Distribution of pituitary adenylate cyclase-activating polypeptide (PACAP) in the human testis and in testicular germ cell tumors

Andrologia

Volumn 46, Issue 5, 2014, Pages 465-471

  Nakamura, K ^a,b   Nakamachi, T ^a,c   Endo, K ^a   Ito, K ^a   Machida, T ^b   Oka, T ^b   Hori, M ^a   Ishizaka, K ^d   Shioda, S ^a  

^a SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Mutual Aid Association of Public School Teachers   (Japan)

^c SHOWA UNIVERSITY   (Japan)

^d TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Embryonal carcinoma; Immunostaining; PACAP; Seminoma; Testis

Indexed keywords

ALPHA FETOPROTEIN; CHORIONIC GONADOTROPIN BETA SUBUNIT; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; LACTATE DEHYDROGENASE; RNA; MESSENGER RNA; PRIMER DNA;

ADULT; ARTICLE; CARCINOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; EMBRYONAL CARCINOMA STEM CELL; GERM CELL TUMOR; HUMAN; HUMAN TISSUE; IMMUNOHISTOLOGY; IMMUNOREACTIVITY; MALE; MIDDLE AGED; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEMINOMA; SPERMATID; SPERMATOGENESIS; SPERMATOGONIUM; TESTIS; TISSUE DISTRIBUTION; GENETICS; METABOLISM; NEOPLASM; NUCLEOTIDE SEQUENCE; TESTIS TUMOR;

ADULT; BASE SEQUENCE; DNA PRIMERS; HUMANS; MALE; MIDDLE AGED; NEOPLASMS, GERM CELL AND EMBRYONAL; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TESTICULAR NEOPLASMS; TESTIS;

EID: 84899581605     PISSN: 03034569     EISSN: 14390272     Source Type: Journal    
DOI: 10.1111/and.12102     Document Type: Article

References (22)

1. Arimura A, Shioda S (1995) Pituitary adenylate cyclase activating polypeptide (PACAP) and its receptors: neuroendocrine and endocrine interaction. Front Neuroendocrinol 16:53-88.
2. Arimura A, Somogyvari-Vigh A, Miyata A, Mizuno K, Coy DH, Kitada C (1991) Tissue distribution of PACAP as determined by RIA: highly abundant in the rat brain and testes. Endocrinology 129:2787-2789.
3. Boujelbene N, Cosinschi A, Khanfir K, Bhagwati S, Herrmann E, Mirimanoff RO, Ozsahin M, Zouhair A (2011) Pure seminoma: a review and update. Radiat Oncol 6:90.
4. Brubel R, Kiss P, Vincze A, Varga A, Varnagy A, Bodis J, Mark L, Jambor E, Maasz G, Hashimoto H, Helyes Z, Toth G, Tamas A, Koppan M, Reglodi D (2012) Effects of pituitary adenylate cyclase activating polypeptide on human sperm motility. J Mol Neurosci : MN 48:623-630.
5. Eble JNSG, Epstein JI, Sesterhenn IA (eds). (2004) World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. IARC Press, Lyon, France.
6. Group IGCCC (1997) International germ cell consensus classification: a prognostic factor-based staging system for metastatic germ cell cancers. J Clin Oncol 15:594-603.
7. Harmar AJ, Arimura A, Gozes I, Journot L, Laburthe M, Pisegna JR, Rawlings SR, Robberecht P, Said SI, Sreedharan SP, Wank SA, Waschek JA (1998) International union of pharmacology. XVIII. Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide. Pharmacol Rev 50:265-270.
8. Jones TD, Ulbright TM, Eble JN, Baldridge LA, Cheng L (2004) OCT4 staining in testicular tumors: a sensitive and specific marker for seminoma and embryonal carcinoma. Am J Surg Pathol 28:935-940.
9. de Jong J, Stoop H, Gillis AJ, Van Gurp RJ, Van de Geijn GJ, Boer M, Hersmus R, Saunders PT, Anderson RA, Oosterhuis JW, Looijenga LH (2008) Differential expression of SOX17 and SOX2 in germ cells and stem cells has biological and clinical implications. J Pathol 215:21-30.
10. Li M, Arimura A (2003) Neuropeptides of the pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide/growth hormone-releasing hormone/secretin family in testis. Endocrine 20:201-214.
11. Li M, Funahashi H, Mbikay M, Shioda S, Arimura A (2004) Pituitary adenylate cyclase activating polypeptide-mediated intracrine signaling in the testicular germ cells. Endocrine 23:59-75.
12. Miyata A, Arimura A, Dahl RR, Minamino N, Uehara A, Jiang L, Culler MD, Coy DH (1989) Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells. Biochem Biophys Res Commun 164:567-574.
13. Moretti C, Mammi C, Frajese GV, Mariani S, Gnessi L, Arizzi M, Wannenes F, Frajese G (2006) PACAP and type I PACAP receptors in human prostate cancer tissue. Ann N Y Acad Sci 1070:440-449.
14. Nakamachi T, Ohtaki H, Yofu S, Dohi K, Watanabe J, Hayashi D, Matsuno R, Nonaka N, Itabashi K, Shioda S (2008) Pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1R) co-localizes with activity-dependent neuroprotective protein (ADNP) in the mouse brains. Regul Pept 145:88-95.
15. Nakamachi T, Farkas J, Watanabe J, Ohtaki H, Dohi K, Arata S, Shioda S (2011) Role of PACAP in neural stem/progenitor cell and astrocyte-from neural development to neural repair. Curr Pharm Des 17:973-984.
16. Nakamachi T, Tsuchida M, Kagami N, Yofu S, Wada Y, Hori M, Tsuchikawa D, Yoshikawa A, Imai N, Nakamura K, Arata S, Shioda S (2012) IL-6 and PACAP Receptor Expression and Localization after Global Brain Ischemia in Mice. J Mol Neurosci 48:518-525.
17. Reubi JC, Laderach U, Waser B, Gebbers JO, Robberecht P, Laissue JA (2000) Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor subtypes in human tumors and their tissues of origin. Cancer Res 60:3105-3112.
18. Shioda S, Legradi G, Leung WC, Nakajo S, Nakaya K, Arimura A (1994) Localization of pituitary adenylate cyclase-activating polypeptide and its messenger ribonucleic acid in the rat testis by light and electron microscopic immunocytochemistry and in situ hybridization. Endocrinology 135:818-825.
19. Shioda S, Ohtaki H, Nakamachi T, Dohi K, Watanabe J, Nakajo S, Arata S, Kitamura S, Okuda H, Takenoya F, Kitamura Y (2006) Pleiotropic functions of PACAP in the CNS: neuroprotection and neurodevelopment. Ann N Y Acad Sci 1070:550-560.
20. Tanii I, Aradate T, Matsuda K, Komiya A, Fuse H (2011) PACAP-mediated sperm-cumulus cell interaction promotes fertilization. Reproduction 141:163-171.
21. Vaudry D, Falluel-Morel A, Bourgault S, Basille M, Burel D, Wurtz O, Fournier A, Chow BK, Hashimoto H, Galas L, Vaudry H (2009) Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery. Pharmacol Rev 61:283-357.
22. Young RH (2008) Testicular tumors-some new and a few perennial problems. Arch Pathol Lab Med 132:548-564.