Glomerular Filtration Rate Equations Do Not Accurately Predict Vancomycin Trough Concentrations in Pediatric Patients

Annals of Pharmacotherapy

Volumn 48, Issue 6, 2014, Pages 691-696

  Alford, Elizabeth L ^a,b,c   Chhim, Rebecca F ^a,c   Crill, Catherine M ^a,c   Hastings, M Colleen ^a,c   Ault, Bettina H ^a,c   Shelton, Chasity M ^a,c  

^a LE BONHEUR CHILDREN S HOSPITAL   (United States)

^b Center for Pediatric Pharmacokinetics and Therapeutics   (United States)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Bedside Chronic Kidney Disease in Children equation; pediatrics; Schwartz equation; serum creatinine based glomerular filtration rate estimation; vancomycin

Indexed keywords

CREATININE; VANCOMYCIN; ANTIINFECTIVE AGENT;

ACUTE KIDNEY FAILURE; ARTICLE; BEDSIDE CHRONIC KIDNEY DISEASE IN CHILDREN EQUATION; BODY HEIGHT; BODY WEIGHT; CHILD; CLINICAL ARTICLE; CREATININE BLOOD LEVEL; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; MALE; MATHEMATICAL PARAMETERS; MEDICAL RECORD REVIEW; OBSERVATIONAL STUDY; PRIORITY JOURNAL; UREA NITROGEN BLOOD LEVEL; URINE VOLUME; ALGORITHM; BLOOD; HOSPITAL; PRESCHOOL CHILD; RENAL INSUFFICIENCY, CHRONIC; SAMPLE SIZE; STATISTICAL MODEL;

ALGORITHMS; ANTI-BACTERIAL AGENTS; CHILD; CHILD, PRESCHOOL; FEMALE; GLOMERULAR FILTRATION RATE; HOSPITALS, PEDIATRIC; HUMANS; LINEAR MODELS; MALE; RENAL INSUFFICIENCY, CHRONIC; SAMPLE SIZE; VANCOMYCIN;

EID: 84899727598     PISSN: 10600280     EISSN: 15426270     Source Type: Journal    
DOI: 10.1177/1060028014527908     Document Type: Article

References (12)

1. Arant BS.Developmental patterns of renal functional maturation compared in the human neonate.J Pediatr. 1978;92:705-712.
2. KDOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification.Am J Kidney Dis. 2002;39:S1-S266.
3. Pediatrics. Schwartz GJHaycock GBEdelmann CMSpitzer A, ed. 1976:259-263.
4. Schwartz GJ,Brion LP,Spitzer A.The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children, and adolescents.Pediatr Clin North Am. 1987;34:571-590.
5. Schwartz GJ,Muñoz A,Schneider MF,et al.New equations to estimate GFR in children with CKD.J Am Soc Nephrol. 2009;20:629-637.
6. Matzke GR,McGory RW,Halstenson CE,Keane WF.Pharmacokinetics of vancomycin in patients with various degrees of renal function.Antimicrob Agents Chemother. 1984;25:433-437.
7. Pea F,Porreca L,Baraldo M,Furlanut M.High vancomycin dosage regiments required by intensive care unit patients cotreated with drugs to improve haemodynamics following cardiac surgical procedures.J Antimicrob Chemother. 2000;45:329-335.
8. Chicella M,Adkins J,Mancao MY,Estrada B,Hoff C.Impact of pediatric specific guidelines for vancomycin serum concentration monitoring on patient care.J Pediatr Pharmacol Ther. 1999;4:146-151.
9. Bellomo R,Ronco C,Kellum JA,et al.Acute renal failure: definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group.Crit Care. 2004;8:R204-R212.
10. Staples A,LeBlond R,Watkins S,Wong C,Brandt J.Validation of the revised Schwartz estimating equation in a predominantly non-CKD population.Pediatr Nephrol. 2010;25:2321-2326.
11. Lee CK,Swinford RD,Cerda RD,Portman RJ,Hwang W,Furth SL.Evaluation of serum creatinine concentration-based glomerular filtration rate equations in pediatric patients with chronic kidney disease.Pharmacotherapy. 2012;32:624-628.
12. Golper TA,Noonan HM,Elzinga L,et al.Vancomycin pharmacokinetics, renal handling, and nonrenal clearances in normal human subjects.Clin Pharmacol Ther. 1988;43:565-570.