Hyper-reactive human ventral tegmental area and aberrant mesocorticolimbic connectivity in overgeneralization of fear in generalized anxiety disorder

Journal of Neuroscience

Volumn 34, Issue 17, 2014, Pages 5855-5860

  Cha, Jiook ^a,b   Carlson, Joshua M ^c,d   DeDora, Daniel J ^c   Greenberg, Tsafrir ^a   Proudfit, Greg H ^a   Mujica Parodi, Lilianne R ^a,c,e  

^a STONY BROOK UNIVERSITY   (United States)

^b Department of Psychiatry Columbia University College of Physiciansand Surgeons The New York State Psychiatric Institute ^*  (United States)

^c STONY BROOK UNIVERSITY   (United States)

^d NORTHERN MICHIGAN UNIVERSITY   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Anxiety disorder; Dopaminergic aversion system; Fear generalization; Human fear conditioning; Mesocorticolimbic system; Ventral tegmental area

Indexed keywords

ADULT; ARTICLE; BRAIN CORTEX; BRAIN DEPTH STIMULATION; BRAIN DYSFUNCTION; CLINICAL ARTICLE; CONNECTOME; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; FEAR; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENERALIZED ANXIETY DISORDER; HIPPOCAMPUS; HUMAN; LEARNING; MESOCORTICOLIMB; PRIORITY JOURNAL; PSYCHOPHYSIOLOGY; STRUCTURED CLINICAL INTERVIEW FOR DSM DISORDERS; TASK PERFORMANCE; THREAT; VENTRAL TEGMENTUM; YOUNG ADULT;

ANXIETY DISORDER; DOPAMINERGIC AVERSION SYSTEM; FEAR GENERALIZATION; HUMAN FEAR CONDITIONING; MESOCORTICOLIMBIC SYSTEM; VENTRAL TEGMENTAL AREA;

ADOLESCENT; ADULT; ANXIETY; ANXIETY DISORDERS; BRAIN MAPPING; FEAR; FEMALE; GENERALIZATION (PSYCHOLOGY); HUMANS; MAGNETIC RESONANCE IMAGING; NERVE NET; VENTRAL TEGMENTAL AREA;

EID: 84899471189     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4868-13.2014     Document Type: Article

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