The p97-faf1 protein complex reveals a common mode of p97 adaptor binding

Journal of Biological Chemistry

Volumn 289, Issue 17, 2014, Pages 12077-12084

  Ewens, Caroline A ^a   Panico, Silvia ^a   Kloppsteck, Patrik ^a   McKeown, Ciaran ^a   Ebong, Ima Obong ^b   Robinson, Carol ^b   Zhang, Xiaodong ^a   Freemont, Paul S ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGY;

ADAPTOR PROTEINS; COMMON MODE; PROTEIN COMPLEXES;

PROTEINS;

ADAPTOR PROTEIN; FAS ASSOCIATED FACTOR 1; PROTEIN P97; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN QUATERNARY STRUCTURE; PROTEIN STABILITY; STOICHIOMETRY;

ATPASES; ELECTRON MICROSCOPY (EM); FAF1; FAS; ISOTHERMAL TITRATION CALORIMETRY; P97; PROTEIN CROSS-LINKING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOSINE TRIPHOSPHATASES; CALORIMETRY; CELL CYCLE PROTEINS; CRYOELECTRON MICROSCOPY; PROTEIN BINDING; ULTRACENTRIFUGATION;

EID: 84899450556     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.559591     Document Type: Article

References (31)

1. Meyer, H., Bug, M., and Bremer, S. (2012) Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system. Nat. Cell Biol. 14, 117-123
2. DeLaBarre, B., and Brunger, A. T. (2003) Complete structure of p97/valosin- containing protein reveals communication between nucleotide domains. Nat. Struct. Biol. 10, 856-863
3. Huyton, T., Pye, V. E., Briggs, L. C., Flynn, T. C., Beuron, F., Kondo, H., Ma, J., Zhang, X., and Freemont, P. S. (2003) The crystal structure of murine p97/VCP at 3.6A. J. Struct. Biol. 144, 337-348
4. Chapman, E., Fry, A. N., and Kang, M. (2011) The complexities of p97 function in health and disease. Mol. BioSyst. 7, 700-710
5. Hirsch, C., Gauss, R., Horn, S. C., Neuber, O., and Sommer, T. (2009) The ubiquitylation machinery of the endoplasmic reticulum. Nature 458, 453-460
6. Bug, M., and Meyer, H. (2012) Expanding into new markets - VCP/p97 in endocytosis and autophagy. J. Struct. Biol. 179, 78-82
7. Taylor, E. B., and Rutter, J. (2011) Mitochondrial quality control by the ubiquitin-proteasome system. Biochem. Soc. Trans. 39, 1509-1513
8. Kondo, H., Rabouille, C., Newman, R., Levine, T. P., Pappin, D., Freemont, P., and Warren, G. (1997) p47 is a cofactor for p97-mediated membrane fusion. Nature 388, 75-78 (Pubitemid 27283891)
9. Meerang, M., Ritz, D., Paliwal, S., Garajova, Z., Bosshard, M., Mailand, N., Janscak, P., Hübscher, U., Meyer, H., and Ramadan, K. (2011) The ubiquitin- selective segregase VCP/p97 orchestrates the response toDNAdouble- strand breaks. Nat. Cell Biol. 13, 1376-1382
10. Kloppsteck, P., Ewens, C. A., Förster, A., Zhang, X., and Freemont, P. S. (2012) Regulation of p97 in the ubiquitin-proteasome system by the UBX protein-family. Biochim. Biophys. Acta. 1823, 125-129
11. Schuberth, C., and Buchberger, A. (2008) UBX domain proteins: major regulators of the AAA ATPase Cdc48/p97. Cell Mol. Life Sci. CMLS. 65, 2360-2371
12. Chu, K., Niu, X., and Williams, L. T. (1995) A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis. Proc. Natl. Acad. Sci. U.S.A. 92, 11894-11898
13. Song, E. J., Yim, S. H., Kim, E., Kim, N. S., and Lee, K. J. (2005) Human Fas-associated factor 1, interacting with ubiquitinated proteins and valosin- containing protein, is involved in the ubiquitin-proteasome pathway. Mol. Cell Biol. 25, 2511-2524
14. Song, J., Park, J. K., Lee, J. J., Choi, Y. S., Ryu, K. S., Kim, J. H., Kim, E., Lee, K. J., Jeon, Y. H., and Kim, E. E. (2009) Structure and interaction of ubiquitin- associated domain of human Fas-associated factor 1. Protein Sci. 18, 2265-2276
15. Park, M. Y., Jang, H. D., Lee, S. Y., Lee, K. J., and Kim, E. (2004) Fasassociated factor-1 inhibits nuclear factor-kappaB (NF-kappaB) activity by interfering with nuclear translocation of the RelA (p65) subunit of NF-kappaB. J. Biol. Chem. 279, 2544-2549
16. Novack, D. V. (2011) Role of NF-κB in the skeleton. Cell Res. 21, 169-182
17. Dai, R. M., Chen, E., Longo, D. L., Gorbea, C. M., and Li, C. C. (1998) Involvement of valosin-containing protein, an ATPase Co-purified with IκBα and 26 S proteasome, in ubiquitin-proteasome-mediated degradation of IκBα. J. Biol. Chem. 273, 3562-3573
18. Menges, C. W., Altomare, D. A., and Testa, J. R. (2009) FAS-Associated factor 1 (FAF1): Diverse functions and implications for oncogenesis. Cell Cycle 8, 2528-2534
19. Hänzelmann, P., Buchberger, A., and Schindelin, H. (2011) Hierarchical binding of cofactors to the AAA ATPase p97. Structure 19, 833-843
20. Kim, K. H., Kang, W., Suh, S. W., and Yang, J. K. (2011) Crystal structure of FAF1 UBX domain in complex with p97/VCP N domain reveals a conformational change in the conserved FcisP touch-turn motif of UBX domain. Proteins 79, 2583-2587
21. Lee, J. J., Kim, Y. M., Jeong, J., Bae, D. S., and Lee, K. J. (2012) Ubiquitinassociated (UBA) domain in human Fas-associated factor 1 inhibits tumor formation by promoting Hsp70 degradation. PLoS One 7, e40361
22. Lee, J. J., Park, J. K., Jeong, J., Jeon, H., Yoon, J. B., Kim, E. E., and Lee, K. J. (2013) Complex of FAF1 with VCP-Npl4-Ufd1 and polyubiquitinated proteins promotes endoplasmic reticulum-associated degradation (ERAD). J. Biol. Chem. 288, 6998-7011
23. Jerabek-Willemsen, M., Wienken, C. J., Braun, D., Baaske, P., and Duhr, S. (2011) Molecular interaction studies using microscale thermophoresis. Assay Drug Dev. Technol. 9, 342-353
24. Schuck, P. (2000) Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. Biophys. J. 78, 1606-1619
25. Laue, T. M., Shah, B. D., Ridgeway, T. M., and Pelletier, S. L. (1992) in Analytical Ultracentrifugation in Biochemistry and Polymer Science (Harding, S., and Rowe, A., eds) pp. 90-125, Royal Society of Chemistry, Cambridge, UK
26. van Heel, M., Gowen, B., Matadeen, R., Orlova, E. V., Finn, R., Pape, T., Cohen, D., Stark, H., Schmidt, R., Schatz, M., and Patwardhan, A. (2000) Single-particle electron cryo-microscopy: towards atomic resolution. Q Rev. Biophys. 33, 307-369
27. Bebeacua, C., Förster, A., McKeown, C., Meyer, H. H., Zhang, X., Freemont, P. S. (2012) Distinct conformations of the protein complex p97- Ufd1-Npl4 revealed by electron cryomicroscopy. Proc. Natl. Acad. Sci. U.S.A. 109, 1098-1103
28. Dreveny, I., Kondo, H., Uchiyama, K., Shaw, A., Zhang, X., Freemont, P. S. (2004) Structural basis of the interaction between the AAA ATPase p97/ VCP and its adaptor protein p47. EMBO J. 23, 1030-1039 (Pubitemid 38436868)
29. Alexandru, G., Graumann, J., Smith, G. T., Kolawa, N. J., Fang, R., Deshaies, R. J. (2008) UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1α turnover. Cell 134, 804-816
30. Beuron, F., Dreveny, I., Yuan, X., Pye, V. E., McKeown, C., Briggs, L. C., Cliff, M. J., Kaneko, Y., Wallis, R., Isaacson, R. L., Ladbury, J. E., Matthews, S. J., Kondo, H., Zhang, X., and Freemont, P. S. (2006) Conformational changes in the AAA ATPase p97-p47 adaptor complex. EMBO J. 25, 1967-1976
31. Grant, T. (2007) Advances in Single Particle Electron Microscopy. PhD thesis, Imperial College London, London, UK