-
1
-
-
19944430434
-
The role of RAS oncogene in survival of patients with lung cancer
-
C. Mascaux et al. The role of RAS oncogene in survival of patients with lung cancer Br. J. Cancer 92 2005 131 139
-
(2005)
Br. J. Cancer
, vol.92
, pp. 131-139
-
-
Mascaux, C.1
-
2
-
-
15744372810
-
KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
-
W. Pao et al. KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib PLoS Med. 2 2005 e17
-
(2005)
PLoS Med.
, vol.2
, pp. 17
-
-
Pao, W.1
-
3
-
-
34247245135
-
Oncogenic K-Ras signals through epidermal growth factor receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal carcinoma cells
-
K.A. Cengel et al. Oncogenic K-Ras signals through epidermal growth factor receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal carcinoma cells Neoplasia 9 2007 341 348
-
(2007)
Neoplasia
, vol.9
, pp. 341-348
-
-
Cengel, K.A.1
-
4
-
-
34249810645
-
KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer
-
E. Massarelli et al. KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer Clin. Cancer Res. 13 2007 2890 2896
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 2890-2896
-
-
Massarelli, E.1
-
5
-
-
58249120506
-
Mutations in phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance
-
N.T. Ihle et al. Mutations in phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance Cancer Res. 69 2009 143 150
-
(2009)
Cancer Res.
, vol.69
, pp. 143-150
-
-
Ihle, N.T.1
-
6
-
-
79960051265
-
Therapeutic strategies for targeting Ras proteins
-
S. Gysin et al. Therapeutic strategies for targeting Ras proteins Genes Cancer 2 2011 359 372
-
(2011)
Genes Cancer
, vol.2
, pp. 359-372
-
-
Gysin, S.1
-
7
-
-
0037805547
-
RAS oncogenes: The first 30 years
-
M. Malumbres, and M. Barbacid RAS oncogenes: the first 30 years Nat. Rev. Cancer 3 2003 459 465
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 459-465
-
-
Malumbres, M.1
Barbacid, M.2
-
8
-
-
77949881462
-
The PI3K pathway as drug target in human cancer
-
K.D. Courtney et al. The PI3K pathway as drug target in human cancer J. Clin. Oncol. 28 2010 1075 1083
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 1075-1083
-
-
Courtney, K.D.1
-
9
-
-
80054936061
-
Inhibition of ras for cancer treatment; The search continues
-
A.T. Baines et al. Inhibition of ras for cancer treatment; the search continues Future Med. Chem. 3 2011 1787 1808
-
(2011)
Future Med. Chem.
, vol.3
, pp. 1787-1808
-
-
Baines, A.T.1
-
10
-
-
77954235111
-
Targeting the mitogen-activated protein kinase pathway: Physiological feedback and drug response
-
C.A. Pratilas, and D.B. Solit Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response Clin. Cancer Res. 16 2010 3329 3334
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 3329-3334
-
-
Pratilas, C.A.1
Solit, D.B.2
-
11
-
-
77949678177
-
Drug discovery: Inhibitors that activate
-
K. Cichowski, and P.A. Jeanne Drug discovery: inhibitors that activate Nature 464 2010 358 359
-
(2010)
Nature
, vol.464
, pp. 358-359
-
-
Cichowski, K.1
Jeanne, P.A.2
-
12
-
-
77649333183
-
The Raf inhibitor paradox: Unexpected consequences of targeted drugs
-
A.D. Cox, and C.J. Der The Raf inhibitor paradox: unexpected consequences of targeted drugs Cancer Cell 17 2010 221 223
-
(2010)
Cancer Cell
, vol.17
, pp. 221-223
-
-
Cox, A.D.1
Der, C.J.2
-
13
-
-
58349091262
-
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition
-
O.K. Mirzoeva et al. Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition Cancer Res. 69 2009 565 572
-
(2009)
Cancer Res.
, vol.69
, pp. 565-572
-
-
Mirzoeva, O.K.1
-
14
-
-
70449995469
-
Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer
-
M.L. Sos et al. Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer Proc. Natl. Acad. Sci. U. S. A. 106 2009 18351 18356
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 18351-18356
-
-
Sos, M.L.1
-
15
-
-
33745307617
-
PI(3)K and mTOR signaling controls tumor cell growth
-
R. Shaw, and L. Cantley PI(3)K and mTOR signaling controls tumor cell growth Nature 441 2006 424 430
-
(2006)
Nature
, vol.441
, pp. 424-430
-
-
Shaw, R.1
Cantley, L.2
-
16
-
-
51349100763
-
A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition
-
N.E. Torbett et al. A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition Biochem. J. 415 2008 97 110
-
(2008)
Biochem. J.
, vol.415
, pp. 97-110
-
-
Torbett, N.E.1
-
17
-
-
57349194139
-
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
-
J.A. Engelman et al. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers Nat. Med. 14 2008 1351 1356
-
(2008)
Nat. Med.
, vol.14
, pp. 1351-1356
-
-
Engelman, J.A.1
-
18
-
-
61449182121
-
Principles of cancer therapy: Oncogene and non-oncogene addiction
-
J. Luo et al. Principles of cancer therapy: oncogene and non-oncogene addiction Cell 136 2009 823 837
-
(2009)
Cell
, vol.136
, pp. 823-837
-
-
Luo, J.1
-
19
-
-
79957722003
-
Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress
-
A.T. Shaw et al. Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress Proc. Natl. Acad. Sci. U. S. A. 108 2011 8773 8778
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 8773-8778
-
-
Shaw, A.T.1
-
20
-
-
80052557069
-
Exploiting cancer cell vulnerabilities to develop a combination therapy for Ras-driven tumors
-
T. De Raedt et al. Exploiting cancer cell vulnerabilities to develop a combination therapy for Ras-driven tumors Cancer Cell 20 2011 400 413
-
(2011)
Cancer Cell
, vol.20
, pp. 400-413
-
-
De Raedt, T.1
-
21
-
-
84872387485
-
Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models
-
R.B. Corcoran et al. Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models Cancer Cell 23 2013 121 128
-
(2013)
Cancer Cell
, vol.23
, pp. 121-128
-
-
Corcoran, R.B.1
-
22
-
-
84877630250
-
Coordinate direct input of both KRAS and IGF1 receptor to activation of PI3kinase in KRAS-mutant lung cancer
-
M. Molina-Arcas et al. Coordinate direct input of both KRAS and IGF1 receptor to activation of PI3kinase in KRAS-mutant lung cancer Cancer Discov. 3 2013 548 563
-
(2013)
Cancer Discov.
, vol.3
, pp. 548-563
-
-
Molina-Arcas, M.1
-
23
-
-
84899547491
-
Preclinical systems to study the biodistribution of nanoparticle delivery in pancreatic ductal adenocarcinoma
-
Abstr. 2906
-
E.A. Collisson et al. Preclinical systems to study the biodistribution of nanoparticle delivery in pancreatic ductal adenocarcinoma Cancer Res. 72 Suppl. 8 2012 Abstr. 2906
-
(2012)
Cancer Res.
, vol.72
, Issue.SUPPL. 8
-
-
Collisson, E.A.1
-
24
-
-
0026079139
-
Identification of an autocrine negative growth factor: Mouse-β-galactoside binding protein is a cytostatic factor and cell growth regulator
-
V. Wells, and L. Mallucci Identification of an autocrine negative growth factor: mouse-β-galactoside binding protein is a cytostatic factor and cell growth regulator Cell 64 1991 91 97
-
(1991)
Cell
, vol.64
, pp. 91-97
-
-
Wells, V.1
Mallucci, L.2
-
25
-
-
0031928667
-
β-Galactoside binding protein secreted by activated T cells inhibits antigen-induced proliferation of T cells
-
C. Blaser et al. β-Galactoside binding protein secreted by activated T cells inhibits antigen-induced proliferation of T cells Eur. J. Immunol. 28 1998 2311 2319
-
(1998)
Eur. J. Immunol.
, vol.28
, pp. 2311-2319
-
-
Blaser, C.1
-
26
-
-
36849006081
-
Functional inhibition of PI3K by the βgBP molecule suppresses Ras-MAPK signaling to block cell proliferation
-
/sb:authors>
-
V. Wells /sb:authors> et al. Functional inhibition of PI3K by the βGBP molecule suppresses Ras-MAPK signaling to block cell proliferation Oncogene 26 2007 7709 7714
-
(2007)
Oncogene
, vol.26
, pp. 7709-7714
-
-
Wells, V.1
-
27
-
-
84866109019
-
Killing of Kras-mutant colon cancer cells via Rac-independent actin remodeling by the βgBP cytokine, a physiological PI3K inhibitor therapeutically effective in vivo
-
L. Mallucci et al. Killing of Kras-mutant colon cancer cells via Rac-independent actin remodeling by the βGBP cytokine, a physiological PI3K inhibitor therapeutically effective in vivo Mol. Cancer Ther. 11 2012 1884 1893
-
(2012)
Mol. Cancer Ther.
, vol.11
, pp. 1884-1893
-
-
Mallucci, L.1
-
28
-
-
20444374445
-
Mutant PIK3CA promotes cell growth and invasion of human cancer cells
-
Y. Samuels et al. Mutant PIK3CA promotes cell growth and invasion of human cancer cells Cancer Cell 7 2005 561 573
-
(2005)
Cancer Cell
, vol.7
, pp. 561-573
-
-
Samuels, Y.1
-
29
-
-
1542353401
-
Control of apoptosis by p53
-
J.S. Fridman, and S.W. Lowe Control of apoptosis by p53 Oncogene 22 2003 9030 9040
-
(2003)
Oncogene
, vol.22
, pp. 9030-9040
-
-
Fridman, J.S.1
Lowe, S.W.2
-
30
-
-
70450270900
-
Awakening guardian angels: Drugging the p53 pathway
-
C.J. Brown et al. Awakening guardian angels: drugging the p53 pathway Nat. Rev. Cancer 9 2009 862 873
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 862-873
-
-
Brown, C.J.1
-
31
-
-
0036632368
-
The phosphatidylinositol 3-kinase-Akt pathway in human cancer
-
I. Vivanco, and C.L. Sawyers The phosphatidylinositol 3-kinase-Akt pathway in human cancer Nat. Rev. Cancer 2 2002 489 501
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
32
-
-
40949135397
-
PI3Kmutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab
-
M. Jhawer et al. PI3Kmutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab Cancer Res. 68 2008 1953 1961
-
(2008)
Cancer Res.
, vol.68
, pp. 1953-1961
-
-
Jhawer, M.1
-
33
-
-
84875490185
-
Cancer genomic landscapes
-
B. Vogelstein et al. Cancer genomic landscapes Science 339 2013 1546 1558
-
(2013)
Science
, vol.339
, pp. 1546-1558
-
-
Vogelstein, B.1
-
34
-
-
0642314378
-
Turning cell cycle controller genes into cancer drugs. A role for an antiproliferative cytokine (βGBP)
-
L. Mallucci et al. Turning cell cycle controller genes into cancer drugs. A role for an antiproliferative cytokine (βGBP) Biochem. Pharmacol. 66 2003 1563 1569
-
(2003)
Biochem. Pharmacol.
, vol.66
, pp. 1563-1569
-
-
Mallucci, L.1
-
35
-
-
67549095234
-
Phosphoinositide 3-kinase targeting by the β-galactoside binding protein cytokine negates akt gene expression and leads aggressive breast cancer cells to apoptotic death
-
V. Wells, and L. Mallucci Phosphoinositide 3-kinase targeting by the β-galactoside binding protein cytokine negates akt gene expression and leads aggressive breast cancer cells to apoptotic death Breast Cancer Res. 11 2009 R2
-
(2009)
Breast Cancer Res.
, vol.11
, pp. 2
-
-
Wells, V.1
Mallucci, L.2
-
37
-
-
84872853570
-
Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling
-
A. Young et al. Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling Cancer Discov. 3 2013 112 123
-
(2013)
Cancer Discov.
, vol.3
, pp. 112-123
-
-
Young, A.1
-
38
-
-
70349091845
-
+ T cells to block their TCR-mediated ERK activity and proliferation
-
+ T cells to block their TCR-mediated ERK activity and proliferation Brain Behav. Immun. 23 2009 1028 1037
-
(2009)
Brain Behav. Immun.
, vol.23
, pp. 1028-1037
-
-
Baatar, D.1
-
39
-
-
84899526489
-
Alternative use of signaling by the βgBP cytokine in cell growth and cancer control
-
R. Srivastava, Humana Press NJ
-
L. Mallucci, and V. Wells Alternative use of signaling by the βGBP cytokine in cell growth and cancer control R. Srivastava, Apoptosis, Cell Signaling and Human Diseases: Molecular Mechanisms Vol 1 2007 Humana Press NJ 203 216
-
(2007)
Apoptosis, Cell Signaling and Human Diseases: Molecular Mechanisms
, vol.1
, pp. 203-216
-
-
Mallucci, L.1
Wells, V.2
-
40
-
-
16444368030
-
Circumventing multidrug resistance in cancer by β-galactoside binding protein, an antiproliferative cytokine
-
R. Ravatn et al. Circumventing multidrug resistance in cancer by β-galactoside binding protein, an antiproliferative cytokine Cancer Res. 65 2005 1631 1634
-
(2005)
Cancer Res.
, vol.65
, pp. 1631-1634
-
-
Ravatn, R.1
|