The relationship between endogenous testosterone and lipid profile in middle-aged and elderly Chinese men

European Journal of Endocrinology

Volumn 170, Issue 4, 2014, Pages 487-494

  Zhang, Nan ^a,b   Zhang, Haiqing ^a,b   Zhang, Xu ^a,b   Zhang, Bingchang ^a   Wang, Furong ^c   Wang, Chenggang ^c   Zhao, Meng ^a,b   Yu, Chunxiao ^a,b   Gao, Ling ^a   Zhao, Jiajun ^a,b   Guan, Qingbo ^a,b  

^a SHANDONG UNIVERSITY   (China)

^b Institute of Endocrinology and Metabolism Shandong Academy of Clinical Medicine ^*  (China)

^c SHANDONG UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIOTHYRONINE; LIPID; TESTOSTERONE; THYROID HORMONE; THYROTROPIN; THYROXINE; TRIACYLGLYCEROL;

ADULT; AGE; AGED; ARTICLE; BODY MASS; CHINESE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS-SECTIONAL STUDY; GLUCOSE BLOOD LEVEL; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTRIGLYCERIDEMIA; LINEAR SYSTEM; LIPID BLOOD LEVEL; MALE; MIDDLE AGED; MULTIPLE LINEAR REGRESSION ANALYSIS; POPULATION RESEARCH; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR; SYSTOLIC BLOOD PRESSURE; TESTOSTERONE BLOOD LEVEL; THYROID HORMONE BLOOD LEVEL; THYROTROPIN BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CHOLESTEROL, HDL; CHOLESTEROL, LDL; HUMANS; HYPERCHOLESTEROLEMIA; MALE; MIDDLE AGED; ODDS RATIO; RETROSPECTIVE STUDIES; RISK FACTORS; TESTOSTERONE; TRIGLYCERIDES;

EID: 84899487303     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-13-0802     Document Type: Article

References (49)

1. Morrison JA, Barton BA, Biro FM & Sprecher DL. Sex hormones and the changes in adolescent male lipids: longitudinal studies in a biracial cohort. Journal of Pediatrics 2003 142 637-642. (doi:10.1067/mpd.2003.246)
2. Tunstall-Pedoe H, Kuulasmaa K, Amouyel P, Arveiler D, Rajakangas AM & Pajak A. Myocardial infarction and coronary deaths in the World Health Organization MONICA Project. Registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents. Circulation 1994 90 583-612. (doi:10.1161/01. CIR. 90.1.583)
3. Morales A, Madrazo Y, Ramírez JI, Castañeda L, Machín W, Álvarez L, Angulo R, Dueñas R & Bermúdez R. Acute myocardial infarction incidence, mortality and case fatality in Santa Clara, Cuba, 2007-2008. MEDICC Review 2011 13 23-29. (doi:10.1590/S1555-796020110 00300006)
4. Mäkinen J, Jarvisalo MJ, Pollanen P, Perheentupa A, Irjala K, Koskenvuo M, Mäkinen J, Huhtaniemi I & Raitakari OT. Increased carotid atherosclerosis in andropausal middle-aged men. Journal of the American College of Cardiology 2005 45 1603-1608. (doi:10.1016/j.jacc. 2005.01.052)
5. Zmuda JM, Cauley JA, Kriska A, Glynn NW, Gutai JP & Kuller LH. Longitudinal relation between endogenous testosterone and cardiovascular disease risk factors in middle-aged men. A 13-year follow-up of former Multiple Risk Factor Intervention Trial participants. American Journal of Epidemiology 1997 148 609-617. (doi:10.1093/oxfordjournals. aje.a009326)
6. Rosano GM, Sheiban I, Massaro R, Pagnotta P, Marazzi G, Vitale C, Mercuro G, Volterrani M, Avera A & Fini M. Low testosterone levels are associated with coronary artery disease in male patients with angina. International Journal of Impotence Research 2007 19 176-182. (doi:10.1038/sj.ijir.3901504)
7. Araujo AB, Dixon JM, Suarez EA, Murad MH, Guey LT & Wittert GA. Clinical review: endogenous testosterone and mortality in men: a systematic review and meta-analysis. Journal of Clinical Endocrinology and Metabolism 2011 96 3007-3019. (doi:10.1210/jc.2011-1137)
8. Corona G, Rastrelli G, Monami M, Guay A, Buvat J, Sforza A, Forti G, Mannucci E & Maggi M. Hypogonadism as a risk factor for cardiovascular mortality in men: a meta-analytic study. European Journal of Endocrinology 2011 165 687-701. (doi:10.1530/EJE-11-0447)
9. Tsai EC, Matsumoto AM, Fujimoto WY & Boyko EJ. Association of bioavailable, free, and total testosterone with insulin resistance: influence of sex hormone-binding globulin and body fat. Diabetes Care 2004 27 861-868. (doi:10.2337/diacare.27.4.861)
10. Ding EL, Song Y, Malik VS & Liu S. Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis. Journal of the American Medical Association 2006 295 1288-1299. (doi:10.1001/jama.295.11.1288)
11. Kalyani RR & Dobs AS. Androgen deficiency, diabetes, and the metabolic syndrome in men. Current Opinion in Endocrinology, Diabetes, and Obesity 2007 14 226-234. (doi:10.1097/MED.0b013e32814db856)
12. Laughlin GA, Barrett-Connor E & Bergstrom J. Low serum testosterone and mortality in older men. Journal of Clinical Endocrinology and Metabolism 2008 93 68-75. (doi:10.1210/jc.2007-1792)
13. Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS, Montori VM, Task Force & Endocrine Society. Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism 2010 95 2536-2559. (doi:10.1210/jc. 2009-2354)
14. Kang HY. Beyond the male sex hormone: deciphering the metabolic and vascular actions of testosterone. Journal of Endocrinology 2013 217 C1-C3. (doi:10.1530/JOE-13-0052)
15. Mäkinen JI, Perheentupa A, Irjala K, Pöllänen P, Mäkinen J, Huhtaniemi I & Raitakari OT. Endogenous testosterone and serum lipids in middle-aged men. Atherosclerosis 2008 197 688-693. (doi:10.1016/j.atherosclerosis.2007.05.009)
16. Simon D, Charles MA, Nahoul K, Orssaud G, Kremski J, Hully V, Joubert E, Papoz L & Eschwege E. Association between plasma total testosterone and cardiovascular risk factors in healthy adult men: the Telecom Study. Journal of Clinical Endocrinology and Metabolism 1997 82 682-685. (doi:10.1210/jcem.82.2. 3766)
17. Agledahl I, Skjaerpe PA, Hansen JB & Svartberg J. Low serum testosterone in men is inversely associated with non-fasting serum triglycerides: the Tromsø study. Nutrition, Metabolism, and Cardiovascular Diseases 2008 18 256-262. (doi:10.1016/j.numecd.2007.01.014)
18. Akishita M, Fukai S, Hashimoto M, Kameyama Y, Nomura K, Nakamura T, Ogawa S, Iijima K, Eto M & Ouchi Y. Association of low testosterone with metabolic syndrome and its components in middle-aged Japanese men. Hypertension Research 2010 33 587-591. (doi:10.1038/hr.2010.43)
19. Haring R, Baumeister SE, Völzke H, Dörr M, Felix SB, Kroemer HK, Nauck M & Wallaschofski H. Prospective association of low total testosterone concentrations with an adverse lipid profile and increased incident dyslipidemia. European Journal of Cardiovascular Prevention and Rehabilitation 2011 18 86-96. (doi:10.1097/HJR.0b013e32833c1a8d)
20. Kabakci G, Yildirir A, Can I, Unsal I & Erbas B. Relationship between endogenous sex hormone levels, lipoproteins and coronary atherosclerosis in men undergoing coronary angiography. Cardiology 1999 92 221-225. (doi:10.1159/000006977)
21. Isidori AM, Giannetta E, Greco EA, Gianfrilli D, Bonifacio V, Isidori A, Lenzi A & Fabbri A. Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis. Clinical Endocrinology 2005 63 280-293. (doi:10.1111/j.1365-2265.2005.02339.x)
22. Corona G, Monami M, Rastrelli G, Aversa A, Tishova Y, Saad F, Lenzi A, Forti G, Mannucci E & Maggi M. Testosterone and metabolic syndrome: a meta-analysis study. Journal of Sexual Medicine 2011 8 272-283. (doi:10.1111/j.1743-6109.2010.01991.x)
23. Corona G, Rastrelli G & Maggi M. Diagnosis and treatment of late-onset hypogonadism: systematic review and meta-analysis of TRT outcomes. Best Practice & Research. Clinical Endocrinology & Metabolism 2013 27 557-579. (doi:10.1016/j.beem.2013.05.002)
24. Allan CA, Strauss BJ, Burger HG, Forbes EA & McLachlan RI. Testosterone therapy prevents gain in visceral adipose tissue and loss of skeletal muscle in nonobese aging men. Journal of Clinical Endocrinology and Metabolism 2008 93 139-146. (doi:10.1210/jc.2007-1291)
25. Berg G, Schreier L, Geloso G, Otero P, Nagelberg A & Levalle O. Impact on lipoprotein profile after long-term testosterone replacement in hypogonadal men. Hormone and Metabolic Research 2002 34 87-92. (doi:10.1055/s-2002-20521)
26. Fernández-Balsells MM, Murad MH, Lane M, Lampropulos JF, Albuquerque F, Mullan RJ, Agrwal N, Elamin MB, Gallegos-Orozco JF, Wang AT et al. Clinical review 1: adverse effects of testosterone therapy in adult men: a systematic review and meta-analysis. Journal of Clinical Endocrinology and Metabolism 2010 95 2560-2575. (doi:10.1210/jc. 2009-2575)
27. Schleich F & Legros JJ. Effects of androgen substitution on lipid profile in the adult and aging hypogonadal male. European Journal of Endocrinology 2004 151 415-424. (doi:10.1530/eje.0.1510415)
28. Wang F, Tan Y, Wang C, Zhang X, Zhao Y, Song X, Zhang B, Guan Q, Xu J, Zhang J et al. Thyroid-stimulating hormone levels within the reference range are associated with serum lipid profiles independent of thyroid hormones. Journal of Clinical Endocrinology and Metabolism 2012 97 2724-2731. (doi:10.1210/jc. 2012-1133)
29. Tian L, Song Y, Xing M, Zhang W, Ning G, Li X, Yu C, Qin C, Liu J, Tian X et al. A novel role for thyroid-stimulating hormone: up-regulation of hepatic 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase expression through the cyclic adenosine monophosphate/protein kinase A/cyclic adenosine monophosphate- responsive element binding protein pathway. Hepatology 2010 52 1401-1409. (doi:10.1002/hep. 23800)
30. Garduño-Garcia Jde J, Alvirde-Garcia U, López-Carrasco G, Padilla Mendoza ME, Mehta R, Arellano-Campos O, Choza R, Sauque L, Garay-Sevilla ME, Malacara JM et al. TSH and free thyroxine concentrations are associated with differing metabolic markers in euthyroid subjects. European Journal of Endocrinology 2010 163 273-278. (doi:10.1530/EJE-10-0312)
31. Jellinger PS, Smith DA, Mehta AE, Ganda O, Handelsman Y, Rodbard HW, Shepherd MD, Seibel JA & AACE Task Force for Management of Dyslipidemia and Prevention of Atherosclerosis. American Association of Clinical Endocrinologists' Guidelines for Management of Dyslipidemia and Prevention of Atherosclerosis. Endocrine Practice 2012 18 (Suppl 1) 1-78.
32. Sharma R, Sharma TK, Kaushik GG, Sharma S, Vardey SK & Sinha M. Subclinical hypothyroidism and its association with cardiovascular risk factors. Clinical Laboratory 2011 57 719-724.
33. Asvold BO, Vatten LJ, Nilsen TI & Bjøro T. The association between TSH within the reference range and serum lipid concentrations in a population-based study. The HUNT Study. European Journal of Endocrinology 2007 156 181-186. (doi:10.1530/eje.1.02333)
34. Fernández-Real JM, López-Bermejo A, Castro A, Casamitjana R & Ricart W. Thyroid function is intrinsically linked to insulin sensitivity and endothelium-dependent vasodilation in healthy euthyroid subjects. Journal of Clinical Endocrinology and Metabolism 2006 91 3337-3343. (doi:10.1210/jc. 2006-0841)
35. Neves C, Alves M, Medina JL & Delgado JL. Thyroid diseases, dyslipidemia and cardiovascular pathology. Revista Portuguesa de Cardiologia 2008 27 1211-1236.
36. Pearce EN. Update in lipid alterations in subclinical hypothyroidism. Journal of Clinical Endocrinology and Metabolism 2012 97 326-333. (doi:10.1210/jc.2011-2532)
37. Tan KC, Shiu SW, Pang RW & Kung AW. Effects of testosterone replacement on HDL subfractions and apolipoprotein A-I containing lipoproteins. Clinical Endocrinology 1998 48 187-194. (doi:10.1046/j.1365-2265.1998.3721211.x)
38. Stanworth RD, Kapoor D, Channer KS & Jones TH. Dyslipidaemia is associated with testosterone, oestradiol and androgen receptor CAG repeat polymorphism in men with type 2 diabetes. Clinical Endocrinology 2011 74 624-630. (doi:10.1111/j.1365-2265.2011.03969.x)
39. Langer C, Gansz B, Goepfert C, Engel T, Uehara Y, Von Dehn G, Jansen H, Assmann G & Von Eckardstein A. Testosterone up-regulates scavenger receptor B1 and stimulates cholesterol efflux from macrophages. Biochemical and Biophysical Research Communications 2002 296 1051-1057. (doi:10.1016/S0006-291X (02) 02038-7)
40. Gannagé-Yared MH, Khalife S, Semaan M, Fares F, Jambart S & Halaby G. Serum adiponectin and leptin levels in relation to the metabolic syndrome, androgenic profile and somatotropic axis in healthy non-diabetic elderly men. European Journal of Endocrinology 2006 155 167-176. (doi:10.1530/eje.1.02175)
41. Isidori AM, Caprio M, Strollo F, Moretti C, Frajese G, Isidori A & Fabbri A. Leptin and androgens in male obesity: evidence for leptin contribution to reduced androgen levels. Journal of Clinical Endocrinology and Metabolism 1999 84 3673-3680. (doi:10.1210/jcem. 84.10.6082)
42. Tang JJ, Srivastava RA, Krul ES, Baumann D, Pfleger BA, Kitchens RT & Schonfeld G. In vivo regulation of apolipoprotein A-I gene expression by estradiol and testosterone occurs by different mechanisms in inbred strains of mice. Journal of Lipid Research 1991 32 1571-1585.
43. Laaksonen DE, Niskanen L, Punnonen K, Nyyssönen K, Tuomainen TP, Valkonen VP, Salonen R & Salonen JT. Testosterone and sex hormonebinding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care 2004 27 1036-1041. (doi:10.2337/diacare.27.5.1036)
44. Somani B, Khan S & Donat R. Screening for metabolic syndrome and testosterone deficiency in patients with erectile dysfunction: results from the first UK prospective study. BJU International 2010 106 688-690. (doi:10.1111/j.1464-410X.2009.09145.x)
45. Yeap BB, Chubb SA, Hyde Z, Jamrozik K, Hankey GJ, Flicker L & Norman PE. Lower serum testosterone is independently associated with insulin resistance in non-diabetic older men: the Health In Men Study. European Journal of Endocrinology 2009 161 591-598. (doi:10.1530/EJE-09-0348)
46. Rastrelli G, Corona G, Lotti F, Boddi V, Mannucci E & Maggi M. Relationship of testis size and LH levels with incidence of major adverse cardiovascular events in older men with sexual dysfunction. Journal of Sexual Medicine 2013 10 2761-2773. (doi:10.1111/jsm.12270)
47. Hyde Z, Norman PE, Flicker L, Hankey GJ, McCaul KA, Almeida OP, Chubb SA & Yeap BB. Elevated LH predicts ischaemic heart disease events in older men: the Health in Men Study. European Journal of Endocrinology 2011 164 569-577. (doi:10.1530/EJE-10-1063)
48. Hyde Z, Norman PE, Flicker L, Hankey GJ, Almeida OP, McCaul KA, Chubb SA & Yeap BB. Low free testosterone predicts mortality from cardiovascular disease but not other causes: the Health in Men Study. Journal of Clinical Endocrinology and Metabolism 2012 97 179-189. (doi:10.1210/jc.2011-1617)
49. Yeap BB, Hyde Z, Norman PE, Chubb SA & Golledge J. Associations of total testosterone, sex hormone-binding globulin, calculated free testosterone, and luteinizing hormone with prevalence of abdominal aortic aneurysm in older men. Journal of Clinical Endocrinology and Metabolism 2010 95 1123-1130. (doi:10.1210/jc.2009-1696)