.org/10.1128/IAI.71.9.5042-5055.2003. (Pubitemid 37070747)
38. Embers ME, Hasenkampf NR, Jacobs MB, Philipp MT. 2012. Dynamic longitudinal antibody responses during Borrelia burgdorferi infection and antibiotic treatment of rhesus macaques. Clin. Vaccine Immunol. 19:1218-1226. http://dx.doi.org/10.1128/CVI.00228-12; http://dx.doi.org/10.1128/CVI.00228-12.
39. Bono JL, Tilly K, Stevenson B, Hogan D, Rosa P. 1998. Oligopeptide permease in Borrelia burgdorferi: putative peptide-binding components encoded by both chromosomal and plasmid loci. Microbiology 144(Pt 4):1033-1044. (Pubitemid 28187929)