Synthesis, characterization, and anticancer studies of S and N alkyl piperazine-substituted positional isomers of 1,2,4-triazole derivatives

Medicinal Chemistry Research

Volumn 23, Issue 4, 2014, Pages 1661-1671

  Murty, M S R ^a   Ram, Kesur R ^a   Rao, B Ramalingeswara ^a   Rao, Rayudu Venkateswara ^a   Katiki, Mohana Rao ^a   Rao, Janapala Venkateswara ^a   Pamanji, R ^a   Velatooru, L R ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

3 Mercapto 1,2,4 triazoles; Acid hydrazides; Anticancer; Piperazines

Indexed keywords

1 3 [4 (3 CHLOROPHENYL)PIPERAZINO]PROPYL 3 (4 METHYLPHENYL) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 1 [3 (4 BENZYLPIPERAZINO)PROPYL] 3 (4 FLUOROPHENYL) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 1,2,4 TRIAZOLE DERIVATIVE; 3 (3,4 DIMETHOXYPHENYL) 1 (3 MORPHOLINOPROPYL) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 3 (3,4 DIMETHOXYPHENYL) 1 [3 (4 ETHYLPIPERAZINO)PROPYL] 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 3 (4 BENZYLPIPERAZINO)PROPYL[5 (4 FLUOROPHENYL) 4H 1,2,4 TRIAZOL 3 YL]SULFIDE; 3 (4 CHLOROPHENYL) 1 3 [4 (3 CHLOROPHENYL)PIPERAZINO]PROPYL 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE THIONE; 3 (4 ETHYLPIPERAZINO)PROPYL[5 (4 METHYLPHENYL) 4H 1,2,4 TRIAZOL 3 YL]SULFIDE; 3 [4 (3 CHLOROPHENYL)PIPERAZINO]PROPYL[5 (4 CHLOROPHENYL) 4H 1,2,4 TRIAZOL 3 YL]SULFIDE; 3 [4 (3 CHLOROPHENYL)PIPERAZINO]PROPYL[5 (4 METHYLPHENYL) 4H 1,2,4 TRIAZOL 3 YL]SULFIDE; 3 [4 (TERT BUTYL)PHENYL] 1 3 [4 (3CHLOROPHENYL)PIPERAZINO]PROPYL 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 3 [4 (TERT BUTYL)PHENYL] 1 [3 (4 PHENYLPIPERAZINO)PROPYL] 4,5 DIHYDRO 1H 1,2,4 TRAZOLE 5 THIONE; 5 (2 CHLOROPHENYL) 4H 1,2,4 TRIAZOL 3 YL 3 [4 (2 PYRIDYL)PIPERAZINO]PROPYL SULFIDE; 5 (2 CHLOROPHENYL) 4H 1,2,4 TRIAZOL 3 YL[3 (4 ETHYLPIPERAZINO)PROPYL]SULFIDE; 5 (3 CHLOROPHENYL) 4H 1,2,4 TRIAZOL 3 YL 3 [4 (2 PYRIMIDINYL)PIPERAZINO]PROPYL SULFIDE; 5 (3 METHYLPHENYL) 4H 1,2,4 TRIAZOL 3 YL 3 [4 (2 PYRIDYL)PIPERAZINO]PROPYL SULFIDE; 5 (3 METHYLPHENYL) 4H 1,2,4 TRIAZOL 3 YL[3 (4PHENYLPIPERAZINO)PROPYL]SULFIDE; 5 (4 CHLOROPHENYL) 4H 1,2,4 TRIAZOL 3 YL 3 [4 (2PYRIMIDINYL)PIPERAZINO]PROPYL SULFIDE; 5 BENZYL 4H 1,2,4 TRIAZOL 3 YL 3 [4 (2 PYRIDYL)PIPERAZINO]PROPYL SULFIDE; 5 [4 (TERT BUTYL)PHENYL] 4H 1,2,4 TRIAZOL 3 YL(3 MORPHOLINOPROPYL)SULFIDE; 5 [4 TERT BUTYL)PHENYL] 4H 1,2,4 TRIAZOL 3 YL[3 (4 PHENYLPIPERAZINO)PROPYL]SULFIDE; ANTINEOPLASTIC AGENT; ETOPOSIDE; PIPERAZINE DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CANCER CELL; CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; ISOMER;

EID: 84899429972     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-013-0757-3     Document Type: Article

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