MicroRNA-518d regulates PPARα protein expression in the placentas of females with gestational diabetes mellitus

Molecular Medicine Reports

Volumn 9, Issue 6, 2014, Pages 2085-2090

  Zhao, Chun ^a   Zhang, Ting ^a   Shi, Zhonghua ^a   Ding, Hongjuan ^a   Ling, Xiufeng ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Gestational diabetes; Micro RNA; miR 518d; Peroxisome proliferator activated receptor ; Placenta

Indexed keywords

MICRORNA; MICRORNA 518D; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; MESSENGER RNA; MIRN518 MICRORNA, HUMAN;

ADULT; ARTICLE; BINDING SITE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; PATHOGENESIS; PLACENTA; PREGNANCY DIABETES MELLITUS; PROTEIN EXPRESSION; REGULATORY MECHANISM; UPREGULATION; 3' UNTRANSLATED REGION; CASE CONTROL STUDY; CELL LINE; CHEMISTRY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PREGNANCY; PROTEIN TRANSPORT; RNA INTERFERENCE;

3' UNTRANSLATED REGIONS; ADULT; BASE SEQUENCE; BINDING SITES; CASE-CONTROL STUDIES; CELL LINE; DIABETES, GESTATIONAL; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MICRORNAS; PLACENTA; PPAR ALPHA; PREGNANCY; PROTEIN TRANSPORT; RNA INTERFERENCE; RNA, MESSENGER; TRANSFECTION;

EID: 84899677517     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2058     Document Type: Article

References (21)

1. Barnes-Powell LL: Infants of diabetic mothers: the effects of hyperglycemia on the fetus and neonate. Neonatal Netw 26: 283-290, 2007.
2. Uzelac PS, Li X, Lin J, Neese LD, Lin L, Nakajima ST, Bohler H and Lei Z: Dysregulation of leptin and testosterone production and their receptor expression in the human placenta with gestational diabetes mellitus. Placenta 31: 581-588, 2010.
3. Ferrara A: Increasing prevalence of gestational diabetes mellitus: a public health perspective. Diabetes Care 30 (Suppl 2): S141-S146, 2007.
4. Lee AJ, Hiscock RJ, Wein P, et al: Gestational diabetes mellitus: clinical predictors and long-term risk of developing type 2 diabetes: a retrospective cohort study using survival analysis. Diabetes Care 30: 878-883, 2007. (Pubitemid 46556581)
5. Thadhani R, Powe CE, Tjoa ML, et al: First-trimester follistatin-like-3 levels in pregnancies complicated by subsequent gestational diabetes mellitus. Diabetes Care 33: 664-669, 2010.
6. Murphy VE, Smith R, Giles WB and Clifton VL: Endocrine regulation of human fetal growth: The role of the mother, placenta, and fetus. Endocr Rev 27: 141-169, 2006.
7. Luo SS, Ishibashi O, Ishikawa G, et al: Human villous trophoblasts express and secrete placental-specific microRNAs into maternal circulation via exosomes. Biol Reprod 81: 717-729, 2009.
8. Fu GD, Brkić J, Hayder H and Peng C: MicroRNAs in human placental development and pregnancy complications. Int J Mol Sci 14: 5519-5544, 2013.
9. Kotlabova K, Doucha J and Hromadnikova I: Placental-specific microRNA in maternal circulation - identification of appropriate pregnancy-associated microRNAs with diagnostic potential. J Reprod Immuno 89: 185-191, 2011.
10. Gauster M, Desoye G, Tötsch M and Hiden U: The placenta and gestational diabetes mellitus. Cure Diab Rep 12: 16-23, 2012.
11. Yilmaz-Aydogan H, Kurnaz O, Kucukhuseyin O, et al: Different effects of PPARα, PPARG and apoE SNPs on serum lipids in patients with coronary heart disease based on the presence of diabetes. Gene 523: 20-26, 2013.
12. Arck P, Toth B, Pestka A and Jeschke U: Nuclear receptors of the perocisome proliferator-activated receptor (PPAR) family in gestational diabetes: from animal models to clinical trials. Biol Reprod 83: 168-176, 2010.
13. Shi ZM, Wang J, Yan Z, et al: MiR-128 inhibits tumor growth and angiogenesis by targeting p70S6K1. PLoS One 7: e32709, 2012.
14. Morales-Prieto DM, Chaiwangyen W, Ospina-Prieto S, Schneider U, Herrmann J, Gruhn B and Markert UR: MicroRNA expression profiles of trophoblastic cells. Placenta 33: 725-734, 2012.
15. Holdsworth-Carson SJ, Lim R, Mitton A, Whitehead C, Rice GE, Permezel M and Lappas M: Peroxisome proliferator-activated receptors are altered in pathologies of the human placenta: gestational diabetes mellitus, intrauterine growth restriction and preeclampsia. Placenta 31: 222-229, 2010.
16. Cresci S, Huss JM, Beitelshees AL, et al: A PPARα promoter variant impairs ERR-dependent transactivation and decreases mortality after acute coronary ischemia in patients with diabetes. PLoS One 5: e12584, 2010.
17. Beaven SW and Tontonoz P: Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia. Annu Rev Med 57: 313-329, 2006. (Pubitemid 43261994)
18. Flavell DM, Pineda Torra I, Jamshidi Y, et al: variation in the PPARα gene is associated with altered function in vitro and plasma lipid concentrations in Type II diabetic subjects. Diabetologia 43: 673-680, 2010.
19. Matsuda S, Kobayashi M and Kitagishi Y: Expression and function of PPARs in placenta. PPAR Res 2013: 256508, 2013.
20. Arck P, Toth B, Pestka A and Jeschke U: Nuclear receptors of the peroxisome proliferator-activated receptor (PPAR) family in gestational diabetes: from animal models to clinical trials. Biol Reprod 83: 168-176, 2010.
21. Dubé E, Ethier-Chiasson M and Lafond J: Modulation of cholesterol transport by insulin-treated gestational diabetes mellitus in human full-term placenta. Biol Reprod 88: 16, 2013.