miR-21 expression in the tumor stroma of oral squamous cell carcinoma: An independent biomarker of disease free survival

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Hedbäck, Nora ^a   Jensen, David H ^a   Specht, Lena ^a   Fiehn, Anne Marie K ^a   Therkildsen, Marianne H ^a   Friis Hansen, Lennart ^a   Dabelsteen, Erik ^b   Von Buchwald, Christian ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA 21; TUMOR MARKER; UNTRANSLATED RNA; MICRORNA; MIRN21 MICRORNA, HUMAN;

ADULT; ARTICLE; CANCER MORTALITY; CANCER PROGNOSIS; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MAJOR CLINICAL STUDY; MALE; MOUTH SQUAMOUS CELL CARCINOMA; PERINEURAL INVASION; POSTTRANSCRIPTIONAL GENE SILENCING; QUANTITATIVE ANALYSIS; ACINAR CELL; ENDOTHELIUM; GENE EXPRESSION REGULATION; GENETICS; IMAGE PROCESSING; METABOLISM; MOUTH TUMOR; MULTIVARIATE ANALYSIS; MYOFIBROBLAST; NONPARAMETRIC TEST; PATHOLOGY; SQUAMOUS CELL CARCINOMA; STROMA CELL;

ACINAR CELLS; CARCINOMA, SQUAMOUS CELL; DISEASE-FREE SURVIVAL; ENDOTHELIUM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IN SITU HYBRIDIZATION; MICRORNAS; MOUTH NEOPLASMS; MULTIVARIATE ANALYSIS; MYOFIBROBLASTS; STATISTICS, NONPARAMETRIC; STROMAL CELLS; TUMOR MARKERS, BIOLOGICAL;

EID: 84899699726     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0095193     Document Type: Article

References (33)

1. Parkin DM, Pisani P, Ferlay J (1999) Global cancer statistics. CA Cancer J Clin 49: 33-64, 31.
2. Hermansen SK, Dahlrot RH, Nielsen BS, Hansen S, Kristensen BW (2013) MiR-21 expression in the tumor cell compartment holds unfavorable prognostic value in gliomas. Journal of neuro-oncology 111: 71-81.
3. Dillhoff M, Liu J, Frankel W, Croce C, Bloomston M (2008) MicroRNA-21 is overexpressed in pancreatic cancer and a potential predictor of survival. Journal of Gastrointestinal Surgery 12: 2171-2176.
4. Yamamichi N, Shimomura R, Inada K-i, Sakurai K, Haraguchi T, et al. (2009) Locked nucleic acid in situ hybridization analysis of miR-21 expression during colorectal cancer development. Clinical Cancer Research 15: 4009-4016.
5. Rask L, Balslev E, Jorgensen S, Eriksen J, Flyger H, et al. (2011) High expression of miR-21 in tumor stroma correlates with increased cancer cell proliferation in human breast cancer. Apmis 119: 663-673.
6. Wang Y, Li J, Tong L, Zhang J, Zhai A, et al. (2013) The Prognostic Value of miR-21 and miR-155 in Non-small-cell Lung Cancer: A Meta-analysis. Japanese journal of clinical oncology 43: 813-820.
7. Frankel LB, Christoffersen NR, Jacobsen A, Lindow M, Krogh A, et al. (2008) Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. Journal of Biological Chemistry 283: 1026-1033.
8. Roy S, Khanna S, Hussain S-RA, Biswas S, Azad A, et al. (2009) MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue. Cardiovascular Research 82: 21-29.
9. Zhu S, Si M-L, Wu H, Mo Y-Y (2007) MicroRNA-21 Targets the Tumor Suppressor Gene Tropomyosin 1 (TPM1). Journal of Biological Chemistry 282: 14328-14336. (Pubitemid 47100416)
10. Sayed D, Rane S, Lypowy J, He M, Chen I-Y, et al. (2008) MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths. Molecular biology of the cell 19: 3272-3282.
11. Li J, Huang H, Sun L, Yang M, Pan C, et al. (2009) MiR-21 Indicates Poor Prognosis in Tongue Squamous Cell Carcinomas as an Apoptosis Inhibitor. Clinical Cancer Research 15: 3998-4008.
12. Fassan M, Realdon S, Pizzi M, Balistreri M, Battaglia G, et al. (2012) Programmed cell death 4 nuclear loss and miR-21 or activated Akt overexpression in esophageal squamous cell carcinogenesis. Diseases of the Esophagus 25: 263-268.
13. Hiyoshi Y, Kamohara H, Karashima R, Sato N, Imamura Y, et al. (2009) MicroRNA-21 regulates the proliferation and invasion in esophageal squamous cell carcinoma. Clinical Cancer Research 15: 1915-1922.
14. Cervigne NK, Reis PP, Machado J, Sadikovic B, Bradley G, et al. (2009) Identification of a microRNA signature associated with progression of leukoplakia to oral carcinoma. Hum Mol Genet 18: 4818-4829.
15. Nielsen BS, Jorgensen S, Fog JU, Sokilde R, Christensen IJ, et al. (2011) High levels of microRNA-21 in the stroma of colorectal cancers predict short disease-free survival in stage II colon cancer patients. Clin Exp Metastasis 28: 27-38.
16. Bullock MD, Pickard KM, Nielsen BS, Sayan AE, Jenei V, et al. (2013) Pleiotropic actions of miR-21 highlight the critical role of deregulated stromal microRNAs during colorectal cancer progression. Cell Death Dis 4: e684.
17. Yamashita M, Ogawa T, Zhang X, Hanamura N, Kashikura Y, et al. (2012) Role of stromal myofibroblasts in invasive breast cancer: stromal expression of alpha-smooth muscle actin correlates with worse clinical outcome. Breast Cancer 19: 170-176.
18. Kellermann MG, Sobral LM, Silva SDd, Zecchin KG, Graner E, et al. (2007) Myofibroblasts in the stroma of oral squamous cell carcinoma are associated with poor prognosis. Histopathology 51: 849-853. (Pubitemid 350179411)
19. Marsh D, Suchak K, Moutasim KA, Vallath S, Hopper C, et al. (2011) Stromal features are predictive of disease mortality in oral cancer patients. The Journal of Pathology 223: 470-481.
20. van Beurden HE, Von den Hoff JW, Torensma R, Maltha JC, Kuijpers-Jagtman AM (2005) Myofibroblasts in Palatal Wound Healing: Prospects for the Reduction of Wound Contraction after Cleft Palate Repair. Journal of Dental Research 84: 871-880. (Pubitemid 43827793)
21. Dabelsteen E, Kremenak CR (1978) Demonstration of actin in the fibroblasts of healing palatal wounds. Plast Reconstr Surg 62: 429-435. (Pubitemid 9047281)
22. Lajer C, Nielsen F, Friis-Hansen L, Norrild B, Borup R, et al. (2011) Different miRNA signatures of oral and pharyngeal squamous cell carcinomas: a prospective translational study. British journal of cancer 104: 830-840.
23. Thode C, Jørgensen TG, Dabelsteen E, Mackenzie I, Dabelsteen S (2011) Significance of myofibroblasts in oral squamous cell carcinoma. Journal of Oral Pathology & Medicine 40: 201-207.
24. DAHANCA Website (Danish Head and Neck Cancer Group) Database registering of head and neck cancer in Denmark. Available: http://www.dahanca.dk. Accessed 2013 June 1.
25. Barnes L, Eveson J, Reichart P, Sidransky D (2005) World Health Organization Classification of Tumours: Pathology and Genetics of Head and Neck Tumours. Lyon: IARC Press.
26. Sempere LF, Preis M, Yezefski T, Ouyang H, Suriawinata AA, et al. (2010) Fluorescence-Based Codetection with Protein Markers Reveals Distinct Cellular Compartments for Altered MicroRNA Expression in Solid Tumors. Clinical Cancer Research 16: 4246-4255.
27. Nielsen B, Jørgensen S, Fog J, Søkilde R, Christensen I, et al. (2011) High levels of microRNA-21 in the stroma of colorectal cancers predict short disease-free survival in stage II colon cancer patients. Clinical & Experimental Metastasis 28: 27-38.
28. Yao Q, Cao S, Li C, Mengesha A, Kong B, et al. (2011) Micro-RNA-21 regulates TGF-b-induced myofibroblast differentiation by targeting PDCD4 in tumor-stroma interaction. International Journal of Cancer 128: 1783-1792.
29. Kalluri R, Zeisberg M (2006) Fibroblasts in cancer. Nature Reviews Cancer 6: 392-401.
30. Vered M, Dobriyan A, Dayan D, Yahalom R, Talmi YP, et al. (2010) Tumor-host histopathologic variables, stromal myofibroblasts and risk score, are significantly associated with recurrent disease in tongue cancer. Cancer science 101: 274-280.
31. Wikberg ML, Edin S, Lundberg IV, Van Guelpen B, Dahlin AM, et al. (2013) High intratumoral expression of fibroblast activation protein (FAP) in colon cancer is associated with poorer patient prognosis. Tumor Biology: 1-8.
32. Hase K, Shatney C, Johnson D, Trollope M, Vierra M (1993) Prognostic value of tumor "budding" in patients with colorectal cancer. Diseases of the colon & rectum 36: 627-635. (Pubitemid 23206317)
33. Yan LX, Wu QN, Zhang Y, Li YY, Liao DZ, et al. (2011) Knockdown of miR-21 in human breast cancer cell lines inhibits proliferation, in vitro migration and in vivo tumor growth. Breast Cancer Research 13: R2.