Importance of biofilm formation and dipeptidyl peptidase IV for the pathogenicity of clinical Porphyromonas gingivalis isolates

Pathogens and Disease

Volumn 70, Issue 3, 2014, Pages 408-413

  Clais, Sofie ^a   Boulet, Gaëlle ^a   Kerstens, Monique ^a   Horemans, Tessa ^a   Teughels, Wim ^b   Quirynen, Marc ^b   Lanckacker, Ellen ^a   de Meester, Ingrid ^a   Lambeir, Anne Marie ^a   Delputte, Peter ^a   Maes, Louis ^a   Cos, Paul ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b CATHOLIC UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Biofilm; Dipeptidyl peptidase IV; In vitro; In vivo; Porphyromonas gingivalis; Virulence

Indexed keywords

DIPEPTIDYL PEPTIDASE IV;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GROWTH; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; BIOFILM; ENZYME ACTIVITY; NONHUMAN; PATHOGENICITY; PLANKTON; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; SESSILE SPECIES; SKIN ABSCESS; ABSCESS; ANIMAL; BIOSYNTHESIS; DISEASE MODEL; ENZYME ACTIVATION; FEMALE; GROWTH, DEVELOPMENT AND AGING; HUMAN; MICROBIOLOGY; MOUSE; PERIODONTITIS; PHYSIOLOGY; VIRULENCE;

ABSCESS; ANIMALS; BIOFILMS; DIPEPTIDYL PEPTIDASE 4; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; FEMALE; HUMANS; MICE; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; VIRULENCE;

EID: 84899573335     PISSN: None     EISSN: 2049632X     Source Type: Journal    
DOI: 10.1111/2049-632X.12156     Document Type: Article

References (23)

1. Banbula A, Bugno M, Goldstein J, Yen J, Nelson D, Travis J & Potempa J (2000) Emerging family of proline-specific peptidases of Porphyromonas gingivalis: purification and characterization of serine dipeptidyl peptidase, a structural and functional homologue of mammalian prolyl dipeptidyl peptidase IV. Infect Immun 68: 1176-1182.
2. Biyikoglu B, Ricker A & Diaz PI (2012) Strain-specific colonization patterns and serum modulation of multi-species oral biofilm development. Anaerobe 18: 459-470.
3. Cos P, Tote K, Horemans T & Maes L (2010) Biofilms: an extra hurdle for effective antimicrobial therapy. Curr Pharm Des 16: 2279-2295.
4. Cugini C, Klepac-Ceraj V, Rackaityte E, Riggs JE & Davey ME (2013) Porphyromonas gingivalis: keeping the pathos out of the biont. J Oral Microbiol 5: DOI: 10.3402/jom.v5i0.19804.
5. Dashper S, Ang CS, Liu SW, Paolini R, Veith P & Reynolds E (2010) Inhibition of Porphyromonas gingivalis biofilm by oxantel. Antimicrob Agents Chemother 54: 1311-1314.
6. Davey ME (2006) Techniques for the growth of Porphyromonas gingivalis biofilms. Periodontol 2000 42: 27-35.
7. Dierickx K, Pauwels M, Laine ML, Van Eldere J, Cassiman JJ, van Winkelhoff AJ, van Steenberghe D & Quirynen M (2003) Adhesion of Porphyromonas gingivalis serotypes to pocket epithelium. J Periodontol 74: 844-848.
8. Durinx C, Lambeir AM, Bosmans E, Falmagne JB, Berghmans R, Haemers A, Scharpe S & De Meester I (2000) Molecular characterization of dipeptidyl peptidase activity in serum: soluble CD26/dipeptidyl peptidase IV is responsible for the release of X-Pro dipeptides. Eur J Biochem 267: 5608-5613.
9. Escaich S (2008) Antivirulence as a new antibacterial approach for chemotherapy. Curr Opin Chem Biol 12: 400-408.
10. Grenier D, Roy S, Chandad F, Plamondon P, Yoshioka M, Nakayama K & Mayrand D (2003) Effect of inactivation of the Arg- and/or Lys-gingipain gene on selected virulence and physiological properties of Porphyromonas gingivalis. Infect Immun 71: 4742-4748.
11. Hayashi C, Gudino CV, Gibson FC 3rd & Genco CA (2010) Review: pathogen-induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell-specific innate immune inflammatory pathways. Mol Oral Microbiol 25: 305-316.
12. Holt SC, Kesavalu L, Walker S & Genco CA (1999) Virulence factors of Porphyromonas gingivalis. Periodontol 2000 20: 168-238.
13. Kumagai Y, Konishi K, Gomi T, Yagishita H, Yajima A & Yoshikawa M (2000) Enzymatic properties of dipeptidyl aminopeptidase IV produced by the periodontal pathogen Porphyromonas gingivalis and its participation in virulence. Infect Immun 68: 716-724.
14. Kumagai Y, Yagishita H, Yajima A, Okamoto T & Konishi K (2005) Molecular mechanism for connective tissue destruction by dipeptidyl aminopeptidase IV produced by the periodontal pathogen Porphyromonas gingivalis. Infect Immun 73: 2655-2664.
15. Laine ML, Appelmelk BJ & van Winkelhoff AJ (1996) Novel polysaccharide capsular serotypes in Porphyromonas gingivalis. J Periodontal Res 31: 278-284.
16. Lo AW, Seers CA, Boyce JD, Dashper SG, Slakeski N, Lissel JP & Reynolds EC (2009) Comparative transcriptomic analysis of Porphyromonas gingivalis biofilm and planktonic cells. BMC Microbiol 9: 18.
17. Matheeussen V, Lambeir AM, Jungraithmayr W, Gomez N, Mc Entee K, Van der Veken P, Scharpe S & De Meester I (2012) Method comparison of dipeptidyl peptidase IV activity assays and their application in biological samples containing reversible inhibitors. Clin Chim Acta 413: 456-462.
18. Rasko DA & Sperandio V (2010) Anti-virulence strategies to combat bacteria-mediated disease. Nat Rev Drug Discov 9: 117-128.
19. Rea D, Lambeir AM, Kumagai Y, De Meester I, Scharpe S & Fulop V (2004) Expression, purification and preliminary crystallographic analysis of dipeptidyl peptidase IV from Porphyromonas gingivalis. Acta Crystallogr Sect D: Biol Crystallogr 60: 1871-1873.
20. Tokuda M, Duncan M, Cho MI & Kuramitsu HK (1996) Role of Porphyromonas gingivalis protease activity in colonization of oral surfaces. Infect Immun 64: 4067-4073.
21. Tote K, Horemans T, Vanden Berghe D, Maes L & Cos P (2010) Inhibitory effect of biocides on the viable masses and matrices of Staphylococcus aureus and Pseudomonas aeruginosa biofilms. Appl Environ Microbiol 76: 3135-3142.
22. van Winkelhoff AJ, Appelmelk BJ, Kippuw N & de Graaff J (1993) K-antigens in Porphyromonas gingivalis are associated with virulence. Oral Microbiol Immunol 8: 259-265.
23. Yagishita H, Kumagai Y, Konishi K, Takahashi Y, Aoba T & Yoshikawa M (2001) Histopathological studies on virulence of dipeptidyl aminopeptidase IV (DPPIV) of Porphyromonas gingivalis in a mouse abscess model: use of a DPPIV-deficient mutant. Infect Immun 69: 7159-7161.