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Volumn 25, Issue 5, 2014, Pages 1535-1545

The biomaterial-mediated healing of critical size bone defects in the ovariectomized rat

Author keywords

Animal model; Biomaterial; Bone regeneration; Osteoporosis

Indexed keywords

ALKALINE PHOSPHATASE; BIOMATERIAL; CALCIUM; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHORUS;

EID: 84899633040     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-014-2656-y     Document Type: Article
Times cited : (38)

References (42)
  • 1
    • 84930606426 scopus 로고    scopus 로고
    • Osteoporosis: Pathophysiology and clinical aspects
    • Pietschmann (eds) Springer Vienna 10.1007/978-3-7091-0520-7-7
    • Mikosch P (2012) Osteoporosis: pathophysiology and clinical aspects. In: Pietschmann P (ed) Principles of osteoimmunology. Springer, Vienna, pp 137-167
    • (2012) Principles of Osteoimmunology , pp. 137-167
    • Mikosch, P.1
  • 2
    • 0035857351 scopus 로고    scopus 로고
    • Osteoporosis prevention, diagnosis, and therapy
    • NIH Consensus Development Panel on Osteoporosis Prevention 10.1001/jama.285.6.785
    • NIH Consensus Development Panel on Osteoporosis Prevention (2001) Osteoporosis prevention, diagnosis, and therapy. J Am Med Assoc 285:785-795
    • (2001) J Am Med Assoc , vol.285 , pp. 785-795
  • 3
    • 79251585268 scopus 로고    scopus 로고
    • Targeted regeneration of bone in the osteoporotic human femur
    • 10.1371/journal.pone.0016190
    • Poole K, Treece G, Ridgway G, Mayhew P, Borggrefe J, Gee A (2011) Targeted regeneration of bone in the osteoporotic human femur. PLoS One 14:e16190
    • (2011) PLoS One , vol.14 , pp. 16190
    • Poole, K.1    Treece, G.2    Ridgway, G.3    Mayhew, P.4    Borggrefe, J.5    Gee, A.6
  • 4
    • 49749143702 scopus 로고    scopus 로고
    • Pathogenesis of age-related osteoporosis: Impaired mechano-responsiveness of bone is not the culprit
    • 10.1371/journal.pone.0002540
    • Leppänen O, Sievänen H, Jokihaara J, Pajamäki I, Kannus P, Järvinen T (2008) Pathogenesis of age-related osteoporosis: impaired mechano-responsiveness of bone is not the culprit. PLoS One 2:e2540
    • (2008) PLoS One , vol.2 , pp. 2540
    • Leppänen, O.1    Sievänen, H.2    Jokihaara, J.3    Pajamäki, I.4    Kannus, P.5    Järvinen, T.6
  • 5
    • 38849178302 scopus 로고    scopus 로고
    • Building bone to reverse osteoporosis and repair fractures
    • 1:CAS:528:DC%2BD1cXhsFOnurg%3D 2214701 18246192 10.1172/JCI33612
    • Khosla S, Westendorf JJ, Oursler MJ (2008) Building bone to reverse osteoporosis and repair fractures. J Clin Invest 118:421-428
    • (2008) J Clin Invest , vol.118 , pp. 421-428
    • Khosla, S.1    Westendorf, J.J.2    Oursler, M.J.3
  • 6
    • 84875981209 scopus 로고    scopus 로고
    • Therapeutic options in osteoporosis
    • 20518192
    • Dominguez L, Scalisi R, Barbagallo M (2010) Therapeutic options in osteoporosis. Acta Biomed 81(Suppl 1):55-65
    • (2010) Acta Biomed , vol.81 , Issue.SUPPL. 1 , pp. 55-65
    • Dominguez, L.1    Scalisi, R.2    Barbagallo, M.3
  • 7
    • 0030833666 scopus 로고    scopus 로고
    • Biomaterials for orthopedic surgery in osteoporotic bone: A comparative study in osteopenic rats
    • 1:CAS:528:DyaK2sXls1GmtL8%3D 9209931
    • Fini M, Nicoli Aldini N, Gandolfi MG et al (1997) Biomaterials for orthopedic surgery in osteoporotic bone: a comparative study in osteopenic rats. Int J Artif Organs 20:291-297
    • (1997) Int J Artif Organs , vol.20 , pp. 291-297
    • Fini, M.1    Nicoli Aldini, N.2    Gandolfi, M.G.3
  • 8
    • 0024443425 scopus 로고
    • The affinity of bone to hydroxyapatite and alumina in experimentally induced osteoporosis
    • 1:STN:280:DyaK3c%2FhtFSkuw%3D%3D 2552019 10.1016/S0883-5403(89)80022-1
    • Hayashi K, Uenoyama K, Matsuguchi N, Nakagawa S, Sugioka Y (1989) The affinity of bone to hydroxyapatite and alumina in experimentally induced osteoporosis. J Arthroplasty 4:257-262
    • (1989) J Arthroplasty , vol.4 , pp. 257-262
    • Hayashi, K.1    Uenoyama, K.2    Matsuguchi, N.3    Nakagawa, S.4    Sugioka, Y.5
  • 9
    • 3342897648 scopus 로고    scopus 로고
    • Bone healing in osteoporotic female rats following intra-alveolar grafting of bioactive glass
    • 1:CAS:528:DC%2BD2cXmtVSksb8%3D 15275863 10.1016/j.archoralbio.2004.02.013
    • Teofilo JM, Brentegani LG, Lamano-Carvalho TL (2004) Bone healing in osteoporotic female rats following intra-alveolar grafting of bioactive glass. Arch Oral Biol 49:755-762
    • (2004) Arch Oral Biol , vol.49 , pp. 755-762
    • Teofilo, J.M.1    Brentegani, L.G.2    Lamano-Carvalho, T.L.3
  • 10
    • 0034282320 scopus 로고    scopus 로고
    • The effect of osteopenia on the osteointegration of different biomaterials: Histomorphometric study in rats
    • 1:CAS:528:DC%2BD3cXnsFyjt7o%3D 15348388 10.1023/A:1008932303913
    • Fini M, Giavaresi G, Aldini N et al (2000) The effect of osteopenia on the osteointegration of different biomaterials: histomorphometric study in rats. J Mater Sci Mater Med 11:579-585
    • (2000) J Mater Sci Mater Med , vol.11 , pp. 579-585
    • Fini, M.1    Giavaresi, G.2    Aldini, N.3
  • 11
    • 0033978451 scopus 로고    scopus 로고
    • Osseous tissue reaction around hydroxyapatite block implanted into proximal metaphysis of tibia of rat with collagen-induced arthritis
    • 1:CAS:528:DC%2BD3cXhtVyktL0%3D 10674813 10.1016/S0142-9612(99)00198-2
    • Okazaki A, Koshino T, Saito T, Takagi T (2000) Osseous tissue reaction around hydroxyapatite block implanted into proximal metaphysis of tibia of rat with collagen-induced arthritis. Biomaterials 21:483-487
    • (2000) Biomaterials , vol.21 , pp. 483-487
    • Okazaki, A.1    Koshino, T.2    Saito, T.3    Takagi, T.4
  • 12
    • 70350247738 scopus 로고    scopus 로고
    • Hydroxyapatite particles maintain peri-implant bone mantle during osseointegration in osteoporotic bone
    • 1:CAS:528:DC%2BD1MXhtlGit7fP 19679208 10.1016/j.bone.2009.07.090
    • Tami A, Leitner M, Baucke M, Mueller T, van Lenthe G, Müller R, Ito K (2009) Hydroxyapatite particles maintain peri-implant bone mantle during osseointegration in osteoporotic bone. Bone 45:1117-1124
    • (2009) Bone , vol.45 , pp. 1117-1124
    • Tami, A.1    Leitner, M.2    Baucke, M.3    Mueller, T.4    Van Lenthe, G.5    Müller, R.6    Ito, K.7
  • 13
    • 18444365600 scopus 로고    scopus 로고
    • Stereological measures of trabecular bone structure: Comparison of 3D micro computed tomography with 2D histological sections in human proximal tibial bone biopsies
    • 1:STN:280:DC%2BD2M3itlantg%3D%3D 15857378 10.1111/j.1365-2818.2005.01469. x
    • Thomsen J, Laib A, Koller B, Prohaska S, Mosekilde L, Gowin W (2005) Stereological measures of trabecular bone structure: comparison of 3D micro computed tomography with 2D histological sections in human proximal tibial bone biopsies. J Microsc 218:171-179
    • (2005) J Microsc , vol.218 , pp. 171-179
    • Thomsen, J.1    Laib, A.2    Koller, B.3    Prohaska, S.4    Mosekilde, L.5    Gowin, W.6
  • 14
    • 77950648117 scopus 로고    scopus 로고
    • Biodegradation of porous calcium phosphate scaffolds in an ectopic bone formation model studied by X-ray computed microtomograph
    • 1:CAS:528:DC%2BC3cXkvVSgurk%3D 20349404
    • Komlev V, Mastrogiacomo M, Pereira R, Peyrin F, Rustichelli F, Cancedda R (2010) Biodegradation of porous calcium phosphate scaffolds in an ectopic bone formation model studied by X-ray computed microtomograph. Eur Cell Mater 19:136-146
    • (2010) Eur Cell Mater , vol.19 , pp. 136-146
    • Komlev, V.1    Mastrogiacomo, M.2    Pereira, R.3    Peyrin, F.4    Rustichelli, F.5    Cancedda, R.6
  • 15
    • 79952742634 scopus 로고    scopus 로고
    • The effect of BMP-2 on the osteoconductive properties of β-tricalcium phosphate in rat calvaria defects
    • 1:CAS:528:DC%2BC3MXjvVSrtLo%3D 21376389 10.1016/j.biomaterials.2011.01. 076
    • Luvizuto E, Tangl S, Zanoni G, Okamoto T, Sonoda C, Gruber R, Okamoto R (2011) The effect of BMP-2 on the osteoconductive properties of β-tricalcium phosphate in rat calvaria defects. Biomaterials 32:3855-3861
    • (2011) Biomaterials , vol.32 , pp. 3855-3861
    • Luvizuto, E.1    Tangl, S.2    Zanoni, G.3    Okamoto, T.4    Sonoda, C.5    Gruber, R.6    Okamoto, R.7
  • 16
    • 84911307627 scopus 로고
    • The critical size defect as an experimental model to test bone repair materials
    • 1:STN:280:DyaK3M3gvVaqtA%3D%3D 1965154 10.1097/00001665-199001000-00011
    • Hollinger JO, Kleinschmidt JC (1990) The critical size defect as an experimental model to test bone repair materials. J Craniofac Surg 1:60-68
    • (1990) J Craniofac Surg , vol.1 , pp. 60-68
    • Hollinger, J.O.1    Kleinschmidt, J.C.2
  • 17
    • 78751686333 scopus 로고    scopus 로고
    • Rodent models in bone-related research: The relevance of calvarial defects in the assessment of bone regeneration strategies
    • 1:CAS:528:DC%2BC3MXpvVyjtLg%3D 21156759 10.1258/la.2010.010085
    • Gomes P, Fernandes M (2011) Rodent models in bone-related research: the relevance of calvarial defects in the assessment of bone regeneration strategies. Lab Anim 45:14-24
    • (2011) Lab Anim , vol.45 , pp. 14-24
    • Gomes, P.1    Fernandes, M.2
  • 18
    • 0034768783 scopus 로고    scopus 로고
    • Comparison of osteopenia after gastrectomy, ovariectomy and prednisolone treatment in the young female rat
    • 1:STN:280:DC%2BD3Mnot1Sruw%3D%3D 11728082 10.1080/000164701753532880
    • Surve V, Andersson N, Lehto-Axtelius D, Håkanson R (2001) Comparison of osteopenia after gastrectomy, ovariectomy and prednisolone treatment in the young female rat. Acta Orthop Scand 72:525-532
    • (2001) Acta Orthop Scand , vol.72 , pp. 525-532
    • Surve, V.1    Andersson, N.2    Lehto-Axtelius, D.3    Håkanson, R.4
  • 19
    • 0035071215 scopus 로고    scopus 로고
    • Effects of ovariectomy and/or dietary calcium deficiency on bone dynamics in the rat hard palate, mandible and proximal tibia
    • 1:CAS:528:DC%2BD3MXisVSqu78%3D 11286809 10.1016/S0003-9969(00)00135-7
    • Hara T, Sato T, Oka M, Mori S, Shirai H (2001) Effects of ovariectomy and/or dietary calcium deficiency on bone dynamics in the rat hard palate, mandible and proximal tibia. Arch Oral Biol 46:443-451
    • (2001) Arch Oral Biol , vol.46 , pp. 443-451
    • Hara, T.1    Sato, T.2    Oka, M.3    Mori, S.4    Shirai, H.5
  • 20
    • 68249144622 scopus 로고    scopus 로고
    • Ovariectomy vs hypofunction: Their effects on rat mandibular bone
    • 10.1177/0022034509340132
    • Rawlinson S, Boyde A, Davis G, Howell P, Hughes F, Kingsmill V (2008) Ovariectomy vs. hypofunction: their effects on rat mandibular bone. J Dent Res 88:615-620
    • (2008) J Dent Res , vol.88 , pp. 615-620
    • Rawlinson, S.1    Boyde, A.2    Davis, G.3    Howell, P.4    Hughes, F.5    Kingsmill, V.6
  • 21
    • 26944488042 scopus 로고    scopus 로고
    • Animal models for fracture treatment in osteoporosis
    • 15750681 10.1007/s00198-005-1859-7
    • Egermann M, Goldhahn J, Schneider E (2005) Animal models for fracture treatment in osteoporosis. Osteoporos Int 16:S129-S138
    • (2005) Osteoporos Int , vol.16
    • Egermann, M.1    Goldhahn, J.2    Schneider, E.3
  • 22
    • 0036942572 scopus 로고    scopus 로고
    • Cyclic estradiol treatment normalizes body weight and restores physiological patterns of spontaneous feeding and sexual receptivity in ovariectomized rats
    • 1:CAS:528:DC%2BD38XpsFyitLw%3D 12488112 10.1006/hbeh.2002.1835
    • Asarian L, Geary N (2002) Cyclic estradiol treatment normalizes body weight and restores physiological patterns of spontaneous feeding and sexual receptivity in ovariectomized rats. Horm Behav 42:461-471
    • (2002) Horm Behav , vol.42 , pp. 461-471
    • Asarian, L.1    Geary, N.2
  • 23
    • 77956257843 scopus 로고    scopus 로고
    • Central effects of estradiol in the regulation of food intake, body weight, and adiposity
    • 1:CAS:528:DC%2BC3cXhtFGgsrjP 2889220 20035866 10.1016/j.jsbmb.2009.12.005
    • Brown L, Clegg D (2010) Central effects of estradiol in the regulation of food intake, body weight, and adiposity. J Steroid Biochem Mol Biol 122:65-73
    • (2010) J Steroid Biochem Mol Biol , vol.122 , pp. 65-73
    • Brown, L.1    Clegg, D.2
  • 25
    • 56549120396 scopus 로고    scopus 로고
    • The laboratory rat as an animal model for osteoporosis research
    • 1:CAS:528:DC%2BD1cXhtlCnsbnM 2707131 19004367
    • Lelovas P, Xanthos T, Thoma S, Lyritis G, Dontas I (2008) The laboratory rat as an animal model for osteoporosis research. Comp Med 58:424-430
    • (2008) Comp Med , vol.58 , pp. 424-430
    • Lelovas, P.1    Xanthos, T.2    Thoma, S.3    Lyritis, G.4    Dontas, I.5
  • 27
    • 0031818419 scopus 로고    scopus 로고
    • Importance of the critical-size bone defect in testing bone-regenerating materials
    • 1:STN:280:DyaK1cvlsVajuw%3D%3D 9780924 10.1097/00001665-199807000-00004
    • Bosch C, Melsen B, Vargervik K (1998) Importance of the critical-size bone defect in testing bone-regenerating materials. J Craniofac Surg 9:310-316
    • (1998) J Craniofac Surg , vol.9 , pp. 310-316
    • Bosch, C.1    Melsen, B.2    Vargervik, K.3
  • 28
    • 0028096039 scopus 로고
    • Remodelling of bone around hydroxyapatite and titanium in experimental osteoporosis
    • 1:CAS:528:DyaK2cXisFegsbo%3D 8161651 10.1016/0142-9612(94)90189-9
    • Hayashi K, Uenoyama K, Mashima T, Sugioka Y (1994) Remodelling of bone around hydroxyapatite and titanium in experimental osteoporosis. Biomaterials 15:11-16
    • (1994) Biomaterials , vol.15 , pp. 11-16
    • Hayashi, K.1    Uenoyama, K.2    Mashima, T.3    Sugioka, Y.4
  • 29
    • 79953678362 scopus 로고    scopus 로고
    • The impact of ovariectomy and hyperglycemia on graft consolidation in rat calvaria
    • 21244496 10.1111/j.1600-0501.2010.02048.x
    • Fuegl A, Tangl S, Keibl C, Watzek G, Redl H, Gruber R (2011) The impact of ovariectomy and hyperglycemia on graft consolidation in rat calvaria. Clin Oral Implants Res 22:524-529
    • (2011) Clin Oral Implants Res , vol.22 , pp. 524-529
    • Fuegl, A.1    Tangl, S.2    Keibl, C.3    Watzek, G.4    Redl, H.5    Gruber, R.6
  • 30
    • 0027033847 scopus 로고
    • Osteoconduction of bioceramics in normal and osteopenic rats: Comparison between bioactive and bioinert ceramics
    • 1:STN:280:DyaK3sbgt1Knuw%3D%3D 10171596 10.1002/jab.770030404
    • Iwashita Y, Yamamuro T, Kasai R, Kitsugi T, Nakamura T, Okumura H, Kokubo T (1992) Osteoconduction of bioceramics in normal and osteopenic rats: comparison between bioactive and bioinert ceramics. J Appl Biomater 3:259-268
    • (1992) J Appl Biomater , vol.3 , pp. 259-268
    • Iwashita, Y.1    Yamamuro, T.2    Kasai, R.3    Kitsugi, T.4    Nakamura, T.5    Okumura, H.6    Kokubo, T.7
  • 31
    • 84856010381 scopus 로고    scopus 로고
    • Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats
    • 1:CAS:528:DC%2BC38XpslOqsQ%3D%3D 10.1002/jemt.21035
    • Ribeiro D, Figueira L, Issa J, Vecina C, Dias F, Cunha M (2012) Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats. Microsc Res Tech 75:133-137
    • (2012) Microsc Res Tech , vol.75 , pp. 133-137
    • Ribeiro, D.1    Figueira, L.2    Issa, J.3    Vecina, C.4    Dias, F.5    Cunha, M.6
  • 32
    • 0344131893 scopus 로고    scopus 로고
    • Abnormal osteogenesis in osteoporotic patients is reflected by altered mesenchymal stem cells dynamics
    • 10536365 10.1002/(SICI)1097-4644(19991201)75:3<414: AID-JCB7>3.0.CO;2-C
    • Rodríguez JP, Garat S, Gajardo H, Pino AM, Seitz G (1999) Abnormal osteogenesis in osteoporotic patients is reflected by altered mesenchymal stem cells dynamics. J Cell Biochem 75:414-423
    • (1999) J Cell Biochem , vol.75 , pp. 414-423
    • Rodríguez, J.P.1    Garat, S.2    Gajardo, H.3    Pino, A.M.4    Seitz, G.5
  • 33
    • 70350550255 scopus 로고    scopus 로고
    • Circulating mesenchymal stem cells with abnormal osteogenic differentiation in patients with osteoporosis
    • 10.1002/art.24884
    • Carbonare LD, Valenti MT, Zanatta M, Donatelli L, Lo Cascio V (2009) Circulating mesenchymal stem cells with abnormal osteogenic differentiation in patients with osteoporosis. Arthritis Rheum 60:3356-3365
    • (2009) Arthritis Rheum , vol.60 , pp. 3356-3365
    • Carbonare, L.D.1    Valenti, M.T.2    Zanatta, M.3    Donatelli, L.4    Lo Cascio, V.5
  • 34
    • 84866709603 scopus 로고    scopus 로고
    • The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors
    • 1:CAS:528:DC%2BC38XhsVCmtLvM 3454401 23028809 10.1371/journal.pone. 0045142
    • Benisch P, Schilling T, Klein-Hitpass L et al (2012) The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors. PLoS One 7:e45142
    • (2012) PLoS One , vol.7 , pp. 45142
    • Benisch, P.1    Schilling, T.2    Klein-Hitpass, L.3
  • 35
    • 33746451702 scopus 로고    scopus 로고
    • Osteocytes use estrogen receptor α to respond to strain but their ERα content is regulated by estrogen
    • 1:CAS:528:DC%2BD28XotlKrsb8%3D 16869728 10.1359/jbmr.060504
    • Zaman G, Jessop HL, Muzylak M, De Souza RL, Pitsillides AA, Price JS, Lanyon LL (2006) Osteocytes use estrogen receptor α to respond to strain but their ERα content is regulated by estrogen. J Bone Miner Res 21:1297-1306
    • (2006) J Bone Miner Res , vol.21 , pp. 1297-1306
    • Zaman, G.1    Jessop, H.L.2    Muzylak, M.3    De Souza, R.L.4    Pitsillides, A.A.5    Price, J.S.6    Lanyon, L.L.7
  • 36
    • 79955923309 scopus 로고    scopus 로고
    • Impaired bone healing pattern in mice with ovariectomy-induced osteoporosis: A drill-hole defect model
    • 21421090 10.1016/j.bone.2011.03.720
    • He Y-X, Zhang G, Pan X-H, Liu Z, Zheng L-Z, Chan C-W, Lee K-M, Cao Y-P, Li G, Wei L (2011) Impaired bone healing pattern in mice with ovariectomy-induced osteoporosis: a drill-hole defect model. Bone 48:1388-1400
    • (2011) Bone , vol.48 , pp. 1388-1400
    • He, Y.-X.1    Zhang, G.2    Pan, X.-H.3    Liu, Z.4    Zheng, L.-Z.5    Chan, C.-W.6    Lee, K.-M.7    Cao, Y.-P.8    Li, G.9    Wei, L.10
  • 37
    • 4644360074 scopus 로고    scopus 로고
    • Estrogen receptor-β inhibits skeletal growth and has the capacity to mediate growth plate fusion in female mice
    • 1:CAS:528:DC%2BD2cXnt1Kgsw%3D%3D 14753739 10.1359/jbmr.0301203
    • Chagin A, Lindberg MK, Andersson N, Moverare S, Gustafsson JÅ, Sävendahl L, Ohlsson C (2004) Estrogen receptor-β inhibits skeletal growth and has the capacity to mediate growth plate fusion in female mice. J Bone Miner Res 19:72-77
    • (2004) J Bone Miner Res , vol.19 , pp. 72-77
    • Chagin, A.1    Lindberg, M.K.2    Andersson, N.3    Moverare, S.4    Gustafsson, J.5    Sävendahl, L.6    Ohlsson, C.7
  • 38
    • 23844501071 scopus 로고    scopus 로고
    • In vivo characterization of skeletal phenotype of genetically modified mice
    • 1:CAS:528:DC%2BD2MXmvVynurg%3D 15984421 10.1007/BF03026330
    • Ke HZ (2005) In vivo characterization of skeletal phenotype of genetically modified mice. J Bone Miner Metab 23:84-89
    • (2005) J Bone Miner Metab , vol.23 , pp. 84-89
    • Ke, H.Z.1
  • 39
    • 14144249535 scopus 로고    scopus 로고
    • Estrogen receptor β the antimechanostat?
    • 1:CAS:528:DC%2BD2MXhslWks70%3D 15780944 10.1016/j.bone.2004.08.003
    • Saxon LK, Turner CH (2005) Estrogen receptor β: the antimechanostat? Bone 36:185-192
    • (2005) Bone , vol.36 , pp. 185-192
    • Saxon, L.K.1    Turner, C.H.2
  • 40
    • 2442646220 scopus 로고    scopus 로고
    • Identification of estrogen-regulated genes during fracture healing, using DNA microarray
    • 1:CAS:528:DC%2BD2cXjtlyjtrs%3D 15108064 10.1007/s00774-003-0482-y
    • Hatano H, Siegel H, Yamagiwa H, Bronk J, Turner R, Bolander M, Sarkar G (2004) Identification of estrogen-regulated genes during fracture healing, using DNA microarray. J Bone Miner Metab 22:224-235
    • (2004) J Bone Miner Metab , vol.22 , pp. 224-235
    • Hatano, H.1    Siegel, H.2    Yamagiwa, H.3    Bronk, J.4    Turner, R.5    Bolander, M.6    Sarkar, G.7
  • 41
    • 52749090092 scopus 로고    scopus 로고
    • Involvement of adipogenic potential of human bone marrow mesenchymal stem cells (MSCs) in osteoporosis
    • 18782003 10.2174/157488808785740325
    • Rodríguez J, Astudillo P, Ríos S, Pino A (2008) Involvement of adipogenic potential of human bone marrow mesenchymal stem cells (MSCs) in osteoporosis. Curr Stem Cell Res Ther 3:208-218
    • (2008) Curr Stem Cell Res Ther , vol.3 , pp. 208-218
    • Rodríguez, J.1    Astudillo, P.2    Ríos, S.3    Pino, A.4
  • 42
    • 22944489618 scopus 로고    scopus 로고
    • Osteoporosis is associated with increased marrow fat content and decreased marrow fat unsaturation: A proton MR spectroscopy study
    • 16028245 10.1002/jmri.20367
    • Yeung DKW, Griffith JF, Antonio GE, Lee FKH, Woo J, Leung PC (2005) Osteoporosis is associated with increased marrow fat content and decreased marrow fat unsaturation: a proton MR spectroscopy study. J Magn Reson Imaging 22:279-285
    • (2005) J Magn Reson Imaging , vol.22 , pp. 279-285
    • Yeung, D.K.W.1    Griffith, J.F.2    Antonio, G.E.3    Lee, F.K.H.4    Woo, J.5    Leung, P.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.