The ε4 genotype of apolipoprotein e and white matter integrity in Alzheimer's disease

Alzheimer's and Dementia

Volumn 10, Issue 3, 2014, Pages 401-404

  Kljajevic, Vanja ^a   Meyer, Peter ^b   Holzmann, Carsten ^b   Dyrba, Martin ^a,c   Kasper, Elisabeth ^a   Bokde, Arun L W ^d,e   Fellgiebel, Andreas ^f   Meindl, Thomas ^g   Hampel, Harald ^h   Teipel, Stefan ^a,c  

^a GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^b ROSTOCK UNIVERSITY MEDICAL CENTER   (Germany)

^c UNIVERSITY OF ROSTOCK   (Germany)

^d TRINITY COLLEGE DUBLIN   (Ireland)

^e TRINITY COLLEGE DUBLIN   (Ireland)

^f UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^g LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^h GOETHE UNIVERSITY   (Germany)

Author keywords

Alzheimer's disease; APOE 4; Diffusion tensor imaging; White matter

Indexed keywords

APOLIPOPROTEIN E; APOLIPOPROTEIN E4;

AGED; ALZHEIMER DISEASE; ARTICLE; DIAGNOSIS RELATED GROUP; DIFFUSION TENSOR IMAGING; DISEASE ASSOCIATION; FEMALE; FRACTIONAL ANISOTROPY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; WHITE MATTER; ANISOTROPY; BRAIN; CLINICAL TRIAL; DIFFUSION WEIGHTED IMAGING; GENETICS; HETEROZYGOTE; MIDDLE AGED; MULTICENTER STUDY; PATHOLOGY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANISOTROPY; APOLIPOPROTEIN E4; BRAIN; DIFFUSION MAGNETIC RESONANCE IMAGING; DIFFUSION TENSOR IMAGING; FEMALE; GENOTYPE; HETEROZYGOTE; HUMANS; MALE; MIDDLE AGED; WHITE MATTER;

EID: 84899659401     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2013.02.008     Document Type: Article

References (18)

1. Chalmers K,Wilcock G, Love S. Contributors to white matter damage in the frontal lobe in Alzheimer's disease. Neuropath Appl Neurobiol 2005;31:623-31.
2. Barber R, Gholkar A, Scheltens P, Ballard C, McKeith IG, Morris CM, et al. Apolipoprotein E epsilon4 allele, temporal lobe atrophy, and white matter lesions in late-life dementias. Arch Neurol 1999; 56:961-5.
3. Bronge L, Fernaeus SE, Blomberg M, Ingelson M, Lannfelt L, Isberg B, et al. White matter lesions in Alzheimer patients are influenced by apolipoprotein E genotype. Dement Geriatr Cogn Disord 1999;10:89-96.
4. Hirono N, Yasuda M, Tanimukai S, Kitagaki H, Mori E. Effect of the apolipoprotein E epsilon 4 allele on white matter hyperintensities in dementia. Stroke 2000;31:1263-8.
5. Sawada H, Udaka F, IzumiY, Nishinaka K, Kawakami H, Nakamura S, et al. Cerebral white matter lesions are not associated with apoE genotype but with age and female sex in Alzheimer's disease. J Neurol Neurosurg Psychiatry 2000;68:653-6.
6. Strittmatter WJ, Weisgraber KH, Huang DY, Dong LM, Salvesen GS, Pericak-Vance M, et al. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proc Natl Acad Sci U S A 1993; 90:8098-102.
7. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993;261:921-3.
8. Bagepally BS, Halahalli HN, John JP, Kota L, Purushottam M, Mukherjee O, et al. Apolipoprotein E4 and brain white matter integrity in Alzheimer's disease: tract-based spatial statistics study under 3- Tesla MRI. Neurodegener Dis 2012;10:145-8.
9. Wang C, Stebbins GT, Medina DA, Shah RC, Bammer R, Moseley ME, et al. Atrophy and dysfunction of parahippocampal white matter in mild Alzheimer's disease. Neurobiol Aging 2012; 33:43-52.
10. Teipel SJ, Wegrzyn M, Meindl T, Frisoni G, Bokde AL, Fellgiebel A, et al. Anatomical MRI and DTI in the diagnosis of Alzheimer's disease: a European multicenter study. J Alzheimers Dis, http://www. ncbi.nlm.nih.gov/pubmed/ 22890103; 2012.
11. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDAWork Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-44.
12. Morris JC, Heyman A, Mohs RC, Hughes JP, van Belle G, Fillenbaum G, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease. Neurology 1989;39:1159-65.
13. Talairach J, Tournoux P. Co-Planar Stereotaxic Atlas of the Human Brain. 1st ed. Stuttgart, Germany: Thieme; 1988.
14. Abe O, Aoki S, Hayashi N, Yamada H, Kunimatsu A, Mori H, et al. Normal aging in the central nervous system: quantitative MR diffusion-tensor analysis. Neurobiol Aging 2002;23:433-41.
15. Raz N, Rodrigue KM, Kennedy KM, Head D, Gunning-Dixon F, Acker JD. Differential aging of the human striatum: longitudinal evidence. Am J Neuroradiol 2003;24:1849-56.
16. de Jong LW, van der Hiele K, Veer IM, Houwing JJ, Westendorp RG, Bollen EL, et al. Strongly reduced volumes of putamen and thalamus in Alzheimer's disease: an MRI study. Brain 2008;131:3277-85.
17. Landman BA, Farrell JA, Jones CK, Smith SA, Prince JL, Mori S. Effects of diffusion weighting schemes on the reproducibility of DTI-derived fractional anisotropy, mean diffusivity, and principal eigenvector measurements at 1.5T. Neuroimage 2007; 36:1123-38.
18. Teipel SJ, Reuter S, Stieltjes B, Acosta-Cabronero J, Ernemann U, Fellgiebel A, et al. Multicenter stability of diffusion tensor imaging measures: a European clinical and physical phantom study. Psychiatry Res 2011;194:363-71.