Long-term effects of a ketogenic diet on body composition and bone mineralization in GLUT-1 deficiency syndrome: A case series

Nutrition

Volumn 30, Issue 6, 2014, Pages 726-728

  Bertoli, Simona ^a   Trentani, Claudia ^b   Ferraris, Cinzia ^b   De Giorgis, Valentina ^c   Veggiotti, Pierangelo ^c   Tagliabue, Anna ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

^c C MONDINO NATIONAL NEUROLOGICAL INSTITUTE   (Italy)

Author keywords

Body composition; Bone health; Glucose transporter 1 deficiency syndrome; Ketogenic diet

Indexed keywords

3 HYDROXYBUTYRIC ACID; CARBOHYDRATE DIET; FAT INTAKE; GLUCOSE TRANSPORTER; TRACE ELEMENT;

ADULT; ARTICLE; BODY COMPOSITION; BODY HEIGHT; BODY WEIGHT; BONE MINERALIZATION; CASE REPORT; CLINICAL EFFECTIVENESS; GLUCOSE TRANSPORTER 1 DEFICIENCY SYNDROME; HAIR LOSS; HUMAN; KETOGENIC DIET; NUTRITIONAL DEFICIENCY; PRIORITY JOURNAL; TREATMENT DURATION; TREATMENT RESPONSE; WAIST CIRCUMFERENCE; WEIGHT REDUCTION; ADIPOSE TISSUE; ADMINISTRATION AND DOSAGE; BLOOD; BODY MASS; BONE DENSITY; CALORIC INTAKE; CARBOHYDRATE DIET; DEFICIENCY; DIET THERAPY; DIETARY FIBER; DISORDERS OF CARBOHYDRATE METABOLISM; EPILEPSY; FAT INTAKE; FEMALE; METABOLISM; MOTOR ACTIVITY; PATIENT COMPLIANCE; PHYSIOLOGY; SKELETAL MUSCLE; SKINFOLD THICKNESS; TIME; TREATMENT OUTCOME; YOUNG ADULT;

3-HYDROXYBUTYRIC ACID; ADIPOSE TISSUE; ADULT; BODY COMPOSITION; BODY MASS INDEX; BODY WEIGHT; BONE DENSITY; CALCIFICATION, PHYSIOLOGIC; CARBOHYDRATE METABOLISM, INBORN ERRORS; DIETARY CARBOHYDRATES; DIETARY FATS; DIETARY FIBER; ENERGY INTAKE; EPILEPSY; FEMALE; HUMANS; KETOGENIC DIET; MICRONUTRIENTS; MONOSACCHARIDE TRANSPORT PROTEINS; MOTOR ACTIVITY; MUSCLE, SKELETAL; PATIENT COMPLIANCE; SKINFOLD THICKNESS; TIME FACTORS; TREATMENT OUTCOME; WAIST CIRCUMFERENCE; YOUNG ADULT;

EID: 84899718300     PISSN: 08999007     EISSN: 18731244     Source Type: Journal    
DOI: 10.1016/j.nut.2014.01.005     Document Type: Article

References (20)

1. Leen W.G., Klepper J., Verbeek M.M., Leferink M., Hofste T., van Engelen B.G., et al. Glucose transporter-1 deficiency syndrome: the expanding clinical and genetic spectrum of a treatable disorder. Brain 2010, 133:655-670.
2. Klepper J. GLUT1 deficiency syndrome in clinical practice. Epilepsy Res 2012, 100:272-277.
3. Verrotti A., D'Egidio C., Agostinelli S., Gobbi G. Glut1 deficiency: when to suspect and how to diagnose?. Eur J Paediatr Neurol 2012, 16:3-9.
4. Brockmann K. The expanding phenotype of GLUT1-deficiency syndrome. Brain Dev 2009, 31:545-552.
5. Pearson T.S., Akman C., Hinton V.J., Engelstad K., De Vivo D.C. Phenotypic spectrum of glucose transporter type 1 deficiency syndrome (Glut1 DS). Curr Neurol Neurosci Rep 2013, 13:342.
6. Klepper J. Glucose transporter deficiency syndrome (GLUT1 DS) and the ketogenic diet. Epilepsia 2008, 49(Suppl 8):46-49.
7. Lee M. The use of ketogenic diet in special situations: expanding use in intractable epilepsy and other neurologic disorders. Korean J Pediatr 2012, 55:316-321.
8. Caraballo R.H., Vining E. Ketogenic diet. Handb Clin Neurol 2012, 108:783-793.
9. Rho J.M., Stafstrom C.E. The ketogenic diet: what has science taught us?. Epilepsy Res 2012, 100:210-217.
10. Noh H.S., Kim Y.S., Choi W.S. Neuroprotective effects of the ketogenic diet. Epilepsia 2008, 49(Suppl 8):120-123.
11. Zupec-Kania B., Zupanc M.L. Long-term management of the ketogenic diet:seizure monitoring, nutrition, and supplementation. Epilepsia 2008, 49(Suppl 8):23-26.
12. Kang H.C., Chung D.E., Kim D.W., Kim H.D. Early- and late-onset complications of the ketogenic diet for intractable epilepsy. Epilepsia 2004, 45:1116-1123.
13. Ballaban-Gil K., Callahan C., O'Dell C., Pappo M., Moshé S., Shinnar S. Complications of the ketogenic diet. Epilepsia 1998, 39:744-748.
14. Hahn T.J., Halstead L.R., DeVivo D.C. Disordered mineral metabolism produced by ketogenic diet therapy. Calcif Tissue Int 1979, 28:17-22.
15. Gissel T., Poulsen C.S., Vestergaard P. Adverse effects of antiepileptic drugs on bone mineral density in children. Expert Opin Drug Saf 2007, 6:267-278.
16. Bergqvist A.G., Schall J.I., Stallings V.A., Zemel B.S. Progressive bone mineral content loss in children with intractable epilepsy treated with the ketogenic diet. Am J Clin Nutr 2008, 88:1678-1684.
17. Veggiotti P., Teutonico F., Alfei E., Nardocci N., Zorzi G., Tagliabue A., et al. Glucose transporter type 1 deficiency: ketogenic diet in three patients with atypical phenotype. Brain Dev 2010, 32:404-408.
18. Tagliabue A., Bertoli S., Trentani C., Borrelli P., Veggiotti P. Effects of the ketogenic diet on nutritional status, resting energy expenditure, and substrate oxidation in patients with medically refractory epilepsy: a 6-month prospective observational study. Clin Nutr 2012, 31:246-249.
19. Freeman J., Veggiotti P., Lanzi G., Tagliabue A., Perucca E. The ketogenic diet: From molecular mechanisms to clinical effects. Epilepsy Res 2006, 68:145-180.
20. Veggiotti V., Burlina A., Coppola G., Cusmai R., De Giorgis V., Guerrini R., et al. The ketogenic diet for Dravet syndrome and other epileptic encephalopathies: an Italian consensus. Epilepsia 2011, 52(Suppl 2):83-89.