Intradermal spitz nevi: A rare subtype of spitz nevi analyzed in a clinicopathologic study of 74 cases

American Journal of Dermatopathology

Volumn 36, Issue 4, 2014, Pages 283-297

  Plaza, Jose A ^a   De Stefano, Danielle ^a   Suster, Saul ^a   Prieto, Victor G ^b   Kacerovska, Denisa ^c   Michal, Michal ^c   Sangueza, Martin ^d   Kazakov, Dmitry V ^c  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c CHARLES UNIVERSITY   (Czech Republic)

^d Hospital Obrero   (Bolivia)

Author keywords

Angiomatoid spitz nevus; Desmoplastic spitz nevus; Epithelioid spitz; Intradermal spitz nevus; Pigmented spitz nevus; Spitz; Spitz nevi

Indexed keywords

ADOLESCENT; ADULT; AGED; ARM; ARTICLE; BACK; BUTTOCK; CELL MATURATION; CELL TYPE; CHILD; CHRONIC INFLAMMATION; CLINICAL FEATURE; DIFFERENTIAL DIAGNOSIS; EPITHELIOID CELL; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTRADERMAL SPITZ NEVI; JUVENILE MELANOMA; LEG; MAJOR CLINICAL STUDY; MALE; MITOSIS; NECK; PIGMENTATION; PRIORITY JOURNAL; RARE DISEASE; SPINDLE CELL; THORAX; CASE REPORT; HEAD; MIDDLE AGED; NEVUS, EPITHELIOID AND SPINDLE CELL; PATHOLOGY; PRESCHOOL CHILD; RETROSPECTIVE STUDY; SKIN NEOPLASMS; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BACK; CHILD; CHILD, PRESCHOOL; DIAGNOSIS, DIFFERENTIAL; FEMALE; HEAD; HUMANS; LOWER EXTREMITY; MALE; MIDDLE AGED; NECK; NEVUS, EPITHELIOID AND SPINDLE CELL; RETROSPECTIVE STUDIES; SKIN NEOPLASMS; UPPER EXTREMITY; YOUNG ADULT;

EID: 84899535328     PISSN: 01931091     EISSN: 15330311     Source Type: Journal    
DOI: 10.1097/DAD.0b013e3182a64bb9     Document Type: Article

References (29)

1. Spitz S. Melanoma of childhood. Am J Pathol. 1948;24:591-609.
2. Barnhill RL, Argenyi ZB, From L, et al. Atypical Spitz nevi/tumors: lack of consensus for diagnosis, discrimination from melanoma, and prediction of outcome. Hum Pathol. 1999;30:513-520.
3. Requena C, Rubio L, Traves V, et al. Fluorescence in situ hybridization for the differential diagnosis between Spitz naevus and spitzoid melanoma. Histopathology. 2012;61:899-909.
4. Gerami P, Jewell SS, Morrison LE, et al. Fluorescence in situ hybridization (FISH) as an ancillary diagnostic tool in the diagnosis of melanoma. Am J Surg Pathol. 2009;33:1146-1156.
5. Busam KJ, Barnhill RL. Pagetoid Spitz nevus. Intraepidermal Spitz tumor with prominent pagetoid spread. Am J Surg Pathol. 1995;19:1061-1067.
6. Reed RJ, Ichinose H, Clark WH Jr, et al. Common and uncommon melanocytic nevi and borderline melanomas. Semin Oncol. 1975;2:119-147.
7. Requena L, Sanchez Yus E. Pigmented spindle cell naevus. Br J Dermatol. 1990;123:757-763.
8. Requena C, Requena L, Kutzner H, et al. Spitz nevus: a clinicopathological study of 349 cases. Am J Dermatopathol. 2009;31:107-116.
9. Barr RJ, Morales RV, Graham JH. Desmoplastic nevus: a distinct histologic variant of mixed spindle cell and epithelioid cell nevus. Cancer. 1980;46:557-564.
10. Tetzlaff MT, Xu X, Elder DE, et al. Angiomatoid Spitz nevus: a clinicopathological study of six cases and a review of the literature. J Cutan Pathol. 2009;36:471-476.
11. Harvell JD, Meehan SA, LeBoit PE. Spitz's nevi with halo reaction: a histopathologic study of 17 cases. J Cutan Pathol. 1997;24:611-619.
12. Cesinaro AM, Foroni M, Sighinolfi P, et al. Spitz nevus is relatively frequent in adults: a clinico-pathologic study of 247 cases related to patient's age. Am J Dermatopathol. 2005;27:469-475.
13. Echevarria R, Ackerman LV. Spindle and epitheloid cell nevi in the adult. Clinicopathologic report of 26 cases. Cancer. 1967;20:175-189.
14. Kamino H, Misheloff E, Ackerman AB, et al. Eosinophilic globules in Spitz's nevi: new findings and a diagnostic sign. Am J Dermatopathol. 1979;1:323-324.
15. LeBoit PE. Kamino bodies: what they may mean. Am J Dermatopathol. 2001;23:374-377.
16. Cockerell CJ, Sonnier G, Kelly L, et al. Comparative analysis of neovascularization in primary cutaneous melanoma and Spitz nevus. Am J Dermatopathol. 1994;16:9-13.
17. Fabrizi G, Massi G. Polypoid Spitz naevus: the benign counterpart of polypoid malignant melanoma. Br J Dermatol. 2000;142:128-132.
18. Requena C, Requena L, Sanchez-Yus E, et al. Pigmented epithelioid Spitz naevus: report of two cases. Histopathology. 2006;49:549-551.
19. Choi JH, Sung KJ, Koh JK. Pigmented epithelioid cell nevus: a variant of Spitz nevus?. J Am Acad Dermatol. 1993;28:497-498.
20. Weedon D, Little JH. Spindle and epithelioid cell nevi in children and adults. A review of 211 cases of the Spitz nevus. Cancer. 1977;40:217-225.
21. Paniago-Pereira C, Maize JC, Ackerman AB. Nevus of large spindle and/or epithelioid cells (Spitz's nevus). Arch Dermatol. 1978;114:1811-1823.
22. Suster S. Hyalinizing spindle and epithelioid cell nevus. A study of five cases of a distinctive histologic variant of Spitz's nevus. Am J Dermatopathol. 1994;16:593-598.
23. Liu J, Cohen PR, Farhood A. Hyalinizing Spitz nevus: spindle and epithelioid cell nevus with paucicellular collagenous stroma. South Med J. 2004;97:102-106.
24. Pennacchia I, Gasbarra R, Manente L, et al. Polypoid Spitz nevus: two cases evaluated with genetic technique, prolonged follow up, and sentinel lymph node biopsy. J Cutan Pathol. 2011;38:747-752.
25. Sherrill AM, Crespo G, Prakash AV, et al. Desmoplastic nevus: an entity distinct from spitz nevus and blue nevus. Am J Dermatopathol. 2011;33: 35-39.
26. Akiyama M, Inamoto N, Kuramochi S, et al. Spitz naevus with a predominant epithelioid cell component and halo reaction. Histopathology. 1997;31:292-293.
27. Yasaka N, Furue M, Tamaki K. Histopathological evaluation of halo phenomenon in Spitz nevus. Am J Dermatopathol. 1995;17:484-486.
28. Diaz-Cascajo C, Borghi S, Weyers W. Angiomatoid Spitz nevus: a distinct variant of desmoplastic Spitz nevus with prominent vasculature. Am J Dermatopathol. 2000;22:135-139.
29. Fabrizi G, Massi G. Angiomatoid Spitz naevus: a close simulator of regressing malignant melanoma. Br J Dermatol. 2001;145:845-846.