Renal epithelial sodium channel is critical for blood pressure maintenance and sodium balance in the normal late pregnant rat

Experimental Physiology

Volumn 99, Issue 5, 2014, Pages 816-823

  West, Crystal A ^a   Han, Weiquing ^a   Li, Ningjun ^a   Masilamani, Shyama M E ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY MEDICAL CENTER   (United States)

^b WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZAMIL; EPITHELIAL SODIUM CHANNEL; SHORT HAIRPIN RNA; WATER; AMILORIDE; SMALL INTERFERING RNA; SODIUM;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; FEMALE; FETUS WEIGHT; GENETIC TRANSFECTION; HEART RATE; HOMEOSTASIS; IN VIVO STUDY; KIDNEY EPITHELIUM; MEAN ARTERIAL PRESSURE; NONHUMAN; RAT; SODIUM BALANCE; SODIUM RETENTION; THIRD TRIMESTER PREGNANCY; WATER RETENTION; WEIGHT GAIN; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD PRESSURE; BREEDING; CHEMICALLY INDUCED; DRUG EFFECTS; INTRAUTERINE GROWTH RETARDATION; KIDNEY; METABOLISM; PHYSIOLOGY; PREGNANCY; SPRAGUE DAWLEY RAT;

AMILORIDE; ANIMALS; BLOOD PRESSURE; EPITHELIAL SODIUM CHANNELS; FEMALE; FETAL GROWTH RETARDATION; KIDNEY; PREGNANCY; PREGNANCY, ANIMAL; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; SODIUM; TRANSFECTION;

EID: 84899643146     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2013.076273     Document Type: Article

References (27)

1. Abdul-Karim R & Assali NS (1961). Pressor response to angiotensin in pregnant and nonpregnant women. Am J Obstet Gynecol 82, 246-251.
2. Alexander EA, Churchill S & Bengele HH (1980). Renal hemodynamics and volume homeostasis during pregnancy in the rat. Kidney Int 18, 173-178.
3. Barron W, Brandt CN & Lindheimer MD (1993). Role of adrenal mineralocorticoid in volume homeostasis and pregnancy performance in the rat. Hypertens Pregnancy 12, 53-69.
4. Baylis C (1987). Glomerular filtration and volume regulation in gravid animal models. Baillieres Clin Obstet Gynaecol 1, 789-813.
5. Baylis C & Collins RC (1986). Angiotensin II inhibition on blood pressure and renal hemodynamics in pregnant rats. Am J Physiol Renal Fluid and Electrolyte Physiol 250, F308-F314.
6. Baylis C & Wilson CB (1985). Sex and the single kidney. Am J Kidney Disease 13, 290-298.
7. Brodsky D & Christou H (2004). Current concepts in intrauterine growth restriction. J Intensive Care Med 19, 307-319.
8. Chapman AB, Abraham WT, Zamudio S, Coffin C, Merouani A, Young D, Johnson A, Osorio F, Goldberg C, Moore LG, Dahms T & Schrier RW (1998). Temporal relationships between hormonal and hemodynamic changes in early human pregnancy. Kidney Int 54, 2056-2063.
9. Davison JM (1985). Changes in renal function in early pregnancy in women with one kidney. Kidney Int 27, 74-79.
10. 2+ exchanger. Biochimie 70, 1285-1290.
11. Greenberg S, Lancaster J, Xie J, Sarphie T, Zhao X, Hua L, Freeman T, Kapusta D, Giles T & Powers D (1997). Effects of NO synthase inhibitors, arginine-deficient diet, and amiloride in pregnant rats. Am J Physiol Regul Integr Comp Physiol 273, R1031-R1045.
12. Lifton R, Gharavi A & Geller D (2001). Molecular mechanisms of human hypertension. Cell 104, 545-556.
13. Lindheimer MD, Katz AI, Nolten WE, Oparil S & Ehrilch EN (1977). Sodium and mineralocorticoids in normal and abnormal pregnancy. Adv Nephrol Necker Hosp 7, 22-59.
14. Liu Y, Singh RJ, Usa K, Netzel BC & Liang M (2008). Renal medullary 11β-hydroxysteroid dehydrogenase type 1 in Dahl salt-sensitive hypertension. Physiol Genomics 36, 52-58.
15. Loffing J & Schild L (2005). Functional domains of the epithelial sodium channel. J Am Soc Nephrol 16, 3175-3181.
16. Masilamani S, Kim GH, Mitchell C, Wade JB & Knepper MA (1999). Aldosterone-mediated regulation of ENaC α, β, and γ subunit proteins in rat kidney. J Clin Invest 104, R19-R23.
17. May A, Puoti A, Gaeggeler HP, Horisberger JD & Rossier BC (1997). Early effect of aldosterone on the rate of synthesis of the epithelial sodium channel α subunit in A6 renal cells. J Am Soc Nephrol 8, 1813-1822.
18. Musselman TM, Zhang Z & Masilamani SM (2010). Differential regulation of the bumetanide-sensitive cotransporter (NKCC2) by ovarian hormones. Steroids 75, 760-765.
19. Peeters LL, Sparks JW, Grutters G, Girard J & Battaglia FC (1982). Uteroplacental blood flow during pregnancy in chronically catheterized guinea pigs. Pediatr Res 16, 716-720.
20. Peeters LL, Verkeste CM, Saxena PR & Wallenburg HC (1987). Relationship between maternal hemodynamics and hematocrit and hemodynamic effects of isovolemic hemodilution and hemoconcentration in the awake late-pregnant guinea pig. Pediatr Res 21, 584-589.
21. Pike RL (1976). Sodium requirement of the rat during pregnancy. In Hypertension in Pregnancy, ed. Lindheimer MD, Katz AI & Zuspan FP, pp. 207-216. Wiley, New York.
22. Rosso P, Donoso E, Braun S, Espinoza R & Salas S (1992). Hemodynamic changes in underweight pregnant women. Obstet Gynecol 79, 908-912.
23. Salas S, Rosso P, Espinoza R, Robert J, Valdés G & Donoso E (1993). Maternal plasma volume expansion and hormonal changes in women with idiopathic fetal growth retardation. Obstet Gynecol 81, 1029-1033.
24. Todkar A, Di Chiara M, Loffing-Cueni D, Bettoni C, Mohaupt M, Loffing J & Wagner C (2012). Aldosterone deficiency adversely affects pregnancy outcome in mice. Pflugers Arch 464, 331-343.
25. Wang Z, Zhu Q, Xia M, Li PL, Hinton SJ & Li N (2010). Hypoxia-inducible factor prolyl-hydroxylase 2 senses high-salt intake to increase hypoxia inducible factor 1α levels in the renal medulla. Hypertension 55, 1129-1136.
26. West C, Zhang Z, Ecker G & Masilamani S (2010). Increased renal α epithelial sodium channel (ENaC) protein and increased ENaC activity in normal pregnancy. Am J Physiol Regul Integr Comp Physiol 299, R1326-R1332.
27. Zhu Q, Wang Z, Xia M, Li PL, Van Tassell BW, Abbate A, Dhaduk R & Li N (2011). Silencing of hypoxia-inducible factor-1α gene attenuated angiotensin II-induced renal injury in Sprague-Dawley rats. Hypertension 58, 657-664.