Soluble antigen traffics rapidly and selectively from the corneal surface to the eye draining lymph node and activates T cells when codelivered with CpG oligonucleotides

Journal of Leukocyte Biology

Volumn 95, Issue 3, 2014, Pages 431-440

  Dang, Zexu ^a   Kuffová, Lucia ^a   Liu, Lei ^a   Forrester, John V ^a,b,c  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c LIONS EYE INSTITUTE   (Australia)

Author keywords

Antigen presentation; Perlecan; Trafficking

Indexed keywords

ANTIGEN; CPG OLIGODEOXYNUCLEOTIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TOLL LIKE RECEPTOR; CPG OLIGONUCLEOTIDE; CPG-OLIGONUCLEOTIDE; IMMUNOLOGICAL ADJUVANT; OLIGODEOXYRIBONUCLEOTIDE; PERLECAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; CLONAL ANERGY; CONTROLLED STUDY; CORNEA; IN VIVO STUDY; INNATE IMMUNITY; LYMPHATIC DRAINAGE; LYMPHOCYTE MIGRATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; SURFACE PROPERTY; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE; TRANSPORT KINETICS; ADAPTIVE IMMUNITY; ANIMAL; C57BL MOUSE; CONFOCAL MICROSCOPY; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; LYMPH NODE; LYMPHOCYTE ACTIVATION; PROTEIN TRANSPORT; T LYMPHOCYTE; TRAFFICKING;

ANTIGEN PRESENTATION; PERLECAN; TRAFFICKING;

ADAPTIVE IMMUNITY; ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGEN PRESENTATION; CLONAL ANERGY; CORNEA; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; OLIGODEOXYRIBONUCLEOTIDES; PROTEIN TRANSPORT; T-LYMPHOCYTES;

EID: 84899485058     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.0612294     Document Type: Article

References (28)

1. Catron, D. M., Itano, A. A., Pape, K. A., Mueller, D. L., Jenkins, M. K. (2004) Visualizing the first 50 hr of the primary immune response to a soluble antigen. Immunity 21, 341-347.
2. Jenkins, M. K. (2008) Imaging the immune system. Immunol. Rev. 221, 5-6.
3. Yarke, C. A., Dalheimer, S. L., Zhang, N., Catron, D. M., Jenkins, M. K., Mueller, D. L. (2008) Proliferating CD4+ T cells undergo immediate growth arrest upon cessation of TCR signaling in vivo. J. Immunol. 180, 156-162.
4. Roozendaal, R., Mempel, T. R., Pitcher, L. A., Gonzalez, S. F., Verschoor, A., Mebius, R. E., von Andrian, U. H., Carroll, M. C. (2009) Conduits mediate transport of low-molecular-weight antigen to lymph node follicles. Immunity 30, 264-276.
5. Itano, A. A., Jenkins, M. K. (2003) Antigen presentation to naive CD4 T cells in the lymph node. Nat. Immunol. 4, 733-739.
6. Itano, A. A., McSorley, S. J., Reinhardt, R. L., Ehst, B. D., Ingulli, E., Rudensky, A. Y., Jenkins, M. K. (2003) Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. Immunity 19, 47-57.
7. Sixt, M., Kanazawa, N., Selg, M., Samson, T., Roos, G., Reinhardt, D. P., Pabst, R., Lutz, M. B., Sorokin, L. (2005) The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node. Immunity 22, 19-29.
8. Streilein, J. W., Niederkorn, J. Y. (1981) Induction of anterior chamberassociated immune deviation requires an intact, functional spleen. J. Exp. Med. 153, 1058-1067.
9. Egan, R. M., Yorkey, C., Black, R., Loh, W. K., Stevens, J. L., Woodward, J. G. (1996) Peptide-specific T cell clonal expansion in vivo following immunization in the eye, an immune-privileged site. J. Immunol. 157, 2262-2271.
10. Plskova, J., Duncan, L., Holan, V., Filipec, M., Kraal, G., Forrester, J. V. (2002) The immune response to corneal allograft requires a site-specific draining lymph node. Transplantation 73, 210-215.
11. Camelo, S., Kezic, J., Shanley, A., Rigby, P., McMenamin, P. G. (2006) Antigen from the anterior chamber of the eye travels in a soluble form to secondary lymphoid organs via lymphatic and vascular routes. Invest. Ophthalmol. Vis. Sci. 47, 1039-1046.
12. Forrester, J. V., Xu, H., Lambe, T., Cornall, R. (2008) Immune privilege or privileged immunity? Mucosal Immunol. 1, 372-381.
13. Sosnova-Netukova, M., Kuchynka, P., Forrester, J. V. (2007) The suprabasal layer of corneal epithelial cells represents the major barrier site to the passive movement of small molecules and trafficking leukocytes. Br. J. Ophthalmol. 91, 372-378.
14. Kuffova, L., Netukova, M., Duncan, L., Porter, A., Stockinger, B., Forrester, J. V. (2008) Cross presentation of antigen on MHC class II via the draining lymph node after corneal transplantation in mice. J. Immunol. 180, 1353-1361.
15. Lee, H. K., Zamora, M., Linehan, M. M., Iijima, N., Gonzalez, D., Haberman, A., Iwasaki, A. (2009) Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection. J. Exp. Med. 206, 359-370.
16. Rudensky, A., Rath, S., Preston-Hurlburt, P., Murphy, D. B., Janeway C. A., Jr., (1991) On the complexity of self. Nature 353, 660-662.
17. Rush, C. M., Brewer, J. M. (2010) Tracking dendritic cells in vivo. Methods Mol. Biol. 626, 169-185.
18. Aida, Y., Pabst, M. J. (1990) Removal of endotoxin from protein solutions by phase separation using Triton X-114. J. Immunol. Methods 132, 191-195.
19. Klein, G., Conzelmann, S., Beck, S., Timpl, R., Muller, C. A. (1995) Perlecan in human bone marrow: a growth-factor-presenting, but antiadhesive, extracellular matrix component for hematopoietic cells. Matrix Biol. 14, 457-465.
20. Van den Broeck, W., Derore, A., Simoens, P. (2006) Anatomy and nomenclature of murine lymph nodes: descriptive study and nomenclatory standardization in BALB/cAnNCrl mice. J. Immunol. Methods 312, 12-19.
21. Reinhardt, R. L., Khoruts, A., Merica, R., Zell, T., Jenkins, M. K. (2001) Visualizing the generation of memory CD4 T cells in the whole body. Nature 410, 101-105.
22. Gretz, J. E., Norbury, C. C., Anderson, A. O., Proudfoot, A. E., Shaw, S. (2000) Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex. J. Exp. Med. 192, 1425-1440.
23. Tomei, A. A., Siegert, S., Britschgi, M. R., Luther, S. A., Swartz, M. A. (2009) Fluid flow regulates stromal cell organization and CCL21 expression in a tissue-engineered lymph node microenvironment. J. Immunol. 183, 4273-4283.
24. Hutchison, S., Benson, R. A., Gibson, V. B., Pollock, A. H., Garside, P., Brewer, J. M. (2012) Antigen depot is not required for alum adjuvanticity. FASEB J. 26, 1272-1279.
25. Camelo, S., Shanley, A., Voon, A. S., McMenamin, P. G. (2004) The distribution of antigen in lymphoid tissues following its injection into the anterior chamber of the rat eye. J. Immunol. 172, 5388-5395.
26. Bajenoff, M., Germain, R. N. (2009) B-cell follicle development remodels the conduit system and allows soluble antigen delivery to follicular dendritic cells. Blood 114, 4989-4997.
27. Sharp, F. A., Ruane, D., Claass, B., Creagh, E., Harris, J., Malyala, P., Singh, M., O'Hagan, D. T., Petrilli, V., Tschopp, J., O'Neill, L. A., Lavelle, E. C. (2009) Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome. Proc. Natl. Acad. Sci. USA 106, 870-875.
28. Lambe, T., Leung, J. C., Ferry, H., Bouriez-Jones, T., Makinen, K., Crockford, T. L., Jiang, H. R., Nickerson, J. M., Peltonen, L., Forrester, J. V., Cornall, R. J. (2007) Limited peripheral T cell anergy predisposes to retinal autoimmunity. J. Immunol. 178, 4276-4283.