Plasma lipidomic profiling of treated HIV-positive individuals and the implications for cardiovascular risk prediction

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Wong, Gerard ^a   Trevillyan, Janine M ^b,c   Fatou, Benoit ^a,d   Cinel, Michelle ^a   Weir, Jacquelyn M ^a   Hoy, Jennifer F ^b,c   Meikle, Peter J ^a  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b ALFRED HOSPITAL   (Australia)

^c MONASH UNIVERSITY   (Australia)

^d UNIV LILLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALKENYLPHOSPHATIDYLCHOLINE; ALKENYLPHOSPHATIDYLETHANOLAMINE; ALKYLPHOSPHATIDYLCHOLINE; ALKYLPHOSPHATIDYLETHANOLAMINE; CERAMIDE; CERAMIDE DIHEXOSIDE; CHOLESTEROL; CHOLESTEROL ESTER; DIACYLGLYCEROL; DIHYDROCERAMIDE; GANGLIOSIDE GM3; HIGH DENSITY LIPOPROTEIN; LIPID; LOW DENSITY LIPOPROTEIN; LYSOALKYLPHOSPHATIDYLCHOLINE; LYSOPHOSPHATIDYLCHOLINE; LYSOPHOSPHATIDYLETHANOLAMINE; LYSOPHOSPHATIDYLINOSITOL; MONOHEXOSYLCERAMIDE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLGLYCEROL; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLSERINE; SPHINGOMYELIN; TRIHEXOSYLCERMIDE; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; CARDIOVASCULAR RISK; CASE CONTROL STUDY; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIPID ANALYSIS; LIPID BLOOD LEVEL; LIPIDOMICS; MAJOR CLINICAL STUDY; MALE; RECEIVER OPERATING CHARACTERISTIC; RETROSPECTIVE STUDY; BIOLOGICAL MODEL; BLOOD; CARDIOVASCULAR DISEASES; COMPLICATION; HIV SEROPOSITIVITY; LIPID METABOLISM; MIDDLE AGED; REPRODUCIBILITY; RISK FACTOR;

ADULT; CARDIOVASCULAR DISEASES; FEMALE; HIV SEROPOSITIVITY; HUMANS; LIPID METABOLISM; LIPIDS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; REPRODUCIBILITY OF RESULTS; RISK FACTORS;

EID: 84899640580     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0094810     Document Type: Article

References (33)

1. Mocroft A, Ledergerber B, Katlama C, Kirk O, Reiss P, et al. (2003) Decline in the AIDS and death rates in the EuroSIDA study: an observational study. Lancet 362: 22-29. (Pubitemid 36835816)
2. Lohse N, Hansen AB, Pedersen G, Kronborg G, Gerstoft J, et al. (2007) Survival of persons with and without HIV infection in Denmark, 1995-2005. Annals of internal medicine 146: 87-95. (Pubitemid 351640011)
3. Obel N, Thomsen HF, Kronborg G, Larsen CS, Hildebrandt PR, et al. (2007) Ischemic heart disease in HIV-infected and HIV-uninfected individuals: a population-based cohort study. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America 44: 1625-1631. (Pubitemid 46871511)
4. Triant VA, Lee H, Hadigan C, Grinspoon SK (2007) Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease. The Journal of clinical endocrinology and metabolism 92: 2506-2512. (Pubitemid 47037350)
5. Friis-Moller N, Sabin CA, Weber R, d'Arminio Monforte A, El-Sadr WM, et al. (2003) Combination antiretroviral therapy and the risk of myocardial infarction. The New England journal of medicine 349: 1993-2003.
6. Francisci D, Giannini S, Baldelli F, Leone M, Belfiori B, et al. (2009) HIV type 1 infection, and not short-term HAART, induces endothelial dysfunction. AIDS 23: 589-596.
7. Penzak SR, Chuck SK (2000) Hyperlipidemia associated with HIV protease inhibitor use: pathophysiology, prevalence, risk factors and treatment. Scandinavian journal of infectious diseases 32: 111-123. (Pubitemid 30599192)
8. D'Agostino RB, Sr., Vasan RS, Pencina MJ, Wolf PA, Cobain M, et al. (2008) General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation 117: 743-753. (Pubitemid 351640675)
9. Ridker PM, Buring JE, Rifai N, Cook NR (2007) Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score. JAMA: the journal of the American Medical Association 297: 611-619.
10. Friis-Moller N, Thiebaut R, Reiss P, Weber R, Monforte AD, et al. (2010) Predicting the risk of cardiovascular disease in HIV-infected patients: the data collection on adverse effects of anti-HIV drugs study. Eur J Cardiovasc Prev Rehabil 17: 491-501.
11. Meikle PJ, Wong G, Tsorotes D, Barlow CK, Weir JM, et al. (2011) Plasma lipidomic analysis of stable and unstable coronary artery disease. Arterioscler Thromb Vasc Biol 31: 2723-2732.
12. Trevillyan JM, Cheng AC, Hoy J (2012) Abacavir exposure and cardiovascular risk factors in HIV-positive patients with coronary heart disease: a retrospective case-control study. Sexual health.
13. Weir JM, Wong G, Barlow CK, Greeve MA, Kowalczyk A, et al. (2013) Plasma lipid profiling in a large population-based cohort. J Lipid Res 54: 2898-2908.
14. Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society Series B (Methodological). pp. 289-300.
15. Wong G, Barlow CK, Weir JM, Jowett JB, Magliano DJ, et al. (2013) Inclusion of plasma lipid species improves classification of individuals at risk of type 2 diabetes. PLoS One 8: e76577.
16. Moxon JV, Liu D, Wong G, Weir JM, Behl-Gilhotra R, et al. (2014) Comparison of the serum lipidome in patients with abdominal aortic aneurysm and peripheral artery disease. Circ Cardiovasc Genet 7: 71-79.
17. Chang C, Lin C (2011) LIBSVM: A library for support vector machines. ACM Trans Intell Syst Technol 2: 1-27.
18. Hellerstein MK, Grunfeld C, Wu K, Christiansen M, Kaempfer S, et al. (1993) Increased de novo hepatic lipogenesis in human immunodeficiency virus infection. J Clin Endocrinol Metab 76: 559-565. (Pubitemid 23086466)
19. Rasheed S, Yan JS, Lau A, Chan AS (2008) HIV replication enhances production of free fatty acids, low density lipoproteins and many key proteins involved in lipid metabolism: a proteomics study. PLoS One 3: e3003.
20. Baruchel S, Wainberg MA (1992) The role of oxidative stress in disease progression in individuals infected by the human immunodeficiency virus. J Leukoc Biol 52: 111-114.
21. Pace GW, Leaf CD (1995) The role of oxidative stress in HIV disease. Free Radic Biol Med 19: 523-528.
22. Wiesner P, Leidl K, Boettcher A, Schmitz G, Liebisch G (2009) Lipid profiling of FPLC-separated lipoprotein fractions by electrospray ionization tandem mass spectrometry. J Lipid Res 50: 574-585.
23. Maeba R, Maeda T, Kinoshita M, Takao K, Takenaka H, et al. (2007) Plasmalogens in human serum positively correlate with high-density lipoprotein and decrease with aging. J Atheroscler Thromb 14: 12-18.
24. Grunfeld C (2010) Dyslipidemia and its Treatment in HIV Infection. 112-118 p.
25. Haugaard SB, Andersen O, Pedersen SB, Dela F, Fenger M, et al. (2006) Tumor necrosis factor alpha is associated with insulin-mediated suppression of free fatty acids and net lipid oxidation in HIV-infected patients with lipodystrophy. Metabolism 55: 175-182. (Pubitemid 43098984)
26. Meikle PJ, Wong G, Barlow CK, Weir JM, Greeve MA, et al. (2013) Plasma lipid profiling shows similar associations with prediabetes and type 2 diabetes. PLoS One 8: e74341.
27. Lee GA, Rao MN, Grunfeld C (2004) The Effects of HIV Protease Inhibitors on Carbohydrate and Lipid Metabolism. Curr Infect Dis Rep 6: 471-482. (Pubitemid 39619151)
28. Crane HM, Grunfeld C, Willig JH, Mugavero MJ, Van Rompaey S, et al. (2011) Impact of NRTIs on lipid levels among a large HIV-infected cohort initiating antiretroviral therapy in clinical care. AIDS 25: 185-195.
29. Young J, Weber R, Rickenbach M, Furrer H, Bernasconi E, et al. (2005) Lipid profiles for antiretroviral-naive patients starting PI-and NNRTI-based therapy in the Swiss HIV cohort study. Antivir Ther 10: 585-591. (Pubitemid 41224950)
30. Lenhard JM, Furfine ES, Jain RG, Ittoop O, Orband-Miller LA, et al. (2000) HIV protease inhibitors block adipogenesis and increase lipolysis in vitro. Antiviral Res 47: 121-129.
31. Shahmanesh M, Das S, Stolinski M, Shojaee-Moradie F, Jackson NC, et al. (2005) Antiretroviral Treatment Reduces Very-Low-Density Lipoprotein and Intermediate-Density Lipoprotein Apolipoprotein B Fractional Catabolic Rate in Human Immunodeficiency Virus-Infected Patients with Mild Dyslipidemia. Journal of Clinical Endocrinology & Metabolism 90: 755-760. (Pubitemid 40279192)
32. Spector AA (2006) HIV protease inhibitors and hyperlipidemia: a fatty acid connection. Arterioscler Thromb Vasc Biol 26: 7-9. (Pubitemid 43732221)
33. Carpentier A, Patterson BW, Uffelman KD, Salit I, Lewis GF (2005) Mechanism of highly active anti-retroviral therapy-induced hyperlipidemia in HIV-infected individuals. Atherosclerosis 178: 165-172. (Pubitemid 39600829)