Selection and characterisation of Staphylococcus aureus mutants with reduced susceptibility to the investigational oxazolidinone MRX-I

International Journal of Antimicrobial Agents

Volumn 43, Issue 5, 2014, Pages 418-422

  Huang, Yanqin ^a   Xu, Yunhua ^b   Liu, Shicong ^b   Wang, Hailin ^b   Xu, Xiaogang ^a   Guo, Qinglan ^a   Wu, Baixue ^b   Gordeev, Mikhail F ^c   Wang, Wen ^c   Yuan, Zhengyu ^b,c   Wang, Minggui ^a  

^a FUDAN UNIVERSITY   (China)

^b MicuRx (Shanghai) Pharmaceuticals Inc   (China)

^c MicuRx Pharmaceuticals Inc   (United States)

Author keywords

23S rRNA; MRX I; Oxazolidinone resistance; Protein L3; Staphylococcus aureus

Indexed keywords

LINEZOLID; MRX I; OXAZOLIDINONE DERIVATIVE; RIBOSOMAL PROTEIN L22; RIBOSOMAL PROTEIN L4; RIBOSOME PROTEIN; RIBOSOME PROTEIN L3; RNA 23S; UNCLASSIFIED DRUG; 5-((ISOXAZOL-3-YLAMINO)METHYL)-3-(2,3,5-TRIFLUORO-4-(4-OXO-3,4-DIHYDROPYRIDIN-1(2H)-YL)PHENYL)OXAZOLIDIN-2-ONE; ANTIINFECTIVE AGENT; PYRIDONE DERIVATIVE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; BACTERIAL STRAIN; BACTERIUM EXAMINATION; BACTERIUM ISOLATE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG STRUCTURE; GENE CLUSTER; IN VITRO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MUTANT PREVENTION CONCENTRATION; MUTANT SELECTION WINDOW; NONHUMAN; PRIORITY JOURNAL; RNA SEQUENCE; STAPHYLOCOCCUS AUREUS; DRUG EFFECTS; GENETIC SELECTION; GENETICS; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; MUTATION; MUTATION RATE; VIRUS CULTURE;

ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, BACTERIAL; MICROBIAL SENSITIVITY TESTS; MUTATION; MUTATION RATE; OXAZOLIDINONES; PYRIDONES; RIBOSOMAL PROTEINS; RNA, RIBOSOMAL, 23S; SELECTION, GENETIC; SERIAL PASSAGE; STAPHYLOCOCCUS AUREUS;

EID: 84899573892     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2014.02.008     Document Type: Conference Paper

References (19)

1. H. Aoki, L.Z. Ke, S.M. Poppe, T.J. Poel, E.A. Weaver, and R.C. Gadwood et al. Oxazolidinone antibiotics target the P site on Escherichia coli ribosomes Antimicrob Agents Chemother 46 2002 1080 1085 (Pubitemid 34260354)
2. G.E. Zurenko, B.H. Yagi, R.D. Schaadt, J.W. Allison, J.O. Kilburn, and S.E. Glickman et al. In vitro activities of U-100592 and U-100766, novel oxazolidinone antibacterial agents Antimicrob Agents Chemother 40 1996 839 845 (Pubitemid 26117523)
3. K.R. Lawrence, M. Adra, and P.K. Gillman Serotonin toxicity associated with the use of linezolid: a review of postmarketing data Clin Infect Dis 42 2006 1578 1583
4. A. Endimiani, M. Blackford, E.C. Dasenbrook, M.D. Reed, S. Bajaksouszian, and A.M. Hujer et al. Emergence of linezolid-resistant Staphylococcus aureus after prolonged treatment of cystic fibrosis patients in Cleveland, Ohio Antimicrob Agents Chemother 55 2011 1684 1692
5. C.M. Santoro, K. Bush, and D. Abbanat Characterisation of Staphylococcus aureus and Enterococcus faecalis mutants with reduced susceptibility to the investigational oxazolidinone RWJ-416457 Int J Antimicrob Agents 36 2010 424 429
6. J.B. Locke, M. Hilgers, and K.J. Shaw Novel ribosomal mutations in Staphylococcus aureus strains identified through selection with the oxazolidinones linezolid and torezolid (TR-700) Antimicrob Agents Chemother 53 2009 5265 5274
7. R.K. Flamm, R.E. Mendes, J.E. Ross, H.S. Sader, and R.N. Jonesa Linezolid surveillance results for the United States: LEADER surveillance program 2011 Antimicrob Agents Chemother 57 2013 1077 1081
8. D.M. Zhu, W. Wang, Y.Q. Huang, and Y.Y. Zhang Antibacterial spectrum of oxazolidinone MRX-I: potent activity against multidrug-resistant Gram-positive pathogens 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 9-12 September San Francisco, CA 2012 American Society for Microbiology Washington, DC [abstract F-1497]
9. C.R. Li, G.Q. Li, X.X. Hu, W.X. Zhang, X.K. Wang, and J. Pang et al. Novel oxazolidinone MRX-I is efficacious in mouse models of Gram-positive bacterial infections 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 9-12 September San Francisco, CA 2012 American Society for Microbiology Washington, DC [abstract F-1499]
10. J. Zhang, X.J. Wu, J. Huang, J.C. Yu, B.N. Guo, and G.Y. Cao et al. Hematological effect and pharmacokinetics of multiple oral MRX-I dosing in healthy subjects 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 9-12 September San Francisco, CA 2012 American Society for Microbiology Washington, DC [abstract F-1504]
11. W. Wang, Z. Wang, Y. Chang, H. Yuan, Z.Y. Yuan, and J.L. Zhou et al. In vitro safety of MRX-I, a safer oxazolidinone antibacterial agent 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 9-12 September San Francisco, CA 2012 American Society for Microbiology Washington, DC [abstract F-1501]
12. Clinical and Laboratory Standards Institute Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard Document M07-A8 8th ed. 2009 CLSI Wayne, PA
13. Clinical and Laboratory Standards Institute Performance standards for antimicrobial susceptibility testing: twenty-first informational supplement Document M100-S21 2011 CLSI Wayne, PA
14. G.P. Allen, and L.M. Deshpande Determination of the mutant selection window for clindamycin, doxycycline, linezolid, moxifloxacin and trimethoprim/sulfamethoxazole against community-associated meticillin-resistant Staphylococcus aureus (MRSA) Int J Antimicrob Agents 35 2010 45 49
15. M.H. Wilcox Update on linezolid: the first oxazolidinone antibiotic Expert Opin Pharmacother 6 2005 26 2315
16. R.E. Mendes, L.M. Deshpande, D.J. Farrell, T. Spanu, G. Fadda, and R.N. Jones Assessment of linezolid resistance mechanisms among Staphylococcus epidermidis causing bacteraemia in Rome, Italy J Antimicrob Chemother 65 2010 2329 2335
17. A. Wong, S.P. Reddy, D.S. Smyth, M.E. Aguero-Rosenfeld, G. Sakoulas, and D.A. Robinson Polyphyletic emergence of linezolid-resistant staphylococci in the United States Antimicrob Agents Chemother 54 2010 742 748
18. K.S. Long, and B. Vester Resistance to linezolid caused by modifications at its binding site on the ribosome Antimicrob Agents Chemother 56 2012 603 612
19. K.S. Long, C. Munck, T.M. Andersen, M.A. Schaub, S.N. Hobbie, and E.C. Böttger et al. Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance Antimicrob Agents Chemother 54 2010 4705 4713