Alanine-(87)-threonine polymorphism impairs signaling and internalization of the human P2Y11 receptor, when co-expressed with the P2Y 1 receptor

Journal of Neurochemistry

Volumn 129, Issue 4, 2014, Pages 602-613

  Haas, Michael ^a   Shaaban, Ahmed ^a   Reiser, Georg ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Ala 87 Thr; neuroimmunology; purinergic signaling; single nucleotide polymorphism

Indexed keywords

3' O (4 BENZOYLBENZOYL)ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ALANINE; CYCLIC AMP; PURINERGIC P2Y1 RECEPTOR; PURINERGIC P2Y11 RECEPTOR; THREONINE;

ARTICLE; ASTROCYTOMA CELL; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG POTENCY; FETUS; GENE; GENE MUTATION; INTERNALIZATION; NONHUMAN; P2RY11 GENE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

ALA-87-THR; NEUROIMMUNOLOGY; P2Y1 RECEPTOR; P2Y11 RECEPTOR; PURINERGIC SIGNALING; SINGLE-NUCLEOTIDE POLYMORPHISM;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; AMINO ACID SUBSTITUTION; ASTROCYTOMA; AUTOIMMUNITY; BRAIN; CALCIUM SIGNALING; CELL LINE, TUMOR; CYCLIC AMP; HEK293 CELLS; HUMANS; MUTAGENESIS, SITE-DIRECTED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN INTERACTION MAPPING; PURINERGIC AGONISTS; RECEPTORS, PURINERGIC P2; RECEPTORS, PURINERGIC P2Y1; STRUCTURE-ACTIVITY RELATIONSHIP; THIONUCLEOTIDES; TRANSFECTION;

EID: 84899483369     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12666     Document Type: Article

References (33)

1. Abbracchio M. P., Burnstock G., Boeynaems J. M., et al,. (2006) International union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol. Rev. 58, 281-341. (Pubitemid 44394905)
2. 11. Eur. Heart J. 28, 13-18. (Pubitemid 46134951)
3. Berchtold S., Ogilvie A. L., Bogdan C., Muhl-Zurbes P., Ogilvie A., Schuler G., and, Steinkasserer A., (1999) Human monocyte derived dendritic cells express functional P2X and P2Y receptors as well as ecto-nucleotidases. FEBS Lett. 458, 424-428. (Pubitemid 29433848)
4. Black S., Kushner I., and, Samols D., (2004) C-reactive protein. J. Biol. Chem. 279, 48487-48490. (Pubitemid 39625721)
5. 2Y4 receptor. Eur. J. Pharmacol. 317, 383-389. (Pubitemid 27014046)
6. Communi D., Govaerts C., Parmentier M., and, Boeynaems J. M., (1997) Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase. J. Biol. Chem. 272, 31969-31973. (Pubitemid 28011862)
7. 11 receptor. Br. J. Pharmacol. 128, 1199-1206.
8. Di Virgilio F., Boeynaems J. M., and, Robson S. C., (2009) Extracellular nucleotides as negative modulators of immunity. Curr. Opin. Pharmacol. 9, 507-513.
9. 11 nucleotide receptors by adenosine 5-O-(α-boranotriphosphate) analogues. Br. J. Pharmacol. 149, 416-423. (Pubitemid 44582248)
10. 11 receptor. Biochem. J. 409, 107-116.
11. 6-receptor agonist. J. Med. Chem. 53, 1673-1685.
12. 11 receptor activation. Blood 116, 4492-4500.
13. Haas M., Ben-Moshe I., Fischer B., and, Reiser G., (2013) Sp-2-propylthio-ATP-α-B and Sp-2-propylthio-ATP-α-B, β-γ-dichloromethylene are novel potent and specific agonists of the human P2Y11 receptor. Biochem. Pharmacol. 86, 645-655.
14. Hoffmann C., Ziegler N., Reiner S., Krasel C., and, Lohse M. J., (2008) Agonist-selective, receptor-specific interaction of human P2Y receptors with beta-arrestin-1 and -2. J. Biol. Chem. 283, 30933-30941.
15. Kohout T. A., and, Lefkowitz R. J., (2003) Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization. Mol. Pharmacol. 63, 9-18. (Pubitemid 36043803)
16. Kornum B. R., Kawashima M., Faraco J., et al,. (2011) Common variants in P2RY11 are associated with narcolepsy. Nat. Genet. 43, 66-71.
17. Meis S., Hamacher A., Hongwiset D., et al,. (2010) NF546 [4,4-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene) -car bonylimino))-bis(1,3-xylene-alpha, alpha'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleukin-8 from human monocyte-derived dendritic cells. J. Pharmacol. Exp. Ther. 332, 238-247.
18. Moore D. J., Chambers J. K., Wahlin J. P., Tan K. B., Moore G. B., Jenkins O., Emson P. C., and, Murdock P. R., (2001) Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study. Biochim. Biophys. Acta 1521, 107-119. (Pubitemid 33020772)
19. Mundell S. J., Luo J., Benovic J. L., Conley P. B., and, Poole A. W., (2006) Distinct clathrin-coated pits sort different G protein-coupled receptor cargo. Traffic 7, 1420-1431. (Pubitemid 44364179)
20. i3. J. Biol. Chem. 273, 4695-4704. (Pubitemid 28103217)
21. Sakaki H., Tsukimoto M., Harada H., Moriyama Y., and, Kojima S., (2013) Autocrine regulation of macrophage activation via exocytosis of ATP and activation of P2Y11 receptor. PLoS ONE 8, e59778.
22. 11 receptor signaling. Blood 102, 613-620. (Pubitemid 36841983)
23. Tabas I., (2010) Macrophage death and defective inflammation resolution in atherosclerosis. Nat. Rev. Immunol. 10, 36-46.
24. 2 receptors induced by novel adenosine 5-O-(1-boranotriphosphate) derivatives. Br. J. Pharmacol. 142, 869-878. (Pubitemid 38998100)
25. Tulapurkar M. E., Zündorf G., and, Reiser G., (2006) Internalization and desensitization of a green fluorescent protein-tagged P2Y nucleotide receptor are differently controlled by inhibition of calmodulin-dependent protein kinase II. J. Neurochem. 96, 624-634.
26. 11 receptor. J. Immunol. 179, 8544-8553.
27. Vitiello L., Gorini S., Rosano G., and, la Sala A., (2012) Immunoregulation through extracellular nucleotides. Blood 120, 511-518.
28. Wang L., Östberg O., Wihlborg A. K., Brogren H., Jern S., and, Erlinge D., (2003) Quantification of ADP and ATP receptor expression in human platelets. J. Thromb. Haemost. 1, 330-336.
29. Wang L., Jacobsen S. E., Bengtsson A., and, Erlinge D., (2004) P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34 + stem and progenitor cells. BMC Immunol. 5, 16.
30. 6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction. Circ. Res. 98, 970-976.
31. 11 receptor mediates the ATP-induced maturation of human monocyte-derived dendritic cells. J. Immunol. 166, 7172-7177. (Pubitemid 32525589)
32. Wilkin F., Stordeur P., Goldman M., Boeynaems J. M., and, Robaye B., (2002) Extracellular adenine nucleotides modulate cytokine production by human monocyte-derived dendritic cells: dual effect on IL-12 and stimulation of IL-10. Eur. J. Immunol. 32, 2409-2417.
33. 11 nucleotide receptor deduced from computational modelling and mutational analysis. Biochem. J. 405, 277-286. (Pubitemid 47075163)