The association of Il28b genotype with the histological features of chronic hepatitis C Is HCV genotype dependent

International Journal of Molecular Sciences

Volumn 15, Issue 5, 2014, Pages 7213-7224

  D'Ambrosio, Roberta ^a   Aghemo, Alessio ^a   De Francesco, Raffaele ^b   Rumi, Maria Grazia ^a   Galmozzi, Enrico ^a   De Nicola, Stella ^a   Cheroni, Cristina ^b   Clark, Paul J ^c,d   Ronchi, Guido ^a   Lampertico, Pietro ^a   Colombo, Massimo ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b Istituto Nazionale di Genetica Molecolare   (Italy)

^c DUKE CLINICAL RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Fibrosis; Hepatitis C virus (HCV); Histology; Interleukin 28B (IL28B) polymorphism; Liver biopsy; Natural history; Necroinflammation; Steatosis

Indexed keywords

INTERLEUKIN 28; INTERLEUKIN 28B; IL28B PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE;

ADULT; AGED; ARTICLE; FATTY LIVER; FEMALE; GENETIC ASSOCIATION; GENOTYPE PHENOTYPE CORRELATION; HEPATITIS C; HEPATITIS C VIRUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INFLAMMATION; LIVER BIOPSY; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; RETROSPECTIVE STUDY; SINGLE NUCLEOTIDE POLYMORPHISM; STEATOSIS; COHORT ANALYSIS; COMPLICATION; GENETICS; GENOTYPE; HEPACIVIRUS; ISOLATION AND PURIFICATION; LIVER; LIVER CIRRHOSIS; MIDDLE AGED; PATHOLOGY; VIROLOGY; YOUNG ADULT;

ADULT; AGED; COHORT STUDIES; FATTY LIVER; FEMALE; GENOTYPE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INFLAMMATION; INTERLEUKINS; LIVER; LIVER CIRRHOSIS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; YOUNG ADULT;

EID: 84899654945     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms15057213     Document Type: Article

References (25)

1. Thomas, D.L.; Thio, C.L.; Martin, M.P.; Qi, Y.; Ge, D.; O'hUigin, C.; Kidd, J.; Kidd, K.; Khakoo, S.I.; Alexander G. et al. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 2009, 461, 798-801.
2. Rauch, A.; Kutalik, Z.; descombes, P.; Cai, T.; Iulio, J.D.; Mueller, T.; Bochud, M.; Battegay, M.; Bernasconi, E.; Borovicka, J. et al. Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: A genome-wide association study. Gastroenterology 2010, 138, 1338-1345.
3. Ge, D.; fellay, J.; Thompson, A.J.; Simon, J.S.; Shianna, K.V.; Urban, T.J.; Heinzen, E.L.; Qiu, P.; Bertelsen, A.H.; Muir, A.J. et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 2009, 461, 399-401.
4. Suppiah, V.; Moldovan, M.; Ahlenstiel, G.; Berg, T.; Weltman, M.; Abate, M.L.; Bassendine, M.; Spengler, U.; Dore, G.J.; Powell, E. et al. IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nat. Genet. 2009, 41, 1100-1104.
5. Tanaka, Y.; Nishida, N.; Sugiyama, M.; Kurosaki, M.; Matsuura, K.; Sakamoto, N.; Nakagawa, M.; Korenaga, M.; Hino, K.; Hige, S. et al. Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat. Genet. 2009, 41, 1105-1109.
6. Thompson, A.J.; Muir, A.J.; Sulkowski, M.S.; Ge, D.; Fellay, J.; Shianna, K.V.; Urban T.; Afdhal, N.H.; Jacobson, I.M.; Esteban, R. et al. Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virological response in genotype 1 hepatitis C virus. Gastroenterology 2010, 139, 120-129.
7. Mangia, A.; Thompson, A.J.; Santoro, R.; Piazzolla, V.; Tillmann, H.L.; Patel, K.; Shianna, K.V.; Mottola, L.; Petruzzellis, D.; Bacca, D. et al. An IL28B polymorphism determines treatment response of hepatitis C virus genotype 2 or 3 patients who do not achieve a rapid virological response. Gastroenterology 2010, 139, 821-827.
8. De Nicola, S.; Aghemo, A.; Rumi, M.G.; Galmozzi, E.; Valenti, L.; Soffredini, R.; de Francesco, R.; Prati, G.M.; D'Ambrosio, R.; Cheroniet, C. et al. Interleukin 28B polymorphism predicts pegylated interferon plus ribavirin treatment outcome in chronic hepatitis C genotype 4. Hepatology 2012, 55, 336-342.
9. Asselah, T.; de Muynck, S.; Broët, P.; Masliah-Planchon, J.; Blanluet, M.; Bièche, I.; Lapalus, M.; Martinot-Peignoux, M.; Lada, O.; Estrabaud, E. et al. IL28B polymorphism is associated with treatment response in patients with genotype 4 chronic hepatitis C. J. Hepatol. 2012, 56, 527-532.
10. Noureddin, M.; Wright, E.C.; Alter, H.J.; Clark, S.; Thomas, E.; Chen, R.; Zhao, X.; Conry-Cantilena, C.; Kleiner, D.E.; Liang, T.J. et al. Association of IL28B genotype with fibrosis progression and clinical outcomes in patients with chronic hepatitis C: A longitudinal analysis. Hepatology 2013, 58, 1548-1557.
11. D'Ambrosio, R.; Aghemo, A.; Rumi, M.G.; Ronchi, G.; Donato, M.F.; Paradis, V.; Colombo, M.; Bedossa, P. A morphometrical and immunoistochemical study to assess the benefit of a sustained virological response in hepatitis C virus patients with cirrhosis. Hepatology 2012, 56, 532-543.
12. Golden-Mason, L.; bambha, K.M.; Cheng, L.; Howell, C.D.; Taylor, M.W.; Clark, P.J.; Afdhal, N.; Rosen, H.R. On behalf of the Virahep-C study group Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis C. Hepatology 2011, 54, 1559-1569.
13. Naggie, S.; Osinusi, A.; Katsounas, A.; Lempicki, R.; Herrmann, E.; Thompson, A.J.; Clark, P.J.; Patel, K.; Muir, A.J.; McHutchison, J.G. et al. Dysregulation of innate immunity in hepatitis C virus genotype 1 IL28B-unfavorable genotype patients: impaired viral kinetics and therapeutic response. Hepatology 2012, 56, 444-454.
14. Thompson, A.J.; Clark, P.J.; Zhu, M.; Zhu, Q.; Ge, D.; Sulkowski, M.S.; Muir, A.J.; Tillmann, H.L.; Patel, K.; Naggie, S. et al. Genome wide-association study identifies IL28B polymorphism to be associated with baseline ALT and hepatic necro-inflammatory activity in chronic hepatitis C patients enrolled in the IDEAL study. Hepatology 2010, 52, 1220A.
15. Rembeck, K.; Alsio, A.; Christensen, P.B.; Färkkilä, M.; Langeland, N.; Buhl, M.R.; Pedersen, C.; Mørch, K.; Westin, J.; Lindh, M. et al. Impact of IL28B-related single nucleotide polymorphisms on liver histopathology in chronic hepatitis C genotype 2 and 3. PLoS One 2012, 7, doi:10.1371/journal.pone.0029370.
16. Bochud, P.Y.; Bibert, S.; Kutalik, Z.; Patin, E.; Guergnon, J.; Nalpas, B.; Goossens, N.; Kuske, L.; Müllhaupt, B.; Gerlach, T. et al. IL28B alleles associated with poor HCV clearance protect against inflammation and fibrosis in patients infected with non-1 HCV genotypes. Hepatology 2012, 55, 1038-1047.
17. Check, P.J.; Thompson, A.J.; Vock, D.M.; Kratz, L.E.; Tolun, A.A.; Muir, A.J.; McHutchison, J.G.; Subramanian, M.; Millington, D.M.; Kelley, R.I. et al. Hepatitis C virus selectively perturbs the distal cholesterol synthesis pathway in agenotype-specific manner. Hepatology 2012, 56, 49-56.
18. Bochud, P.Y.; Cai, T.; Overbeck, K.; Bochud, M.; Dufour, J.F.; Müllhaupt, B.; Borovicka, J.; Heim, M.; Moradpour, D.; Cerny, A. et al. Genotype 3 is associated with accelerated fibrosis progression in chronic hepatitis C. J. Hepatol. 2009, 51, 655-666.
19. Tillmann, H.L.; Patel, K.; Muir, A.J.; Guy, C.D.; Li, J.H.; Lao, X.Q.; Thompson, A.; Clark, P.J.; Gardner, S.D.; McHutchison, J.G. et al. Beneficial IL28B genotype associated with lower frequency of hepatic Steatosis in patients with chronic hepatitis C. J. Hepatol. 2011, 55, 1195-1200.
20. Rousselet, M.C.; Michalak, S.; Duprè, F.; Croué, A.; Bedossa, P.; Saint-André, J.P.; Calès, P. Sources of variability in histological scoring of chronic viral hepatitis. Hepatology 2005, 41, 257-264.
21. Rumi, M.G.; Aghemo, A.; Prati, G.M.; D'Ambrosio, R.; Donato, M.F.; Soffredini, R.; del Ninno, E.; Russo, A.; Colombo, M. Randomized study of peginterferon-alpha2a plus ribavirin and peginterferon-alpha2b plus ribavirin in chronic hepatitis C. Gastroenterology 2010, 138, 108-115.
22. Aghemo, A.; Prati, G.M.; Rumi, M.G.; Soffredini, R.; D'Ambrosio, R.; Orsi, E.; de Nicola, S.; Degasperi, E.; Grancini, V.; Colombo, M. Sustained virological response prevents the development of insulin resistance in patients with chronic hepatitis C. Hepatology 2012, 56, doi:10.1002/hep.25867.
23. Bedossa, P. Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. Hepatology 1994, 20, 15-20.
24. Bedossa, P.; Poynard, T. An alghoritm for the grading of activity in chronic hepatitis C. Hepatology 1996, 24, 289-293.
25. Ishak, K.; Baptista, A.; Bianchi, L.; Callea, F.; de Groote, J.; Denk, F.G.; Desmet, V.; Korb, G.; MacSween, R.N.M. Histological grading and staging of chronic hepatitis. J. Hepatol. 1995, 22, 696-699.