The stateville penitentiary malaria experiments: A case study in retrospective ethical assessment

Perspectives in Biology and Medicine

Volumn 56, Issue 4, 2013, Pages 548-567

  Miller, Franklin G ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT;

COGNITION; COMPREHENSION; ETHICS; HISTORY; HUMAN; HUMAN EXPERIMENT; HUMAN RIGHTS ABUSE; INFORMED CONSENT; MALARIA; MEDICAL ETHICS; MORALITY; MOTIVATION; PATIENT SELECTION; PRISON; PRISONER; PSYCHOLOGY; RESEARCH SUBJECT; RETROSPECTIVE STUDY; UNITED STATES; VULNERABLE POPULATION;

ANTIMALARIALS; CODES OF ETHICS; COMPREHENSION; HISTORY, 20TH CENTURY; HUMAN RIGHTS ABUSES; HUMANS; ILLINOIS; INFORMED CONSENT; MALARIA; MOTIVATION; PATIENT SELECTION; PRISONERS; PRISONS; RESEARCH SUBJECTS; RETROSPECTIVE MORAL JUDGMENT; RETROSPECTIVE STUDIES; THERAPEUTIC HUMAN EXPERIMENTATION; VOLITION; VULNERABLE POPULATIONS;

EID: 84899463853     PISSN: 00315982     EISSN: None     Source Type: Journal    
DOI: 10.1353/pbm.2013.0035     Document Type: Article

References (40)

1. Advisory Committee on Human Radiation Experiments (ACHRE). 1995. Final report. Washington, DC: GPO.
2. Alving, A. S., et al. 1948a. Procedures at Stateville Penitentiary for the testing of potential antimalarial agents. J Clin Invest 27(3 pt.1):2-5.
3. Alving, A. S., et al. 1948b. The clinical trial of eighteen analogues of pamaquin (plasmochin) in Vivax malaria (Chesson strain). J Clin Invest 27(3 pt.1):34-45.
4. Annas, G. J., and M., A. Grodin. 1992. The Nazi doctors and the Nuremberg Code. New York: Oxford Univ. Press.
5. Austin, S. C., P. D. Stolley, and T. Lasky. 1992. The history of malariotherapy for neurosyphilis. JAMA 268:516-19.
6. Bach-y-Rita, G. 1974. The prisoner as an experimental subject. JAMA 229:45-46.
7. Beecher, H. K. 1966. Ethics and clinical research. N Engl J Med 274:1354-60.
8. Board for the Coordination of Malarial Studies. 1946. Clinical testing of antimalarial drugs: Final report. Staff of the Malarial Research Unit, Department of Medicine, University of Chicago, Aug. 31, 1946. National Archives, Records of the OSRD, CMR, C-450, L-49, Box 129.
9. Bonham, V. H., and J.D. Moreno. 2008. Research with captive populations: Prisoners, students, and soldiers. In The Oxford textbook of clinical research ethics, ed. E. J. Emanuel, et al., 461-74. New York: Oxford Univ. Press.
10. Comfort, N. 2009. The prisoner as model organism: malaria research at Stateville Penitentiary. Stud Hist Philos Biol Biomed Sci 40:190-203.
11. Church, L. W. P., et al. 1997. Clinical manifestations of Plasmodium facliparum malaria experimentally induced by mosquito challenge. J Infect Dis 175:915-20.
12. Craige, B., et al. 1948. The toxixity of large doses of pentaquine (SN-13,276), a large antimalarial drug. J Clin Invest 27(3 pt.1):17-24.
13. Eckart, W. U., and H. Vondra. 2000. Malaria and World War II: German malaria experiments 1939-45. Parassitologia 42:53-58.
14. Emanuel, E. J., and F. G. Miller. 2007. Money and distorted ethical judgments about research: Ethical assessment of the TeGenero TGN1412 trial. Am J Bioethics 7(2):76-81.
15. Epstein, J. E., et al. 2007. Safety and clinical outcome of experimental challenge of human volunteers with Plasmodium facliparum-infected mosquitoes: An update. J Infect Dis 196:145-54.
16. Grodin, M. A. 1992. Historical origins of the Nuremberg Code. In Annas and Grodin, 121-44.
17. Harcourt, B. E. 2011. Making willing bodies: The University of Chicago human experiments at Stateville Penitentiary. Soc Res 78:443-78.
18. Harkness, J. M. 1996. Nuremberg and the issue of wartime experiments on US prisoners. JAMA 276:1672-75.
19. Hornblum, A. M. 1997. They were cheap and available: Prisoners as research subjects in twentieth century America. BMJ 315:1437-41.
20. Howard, W. A., et al. 1973. Spontaneous splenic rupture in vivax malaria: Case report. Mil Med 138:32-35.
21. Lederer, S. E. 1995. Subjected to science. Baltimore: Johns Hopkins Univ. Press.
22. Leopold, N. 1958. Life plus 99 years. Garden City, NY: Doubleday.
23. Life. 1945. Prison malaria. 18(23):43-46.
24. Marks, H. M. 1997. The progress of experiment. Cambridge: Cambridge Univ. Press.
25. Miller, F. G., and C. Grady. 2001. The ethical challenge of infection-inducing challenge experiments. Clin Infect Dis 33:1028-33.
26. Mills, M., and N. Morris. 1974. Prisoners and laboratory animals. Society 11(5):60-66.
27. Mitford, J. 1973. Experiments behind bars. Atlantic Monthly 231:64-73.
28. National Commission for Protection of Human Subjects of Biomedical and Behavioral Research. 1976. Research involving prisoners: Report and recommendations. Washington, DC: GPO.
29. National Commission for Protection of Human Subjects of Biomedical and Behavioral Research. 1979. The Belmont Report. Washington, DC: GPO.
30. Ockenhouse, C. F., et al. 2005. History of U.S. military contributions to the study of malaria. Mil Med 170(4 suppl.):12-16.
31. Pappworth, M. H. 1967. Human guinea pigs: Experimentation on man. London: RKP.
32. Presidential Commission for the Study of Bioethical Issues. 2011. "Ethically impossible" STD research in Guatemala from 1946 to 1948. Washington, DC. http://www.bioethics. gov.
33. Remsberg, C. 1961. The convict and medical research. Kiwanis Mag 46:38-50.
34. Report of a Committee Appointed by Governor Dwight H. Green. 1948. Ethics governing the service of prisoners as subjects in medical experiments. JAMA 136:457-58.
35. Rothman, D. J. 1991. Strangers at the bedside. New York: Basic Books.
36. Sauerwein, R. W., M. Roestenberg, and V. S. Moorthy. 2011. Experimental human challenge infections can accelerate clinical malaria vaccine development. Nat Rev Immunol 11:57-64.
37. Shevell, M. I. 1998. Neurology's witness to history: Part II. Leo Alexander's contributions to the Nuremberg Code. Neurology 50:274-78.
38. Stewart, I. 1948. Organizing scientific research for war. Boston: Little, Brown.
39. Wertheimer, A., and F. G. Miller. 2008. Payment for research participation: A coercive offer? J Med Ethics 34:389-92.
40. Whorton, C. M., et al. 1947. The Chesson strain of plasmodium vivax malaria: III. Clinical aspects. J Infect Dis 80:237-49.