Stimulation of the α7 nicotinic acetylcholine receptor protects against sepsis by inhibiting toll-like receptor via phosphoinositide 3-kinase activation

Journal of Infectious Diseases

Volumn 209, Issue 10, 2014, Pages 1668-1677

  Kim, Tae Hoon ^a   Kim, So Jin ^a   Lee, Sun Mee ^a  

^a Sungkyunkwan University   (South Korea)

Author keywords

nicotine; PI3K; PU.1.; sepsis; TLR; 7nAChR

Indexed keywords

BUNGAROTOXIN RECEPTOR; MESSENGER RNA; METHYLLYCACONITINE; NICOTINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; TOLL LIKE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHOLINERGIC SYSTEM; DNA BINDING; DRUG POTENCY; ENDOTOXEMIA; ENZYME ACTIVATION; IMMUNOMODULATION; MALE; MORTALITY; MOUSE; NONHUMAN; PHARMACOLOGICAL STIMULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPSIS; TISSUE INJURY; TLR4 GENE; TREATMENT OUTCOME;

NICOTINE; PI3K; PU.1; SEPSIS; TLR; Α7NACHR;

ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; ANIMALS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; NICOTINE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER; SEPSIS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TRANS-ACTIVATORS;

EID: 84899575657     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jit669     Document Type: Article

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