MTOR-targeted therapy: Differential perturbation to mitochondrial membrane potential and permeability transition pore plays a role in therapeutic response

Biochemical and Biophysical Research Communications

Volumn 447, Issue 1, 2014, Pages 184-191

  Kim, Jae Eun ^b   He, Qun ^a   Chen, Yaqing ^a   Shi, Celine ^b   Yu, Ker ^a,b  

^a FUDAN UNIVERSITY   (China)

^b PFIZER INC   (United States)

Author keywords

Anticancer; Mitochondria; mTOR inhibitor

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; SHORT HAIRPIN RNA;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CULTURE; CELL MEMBRANE PERMEABILITY; CELL PROLIFERATION ASSAY; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GROWTH INHIBITION; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOFLUORESCENCE TEST; IMMUNOPRECIPITATION; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; OSTEOSARCOMA CELL; PRIORITY JOURNAL; TREATMENT RESPONSE;

ANTICANCER; MITOCHONDRIA; MTOR INHIBITOR;

GLYCOGEN SYNTHASE KINASE 3; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; NEOPLASMS; PHENYLUREA COMPOUNDS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; PYRAZOLES; TOR SERINE-THREONINE KINASES; TUMOR CELLS, CULTURED; VOLTAGE-DEPENDENT ANION CHANNEL 1;

EID: 84899484080     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.03.124     Document Type: Article

References (26)

1. X.M. Ma, and J. Blenis Molecular mechanisms of mTOR-mediated translational control Nat. Rev. Mol. Cell Biol. 10 2009 307 318
2. P. Polak, and M.N. Hall MTOR and the control of whole body metabolism Curr. Opin. Cell Biol. 21 2009 209 218
3. I.J. Sipula, N.F. Brown, and G. Perdomo Rapamycin-mediated inhibition of mammalian target of rapamycin in skeletal muscle cells reduces glucose utilization and increases fatty acid oxidation Metabolism 55 2006 1637 1644
4. J.T. Cunningham, J.T. Rodgers, and D.H. Arlow et al. MTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex Nature 450 2007 736 740
5. S.M. Schieke, D. Phillips, and J.P. McCoy et al. The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity J. Biol. Chem. 281 2006 27643 27652
6. S.M. Schieke, J.P. McCoy, and T. Finkel Coordination of mitochondrial bioenergetics with G1 phase cell cycle progression Cell Cycle 7 2008 1782 1787
7. S.M. Schieke, M. Ma, and L. Cao et al. Mitochondrial metabolism modulates differentiation and teratoma formation capacity in mouse embryonic stem cells J. Biol. Chem. 283 2008 28506 28512
8. B.N. Desai, B.R. Myers, and S.L. Schreiber FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction Proc. Natl. Acad. Sci. U S A 99 2002 4319 4324
9. C. Betz, D. Stracka, and C. Prescianotto-Baschong et al. MTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology Proc. Natl. Acad. Sci. U S A 110 2013 12526 12534
10. M. Colombi, K.D. Molle, and D. Benjamin et al. Genome-wide shRNA screen reveals increased mitochondrial dependence upon mTORC2 addiction Oncogene 30 2011 1551 1565
11. A. Ramanathan, and S.L. Schreiber Direct control of mitochondrial function by mTOR Proc. Natl. Acad. Sci. U S A 106 2009 22229 22232
12. S.P. Mathupala, Y.H. Ko, and P.L. Pedersen Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy Semin. Cancer Biol. 19 2009 17 24
13. K. Yu, C. Shi, and L. Toral-Barza et al. Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2 Cancer Res. 70 2010 621 631
14. B. Shor, J.J. Gibbons, and R.T. Abraham et al. Targeting mTOR globally in cancer: thinking beyond rapamycin Cell Cycle 8 2009 3831 3837
15. V. Petronilli, G. Miotto, and M. Canton et al. Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence Biophys. J. 76 1999 725 734
16. D.H. Suh, M.K. Kim, and H.S. Kim et al. Mitochondrial permeability transition pore as a selective target for anti-cancer therapy Front. Oncol. 3 2013 41
17. 2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress Biochem. J. 255 1988 357 360
18. N. Majewski, V. Nogueira, and P. Bhaskar et al. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak Mol. Cell 16 2004 819 830
19. H. Azoulay-Zohar, A. Israelson, and S. Abu-Hamad et al. In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death Biochem. J. 377 2004 347 355
20. M. Juhaszova, D.B. Zorov, and S.H. Kim et al. Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore J. Clin. Invest. 113 2004 1535 1549
21. S. Das, R. Wong, and N. Rajapakse et al. Glycogen synthase kinase 3 inhibition slows mitochondrial adenine nucleotide transport and regulates voltage-dependent anion channel phosphorylation Circ. Res. 103 2008 83 91
22. L. Galluzzi, O. Kepp, and N. Tajeddine et al. Disruption of the hexokinase-VDAC complex for tumor therapy Oncogene 27 2008 4633 4635
23. N. Goldin, L. Arzoine, and A. Heyfets et al. Methyl jasmonate binds to and detaches mitochondria-bound hexokinase Oncogene 27 2008 4636 4643
24. S. Paglin, N.Y. Lee, and C. Nakar et al. Rapamycin-sensitive pathway regulates mitochondrial membrane potential, autophagy, and survival in irradiated MCF-7 cells Cancer Res. 65 2005 11061 11070
25. L. Meng, M. Shu, and Y. Chen et al. A novel lead compound CM-118: antitumor activity and new insight into the molecular mechanism and combination therapy strategy in c-Met- and ALK-dependent cancers Cancer Biol. Ther. 15 6 2014 [Epub ahead of print]
26. E.N. Maldonado, J. Patnaik, and M.R. Mullins et al. Free tubulin modulates mitochondrial membrane potential in cancer cells Cancer Res. 70 2010 10192 10201