Molecular modification of protein A to improve the elution pH and alkali resistance in affinity chromatography

Applied Biochemistry and Biotechnology

Volumn 172, Issue 8, 2014, Pages 4002-4012

  Xia, Hai Feng ^a   Liang, Zhen Dong ^a   Wang, Sha Li ^a   Wu, Pu Qiang ^a   Jin, Xiong Hua ^b  

^a JIANGNAN UNIVERSITY   (China)

^b Zhejiang Hisun Pharmaceutical Co Ltd   (China)

Author keywords

Affinity chromatography; Alkali resistance; Elution pH; Modification; Protein A; Z domain

Indexed keywords

AFFINITY CHROMATOGRAPHY; ALKALINITY; AMINO ACIDS; ANTIBODIES; BACTERIA; PURIFICATION;

ALKALI RESISTANCE; ELUTION PH; MODIFICATION; PROTEIN A; Z-DOMAIN;

RECOMBINANT PROTEINS;

ALKALI; IMMUNOGLOBULIN G; STAPHYLOCOCCUS PROTEIN A;

ADSORPTION; AFFINITY CHROMATOGRAPHY; AMINO ACID SEQUENCE; ANIMAL; BOVINAE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; ISOLATION AND PURIFICATION; MOLECULAR GENETICS; MUTATION; PH; PROCEDURES; PROTEIN ENGINEERING; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE;

ADSORPTION; ALKALIES; AMINO ACID SEQUENCE; ANIMALS; CATTLE; CHROMATOGRAPHY, AFFINITY; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN G; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN ENGINEERING; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; STAPHYLOCOCCAL PROTEIN A;

EID: 84899421505     PISSN: 02732289     EISSN: 15590291     Source Type: Journal    
DOI: 10.1007/s12010-014-0818-1     Document Type: Article

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