TR alpha 2 exerts dominant negative effects on hypothalamic Trh transcription in Vivo

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Guissouma, Hajer ^a,b   Ghaddab Zroud, Rym ^b   Seugnet, Isabelle ^b   Decherf, Stéphanie ^b   Demeneix, Barbara ^b   Clerget Froidevaux, Marie Stéphanie ^b  

^a UNIVERSITY OF TUNIS EL MANAR   (Tunisia)

^b MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

LIOTHYRONINE; MESSENGER RNA; PROTIRELIN; THYROID HORMONE RECEPTOR ALPHA; THYROID HORMONE RECEPTOR ALPHA 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GAIN OF FUNCTION MUTATION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE REPRESSION; GENE TRANSFER; GENETIC ANALYSIS; HORMONAL REGULATION; HYPOTHALAMUS; IN VIVO STUDY; LOSS OF FUNCTION MUTATION; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; POLYMERASE CHAIN REACTION; REPORTER GENE; TRANSCRIPTION REGULATION; TRH GENE; ANIMAL; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; PHYSIOLOGY;

ANIMALS; HYPOTHALAMUS; MICE; POLYMERASE CHAIN REACTION; THYROID HORMONE RECEPTORS ALPHA; TRANSCRIPTION, GENETIC;

EID: 84899680811     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0095064     Document Type: Article

References (34)

1. Guissouma H, Ghorbel TM, Seugnet I, Ouatas T, Demeneix AB (1998) Physiological regulation of hypothalamic TRH transcription in vivo is T3 receptor isoform-specific. FASEB J 12: 1755-1764. (Pubitemid 28553671)
2. Dupre SM, Guissouma H, Flamant F, Seugnet I, Scanlan TS, et al. (2004) Both thyroid hormone receptor (TR)beta 1 and TR beta 2 isoforms contribute to the regulation of hypothalamic thyrotropin-releasing hormone. Endocrinology 145: 2337-2345. (Pubitemid 38535063)
3. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, et al. (1995) The nuclear receptor superfamily: the second decade. Cell 83: 835-839.
4. Sap J, Munoz A, Damm K, Goldberg Y, Ghysdael J, et al. (1986) The c-erb-A protein is a high-affinity receptor for thyroid hormone. Nature 324: 635-640. (Pubitemid 17206350)
5. Weinberger C, Thompson CC, Ong ES, Lebo R, Gruol DJ, et al. (1986) The c-erb-A gene encodes a thyroid hormone receptor. Nature 324: 641-646. (Pubitemid 17206351)
6. Bradley DJ, Towle HC, Young WS, 3rd (1992) Spatial and temporal expression of alpha- and beta-thyroid hormone receptor mRNAs, including the beta 2-subtype, in the developing mammalian nervous system. J Neurosci 12: 2288-2302.
7. Clerget-Froidevaux MS, Seugnet I, Demeneix BA (2004) Thyroid status coregulates thyroid hormone receptor and co-modulator genes specifically in the hypothalamus. FEBS Lett 569: 341-345. (Pubitemid 38844642)
8. Lechan RM, Qi Y, Jackson IM, Mahdavi V (1994) Identification of thyroid hormone receptor isoforms in thyrotropin-releasing hormone neurons of the hypothalamic paraventricular nucleus. Endocrinology 135: 92-100.
9. Alkemade A, Vuijst CL, Unmehopa UA, Bakker O, Vennstrom B, et al. (2005) Thyroid hormone receptor expression in the human hypothalamus and anterior pituitary. J Clin Endocrinol Metab 90: 904-912. (Pubitemid 40279215)
10. Lazar MA, Hodin RA, Darling DS, Chin WW (1988) Identification of a rat c-erbA alpha-related protein which binds deoxyribonucleic acid but does not bind thyroid hormone. Mol Endocrinol 2: 893-901.
11. Mitsuhashi T, Tennyson GE, Nikodem VM (1988) Alternative splicing generates messages encoding rat c-erbA proteins that do not bind thyroid hormone. Proc Natl Acad Sci U S A 85: 5804-5808.
12. Yang YZ, Burgos-Trinidad M, Wu Y, Koenig RJ (1996) Thyroid hormone receptor variant alpha2. Role of the ninth heptad in dna binding, heterodimerization with retinoid X receptors, and dominant negative activity. J Biol Chem 271: 28235-28242. (Pubitemid 26374635)
13. Tagami T, Kopp P, Johnson W, Arseven OK, Jameson JL (1998) The thyroid hormone receptor variant alpha2 is a weak antagonist because it is deficient in interactions with nuclear receptor corepressors. Endocrinology 139: 2535-2544. (Pubitemid 28513783)
14. Rentoumis A, Chatterjee VK, Madison LD, Datta S, Gallagher GD, et al. (1990) Negative and positive transcriptional regulation by thyroid hormone receptor isoforms. Mol Endocrinol 4: 1522-1531. (Pubitemid 20356614)
15. Katz D, Lazar MA (1993) Dominant negative activity of an endogenous thyroid hormone receptor variant (alpha 2) is due to competition for binding sites on target genes. J Biol Chem 268: 20904-20910. (Pubitemid 23292269)
16. Burgos-Trinidad M, Koenig RJ (1999) Dominant negative activity of thyroid hormone receptor variant alpha2 and interaction with nuclear corepressors. Mol Cell Endocrinol 149: 107-114. (Pubitemid 29236229)
17. Liu RT, Suzuki S, Miyamoto T, Takeda T, Ozata M, et al. (1995) The dominant negative effect of thyroid hormone receptor splicing variant alpha 2 does not require binding to a thyroid response element. Mol Endocrinol 9: 86-95.
18. Strait KA, Schwartz HL, Perez-Castillo A, Oppenheimer JH (1990) Relationship of c-erbA mRNA content to tissue triiodothyronine nuclear binding capacity and function in developing and adult rats. J Biol Chem 265: 10514-10521.
19. Forrest D, Sjoberg M, Vennstrom B (1990) Contrasting developmental and tissue-specific expression of alpha and beta thyroid hormone receptor genes. EMBO J 9: 1519-1528.
20. Salto C, Kindblom JM, Johansson C, Wang Z, Gullberg H, et al. (2001) Ablation of TRalpha2 and a concomitant overexpression of alpha1 yields a mixed hypo- and hyperthyroid phenotype in mice. Mol Endocrinol 15: 2115-2128. (Pubitemid 33141131)
21. Guissouma H, Dupre SM, Becker N, Jeannin E, Seugnet I, et al. (2002) Feedback on hypothalamic TRH transcription is dependent on thyroid hormone receptor N terminus. Mol Endocrinol 16: 1652-1666. (Pubitemid 34743680)
22. Robert JJ, Geoffroy MC, Finiels F, Mallet J (1997) An adenoviral vector-based system to study neuronal gene expression: analysis of the rat tyrosine hydroxylase promoter in cultured neurons. J Neurochem 68: 2152-2160. (Pubitemid 27176153)
23. Decherf S, Seugnet I, Kouidhi S, Lopez-Juarez A, Clerget-Froidevaux MS, et al. (2010) Thyroid hormone exerts negative feedback on hypothalamic type 4 melanocortin receptor expression. Proc Natl Acad Sci U S A 107: 4471-4476.
24. Dratman MB, Crutchfield FL, Futaesaku Y, Goldberger ME, Murray M (1987) [125I] triiodothyronine in the rat brain: evidence for neural localization and axonal transport derived from thaw-mount film autoradiography. J Comp Neurol 260: 392-408. (Pubitemid 17099126)
25. Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, et al. (2009) The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem 55: 611-622.
26. Lebel JM. Dussault JH (1994) The thyroid and brain development. Cu Opin Endocrinol Diabetes 1: 167-174.
27. Lezoualc'h F, Hassan AH, Giraud P, Loeffler JP, Lee SL, et al. (1992) Assignment of the beta-thyroid hormone receptor to 3,5,3′- triiodothyronine-dependent inhibition of transcription from the thyrotropin-releasing hormone promoter in chick hypothalamic neurons. Mol Endocrinol 6: 1797-1804.
28. Hadj-Sahraoui N, Seugnet I, Ghorbel MT, Demeneix B (2000) Hypothyroidism prolongs mitotic activity in the post-natal mouse brain. Neurosci Lett 280: 79-82. (Pubitemid 30109137)
29. Becker N, Seugnet I, Guissouma H, Dupre SM, Demeneix BA (2001) Nuclear corepressor and silencing mediator of retinoic and thyroid hormone receptors corepressor expression is incompatible with T(3)-dependent TRH regulation. Endocrinology 142: 5321-5331. (Pubitemid 33131965)
30. Lazar AL (1993) Thyroid hormone receptors: multiple forms, multiple possibilities. Endocrine Rev 14: 184-193.
31. Zhang J, Zamir I, Lazar MA (1997) Differential recognition of liganded and unliganded thyroid hormone receptor by retinoid X receptor regulates transcriptional repression. Mol Cell Biol 17: 6887-6897. (Pubitemid 27505918)
32. Koller KJ, Wolff RS, Warden MK, Zoeller RT (1987) Thyroid hormones regulate levels of thyrotropin-releasing-hormone mRNA in the paraventricular nucleus. Proc Natl Acad Sci U S A 84: 7329-7333. (Pubitemid 18017339)
33. Segerson TP, Kauer J, Wolfe HC, Mobtaker H, Wu P, et al. (1987) Thyroid hormone regulates TRH biosynthesis in the paraventricular nucleus of the rat hypothalamus. Science 238: 78-80. (Pubitemid 17150486)
34. Mittag J, Friedrichsen S, Heuer H, Polsfuss S, Visser TJ, et al. (2005) Athyroid Pax8-/- mice cannot be rescued by the inactivation of thyroid hormone receptor alpha1. Endocrinology 146: 3179-3184. (Pubitemid 41002827)