Evaluation of antibacterial and remineralizing nanocomposite and adhesive in rat tooth cavity model

Acta Biomaterialia

Volumn 10, Issue 6, 2014, Pages 2804-2813

  Li, Fang ^a,b   Wang, Ping ^b   Weir, Michael D ^b   Fouad, Ashraf F ^b   Xu, Hockin H K ^b,c,d  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF MARYLAND DENTAL SCHOOL   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d Baltimore County   (United States)

Author keywords

Bonding agent; Calcium phosphate nanoparticles; Dental nanocomposite; Quaternary ammonium methacrylate; Rat tooth cavity

Indexed keywords

BIOCOMPATIBILITY; BIOFILMS; CALCIUM PHOSPHATE; NANOCOMPOSITES; RATS; RESTORATION; SYNTHESIS (CHEMICAL);

AMORPHOUS CALCIUM PHOSPHATE; ANTIBACTERIALS; BONDING AGENT; CALCIUM PHOSPHATE NANOPARTICLES; CAVITIES MODEL; DENTAL NANOCOMPOSITES; IN-VIVO; QUATERNARY AMMONIUM; QUATERNARY AMMONIUM METHACRYLATE; RAT TOOTH CAVITY;

NANOPARTICLES;

ADHESIVE AGENT; CALCIUM PHOSPHATE NANOPARTICLE; DIMETHYLAMINODODECYL METHACRYLATE; METHACRYLIC ACID; NANOCOMPOSITE; NANOPARTICLE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; TOOTH CEMENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BIOCOMPATIBILITY; CONTROLLED STUDY; INFLAMMATION; INFRARED SPECTROSCOPY; MALE; NONHUMAN; ODONTOBLAST; PRIORITY JOURNAL; RAT; SYNTHESIS; TOOTH CAVITY; TOOTH DEVELOPMENT; TOOTH DISEASE; TOOTH PULP; ANIMAL; BONE MINERALIZATION; DENTAL CARIES;

RATTUS;

ANIMALS; ANTI-BACTERIAL AGENTS; CALCIFICATION, PHYSIOLOGIC; DENTAL CARIES; DENTAL CEMENTS; NANOCOMPOSITES; RATS;

EID: 84899622915     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2014.02.033     Document Type: Article

References (64)

1. Watts DC, Marouf AS, Al-Hindi AM. Photo-polymerization shrinkage-stress kinetics in resin-composites: methods development. Dent Mater 2003;19: 1-11.
2. Drummond JL. Degradation, fatigue, and failure of resin dental composite materials. J Dent Res 2008;87:710-9.
3. Ferracane JL. Resin composite - state of the art. Dent Mater 2011;27:29-38.
4. Garcia-Godoy F, Kramer N, Feilzer AJ, Frankenberger R. Long-term degradation of enamel and dentin bonds: 6-year results in vitro vs. in vivo. Dent Mater 2010;26:1113-8.
5. Mjor IA, Moorhead JE, Dahl JE. Reasons for replacement of restorations in permanent teeth in general dental practice. Int Dent J 2000;50:361-6.
6. Sarrett DC. Clinical challenges and the relevance of materials testing for posterior composite restorations. Dent Mater 2005;21:9-20.
7. Sakaguchi RL. Review of the current status and challenges for dental posterior restorative composites: clinical, chemistry, and physical behavior considerations. Summary of discussion from the Portland Composites Symposium (POCOS) June 17-19, Oregon Health and Science University, Portland, Oregon. Dent Mater 2004;2005(21):3-6.
8. Deligeorgi V, Mjor IA, Wilson NH. An overview of reasons for the placement and replacement of restorations. Prim Dent Care 2001;8:5-11.
9. Frost PM. An audit on the placement and replacement of restorations in a general dental practice. Prim Dent Care 2002;9:31-6.
10. Loesche WJ. Role of Streptococcus mutans in human dental decay. Microbiol Rev 1986;50:353-80.
11. van Houte J. Role of micro-organisms in caries etiology. J Dent Res 1994;73: 672-81.
12. Featherstone JD. The science and practice of caries prevention. J AmDent Assoc 2000;131:887-99.
13. Featherstone JD. The continuum of dental caries - evidence for a dynamic disease process. J Dent Res 2004;83. Spec No C:C39-42.
14. Deng DM, ten Cate JM. Demineralization of dentin by Streptococcus mutans biofilms grown in the constant depth film fermentor. Caries Res 2004;38: 54-61.
15. Totiam P, Gonzalez-Cabezas C, Fontana MR, Zero DT. A new in vitro model to study the relationship of gap size and secondary caries. Caries Res 2007;41:467-73.
16. Sarasam AR, Brown P, Khajotia SS, Dmytryk JJ, Madihally SV. Antibacterial activity of chitosan-based matrices on oral pathogens. J Mater Sci Mater Med 2008;19:1083-90.
17. Imazato S. Bio-active restorative materials with antibacterial effects: new dimension of innovation in restorative dentistry. Dent Mater J 2009;28:11-9.
18. Li F, Chai ZG, Sun MN, Wang F, Ma S, Zhang L, et al. Anti-biofilm effect of dental adhesive with cationic monomer. J Dent Res 2009;88:372-6.
19. Xie D, Weng Y, Guo X, Zhao J, Gregory RL, Zheng C. Preparation and evaluation of a novel glass-ionomer cement with antibacterial functions. Dent Mater 2011;27:487-96.
20. Xu X, Wang Y, Liao S, Wen ZT, Fan Y. Synthesis and characterization of antibacterial dental monomers and composites. J Biomed Mater Res B Appl Biomater 2012;100:1151-62.
21. Weng Y, Howard L, Guo X, Chong VJ, Gregory RL, Xie D. A novel antibacterial resin composite for improved dental restoratives. J Mater Sci Mater Med 2012;23:1553-61.
22. Imazato S. Antibacterial properties of resin composites and dentin bonding systems. Dent Mater 2003;19:449-57.
23. Antonucci JM, Zeiger DN, Tang K, Lin-Gibson S, Fowler BO, Lin NJ. Synthesis and characterization of dimethacrylates containing quaternary ammonium functionalities for dental applications. Dent Mater 2012;28:219-28.
24. Cheng L, Weir MD, Zhang K, Arola DD, Zhou X, Xu HH. Dental primer and adhesive containing a new antibacterial quaternary ammonium monomer dimethylaminododecyl methacrylate. J Dent 2013.
25. Zhang K, Cheng L, Wu EJ, Weir MD, Bai Y, Xu HH. Effect of water-aging on dentin bond strength and anti-biofilm activity of bonding agent containing antibacterial monomer dimethylaminododecyl methacrylate. J Dent 2013. in review.
26. Imazato S, Ebi N, Tarumi H, Russell RR, Kaneko T, Ebisu S. Bactericidal activity and cytotoxicity of antibacterial monomer MDPB. Biomaterials 1999;20: 899-903.
27. Imazato S, Tarumi H, Ebi N, Ebisu S. Cytotoxic effects of composite restorations employing self-etching primers or experimental antibacterial primers. J Dent 2000;28:61-7.
28. Nishida M, Imazato S, Takahashi Y, Ebisu S, Ishimoto T, Nakano T, et al. The influence of the antibacterial monomer 12-methacryloyloxydodecylpy ridinium bromide on the proliferation, differentiation and mineralization of odontoblast-like cells. Biomaterials 2010;31:1518-32.
29. Li F, Weir MD, Fouad AF, Xu HH. Time-kill behaviour against eight bacterial species and cytotoxicity of antibacterial monomers. J Dent 2013;41: 881-91.
30. Cox CF, White KC, Ramus DL, Farmer JB, Snuggs HM. Reparative dentin: factors affecting its deposition. Quintessence Int 1992;23:257-70.
31. Tziafas D, Alvanou A, Papadimitriou S, Gasic J, Komnenou A. Effects of recombinant basic fibroblast growth factor, insulin-like growth factor-II and transforming growth factor-beta 1 on dog dental pulp cells in vivo. Arch Oral Biol 1998;43:431-44.
32. Smith AJ, Tobias RS, Plant CG, Browne RM, Lesot H, Ruch JV. In vivo morphogenetic activity of dentine matrix proteins. J Biol Buccale 1990;18: 123-9.
33. Six N, Lasfargues JJ, Goldberg M. In vivo study of the pulp reaction to Fuji IX, a glass ionomer cement. J Dent 2000;28:413-22.
34. Dammaschke T. Rat molar teeth as a study model for direct pulp capping research in dentistry. Lab Anim 2010;44:1-6.
35. Fachin EV, Scarparo RK, Pezzi AP, Luisi SB. Sant'ana Filho M. Effect of betamethasone on the pulp after topical application to the dentin of rat teeth: vascular aspects of the inflammation. J Appl Oral Sci 2009;17:335-9.
36. Dammaschke T, Stratmann U, Fischer RJ, Sagheri D, Schafer E. A histologic investigation of direct pulp capping in rodents with dentin adhesives and calcium hydroxide. Quintessence Int 2010;41:e62-71.
37. Dammaschke T, Stratmann U, Fischer RJ, Sagheri D, Schafer E. Proliferation of rat molar pulp cells after direct pulp capping with dentine adhesive and calcium hydroxide. Clin Oral Investig 2011;15:577-87.
38. Kawagishi E, Nakakura-Ohshima K, Nomura S, Ohshima H. Pulpal responses to cavity preparation in aged rat molars. Cell Tissue Res 2006;326:111-22.
39. Dickens SH, Flaim GM, Takagi S. Mechanical properties and biochemical activity of remineralizing resin-based Ca-PO4 cements. Dent Mater 2003;19: 558-66.
40. Langhorst SE, O'Donnell JN, Skrtic D. In vitro remineralization of enamel by polymeric amorphous calcium phosphate composite: quantitative microradiographic study. Dent Mater 2009;25:884-91.
41. Xu HH, Sun L, Weir MD, Antonucci JM, Takagi S, Chow LC, et al. Nano DCPAwhisker composites with high strength and Ca and PO(4) release. J Dent Res 2006;85:722-7.
42. Xu HH, Weir MD, Sun L, Moreau JL, Takagi S, Chow LC, et al. Strong nanocomposites with Ca, PO(4), and F release for caries inhibition. J Dent Res 2010;89:19-28.
43. Katoh Y, Suzuki M, Kato C, Shinkai K, Ogawa M, Yamauchi J. Observation of calcium phosphate powder mixed with an adhesive monomer experimentally developed for direct pulp capping and as a bonding agent. Dent Mater J 2010;29:15-24.
44. Xu HH, Moreau JL, Sun L, Chow LC. Nanocomposite containing amorphous calcium phosphate nanoparticles for caries inhibition. Dent Mater 2011;27: 762-9.
45. Weir MD, Chow LC, Xu HH. Remineralization of demineralized enamel via calcium phosphate nanocomposite. J Dent Res 2012;91:979-84.
46. Melo MA, Cheng L, Zhang K, Weir MD, Rodrigues LK, Xu HH. Novel dental adhesives containing nanoparticles of silver and amorphous calcium phosphate. Dent Mater 2013;29:199-210.
47. Orhan EO, Maden M, Senguuven B. Odontoblast-like cell numbers and reparative dentine thickness after direct pulp capping with platelet-rich plasma and enamel matrix derivative: a histomorphometric evaluation. Int Endod J 2012;45:317-25.
48. Koliniotou-Koumpia E, Tziafas D. Pulpal responses following direct pulp capping of healthy dog teeth with dentine adhesive systems. J Dent 2005;33: 639-47.
49. Dammaschke T, Stratmann U, Wolff P, Sagheri D, Schafer E. Direct pulp capping with mineral trioxide aggregate: an immunohistologic comparison with calcium hydroxide in rodents. J Endod 2010;36:814-9.
50. Aeinehchi M, Eslami B, Ghanbariha M, Saffar AS. Mineral trioxide aggregate (MTA) and calcium hydroxide as pulp-capping agents in human teeth: a preliminary report. Int Endod J 2003;36:225-31.
51. de Souza Costa CA. Teixeira HM, Lopes do Nascimento AB, Hebling J. Biocompatibility of resin-based dental materials applied as liners in deep cavities prepared in human teeth. J Biomed Mater Res B Appl Biomater 2007;81:175-84.
52. Costa CA, Ribeiro AP, Giro EM, Randall RC, Hebling J. Pulp response after application of two resin modified glass ionomer cements (RMGICs) in deep cavities of prepared human teeth. Dent Mater 2011;27:e158-70.
53. Zhou C, Weir MD, Zhang K, Deng D, Cheng L, Xu HH. Synthesis of new antibacterial quaternary ammonium monomer for incorporation into CaP nanocomposite. Dent Mater 2013;29:859-70.
54. Hanks CT, Wataha JC, Parsell RR, Strawn SE. Delineation of cytotoxic concentrations of two dentin bonding agents in vitro. J Endod 1992;18: 589-96.
55. Pashley DH, Carvalho RM. Dentine permeability and dentine adhesion. J Dent 1997;25:355-72.
56. Sauro S, Pashley DH, Montanari M, Chersoni S, Carvalho RM, Toledano M, et al. Effect of simulated pulpal pressure on dentin permeability and adhesion of self-etch adhesives. Dent Mater 2007;23:705-13.
57. Tay FR, Frankenberger R, Krejci I, Bouillaguet S, Pashley DH, Carvalho RM, et al. Single-bottle adhesives behave as permeable membranes after polymerization. I. In vivo evidence. J Dent 2004;32:611-21.
58. Floyd CJ, Dickens SH. Network structure of Bis-GMA- and UDMA-based resin systems. Dent Mater 2006;22:1143-9.
59. Cetinguc A, Olmez S, Vural N. HEMA diffusion from dentin bonding agents in young and old primary molars in vitro. Dent Mater 2007;23:302-7.
60. de Souza Costa CA, do Nascimento AB, Teixeira HM. Response of human pulps following acid conditioning and application of a bonding agent in deep cavities. Dent Mater 2002;18:543-51.
61. Li F, Weir MD, Xu HH. Effects of quaternary ammonium chain length on antibacterial bonding agents. J Dent Res 2013;92:932-8.
62. Dickens SH, Flaim GM, Schumacher GE, Eichmiller FC, Schafer DR, Rutherford RB. Preclinical effectiveness of a novel pulp capping material. J Endod 2010;36: 1222-5.
63. Ruhe PQ, Hedberg-Dirk EL, Padron NT, Spauwen PH, Jansen JA, Mikos AG. Porous poly(DL-lactic-co-glycolic acid)/calcium phosphate cement composite for reconstruction of bone defects. Tissue Eng 2006;12:789-800.
64. Lee SK, Lee SI, Park JH, Jang JH, Kim HW, Kim EC. Effect of calcium phosphate cements on growth and odontoblastic differentiation in human dental pulp cells. J Endod 2010;36:1537-42.