The effect of shear and extensional viscosity on atomization in medical inhaler

International Journal of Pharmaceutics

Volumn 468, Issue 1-2, 2014, Pages 199-206

  Broniarz Press, L ^a   Ochowiak, M ^a   Matuszak, M ^a   Wlodarczak S ^a  

^a POZNAN UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

Atomization; Drop size histogram; Extensional viscosity; Inhaler; Sauter mean diameter; Shear viscosity

Indexed keywords

GLYCEROL; MACROGOL; WATER; AEROSOL; MACROGOL DERIVATIVE;

AQUEOUS SOLUTION; ARTICLE; FLOW KINETICS; INHALATIONAL DRUG ADMINISTRATION; INHALER; MICROPHOTOGRAPHY; NEBULIZATION; PARTICLE SIZE; PRIORITY JOURNAL; VISCOMETRY; VISCOSITY; AEROSOL; CHEMICAL MODEL; CHEMISTRY; COMPARATIVE STUDY; EQUIPMENT DESIGN; MECHANICAL STRESS; MEDICINAL CHEMISTRY; MICROSCOPY; NEBULIZER; PHARMACEUTICS; PROCEDURES;

ADMINISTRATION, INHALATION; AEROSOLS; CHEMISTRY, PHARMACEUTICAL; EQUIPMENT DESIGN; GLYCEROL; MICROSCOPY; MODELS, CHEMICAL; NEBULIZERS AND VAPORIZERS; PARTICLE SIZE; POLYETHYLENE GLYCOLS; RHEOLOGY; STRESS, MECHANICAL; TECHNOLOGY, PHARMACEUTICAL; VISCOSITY; WATER;

EID: 84899534865     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.04.032     Document Type: Article

References (36)

1. B.J. Azzopardi Measurements of drop sizes International Journal of Heat and Mass Transfer 22 1979 1245 1279
2. K. Bechtold-Peters, and H. Luessen Pulmonary Drug Delivery 2007 Editio Cantor Verlag Aulendorf
3. H. Bisgaard, C. O'Callaghan, and G.C. Smaldone Drug Delivery to the Lung 2002 Marcel Dekker Inc. New York
4. L. Broniarz-Press, M. Ochowiak, M. Markuszewska, and S. Wlodarczak The effect of polyethylene oxide addition on the drop size histograms for Medel Family inhaler Chemical Engineering and Equipment 52 2013 157 158 (in Polish)
5. L. Broniarz-Press, M. Ochowiak, M. Markuszewska, and S. Wlodarczak The effect of viscosity on the atomization process in medical inhaler Chemical Engineering and Equipment 4 2013 291 292 (in Polish)
6. B.A.S. Brown Dispelling the myths of MDIs Drug Delivery Technology 2 2002 1 7
7. T.E. Corcoran, R. Hitron, W. Humphrey, and N. Chigier Optical measurement of nebulizer sprays: a quantitative comparison of diffraction, phase Doppler interferometry, and time of flight techniques Journal of Aerosol Science 31 2000 35 50
8. S.G. Devadason Recent advances in aerosol therapy for children with asthma Journal of Aerosol Medicine 19 2006 61 66
9. P. Dontula, M. Pasquali, L.E. Scriven, and C.W. Macosko Can extensional viscosity be measured with opposed-nozzle devices? Rheologica Acta 36 1997 429 448
10. L. Gradon, and J.C.M. Marijnissen Optimization of Aerosol Drug Delivery 2003 Kluwer Academic Publisher Dordrecht
11. L. Gradon, and A. Podgorski Production of nanostructured particles for medical applications Inżynieria Chemiczna i Procesowa 25 2004 1915 1923 (in Polish)
12. G.M. Harrison, R.P. Mun, G. Cooper, and D.V. Boger A note on the effect of polymer rigidity and concentration on spray atomization Journal of Non-Newtonian Fluid Mechanics 85 1999 93 104 (Pubitemid 29496982)
13. D. Hasson, and J. Mizrahi The drop size of fan spray nozzles Transactions of the Institution of Chemical Engineers 39 1961 415 422
14. W.C. Hinds, J.M. Macher, and M.W. First Size distribution of aerosols produced by the Laskin aerosol generator using substitute materials for DOP American Industrial Hygiene Association 44 1983 495 500 (Pubitemid 13033330)
15. R.J. Lang Ultrasonic atomization of liquids Journal of the Acoustical Society of America 34 1962 6 8
16. A.H. Lefebvre Atomization and Sprays 1989 Hemisphere Publishing Corporation New York
17. M. Markuszewska The Effect of Liquid Viscosity on the Atomization Process in the Pneumatic Inhaler. MSc. Thesis 2012 Poznan University of Technology Poznan (in Polish)
18. O.N.M. McCallion, and M.J. Patel Viscosity effects on nebulisation of aqueous solutions International Journal of Pharmaceutics 130 1996 245 249 (Pubitemid 26129803)
19. O.N.M. McCallion, K.M.G. Taylor, P.A. Bridges, M. Thomas, and A.J. Taylor Jet nebulisers for pulmonary drug delivery International Journal of Pharmaceutics 130 1996 1 11 (Pubitemid 26129782)
20. O.N.M. McCallion, K.M.G. Taylor, M. Thomas, and A.J. Taylor Nebulization of fluids of different physicochemical properties with air-jet and ultrasonic nebulizers Pharmaceutical Research 12 1995 1682 1688 (Pubitemid 26004694)
21. O.N.M. McCallion, K.M.G. Taylor, M. Thomas, and A.J. Taylor The influence of surface tension on aerosols produced by medical nebulisers International Journal of Pharmaceutics 129 1996 123 136 (Pubitemid 26097980)
22. T.T. Mercer Production of therapeutic aerosols Chest 80 1981 813 817
23. A. Moskal, and T.R. Sosnowski Dynamics of aerosol pulse in a simplified mouth-throat geometry and its significance for inhalation drug delivery Chemical and Process Engineering 30 2009 545 558
24. P.R. Mun, B.W. Young, and D.V. Boger Atomisation of dilute polymer solutions in agricultural spray nozzles Journal of Non-Newtonian Fluid Mechanics 83 1999 163 178 (Pubitemid 29358356)
25. R.P. Mun, J.A. Byars, and D.V. Boger The effects of polymer concentration and molecular weight on the breakup of laminar capillary jets Journal of Non-Newtonian Fluid Mechanics 74 1998 285 297
26. M.W. Nagel, K.J. Wiersema, L.S. Bates, and J.P. Mitchell Performance of large- and small-volume valved holding chambers with a new combination long-term bronchodilator/anti-inflammatory formulation delivered by pressurized metered dose inhaler Journal of Aerosol Medicine 15 2002 427 433 (Pubitemid 36105907)
27. M. Ochowiak, L. Broniarz-Press, and S. Woziwodzki The analysis of silica suspensions atomization International Journal of Heat and Fluid Flow 32 2011 1208 1215
28. A. Qi, J.R. Friend, L.Y. Yeo, D.A.V. Morton, M.P. McIntosh, and L. Spiccia Miniature inhalation therapy platform using surface acoustic wave microfluidic atomization Lab on a Chip 9 2009 2184 2193
29. F.J. Petersen A new approach for pharmaceutical sprays. effervescent atomization. atomizer design and spray characterization Ph.D. Thesis 2004 The Danish University of Pharmaceutical Sciences, Department of Pharmaceutics
30. F.J. Petersen, O. Worts, T. Schaefer, and P.E. Sojka Design and atomization properties for an inside-out type effervescent atomizer Drug Development and Industrial Pharmacy 30 2004 319 326 (Pubitemid 38451756)
31. C.J.S. Petrie Extensional viscosity: a critical discussion Journal of Non-Newtonian Fluid Mechanics 137 2006 15 23 (Pubitemid 44309367)
32. G. Pilcer, and K. Amighi Formulation strategy and use of excipients in pulmonary drug delivery International Journal of Pharmaceutics 392 2010 1 19
33. S. Rozanska, L. Broniarz-Press, J. Rozanski, P.T. Mitkowski, M. Ochowiak, and S. Woziwodzki Extensional viscosity and stability of oil-in-water emulsions with addition poly(ethylene oxide) Procedia Engineering 42 2012 733 741
34. P. Sheth, S.W. Stein, and P.B. Myrdal The influence of initial atomized droplet size on residual particle size from pressurized metered dose inhalers International Journal of Pharmaceutics 455 2013 57 65
35. S.D. Sovani, P.E. Sojka, and A.H. Lefebvre Effervescent atomization Progress in Energy and Combustion Science 27 2001 483 521
36. F.T. Trouton On the coefficient of viscous traction and its relation to that of viscosity Proceedings of the Royal Society 1 1906 426 440