Multiple consecutive infections might explain the lack of protection by bcg

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Cardona, Pere Joan ^a,b,c   Vilaplana, Cristina ^a,b,c  

^a FUNDACIÓ INSTITUT D INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOL   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE;

ARTICLE; BACILLUS; BACTERIAL LOAD; BCG VACCINATION; CONCENTRATION (PARAMETERS); EXPERIMENTAL MODEL; IMMUNE RESPONSE; INFECTION; INFECTION PREVENTION; LUNG; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MINIMAL BACILLARY CONCENTRATION; MOUSE; MULTIPLE CONSECUTIVE INFECTION; NONHUMAN; TUBERCULOSIS; ALGORITHM; ANIMAL; BIOLOGICAL MODEL; HUMAN; IMMUNOLOGY; MYCOBACTERIUM TUBERCULOSIS; REPRODUCIBILITY; STANDARDS; TIME; TUBERCULIN TEST; VACCINATION; AEROSOL; ANIMAL EXPERIMENT; ANIMAL MODEL; CONTROLLED STUDY; IMMUNOPROPHYLAXIS; MIXED INFECTION;

ALGORITHMS; ANIMALS; BCG VACCINE; HUMANS; MICE; MODELS, IMMUNOLOGICAL; MYCOBACTERIUM TUBERCULOSIS; REPRODUCIBILITY OF RESULTS; TIME FACTORS; TUBERCULIN TEST; TUBERCULOSIS; VACCINATION;

EID: 84899689480     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0094736.g001     Document Type: Article

References (18)

1. Parrish NM, Dick JD, Bishai WR (1998) Mechanisms of latency in Mycobacterium tuberculosis. Trends Microbiol 6: 107-112. (Pubitemid 28123330)
2. Rieder HL (2003) Contacts of tuberculosis patients in high-incidence countries. Int J Tuberc Lung Dis 7: S333-336. (Pubitemid 38004705)
3. Pai M, Menzies D (2007) The new IGRA and the old TST: making good use of disagreement. Am J Respir Crit Care Med 175: 529-531. (Pubitemid 46438935)
4. Mollenkopf H, Kursar M, Kaufmann S (2004) Immune response to postprimary tuberculosis in mice: Mycobacterium tuberculosis and Miycobacterium bovis bacille Calmette-Guérin induce equal protection. J Infect Dis 190: 588-597. (Pubitemid 38982100)
5. Trunz BB, Fine P, Dye C (2006) Effect of BCG vaccination on childhood tuberculous meningitis and miliary tuberculosis worldwide: a meta-analysis and assessment of cost-effectiveness. Lancet 367: 1173-1180.
6. Tameris MD, Hatherill M, Landry BS, Scriba TJ, Snowden MA, et al. (2013) Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial. Lancet 381: 1021-1028.
7. Delogu G, Manganelli R, Brennan MJ (2013) Critical research concepts in tuberculosis vaccine development. Clin Microbiol Infect.
8. Brennan MJ, Thole J (2012) Tuberculosis vaccines: a strategic blueprint for the next decade. Tuberculosis (Edinb) 92 Suppl 1: S6-13.
9. Orme IM (2005) Mouse and guinea pig models for testing new tuberculosis vaccines. Tuberculosis (Edinb) 85: 13-17. (Pubitemid 40431310)
10. Jung Y, Ryan L, LaCourse R, North R (2005) Properties and protective value of the secondary versus primary T helper type 1 response to airborne Mycobacterium tuberculosis infection in mice. J Exp Med 201: 1915-1924. (Pubitemid 41002928)
11. Bru A, Cardona P (2010) Mathematical modeling of tuberculosis bacillary counts and cellular populations in the organs of infected mice. PLoS One 5: e12985.
12. Johnson L, Dean G, Rhodes S, Hewinson G, Vordermeier M, et al. (2007) Lowdose Mycobacterium bovis infection in cattle results in pathology indistinguishable from that of high-dose infection. Tuberculosis (Edinb) 87: 71-76. (Pubitemid 44960167)
13. Gil O, Díaz I, Vilaplana C, Tapia G, Díaz J, et al. (2010) Granuloma encapsulation is a key factor for containing tuberculosis infection in minipigs. PLoS One 5: e10030.
14. Lewinsohn DA, Gold MC, Lewinsohn DM (2011) Views of immunology: effector T cells. Immunol Rev 240: 25-39.
15. Cardona P (2009) A dynamic reinfection hypothesis of latent tuberculosis infection. Infection 37: 80-86.
16. Chackerian AA, Alt JM, Perera TV, Dascher CC, Behar SM (2002) Dissemination of Mycobacterium tuberculosis is influenced by host factors and precedes the initiation of T-cell immunity. Infect Immun 70: 4501-4509. (Pubitemid 34790962)
17. Wolf AJ, Desvignes L, Linas B, Banaiee N, Tamura T, et al. (2008) Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs. J Exp Med 205: 105-115. (Pubitemid 351185719)
18. Cardona P, Ruiz-Manzano J (2004) On the nature of Mycobacterium tuberculosis-latent bacilli. Eur Respir J 24: 1044-1051 (Pubitemid 39642298)