A descriptive study of colorectal function in adults with Prader-Willi Syndrome: High prevalence of constipation

BMC Gastroenterology

Volumn 14, Issue 1, 2014, Pages

  Kuhlmann, Louise ^a   Joensson, Iben M ^a   Froekjaer, Jens B ^b   Krogh, Klaus ^a   Farholt, Stense ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AALBORG UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Colon; Constipation; Developmental disabilities; Gastrointestinal transit; Prader Willi Syndrome; Rectum; Ultrasonography

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CONSTIPATION; CONTROLLED STUDY; DEFECATION DISORDER; DESCRIPTIVE RESEARCH; DIGITAL RECTAL EXAMINATION; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; ECHOGRAPHY; FECES ANALYSIS; FECES INCONTINENCE; FEMALE; HARD FECES; HUMAN; INTESTINE FUNCTION; INTESTINE MOTILITY; INTESTINE OBSTRUCTION; INTESTINE PARAMETERS; INTESTINE TRANSIT TIME; MALE; PRADER WILLI SYNDROME; RECTAL DIAMETER; ROME III CONSTIPATION CRITERIA; SYMPTOM ASSESSMENT; URINE INCONTINENCE; AGED; ANATOMY AND HISTOLOGY; CASE CONTROL STUDY; COHORT ANALYSIS; DEFECATION; GASTROINTESTINAL DISEASES; GASTROINTESTINAL TRANSIT; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; PRADER-WILLI SYNDROME; PREVALENCE; RECTUM; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; CASE-CONTROL STUDIES; COHORT STUDIES; CONSTIPATION; DEFECATION; DIGITAL RECTAL EXAMINATION; FEMALE; GASTROINTESTINAL DISEASES; GASTROINTESTINAL TRANSIT; HUMANS; MALE; MIDDLE AGED; PRADER-WILLI SYNDROME; PREVALENCE; RECTUM; YOUNG ADULT;

EID: 84899480021     PISSN: None     EISSN: 1471230X     Source Type: Journal    
DOI: 10.1186/1471-230X-14-63     Document Type: Article

References (31)

1. Prader A, Labhart A, Willi H. Ein Syndrom von Adipositas, Kleinwuchs, Kryptorchismus und Oligophrenie nach myotonieartigen Zustand im Neugeborenalter. Schweiz Med Wochenschr 1956, 86:1260-1261.
2. Cassidy SB, Driscoll DJ. Prader-Willi syndrome. Eur J Hum Genet 2009, 17(1):3-13. 10.1038/ejhg.2008.165, 2985966, 18781185.
3. Whittington J, Holland A. Neurobehavioral phenotype in Prader-Willi syndrome. Am J Med Genet C Semin Med Genet 2010, 154C(4):438-447. 10.1002/ajmg.c.30283, 20981773.
4. Choe YH, Jin DK, Kim SE, Song SY, Paik KH, Park HY, Oh YJ, Kim AH, Kim JS, Kim CW, Chu SH, Kwon EK, Lee KH. Hyperghrelinemia does not accelerate gastric emptying in Prader-Willi syndrome patients. J Clin Endocrinol Metab 2005, 90(6):3367-3370. 10.1210/jc.2004-1651, 15657368.
5. Hoybye C, Barkeling B, Naslund E, Thoren M, Hellstrom PM. Eating behavior and gastric emptying in adults with Prader-Willi syndrome. Ann Nutr Metab 2007, 51(3):264-269. 10.1159/000105447, 17622785.
6. Arenz T, Schwarzer A, Pfluger T, Koletzko S, Schmidt H. Delayed gastric emptying in patients with Prader Willi Syndrome. J Pediatr Endocrinol Metab 2010, 23(9):867-871.
7. Morad M, Nelson NP, Merrick J, Davidson PW, Carmeli E. Prevalence and risk factors of constipation in adults with intellectual disability in residential care centers in Israel. Res Dev Disabil 2007, 28(6):580-586. 10.1016/j.ridd.2006.08.002, 17336497.
8. Stevenson DA, Heinemann J, Angulo M, Butler MG, Loker J, Rupe N, Kendell P, Cassidy SB, Scheimann A. Gastric rupture and necrosis in Prader-Willi syndrome. J Pediatr Gastroenterol Nutr 2007, 45(2):272-274. 10.1097/MPG.0b013e31805b82b5, 3241991, 17667731.
9. Alexander RC, Greenswag LR, Nowak AJ. Rumination and vomiting in Prader-Willi syndrome. Am J Med Genet 1987, 28(4):889-895. 10.1002/ajmg.1320280414, 3688027.
10. Bohmer CJ, Taminiau JA, Klinkenberg-Knol EC, Meuwissen SG. The prevalence of constipation in institutionalized people with intellectual disability. J Intellect Disabil Res 2001, 45(Pt 3):212-218.
11. Drossman DA, Dumitrascu DL. Rome III: New standard for functional gastrointestinal disorders. J Gastrointestin Liver Dis 2006, 15(3):237-241.
12. Vande Velde S, Van Biervliet S, Van Goethem G, De Looze D, Van Winckel M. Colonic transit time in mentally retarded persons. Int J Colorectal Dis 2010, 25(7):867-871. 10.1007/s00384-010-0928-3, 20306060.
13. Abrahamsson H, Antov S, Bosaeus I. Gastrointestinal and colonic segmental transit time evaluated by a single abdominal x-ray in healthy subjects and constipated patients. Scand J Gastroenterol Suppl 1988, 152:72-80.
14. Joensson IM, Siggaard C, Rittig S, Hagstroem S, Djurhuus JC. Transabdominal ultrasound of rectum as a diagnostic tool in childhood constipation. J Urol 2008, 179(5):1997-2002. 10.1016/j.juro.2008.01.055, 18355856.
15. Karaman A, Ramadan SU, Karaman I, Gokharman D, Erdogan D, Kacar M, Cavusoglu YH, Kosar U. Diagnosis and follow-up in constipated children: should we use ultrasound?. J Pediatr Surg 2010, 45(9):1849-1855. 10.1016/j.jpedsurg.2010.05.006, 20850631.
16. Klijn AJ, Asselman M, Vijverberg MA, Dik P, de Jong TP. The diameter of the rectum on ultrasonography as a diagnostic tool for constipation in children with dysfunctional voiding. J Urol 2004, 172(5 Pt 1):1986-1988.
17. Singh SJ, Gibbons NJ, Vincent MV, Sithole J, Nwokoma NJ, Alagarswami KV. Use of pelvic ultrasound in the diagnosis of megarectum in children with constipation. J Pediatr Surg 2005, 40(12):1941-1944. 10.1016/j.jpedsurg.2005.08.012, 16338324.
18. Fynne L, Worsoe J, Gregersen T, Schlageter V, Laurberg S, Krogh K. Gastrointestinal transit in patients with systemic sclerosis. Scand J Gastroenterol 2011, 46(10):1187-1193.
19. de Graaf EJ, Gilberts EC, Schouten WR. Role of segmental colonic transit time studies to select patients with slow transit constipation for partial left-sided or subtotal colectomy. Br J Surg 1996, 83(5):648-651. 10.1002/bjs.1800830520, 8689210.
20. Metcalf AM, Phillips SF, Zinsmeister AR, MacCarty RL, Beart RW, Wolff BG. Simplified assessment of segmental colonic transit. Gastroenterology 1987, 92(1):40-47.
21. Mugie SM, Benninga MA, Di Lorenzo C. Epidemiology of constipation in children and adults: a systematic review. Best Pract Res Clin Gastroenterol 2011, 25(1):3-18.
22. Sinnema M, Maaskant MA, van Schrojenstein Lantman-De Valk HM, van Nieuwpoort IC, Drent ML, Curfs LM, Schrander-Stumpel CT. Physical health problems in adults with Prader-Willi syndrome. Am J Med Genet A 2011, 155A(9):2112-2124.
23. Pourhoseingholi MA, Kaboli SA, Pourhoseingholi A, Moghimi-Dehkordi B, Safaee A, Mansoori BK, Habibi M, Zali MR. Obesity and functional constipation; a community-based study in Iran. J Gastrointestin Liver Dis 2009, 18(2):151-155.
24. Frattini JC, Nogueras JJ. Slow transit constipation: a review of a colonic functional disorder. Clin Colon Rectal Surg 2008, 21(2):146-152. 10.1055/s-2008-1075864, 2780201, 20011411.
25. Rao SS, Kuo B, McCallum RW, Chey WD, DiBaise JK, Hasler WL, Koch KL, Lackner JM, Miller C, Saad R, Semler JR, Sitrin MD, Wilding GE, Parkman HP. Investigation of colonic and whole-gut transit with wireless motility capsule and radiopaque markers in constipation. Clin Gastroenterol Hepatol 2009, 7(5):537-544. 10.1016/j.cgh.2009.01.017, 19418602.
26. Worsoe J, Fynne L, Gregersen T, Schlageter V, Christensen LA, Dahlerup JF, Rijkhoff NJ, Laurberg S, Krogh K. Gastric transit and small intestinal transit time and motility assessed by a magnet tracking system. BMC Gastroenterol 2011, 11(1):145. 10.1186/1471-230X-11-145, 3295650, 22206545.
27. Choe YH, Song SY, Paik KH, Oh YJ, Chu SH, Yeo SH, Kwon EK, Kim EM, Rha MY, Jin DK. Increased density of ghrelin-expressing cells in the gastric fundus and body in Prader-Willi syndrome. J Clin Endocrinol Metab 2005, 90(9):5441-5445. 10.1210/jc.2004-1935, 15956087.
28. Paik KH, Jin DK, Song SY, Lee JE, Ko SH, Song SM, Kim JS, Oh YJ, Kim SW, Lee SH, Kim SH, Kwon EK, Choe YH. Correlation between fasting plasma ghrelin levels and age, body mass index (BMI), BMI percentiles, and 24-hour plasma ghrelin profiles in Prader-Willi syndrome. J Clin Endocrinol Metab 2004, 89(8):3885-3889. 10.1210/jc.2003-032137, 15292322.
29. Teitelbaum JE, Sinha P, Micale M, Yeung S, Jaeger J. Obesity is related to multiple functional abdominal diseases. J Pediatr 2009, 154(3):444-446. 10.1016/j.jpeds.2008.09.053, 19874760.
30. Vd Baan-Slootweg OH, Liem O, Bekkali N, van Aalderen WM, Rijcken TH, Di Lorenzo C, Benninga MA. Constipation and colonic transit times in children with morbid obesity. J Pediatr Gastroenterol Nutr 2011, 52(4):442-445. 10.1097/MPG.0b013e3181ef8e3c, 21240026.
31. Eslick GD. Gastrointestinal symptoms and obesity: a meta-analysis. Obes Rev 2012, 13(5):469-479. 10.1111/j.1467-789X.2011.00969.x, 22188520.