Outcomes in a cohort of women who discontinued maternal triple-antiretroviral regimens initially used to prevent mother-to-child transmission during pregnancy and breastfeeding-Kenya, 2003-2009

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Minniear, Timothy D ^a,b,c   Girde, Sonali ^a   Angira, Frank ^d   Mills, Lisa A ^b,d   Zeh, Clement ^b,d   Peters, Philip J ^b   Masaba, Rose ^d   Lando, Richard ^d   Thomas, Timothy K ^b   Taylor, Allan W ^b  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^d KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; LAMIVUDINE; NELFINAVIR; NEVIRAPINE; ZIDOVUDINE;

ADULT; ARTICLE; BREAST FEEDING; CD4 LYMPHOCYTE COUNT; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE TRANSMISSION; DRUG WITHDRAWAL; FEMALE; HEALTH HAZARD; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; KENYA; MAJOR CLINICAL STUDY; PREGNANCY; PROSPECTIVE STUDY; PUERPERIUM; RISK FACTOR; TREATMENT OUTCOME; VERTICAL TRANSMISSION; CLINICAL TRIAL; HIV INFECTIONS; PREVENTION AND CONTROL; TREATMENT WITHDRAWAL; WEANING; YOUNG ADULT;

ADULT; ANTI-RETROVIRAL AGENTS; BREAST FEEDING; CD4 LYMPHOCYTE COUNT; COHORT STUDIES; FEMALE; HIV INFECTIONS; HUMANS; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; KENYA; POSTPARTUM PERIOD; PREGNANCY; TREATMENT OUTCOME; WEANING; WITHHOLDING TREATMENT; YOUNG ADULT;

EID: 84899625088     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0093556     Document Type: Article

References (13)

1. World Health Organization (2012) Use of antiretroviral drugs for treating pregnant women and preventing HIV infection in infants. Geneva, Switzerland: WHO Press. 8 p.
2. Kesho Bora Study Group (2012) Maternal HIV-1 disease progression 18-24 months postdelivery according to antiretroviral prophylaxis regimen (tripleantiretroviral prophylaxis during pregnancy and breastfeeding vs zidovudine/single-dose nevirapine prophylaxis): The Kesho Bora randomized controlled trial. Clin Infect Dis 55: 449-60.
3. Thomas TK, Masaba R, Borkowf CB, Ndivo R, Zeh C, et al. (2011) Highly active antiretroviral therapy to prevent mother-to-child HIV transmission through breastfeeding in Kenya: The Kisumu Breastfeeding Study. PLoS Med 8: 1-12.
4. World Health Organization (2010) Antiretroviral therapy for HIV infection in adults and adolescents. Geneva, Switzerland: WHO Press. 145 p.
5. Cames C, Saher A, Ayassou KA, Cournil A, Meda N, et al. (2010) Acceptability and feasibility of infant-feeding options: experiences of HIV-infected mothers in the World Health Organization Kesho Bora mother-to-child transmission prevention (PMTCT) trial in Burkina Faso. Matern Child Nutr 6: 253-65.
6. Coovadia HM, Brown ER, Fowler MG, Chipato T, Moodley D, et al. (2012) Efficacy and safety of an extended nevirapine regimen in infant children of breastfeeding mothers with HIV-1 infection for prevention of postnatal HIV-1 transmission (HPTN 046): a randomised, double-blind, placebo-controlled trial. Lancet 379: 221-8.
7. Mermin J, Were W, Ekwaru JP, Moore D, Downing R, et al. (2008) Mortality in HIV-infected Ugandan adults receiving antiretroviral treatment and survival of their HIV-uninfected children: a prospective cohort study. Lancet 371: 752-9. (Pubitemid 351297773)
8. Strategies for Management of Antiretroviral Therapy (SMART) Study Group, Emery S, Neuhaus JA, Phillips AN, Babiker A, et al. (2008) Major clinical outcomes in antiretroviral therapy (ART)-naive participants and in those not receiving ART at baseline in the SMART study. J Infect Dis 197: 1133-44. (Pubitemid 351590049)
9. Johansson KA, Robberstad B, Norheim OF (2010) Further benefits by early start of HIV treatment in low income countries: survival estimates of early versus deferred antiretroviral therapy. AIDS Res Ther 7: 3.
10. Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, et al. (2011) Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med 365: 493-505.
11. World Health Organization (2010) Transaction prices for antiretroviral medicines and HIV diagnostics from 2008 to March 2010. Available: http://www.who.int/hiv/pub/amds/GPRMsummary-report-may2010.pdf. Accessed 2013 Feb 15.
12. Shah M, Johns B, Abimiku A, Walker DG (2011) Cost-effectiveness of new WHO recommendations for prevention of mother-to-child transmission of HIV in a resource-limited setting. AIDS 25: 1093-102.
13. Ciaranello AL, Perez F, Keatinge J, Park JE, Engelsmann B, et al. (2012) What will it take to eliminate pediatric HIV? Reaching WHO target rates of motherto-child HIV transmission in Zimbabwe: a model-based analysis. PLoS Med 9:e1001156.